Articles tagged with Insulin
A new study by Joslin researchers found that dietary fat can impact glucose levels and insulin dosing for people with type 1 diabetes. The study's findings have significant implications for managing the condition, highlighting the need to consider both carbohydrates and fats in insulin calculations.
Researchers found high activity levels of miR-93 in fat cells of women with PCOS and insulin resistance, contributing to glucose impairment. This study provides a new molecular mechanism for PCOS and insulin resistance, pointing towards targeted therapies.
Researchers led by Dr. Michael A. Weiss are developing a rapid-acting, glucose-responsive insulin that can reduce the risk of hypoglycemia in diabetes patients. The new form of insulin will be designed to detect high or low glucose levels and release only as needed.
Research shows PCOS affects both insulin and non-insulin approaches to glucose control, with declines in non-insulin activity seen in women with high insulin resistance. The study found visceral fat predicted difficulty controlling glucose via insulin, while subcutaneous fat was linked to regulation by non-insulin means.
A second-phase human clinical trial showed the predictive glucose control system can reduce insulin delivery in advance of hypoglycemia and trigger timely warnings. The system demonstrated promising results, keeping glucose levels at an average of 133 mg/dL for the entire cohort.
Harvard researchers show that insulin-like peptides play a crucial role in regulating learning and memory by fine-tuning neuronal activity. The study reveals a bidirectional regulation of learning, with some peptides inhibiting learning while others facilitate it.
A new class of diabetes drugs has been linked to a doubling of the risk of pancreatitis in people taking them. Researchers found that patients who took glucagon-like peptide-1-based therapies were twice as likely to be hospitalized with acute pancreatitis as those on other medications.
Researchers found that insulin action follows a 24-hour circadian rhythm, with mice becoming insulin-resistant during the day. Mice unable to keep the time of day get stuck in an obesity-prone mode.
Research at Vanderbilt University reveals a direct link between the body's circadian rhythm and insulin activity, which controls metabolism. The study found that disruption in the circadian clock can lead to increased risk of obesity, diabetes, and heart disease.
New research reveals insulin's role in reducing desire for food after eating, impacting environmental triggers of overeating. The study found that insulin affects the ventral tegmental area, a region linked to reward-seeking behavior and addictive behaviors.
Researchers discovered a paradoxical relationship between diminished mitochondrial function and increased insulin sensitivity in mice. The study found that mice with mitochondrial mutations lived longer and had reduced body fat due to increased fat utilization.
Researchers developed an artificial pancreas that simulates normal pancreatic function by adapting insulin delivery based on changes in glucose levels. The system showed a 15% improvement in glucose control and significantly reduced the risk of hypoglycemia compared to conventional insulin pump therapy.
Researchers found a significant decrease in carotid intima-media thickness one year after islet transplant, indicating slower atherosclerosis progression. Patients achieved insulin independence and showed improved glycemic control.
Researchers have captured the intricate mechanism of insulin binding to cells, a crucial step in glucose uptake. This breakthrough could lead to novel insulins with improved properties, such as longer activity and reduced degradation.
A team of researchers from Case Western Reserve University School of Medicine has discovered the definitive answer to how insulin binds to cells. This breakthrough could lead to dramatic improvements in treating diabetes, including alternative oral medications and fewer injections per day.
Researchers found that combining insulin and an EGF inhibitor preserved vascular integrity in diabetic mice, limiting vision damage from diabetic macular edema. The study suggests a potential therapeutic combination to prevent DME in people with diabetes.
A study found that pregnant women who follow a Western diet, high in saturated fats but low in carbohydrates, increase the risk of their child being born with a diabetogenic profile. The researchers emphasize the importance of a balanced Mediterranean diet during pregnancy to avoid this risk.
A new mouse study challenges the widely held view that obesity is caused by high insulin levels. Instead, it suggests that chronically low insulin levels can help prevent weight gain on a high-fat diet. The research provides direct evidence in mammals that circulating insulin drives obesity.
Researchers at Karolinska Institutet have discovered that glucagon stimulates its own synthesis, activating a self-reinforcing cycle of hormone production. This finding has significant implications for understanding the regulation of hormone secretion and may hold the key to studying defects in diabetes.
Scientists have identified stem cells in the adult pancreas that can be turned into insulin-producing cells, offering a potential cure for type 1 diabetes. This breakthrough discovery provides further evidence of the existence of stem cells beyond embryos and may lead to new treatments for the condition.
A study from Boston University School of Medicine found that achieving SCIP benchmarks for glycemic control may not be relevant among patients undergoing CABG surgery who receive perioperative continuous insulin infusions. These patients had excellent glycemic control, despite being outliers in the SCIP guidelines.
Research highlights the potential impact of airport security scanners on diabetes devices, including insulin pumps and continuous glucose monitoring systems. The Editorial calls for more research to understand and potentially repair this issue affecting hundreds of thousands of people worldwide who use insulin pump therapy.
A new systematic review and meta-analysis suggests that intermediate glucose control is associated with better outcomes in neurocritical care patients, including reduced mortality and improved recovery. This challenges the conventional approach of tight glycemic control, which may lead to more neurological damage.
Overeating can cause a malfunction in brain insulin signaling, leading to increased fatty acid levels, inflammation, and worsened insulin resistance. The study suggests that the brain's response plays a crucial role in developing type 2 diabetes, making it a potential target for improving insulin function.
Researchers at the University of Chicago Medical Center discovered that not getting enough sleep has a harmful impact on fat cells, reducing their ability to respond to insulin. This finding suggests that sleep plays a crucial role in energy metabolism, comparable to its role in brain function.
Researchers develop novel mathematical models for injection of insulin in type 1 and type 2 diabetes, simulating injections of insulin in the manner of insulin pumps. The models simulate open-loop and closed-loop systems, achieving real-time feedback between glucose levels and insulin delivery.
A new study suggests that oral insulin may prevent or delay the onset of type 1 diabetes among individuals with autoantibodies against insulin. The study found that participants who took oral insulin had a delayed development of type 1 diabetes compared to those who took placebo capsules. The delaying effect was attributed to the immun...
Cystic fibrosis causes two abnormalities in the pancreas that affect insulin production, leading to diabetes. The study also found that CF can disrupt insulin regulation as early as birth, with defects in chloride channel protein potentially contributing to the problem.
Wolfram syndrome is a rare disorder that causes diabetes, hearing and vision loss, nerve cell damage, and early death. Researchers have identified a mechanism related to mutations in the WFS1 gene that affects insulin-secreting beta cells, which could lead to new treatment targets for the disease.
Researchers develop a human liver-chimeric mouse model to study malaria parasites and understand human host/parasite interactions. Additionally, studies reveal the link between serum ferritin levels and insulin sensitivity, as well as the role of granulocyte-colony stimulating factor in protecting against influenza infection.
Researchers found that A-kinase anchoring proteins (AKAPs) regulate glucose levels by coordinating phosphatases in cells. Mice lacking AKAP150 produced less insulin but coped better with limited hormone due to increased sensitivity in target tissues.
Researchers at Mayo Clinic found that patients without a pancreas can control their blood sugar levels as effectively as type 1 diabetes patients using insulin replacement. The study's findings suggest that removing the entire pancreas is reasonably safe and effective for diabetes management.
The ORIGIN-GRACE study found that insulin glargine significantly reduced secondary outcomes of atherosclerosis progression, but had no effect on primary outcomes. Omega-3 fatty acid supplements also showed no significant effect on either outcome.
Researchers have identified 38 new genetic regions linked to glucose and insulin levels, expanding the total number of associated genetic regions to 53. The study used a powerful technology to analyze DNA sequence variations for multiple traits at once.
Professor Michael Zemel's NuShape supplement increases fat oxidation by up to 300 calories a day, with participants maintaining 60-70% of initial weight loss over six months. NuControl promotes healthy blood sugar levels by converging on the same metabolic pathway as resveratrol.
A UCSF study reveals TXNIP's role in amplifying stress in the earliest stages of diabetes, leading to pancreatic cell death and insulin production loss. The molecule is central to the inflammatory process, making it a promising new drug target for preventing or stalling diabetes.
Researchers at UNIGE have developed a new model to study the protein Cx36, which plays a crucial role in insulin production. By analyzing 1040 molecules, they aim to identify those that stimulate or inhibit insulin production, paving the way for new pharmacological treatment strategies for type 2 diabetes.
Elk and rhinoceros beetles use insulin to grow big horns and attract mates. A study by Michigan State University found that these traits are not handicaps, but rather honest indicators of quality. The research suggests that the males' insulin dependence provides a way for them to show off their strength and suitability as partners.
A UCSF study found that women with diabetes are more likely to report low overall sexual satisfaction compared to non-diabetic women. Insulin-treated diabetic women were at higher risk for lubrication and orgasm complications, while end-organ complications such as heart disease and peripheral neuropathy also impacted sexual function.
A new study published in Diabetologia found that overexpressing the c-Kit receptor increases insulin production and counteracts early diabetic effects of high-fat diets. This breakthrough research provides a promising lead for developing strategies to preserve and restore function to beta cells.
The American College of Physicians developed a free curriculum to train internal medicine residents in identifying and eliminating wasteful treatment options. The high-value, cost-conscious care curriculum focuses on patient cases requiring careful analysis of benefits, harms, costs, and evidence-based decision making.
Researchers found that continuous glucose monitoring devices and insulin pumps improve blood sugar levels and reduce time spent with high levels in patients with type 1 diabetes. These new technologies offer a more convenient alternative to traditional methods, but adherence is key to effectiveness.
Researchers at Duke University Medical Center have found a hormone that stimulates insulin secretion from islet cells and protects them against toxic factors. This discovery could lead to new prevention and treatment options for type 1 and type 2 diabetes.
A UT Southwestern study found that early intensive treatment of type 2 diabetes slows down the progression of the disease by preserving the body's insulin-producing capacity. The intensive treatment regimen was shown to be effective in maintaining steady insulin-producing beta-cell function for three and a half years after diagnosis.
Researchers at UBC successfully reversed diabetes in mice using stem cells, restoring insulin production and reversing the disease. The study re-created the 'feedback loop' that enables insulin levels to automatically rise or fall based on blood glucose levels.
A new study has found that insulin degludec, a long-lasting insulin, reduces the risk of nighttime low blood sugar in elderly diabetic adults compared to insulin glargine. The meta-analysis of phase 3 clinical trials shows that insulin degludec lowers major side effects like hypoglycemia in these patients.
A new study found that adding liraglutide to insulin therapy improves blood sugar control in obese adults with poorly controlled Type 1 diabetes. Patients also experienced significant weight loss and lower blood pressure.
Researchers found that sitagliptin improves the severity of reactive hypoglycemia by enhancing insulin secretion during meals. This study suggests a novel approach to treating this condition, currently with no medical therapy.
A new study found that an experimental insulin drug, degludec, prevented low blood sugar among diabetic patients more frequently than a popular drug, glargine. Degludec caused 14% fewer low blood sugar incidents overall and 37% less at night compared to glargine.
A 9-year study by UCSF researchers found that preventing or better managing diabetes can help prevent cognitive decline. The study linked the severity of diabetes to increased risk of cognitive decline and showed that patients with uncontrolled blood sugar levels suffered faster declines.
A systematic review found that aggressive blood sugar control can prevent diabetic neuropathy, a disabling condition affecting nerves in the feet and legs. However, the review suggests that optimal target levels for glucose control need to be established to balance benefits and side effects.
Researchers at Oregon Health & Science University and Legacy Health have discovered a method to stabilize liquid glucagon, enabling its use in standard diabetes pumps. This breakthrough could lead to future-generation artificial pancreas systems that dispense both insulin and glucagon for optimal glucose control.
A study of over 12,500 people in 40 countries found that long-term insulin use does not increase the risk of heart disease or cancer. Participants who received daily basal insulin injections had a lower chance of developing type 2 diabetes even after treatment stopped.
In a pilot study, patients with type 2 diabetes who used Almased, a protein-rich meal replacement, lost weight and gained better blood sugar control. After 12 weeks, average insulin doses decreased from 147 to 65 units per day and HbA1c levels dropped by 7.7%.
The Hypoglycemia-Hyperglycemia Minimizer (HHM) System successfully detects blood glucose highs and lows, automatically adjusting insulin delivery to safely manage type 1 diabetes. The study's findings lay the groundwork for further clinical trials and a potential game-changer for millions living with the condition.
Scientists at the Toronto General Hospital Research Institute showed that an experimental bariatric surgery can lower blood sugar levels in non-obese rats with type 1 diabetes. The study demonstrated that duodenal-jejunal bypass surgery activates novel nutrient-sensing signals in the jejunum, rapidly lowering blood sugar levels.
A new UCLA study reveals that a high-fructose diet can slow the brain and impair memory and learning. However, adding omega-3 fatty acids to the diet may help minimize this damage.
A clinical study demonstrates the effectiveness of an automated insulin dosage titration system in improving blood glucose control and reducing hypoglycemic events. The system, developed by Hygieia, Inc., automatically updates insulin dosage for patients with type 2 or type 1 diabetes, leading to improved glycemic targets.
A recent study has found that achieving Surgical Care Improvement Project (SCIP) benchmarks for glycemic control among patients undergoing coronary artery bypass graft (CABG) surgery may be irrelevant when perioperative continuous insulin infusion protocols are implemented. The researchers discovered that 6.6% of patients who received ...
A new study aims to determine whether intravenous insulin delivery is more effective than standard shots in improving stroke outcomes. Researchers hope to find ways to lower high blood glucose levels quickly and safely after a stroke, which can worsen brain damage.