Articles tagged with Insulin
Scientists at Northwestern University have successfully transplanted rat islets into mice, producing insulin for over 300 days without immunosuppressive drugs. This breakthrough method uses a unique approach to control rejection and has significant implications for future interspecies transplants.
A new study by Cincinnati Children's Hospital Medical Center and the University of California Davis has made a significant discovery about insulin's role in lactation. Insulin plays a crucial role in regulating the production of breast milk, particularly for mothers with sub-optimal glucose metabolism.
A new study found that ethnic differences significantly impact insulin response, with East Asians showing improved insulin sensitivity but poorer insulin release. Healthy individuals of all ethnicities maintained normal glucose levels but did so differently, with some groups releasing more or less insulin in response to changes.
Researchers at UC Irvine are working on two groundbreaking projects to treat Type 1 diabetes: islet cell transplantation using ultrapure algae membranes and the development of an accurate insulin sensor for real-time blood sugar monitoring. These innovations aim to improve treatment options and potentially cure the disease.
A clinical trial of a DNA vaccine has delivered promising results, suggesting that it may selectively counter the immune response that causes Type 1 diabetes. The vaccine reduced levels of immune cells believed responsible for the disease and maintained insulin production levels in patients.
Patients with Type 2 diabetes who start on three medications at diagnosis have better glucose control with lower hemoglobin A1c levels and fewer hypoglycemic events compared to conventional therapy. The triple-therapy regimen also promotes weight loss and preserves beta cell function.
The predictive Hypoglycemia-Hyperglycemia Minimizer (HHM) System demonstrated that it can maintain safe glucose levels overnight, with participants spending over 90% of the time within a target range. The system showed encouraging performance in controlling blood glucose values during the critical nighttime period.
Dr. Graeme Bell has been awarded the 2013 Banting Medal for his pioneering work in understanding the role of genetics in diagnosing and treating diabetes. His research focuses on the biology of insulin-secreting pancreatic beta-cells and the use of genetics to personalize treatment.
A meta-analysis study found that insulin degludec has a similar or reduced risk of recurrent hypoglycemia compared to insulin glargine. The study, involving nearly 3,400 adults with type 2 diabetes, suggests that insulin degludec may offer benefits in reducing the major side effect of insulin therapy.
A study by LA BioMed found that men who get more sleep on the weekend can improve their insulin sensitivity, reducing their risk of developing type 2 diabetes. The research, conducted over six months, involved 19 non-diabetic men who slept an average of 6.2 hours per night during the week and caught up on sleep on weekends.
A new study has found that skipping breakfast can lead to acute insulin resistance in overweight women, a condition that increases the risk of developing type 2 diabetes. After just one day of skipping breakfast, insulin levels were significantly higher and glucose levels more elevated than after eating breakfast.
A clinical study found that insulin resistance is associated with weakened bones and a higher risk of bone fractures. The study, presented at The Endocrine Society's annual meeting, showed that bone strength decreased by 10-14% for every doubling of insulin resistance.
Researchers are testing whether a drug called aldesleukin can reduce the number of insulin injections needed for type 1 diabetes patients. The trial aims to slow disease progression and give patients more control over their condition.
Researchers at the University of Missouri School of Medicine have discovered a potential cure for Type 1 diabetes by combining adult stem cells with a new drug. The discovery reveals that blood vessels are essential for insulin production and repairing them can help restore insulin-making cells.
Researchers found that sucralose increased insulin and blood sugar levels in severely obese people without diabetes. This study suggests that artificial sweeteners may have more significant effects on metabolism than previously thought.
The American College of Physicians recommends targeting a blood glucose level of 140-200 mg/dL for surgical and medical intensive care unit patients when using intensive insulin therapy. The guidelines aim to balance the benefits and harms of hyperglycemia management in hospitalized patients.
Australian scientists mapped insulin action in cells with precise detail, providing a comprehensive blueprint for understanding diabetes. The breakthrough study catalogued 37,248 phosphorylation sites on 5,705 proteins, revealing 15% that changed in response to insulin.
Researchers developed an injectable nanogel that can monitor blood-sugar levels and secrete insulin in response, offering a potential solution to Type 1 diabetes. The system consists of nanoparticles with enzyme-loaded dextran spheres that release insulin when glucose levels are high.
Researchers developed a biomaterial that successfully engrafted insulin-producing cells into diabetic mice, reversing symptoms in just 10 days. The material promotes blood vessel formation and allows cells to survive and function within the body.
A team of researchers has developed an innovative injectable nano-network that can effectively control blood sugar levels in diabetics by releasing insulin when needed, maintaining normal levels for over a week. The technology has the potential to improve the health and quality of life of diabetes patients.
Researchers at Harvard University have discovered a hormone called betatrophin that increases insulin-secreting pancreatic beta cells by up to 30 times the normal rate. This could lead to a more natural regulation of insulin and reduced complications associated with diabetes.
A team of researchers from the University of Copenhagen has discovered that PICK1 protein plays a crucial role in regulating hormones such as insulin and growth hormone. This finding has significant implications for understanding diabetes and poor growth, and may lead to better prevention and treatment in the future.
Researchers at Johns Hopkins Children's Center found that a previously minor protein called EPAC2 plays a central role in regulating insulin production. The study suggests that targeting EPAC2 with drugs could potentially restore pancreatic cell function and reverse Type 2 diabetes.
A new study by Joslin researchers found that dietary fat can impact glucose levels and insulin dosing for people with type 1 diabetes. The study's findings have significant implications for managing the condition, highlighting the need to consider both carbohydrates and fats in insulin calculations.
Researchers found high activity levels of miR-93 in fat cells of women with PCOS and insulin resistance, contributing to glucose impairment. This study provides a new molecular mechanism for PCOS and insulin resistance, pointing towards targeted therapies.
Researchers led by Dr. Michael A. Weiss are developing a rapid-acting, glucose-responsive insulin that can reduce the risk of hypoglycemia in diabetes patients. The new form of insulin will be designed to detect high or low glucose levels and release only as needed.
Research shows PCOS affects both insulin and non-insulin approaches to glucose control, with declines in non-insulin activity seen in women with high insulin resistance. The study found visceral fat predicted difficulty controlling glucose via insulin, while subcutaneous fat was linked to regulation by non-insulin means.
A second-phase human clinical trial showed the predictive glucose control system can reduce insulin delivery in advance of hypoglycemia and trigger timely warnings. The system demonstrated promising results, keeping glucose levels at an average of 133 mg/dL for the entire cohort.
Harvard researchers show that insulin-like peptides play a crucial role in regulating learning and memory by fine-tuning neuronal activity. The study reveals a bidirectional regulation of learning, with some peptides inhibiting learning while others facilitate it.
A new class of diabetes drugs has been linked to a doubling of the risk of pancreatitis in people taking them. Researchers found that patients who took glucagon-like peptide-1-based therapies were twice as likely to be hospitalized with acute pancreatitis as those on other medications.
Research at Vanderbilt University reveals a direct link between the body's circadian rhythm and insulin activity, which controls metabolism. The study found that disruption in the circadian clock can lead to increased risk of obesity, diabetes, and heart disease.
Researchers found that insulin action follows a 24-hour circadian rhythm, with mice becoming insulin-resistant during the day. Mice unable to keep the time of day get stuck in an obesity-prone mode.
Researchers discovered a paradoxical relationship between diminished mitochondrial function and increased insulin sensitivity in mice. The study found that mice with mitochondrial mutations lived longer and had reduced body fat due to increased fat utilization.
Researchers developed an artificial pancreas that simulates normal pancreatic function by adapting insulin delivery based on changes in glucose levels. The system showed a 15% improvement in glucose control and significantly reduced the risk of hypoglycemia compared to conventional insulin pump therapy.
Researchers found a significant decrease in carotid intima-media thickness one year after islet transplant, indicating slower atherosclerosis progression. Patients achieved insulin independence and showed improved glycemic control.
New research reveals insulin's role in reducing desire for food after eating, impacting environmental triggers of overeating. The study found that insulin affects the ventral tegmental area, a region linked to reward-seeking behavior and addictive behaviors.
A team of researchers from Case Western Reserve University School of Medicine has discovered the definitive answer to how insulin binds to cells. This breakthrough could lead to dramatic improvements in treating diabetes, including alternative oral medications and fewer injections per day.
Researchers have captured the intricate mechanism of insulin binding to cells, a crucial step in glucose uptake. This breakthrough could lead to novel insulins with improved properties, such as longer activity and reduced degradation.
Researchers found that combining insulin and an EGF inhibitor preserved vascular integrity in diabetic mice, limiting vision damage from diabetic macular edema. The study suggests a potential therapeutic combination to prevent DME in people with diabetes.
A study found that pregnant women who follow a Western diet, high in saturated fats but low in carbohydrates, increase the risk of their child being born with a diabetogenic profile. The researchers emphasize the importance of a balanced Mediterranean diet during pregnancy to avoid this risk.
A new mouse study challenges the widely held view that obesity is caused by high insulin levels. Instead, it suggests that chronically low insulin levels can help prevent weight gain on a high-fat diet. The research provides direct evidence in mammals that circulating insulin drives obesity.
Researchers at Karolinska Institutet have discovered that glucagon stimulates its own synthesis, activating a self-reinforcing cycle of hormone production. This finding has significant implications for understanding the regulation of hormone secretion and may hold the key to studying defects in diabetes.
Scientists have identified stem cells in the adult pancreas that can be turned into insulin-producing cells, offering a potential cure for type 1 diabetes. This breakthrough discovery provides further evidence of the existence of stem cells beyond embryos and may lead to new treatments for the condition.
A study from Boston University School of Medicine found that achieving SCIP benchmarks for glycemic control may not be relevant among patients undergoing CABG surgery who receive perioperative continuous insulin infusions. These patients had excellent glycemic control, despite being outliers in the SCIP guidelines.
Research highlights the potential impact of airport security scanners on diabetes devices, including insulin pumps and continuous glucose monitoring systems. The Editorial calls for more research to understand and potentially repair this issue affecting hundreds of thousands of people worldwide who use insulin pump therapy.
A new systematic review and meta-analysis suggests that intermediate glucose control is associated with better outcomes in neurocritical care patients, including reduced mortality and improved recovery. This challenges the conventional approach of tight glycemic control, which may lead to more neurological damage.
Overeating can cause a malfunction in brain insulin signaling, leading to increased fatty acid levels, inflammation, and worsened insulin resistance. The study suggests that the brain's response plays a crucial role in developing type 2 diabetes, making it a potential target for improving insulin function.
Researchers at the University of Chicago Medical Center discovered that not getting enough sleep has a harmful impact on fat cells, reducing their ability to respond to insulin. This finding suggests that sleep plays a crucial role in energy metabolism, comparable to its role in brain function.
Researchers develop novel mathematical models for injection of insulin in type 1 and type 2 diabetes, simulating injections of insulin in the manner of insulin pumps. The models simulate open-loop and closed-loop systems, achieving real-time feedback between glucose levels and insulin delivery.
A new study suggests that oral insulin may prevent or delay the onset of type 1 diabetes among individuals with autoantibodies against insulin. The study found that participants who took oral insulin had a delayed development of type 1 diabetes compared to those who took placebo capsules. The delaying effect was attributed to the immun...
Cystic fibrosis causes two abnormalities in the pancreas that affect insulin production, leading to diabetes. The study also found that CF can disrupt insulin regulation as early as birth, with defects in chloride channel protein potentially contributing to the problem.
Wolfram syndrome is a rare disorder that causes diabetes, hearing and vision loss, nerve cell damage, and early death. Researchers have identified a mechanism related to mutations in the WFS1 gene that affects insulin-secreting beta cells, which could lead to new treatment targets for the disease.
Researchers develop a human liver-chimeric mouse model to study malaria parasites and understand human host/parasite interactions. Additionally, studies reveal the link between serum ferritin levels and insulin sensitivity, as well as the role of granulocyte-colony stimulating factor in protecting against influenza infection.
Researchers found that A-kinase anchoring proteins (AKAPs) regulate glucose levels by coordinating phosphatases in cells. Mice lacking AKAP150 produced less insulin but coped better with limited hormone due to increased sensitivity in target tissues.
Researchers at Mayo Clinic found that patients without a pancreas can control their blood sugar levels as effectively as type 1 diabetes patients using insulin replacement. The study's findings suggest that removing the entire pancreas is reasonably safe and effective for diabetes management.
The ORIGIN-GRACE study found that insulin glargine significantly reduced secondary outcomes of atherosclerosis progression, but had no effect on primary outcomes. Omega-3 fatty acid supplements also showed no significant effect on either outcome.
Researchers have identified 38 new genetic regions linked to glucose and insulin levels, expanding the total number of associated genetic regions to 53. The study used a powerful technology to analyze DNA sequence variations for multiple traits at once.
Professor Michael Zemel's NuShape supplement increases fat oxidation by up to 300 calories a day, with participants maintaining 60-70% of initial weight loss over six months. NuControl promotes healthy blood sugar levels by converging on the same metabolic pathway as resveratrol.
A UCSF study reveals TXNIP's role in amplifying stress in the earliest stages of diabetes, leading to pancreatic cell death and insulin production loss. The molecule is central to the inflammatory process, making it a promising new drug target for preventing or stalling diabetes.
Researchers at UNIGE have developed a new model to study the protein Cx36, which plays a crucial role in insulin production. By analyzing 1040 molecules, they aim to identify those that stimulate or inhibit insulin production, paving the way for new pharmacological treatment strategies for type 2 diabetes.