Articles tagged with Insulin
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Researchers at Wayne State University are developing a new material formulation to resist foreign body reactions in implantable devices, such as insulin infusion pumps. This project aims to improve the long-term use of these devices by reducing the need for replacements.
New research from the University of Otago suggests that walking after meals can significantly lower blood sugar levels in people with type 2 diabetes. The study found that post-meal physical activity can reduce blood sugar levels by up to 22% compared to taking a single 30-minute walk at any time of the day.
Researchers have found that impaired insulin metabolism affects neighboring cells involved in wound healing, leading to slow and incomplete healing. This discovery opens up new possibilities for treating wounds in diabetics, with local treatment targeting insulin metabolism.
Aerobic exercise improves glycemic control and reduces insulin requirements in T1D patients. The study found that physically active patients had more responsible behavior in monitoring their glucose levels, suggesting an educational program addressing diet, insulin injecting monitoring, and exercise could be highly advantageous.
Researchers at the University of Cambridge have developed a new treatment for type 1 diabetes that targets the immune system's damage, aiming to reduce or eliminate daily insulin injections. The treatment uses aldesleukin, a drug that enhances regulatory T cells to prevent autoimmunity.
Clemson University scientists are using high-tech computer modeling and experimental validation techniques to understand the molecular causes of adult-onset diabetes. They aim to develop new therapeutic approaches by studying peptide protein co-secreted with insulin in the pancreas.
Scientists found that an insulin molecule produced by cone snails may improve upon fast-acting therapeutic insulin, potentially starting to work in as little as five minutes. The study suggests studying complex venom cocktails can lead to new drug discoveries.
Scientists at Joslin Diabetes Center have identified a new molecular pathway that may offer targets for drugs to strengthen angiogenesis and improve blood vessel growth in type 2 diabetes. The study found that CITED2 expression is increased in endothelial cells from patients with diabetes, suggesting its potential as a therapeutic target.
Researchers have developed a new technology called Cholestosomes that can encapsulate insulin and deliver it orally without degrading. The vesicles are made of naturally occurring lipid molecules and can pass through the stomach intact, allowing for high bioavailability and effective insulin delivery.
A recent study challenges the concept of 'healthy obesity,' revealing nearly identical gene expression changes in obese individuals with varying levels of insulin sensitivity. The research suggests that vigorous health interventions may be necessary for all obese individuals, regardless of their metabolic health status.
Women with polycystic ovary syndrome (PCOS) may benefit from incorporating soy isoflavones into their diets, according to a new study. The study found that consuming soy isoflavones regularly can lower levels of insulin in the blood and improve metabolic health.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that a combination of three medications—dapagliflozin, liraglutide, and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight. The therapy also showed impressive improvements in blood glucose management.
A new systematic review found that gliclazide confers the lowest risk of hypoglycemia when added to metformin. This suggests prescribing a medication with a lower risk of low blood sugar may be a rational and affordable alternative for patients with type 2 diabetes.
Researchers have discovered at least four separate subtypes of human insulin-producing beta cells, which could lead to a better understanding of the disease process and the development of new treatments for type 2 diabetes. The study found that these cell subtypes produce different amounts of insulin and may regenerate at varying rates.
Researchers at UT Southwestern Medical Center have identified a key regulatory mechanism of insulin signaling, linking it to the timing of cell division. Three spindle checkpoint proteins, crucial for accurate cell division, also regulate metabolism through their impact on insulin receptors.
The artificial pancreas, a device monitoring blood glucose levels and automatically adjusting insulin doses, is nearing availability. Clinical trials have shown effective glucose control with reduced risk of hypoglycaemia, but challenges remain in addressing speed of action and cybersecurity concerns.
A study found that a cellular sorting protein called SORLA disrupts fat metabolism by recycling molecular receptors for insulin. This causes fat cells to become overly sensitive to insulin, leading to excessive fat deposits and obesity. The researchers discovered this link in human samples, mouse models, and cell cultures.
A study by University of Illinois researchers suggests that protein S supplementation can inhibit beta-cell death and improve blood glucose levels, insulin sensitivity, and kidney damage in mice with type 1 and type 2 diabetes. The findings offer a potential new approach to treating the disease.
Researchers compare model predictive control (MPC) and proportional integral derivative (PID) algorithms for an artificial pancreas. MPC outperformed PID in regulating glucose levels, with the former keeping participants within safe range 74% of the time.
A new study shows that the innovative OnTouch Via patch enabled over 50% of diabetes patients to report improved insulin dose compliance. The wearable patch allows for discreet delivery of rapid-acting insulin at mealtimes, reducing stress and anxiety associated with dosing.
A Yale-led team of researchers identified how altered gut microbiota causes obesity by stimulating insulin secretion through acetate production. The study suggests a causal link between changes in the diet, gut microbiota, and increased food intake, driving a positive feedback loop.
Researchers found that an automated insulin feedback controller improved glucose control and reduced episodes of nocturnal hypoglycemia in children with type 1 diabetes at a diabetes camp. The study's results are promising, particularly for the challenging environment of a diabetes camp.
POSTECH researchers found sensory neurons modulate aging hormone activity through food smells and tastes, shortening lifespan. Insulin-6 produced by sensory neurons alters FOXO protein action, leading to reduced aging effects.
A commentary published in Diabetes Technology & Therapeutics suggests that insulin pump therapy can lead to better blood glucose control and may be beneficial for all patients with type 1 diabetes. The author highlights the importance of pump technology, including sensor-controlled feedback and artificial pancreas systems.
A study published in Cell Metabolism found that a genetic variant of the melatonin receptor gene, MTNR1B, may predispose individuals to type 2 diabetes by increasing sensitivity to insulin-inhibiting effects of melatonin. This increased sensitivity can lead to lower insulin secretion and higher blood sugar levels.
A new study by Cardiff University found that combining insulin with metformin reduces mortality and heart attacks in people with type 2 diabetes. The researchers tracked 12,020 patients for three and a half years on average, finding no difference in cancer risk between single-insulin therapy and combination treatment.
A clinical trial found that islet transplants effectively prevented severe hypoglycemic events and restored awareness in patients with Type 1 diabetes. The study also demonstrated excellent glycemic control, with nearly 88% of subjects remaining free from severe hypoglycemia at one year.
Researchers identified a new hormone, asprosin, generated by fat, which instructs the liver to release glucose into the blood stream. This discovery could lead to a new treatment for type 2 diabetes through immunologic sequestration.
Scientists have discovered a nuclear receptor protein, estrogen-related receptor γ (ERRγ), that enables the maturation of human beta cells in vitro. This breakthrough overcomes a major challenge in diabetes research and holds promise for creating functional insulin-producing cells at will.
Salk researchers have found a hidden energy switch that powers up pancreatic cells to respond to glucose, enabling the production of functional human beta cells. The breakthrough could lead to a viable treatment for type 1 and 2 diabetes.
The cost of insulin more than tripled from $231 to $736 per year between 2002 and 2013, while other diabetes drugs saw a decrease. The study suggests looking again at non-insulin therapies due to the high cost-effectiveness gap.
A study found that the prevalence of treated diabetes increased from 5.2% to 7.7% in the US, while estimated spending for insulin per patient rose from $231 to $736 between 2002 and 2013. Insulin prices skyrocketed, with average prices increasing by 197% over the same period.
Researchers have discovered a new potential therapy that can protect transplanted human pancreatic islets from dying. The study suggests that pretreating cells with a peptide hormone called cholecystokinin (CCK) may enhance the curative potential of islet transplant for Type 1 diabetes.
A recent study by University of Montreal researchers has discovered a common genetic defect in beta cells that may lead to the loss of insulin production in both type 1 and type 2 diabetics. The findings suggest that genetics play a critical role in beta cell survival, with fragile cells being more prone to damage and disease.
A new study discovered that a common genetic defect in beta cells may underlie both form of diabetes. The research found that genetics is critical for the survival of beta cells, and a genetic predisposition for fragile beta cells may lead to diabetes development.
Researchers at IBS created a wearable GP-based patch that allows accurate diabetes monitoring and feedback therapy using human sweat. The device enables systematic corrections of sweat glucose measurements by monitoring pH and temperature, reducing the need for painful treatments like insulin shots.
Patients with maturity-onset diabetes of the young (MODY1) benefit from therapies targeting a specific pathway regulating insulin secretion, not oral medications linked to beta-cell destruction. Research suggests MODY1 patients may become dependent on insulin injections sooner due to cellular stress levels.
Researchers developed a pharmacological approach to improve pancreatic beta cell growth and function. Trimeprazine, an antihistamine, was found to increase IRS2 in human islets and promote pancreatic beta cell growth and function in mice, suggesting its potential as a diabetes therapeutic.
Scientists have developed novel insulin mimetopes that can induce regulatory T cells to produce tolerance against insulin, halting the development of type 1 diabetes in young mice. In a humanized mouse model, the new vaccine efficiently stimulates regulatory T cells, which can impede the immune system's attack on insulin-producing cells.
Researchers at UNC and NC State create a synthetic patch filled with natural beta cells that can secrete insulin on demand, avoiding rejection risks and hypoglycemia. The 'smart cell patch' demonstrated successful blood sugar regulation in small animal models of type-1 diabetes.
A study of 5,644 women found that diabetes treatment decreases mammographic density, while insulin use increases it. The researchers also urge women with and without diabetes to adopt simple lifestyle changes to reduce breast cancer risk.
Researchers at the University of Utah are developing a 'smart' insulin that can automatically lower blood sugar levels after consumption. The grant-funded project aims to create an insulin that deactivates when blood glucose drops below a certain level, reducing the risk of serious health threats associated with improper dosing.
A UC Riverside-led study links thirdhand smoke exposure to insulin resistance and hyperglycemia in mice, a precursor to type 2 diabetes. Exposure to toxins from second-hand smoke causes oxidative stress, damaging proteins and DNA, leading to insulin resistance.
A multinational trial found that injecting a new long-acting insulin with another drug, IDegLira, improved glucose control in Type 2 diabetes patients. Participants on the combination product lost weight and experienced fewer episodes of hypoglycemia compared to those receiving basal insulin alone.
A study found that degludec/liraglutide was associated with greater HbA1c level reduction, weight loss, and lower hypoglycemia rates compared to glargine. The medication also had more nonserious gastrointestinal adverse events.
A study found that subcutaneous insulin infusion does not prevent oxidative stress and inflammation in the liver, despite reducing glycemic variability. The therapy also failed to preserve balance of anti- and pro-oxidant species.
Scientists at the University of Michigan have developed a novel method to observe insulin production in the pancreas of living animals. The technique allows researchers to see how much insulin is present and respond to sugar levels in real-time, revealing surprising insights into pancreatic function.
Researchers developed a new approach to designing insulin-based pharmaceuticals using self-assembling nano-insulin. This method could lead to more personalized medications with fewer side effects for Type 1 Diabetes patients.
Researchers have designed a material that can encapsulate human islet cells before transplanting them, allowing patients to control their blood sugar levels without immunosuppressant drugs. In tests on mice, encapsulated human cells cured diabetes for up to six months.
The article discusses the development and future promise of Continuous Glucose Monitoring (CGM) technology, which combines CGM with an insulin pump and sophisticated algorithms for automating insulin control. Key challenges facing successful commercialization include cost, reimbursement issues, and lack of FDA approval for insulin dosing.
Researchers are conducting one of the largest-ever long-term clinical trials of an artificial pancreas system to regulate blood sugar levels in individuals with type 1 diabetes. The trial aims to test the safety and efficacy of the system, which uses advanced algorithms and sensors to mimic a healthy person's glucose regulating function.
Researchers have developed a novel microencapsulation method using seaweed-derived hydrogel to protect pancreatic islets from ice damage during transplantation. The technique facilitates real-time cell viability assessments and reduces the need for cryoprotectants, promoting a more effective and safer treatment approach.
Researchers found that soaking islet cells in Anti-aging Glycopeptide (AAGP) protects them from tacrolimus, a toxic drug commonly used during transplants. This allows for fewer cells to be used, potentially treating more patients with the Edmonton Protocol.
Researchers at Université de Genève found that cold exposure alters microbiota composition, leading to increased brown fat activation, improved insulin sensitivity, and weight loss. The discovery highlights the key role of Akkermansia muciniphila in regulating nutrient absorption and may lead to new anti-obesity treatments.
A pilot study has demonstrated that a mechanical artificial pancreas can better maintain normal blood glucose levels than multiple daily insulin injections in patients with pancreatitis. The treatment combines an AI-powered pump with islet cell transplantation, enabling the transplanted cells to survive longer and produce more insulin.
Researchers at UC Santa Barbara have developed an insulin pill using novel drug delivery technology that shows early promise as a form of diabetes therapy. The pill's oral delivery system could circumvent the discomfort associated with injections, leading to improved patient compliance and potentially more effective treatment.
A large-scale analysis of three diabetes registries found that insulin pump use is associated with lower mean HbA1c levels and better blood sugar control in children and adolescents with type 1 diabetes. Pump use was also more common among certain subgroups, such as girls and non-minority ethnic groups.
A new study by the University of Colorado shows that sleep deprivation can lead to impaired insulin sensitivity. The longer people are awake during their biological night, the worse their sensitivity to insulin becomes, according to the study's findings.
Researchers found that insulin resistance is associated with a significantly worse prognosis for metastatic breast cancer patients. Lifestyle changes, such as diet and exercise, may help improve outcomes. Insulin targeting therapies could also be beneficial.
Researchers found that insulin stimulates the release of dopamine in the brain, leading to a feeling of pleasure. The study also suggests that people may choose high-carb or low-fat meals based on their insulin levels, potentially affecting weight and type II diabetes.