Articles tagged with Insulin
A new model of healthcare has shown that nurses can improve patient uptake of insulin treatment, leading to better long-term health outcomes. In a recent Australian study, 70% of patients began treatment under the 'Stepping Up' program, compared to just 22% in traditional approaches.
The study focuses on combining SPRA technology with polypseudorotaxane (PPRX) technology to create a sustained and controllable insulin release system. Four types of PPRXs were developed, showing improved blood glucose reduction times and safety profiles.
A fasting-mimicking diet has been shown to reverse diabetes in mice by promoting the growth of new insulin-producing pancreatic cells. In humans, the diet also increased expression of a protein that accelerates insulin production in type 1 diabetes patients, suggesting potential for alleviating symptoms.
Researchers at Linköping University conducted a pilot study showing promising results in treating type 1 diabetes. The study found stable insulin production in six patients who received GAD-alum injections, with significant improvements in blood sugar levels and reduced need for extra insulin.
A pivotal trial demonstrated the safety and efficacy of a hybrid closed-loop insulin delivery system in home use, reducing HbA1c levels and preventing severe hypoglycemic events. The system showed significant improvements in glucose control for both adolescents and adults with type 1 diabetes.
Researchers discovered a subpopulation of beta cells that resists immune attack and acquires stemness to persist despite immune attack. This finding may lead to therapies targeting these cells to restore insulin production in type 1 diabetic patients.
A new study found that high levels of air pollution can make insulin-creating cells less efficient, increasing the risk for type 2 diabetes in obese Latino children. Exposure to poor air quality during childhood increases the risk for obesity and Type 2 diabetes.
Four NIH-funded research projects aim to test and refine fully automated artificial pancreas systems, replacing traditional methods for managing type 1 diabetes. The studies will evaluate safety, efficacy, user-friendliness, and cost, with the goal of bringing these life-changing devices to those who need them.
A new skin patch has been developed to monitor blood glucose levels and release insulin automatically when necessary for people with diabetes. The patch, tested on mice, maintains consistent insulin concentrations in the blood and helps regulate blood sugar levels.
The university will explore a 'molecular diversity' of potential glucose-responsive insulin analogs to develop rapid-acting, glucose-responsive insulins that become active when blood sugar is high and inactive when low. The goal is to mitigate the risk of blood sugar levels being too high or too low for patients with type 1 diabetes.
Chemical modification of insulin enables faster release and improved availability, maintaining efficacy. The study uses computer simulations and experiments to confirm the effect, demonstrating potential for optimizing diabetes treatment.
A new study published in the International Journal of Obesity found that healthy young men who consume sugar, Stevia, monk fruit, or aspartame-sweetened beverages do not experience a significant difference in overall energy intake. However, they did eat more after consuming natural non-nutritive sweeteners.
Insulin resistance is a key mechanism in the pathogenesis of PCOS, leading to metabolic abnormalities and clinical burden. Lifestyle changes and specific medications can improve insulin sensitivity, but personalized treatment approaches are essential.
Researchers at ETH Zurich have created artificial beta cells that can effectively regulate blood sugar levels. These cells work by measuring glucose concentrations in the blood and producing insulin when necessary, making them a promising solution for diabetes treatment.
Researchers found that artemisinins transform glucagon-producing alpha cells into insulin-producing cells by activating GABA receptors, producing insulin. The study uses FDA-approved malaria drugs and has been shown to increase beta cell mass and improve blood sugar homeostasis in animal models.
Researchers used CRISPR/Cas9 to remove an enzyme that regulates the diabetes-associated TXNIP gene, leading to reduced cell death and increased insulin production in genetically modified pancreatic beta cells. The study also found that histone acetyltransferases play a crucial role in regulating the TXNIP gene.
Researchers have successfully reactivated oscillations in insulin-producing pancreatic beta cells using mathematical models and microfluidic devices. By delivering controlled glucose levels to dormant cells, scientists can test how insulin-producing cells get turned off and whether they can be reactivated.
Studies reveal genes respond differently to high insulin levels and sustained low levels, with some expressing quickly and others repressing themselves. Researchers developed a method to control gene expression using temporal patterns and doses of insulin.
Scientists at the University of Michigan are studying protein degradation in pancreatic beta cells to better understand diabetes at the molecular level. They found that proinsulin misfolding can lead to diabetic disease and identified a way to stimulate the degradative pathway to restore normal insulin secretion.
A new study published in Developmental Cell demonstrates that a nerve growth protein plays a crucial role in regulating blood sugar levels by prompting pancreatic cells to release insulin. The research, led by Johns Hopkins University biologist Rejji Kuruvilla, has potential implications for the treatment of type-2 diabetes.
A study published in Diabetologia found that high iron biomarkers are linked to an increased risk of gestational diabetes in pregnant women. Higher iron stores may play a role in developing insulin resistance and oxidative stress, contributing to impaired insulin synthesis and secretion.
A University of Michigan study found that low-carb meals significantly lower insulin resistance by over 30 percent within 24 hours, while high-carb meals sustain it. Exercise before meals also failed to lower insulin resistance, and may even increase blood sugar levels.
A new study found that pulses of glucose can reactivate the insulin clock in beta cells, which regulate blood sugar. The research suggests that controlled glucose solutions may be used to treat Type 2 diabetes.
Researchers at Wayne State University are developing a new material formulation to resist foreign body reactions in implantable devices, such as insulin infusion pumps. This project aims to improve the long-term use of these devices by reducing the need for replacements.
New research from the University of Otago suggests that walking after meals can significantly lower blood sugar levels in people with type 2 diabetes. The study found that post-meal physical activity can reduce blood sugar levels by up to 22% compared to taking a single 30-minute walk at any time of the day.
Researchers have found that impaired insulin metabolism affects neighboring cells involved in wound healing, leading to slow and incomplete healing. This discovery opens up new possibilities for treating wounds in diabetics, with local treatment targeting insulin metabolism.
Researchers at the University of Cambridge have developed a new treatment for type 1 diabetes that targets the immune system's damage, aiming to reduce or eliminate daily insulin injections. The treatment uses aldesleukin, a drug that enhances regulatory T cells to prevent autoimmunity.
Aerobic exercise improves glycemic control and reduces insulin requirements in T1D patients. The study found that physically active patients had more responsible behavior in monitoring their glucose levels, suggesting an educational program addressing diet, insulin injecting monitoring, and exercise could be highly advantageous.
Clemson University scientists are using high-tech computer modeling and experimental validation techniques to understand the molecular causes of adult-onset diabetes. They aim to develop new therapeutic approaches by studying peptide protein co-secreted with insulin in the pancreas.
Scientists found that an insulin molecule produced by cone snails may improve upon fast-acting therapeutic insulin, potentially starting to work in as little as five minutes. The study suggests studying complex venom cocktails can lead to new drug discoveries.
Scientists at Joslin Diabetes Center have identified a new molecular pathway that may offer targets for drugs to strengthen angiogenesis and improve blood vessel growth in type 2 diabetes. The study found that CITED2 expression is increased in endothelial cells from patients with diabetes, suggesting its potential as a therapeutic target.
Researchers have developed a new technology called Cholestosomes that can encapsulate insulin and deliver it orally without degrading. The vesicles are made of naturally occurring lipid molecules and can pass through the stomach intact, allowing for high bioavailability and effective insulin delivery.
A recent study challenges the concept of 'healthy obesity,' revealing nearly identical gene expression changes in obese individuals with varying levels of insulin sensitivity. The research suggests that vigorous health interventions may be necessary for all obese individuals, regardless of their metabolic health status.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that a combination of three medications—dapagliflozin, liraglutide, and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight. The therapy also showed impressive improvements in blood glucose management.
Women with polycystic ovary syndrome (PCOS) may benefit from incorporating soy isoflavones into their diets, according to a new study. The study found that consuming soy isoflavones regularly can lower levels of insulin in the blood and improve metabolic health.
A new systematic review found that gliclazide confers the lowest risk of hypoglycemia when added to metformin. This suggests prescribing a medication with a lower risk of low blood sugar may be a rational and affordable alternative for patients with type 2 diabetes.
Researchers have discovered at least four separate subtypes of human insulin-producing beta cells, which could lead to a better understanding of the disease process and the development of new treatments for type 2 diabetes. The study found that these cell subtypes produce different amounts of insulin and may regenerate at varying rates.
Researchers at UT Southwestern Medical Center have identified a key regulatory mechanism of insulin signaling, linking it to the timing of cell division. Three spindle checkpoint proteins, crucial for accurate cell division, also regulate metabolism through their impact on insulin receptors.
The artificial pancreas, a device monitoring blood glucose levels and automatically adjusting insulin doses, is nearing availability. Clinical trials have shown effective glucose control with reduced risk of hypoglycaemia, but challenges remain in addressing speed of action and cybersecurity concerns.
A study found that a cellular sorting protein called SORLA disrupts fat metabolism by recycling molecular receptors for insulin. This causes fat cells to become overly sensitive to insulin, leading to excessive fat deposits and obesity. The researchers discovered this link in human samples, mouse models, and cell cultures.
A study by University of Illinois researchers suggests that protein S supplementation can inhibit beta-cell death and improve blood glucose levels, insulin sensitivity, and kidney damage in mice with type 1 and type 2 diabetes. The findings offer a potential new approach to treating the disease.
Researchers compare model predictive control (MPC) and proportional integral derivative (PID) algorithms for an artificial pancreas. MPC outperformed PID in regulating glucose levels, with the former keeping participants within safe range 74% of the time.
A new study shows that the innovative OnTouch Via patch enabled over 50% of diabetes patients to report improved insulin dose compliance. The wearable patch allows for discreet delivery of rapid-acting insulin at mealtimes, reducing stress and anxiety associated with dosing.
A Yale-led team of researchers identified how altered gut microbiota causes obesity by stimulating insulin secretion through acetate production. The study suggests a causal link between changes in the diet, gut microbiota, and increased food intake, driving a positive feedback loop.
Researchers found that an automated insulin feedback controller improved glucose control and reduced episodes of nocturnal hypoglycemia in children with type 1 diabetes at a diabetes camp. The study's results are promising, particularly for the challenging environment of a diabetes camp.
POSTECH researchers found sensory neurons modulate aging hormone activity through food smells and tastes, shortening lifespan. Insulin-6 produced by sensory neurons alters FOXO protein action, leading to reduced aging effects.
A commentary published in Diabetes Technology & Therapeutics suggests that insulin pump therapy can lead to better blood glucose control and may be beneficial for all patients with type 1 diabetes. The author highlights the importance of pump technology, including sensor-controlled feedback and artificial pancreas systems.
A study published in Cell Metabolism found that a genetic variant of the melatonin receptor gene, MTNR1B, may predispose individuals to type 2 diabetes by increasing sensitivity to insulin-inhibiting effects of melatonin. This increased sensitivity can lead to lower insulin secretion and higher blood sugar levels.
A new study by Cardiff University found that combining insulin with metformin reduces mortality and heart attacks in people with type 2 diabetes. The researchers tracked 12,020 patients for three and a half years on average, finding no difference in cancer risk between single-insulin therapy and combination treatment.
A clinical trial found that islet transplants effectively prevented severe hypoglycemic events and restored awareness in patients with Type 1 diabetes. The study also demonstrated excellent glycemic control, with nearly 88% of subjects remaining free from severe hypoglycemia at one year.
Researchers identified a new hormone, asprosin, generated by fat, which instructs the liver to release glucose into the blood stream. This discovery could lead to a new treatment for type 2 diabetes through immunologic sequestration.
Scientists have discovered a nuclear receptor protein, estrogen-related receptor γ (ERRγ), that enables the maturation of human beta cells in vitro. This breakthrough overcomes a major challenge in diabetes research and holds promise for creating functional insulin-producing cells at will.
Salk researchers have found a hidden energy switch that powers up pancreatic cells to respond to glucose, enabling the production of functional human beta cells. The breakthrough could lead to a viable treatment for type 1 and 2 diabetes.
The cost of insulin more than tripled from $231 to $736 per year between 2002 and 2013, while other diabetes drugs saw a decrease. The study suggests looking again at non-insulin therapies due to the high cost-effectiveness gap.
A study found that the prevalence of treated diabetes increased from 5.2% to 7.7% in the US, while estimated spending for insulin per patient rose from $231 to $736 between 2002 and 2013. Insulin prices skyrocketed, with average prices increasing by 197% over the same period.
Researchers have discovered a new potential therapy that can protect transplanted human pancreatic islets from dying. The study suggests that pretreating cells with a peptide hormone called cholecystokinin (CCK) may enhance the curative potential of islet transplant for Type 1 diabetes.
A recent study by University of Montreal researchers has discovered a common genetic defect in beta cells that may lead to the loss of insulin production in both type 1 and type 2 diabetics. The findings suggest that genetics play a critical role in beta cell survival, with fragile cells being more prone to damage and disease.
A new study discovered that a common genetic defect in beta cells may underlie both form of diabetes. The research found that genetics is critical for the survival of beta cells, and a genetic predisposition for fragile beta cells may lead to diabetes development.
Researchers at IBS created a wearable GP-based patch that allows accurate diabetes monitoring and feedback therapy using human sweat. The device enables systematic corrections of sweat glucose measurements by monitoring pH and temperature, reducing the need for painful treatments like insulin shots.
Researchers developed a pharmacological approach to improve pancreatic beta cell growth and function. Trimeprazine, an antihistamine, was found to increase IRS2 in human islets and promote pancreatic beta cell growth and function in mice, suggesting its potential as a diabetes therapeutic.