Articles tagged with Insulin
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A new study found that 21% of individuals with insulin-treated diabetes diagnosed after age 30 have severe insulin deficiency, characteristic of late-onset type 1 diabetes. These patients often experience delays in diagnosis and treatment due to misdiagnosis as type 2 diabetes.
A new hybrid closed-loop insulin delivery system was compared to sensor-augmented pump therapy for blood sugar control in patients with poorly controlled type 1 diabetes. The study found that the hybrid closed-loop system achieved significantly better glucose control and reduced the risk of hypoglycaemia.
Researchers found that 79% of insulin temperature logs contained deviations from the recommended range, with fridge storage being the biggest issue. This can lead to reduced potency and variability in dosing for people with diabetes, highlighting the need for proper storage and monitoring practices.
Researchers at DTU Bioengineering have developed a high-tech antivenom against black mamba venom using human antibodies, which can potentially save thousands of lives annually. The breakthrough antivenom uses a biotechnological method to discover human antibodies, allowing for large-scale production and industrial use.
Researchers found significant reductions in mean glucose and other glycemic factors when adding dapagliflozin to metformin or insulin in patients with type 2 diabetes. Greater improvements were seen in patients taking metformin compared to insulin.
Leukemia undercuts normal cells' ability to consume glucose, leading to a diabetic-like condition that favors cancer growth. Researchers have identified key strategies, including manipulating insulin production and gut bacteria, which can be targeted with low-tech therapies like serotonin supplementation.
QUT researchers have discovered a drug that prevents laminitis in ponies with equine metabolic syndrome. The drug, velagliflozin, works by causing the kidneys to excrete more glucose in the urine, taking pressure off the pancreas and lowering insulin levels.
A new study finds that injecting insulin into the rectum can effectively treat chronic bowel inflammation in humans like Colitis Ulcerosa. The treatment strengthens bowel cells' own defence, reducing inflammation and improving symptoms such as weight loss and bloody diarrhoea.
A new study from the University of Iowa found that 8.5% of American adults have been diagnosed with type 2 diabetes, while 0.5% have type 1 diabetes. Type 2 diabetes is overwhelmingly more common, accounting for 91.2% of all diagnosed cases.
Researchers found that low-dose BPA exposure can trigger an insulin response in humans, similar to animal studies showing insulin resistance. The study suggests that exposure to endocrine-disrupting chemicals like BPA may contribute to the development of Type 2 diabetes.
The DIY bio movement is disrupting the pharmaceutical industry with open-source protocols for manufacturing off-patent insulin, increasing competition and potentially making life-saving medicine more affordable. The Open Insulin Project, a case study, aims to develop and release an open-source protocol for manufacturing insulin.
University of Tokyo researchers have developed a trans-omics approach that maps the interactions between molecules inside cells in response to insulin. This comprehensive understanding may lead to better therapies for type 2 diabetes by identifying potential drug targets and optimizing insulin regimens.
Researchers analyzed Twitter conversations around OpenAPS, a DIY system combining off-the-shelf CGMs and insulin pumps, to understand its benefits and limitations. The study found that OpenAPS improved self-reported A1C and glucose variability while reducing daily distress and burden, but also raised concerns about safety and regulation.
Researchers found that nalbuphine effectively treated opioid-induced urine retention in a patient, suggesting it as a potential solution for those unable to use catheters. WHO guidelines also recently made recommendations on treatment intensification for type 2 diabetes and insulin use for type 1 and type 2 diabetes.
Researchers at Toronto General Hospital have identified a specific insulin signaling pathway that revs up the response of T cells in the immune system, enabling them to divide rapidly and secrete cytokines. This finding opens avenues for better regulating the immune system and potentially developing new therapies.
A new collagen-based treatment has shown promise for reversing Type 1 diabetes in both humans and dogs, offering a minimally invasive alternative to traditional therapies. The treatment involves injecting a solution containing pancreatic cells mixed with collagen, which can restore insulin independence for at least 90 days.
A new study sheds light on the evolution of workers and queens in ants by identifying a key gene involved in regulating reproduction. Researchers found that a gene coding for an insulin-like peptide, ILP2, promotes and suppresses reproduction in ants.
A new clinical trial will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting type 1 diabetes progression. The POSEIDON Study aims to reduce inflammation, increase insulin secretion, and promote a potential cure for this autoimmune disease.
A human clinical trial revealed verapamil as a safe and effective therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes. The study found that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin.
A recent study published in Annals of Internal Medicine has found that cross-sex hormone therapy may increase the risk for certain vascular events among transgender women. The researchers compared the incidence rates of acute cardiovascular events in a large cohort of transgender persons with those observed in age-, race-, site-, and m...
A study by Yale School of Medicine researchers found that human insulin is comparable to insulin analogs in terms of safety and effectiveness. The use of more expensive analog insulins did not result in better blood sugar control or reduced risk of hypoglycemia, suggesting they may be unnecessary for many patients with type 2 diabetes.
Researchers at Harvard have developed an oral delivery method that can effectively deliver insulin to the bloodstream, overcoming the major obstacles of protein degradation and absorption. The innovative formulation uses an ionic liquid comprised of choline and geranic acid, which is released in a controlled manner once ingested.
A new oral insulin formulation based on ionic liquids has been successfully developed, showing stability at room temperature and under refrigeration. The formulation significantly reduces blood glucose levels in rats, with up to 45% decrease observed after oral delivery.
A study published in Diabetes Care found that the rapid decline in insulin production associated with Type 1 diabetes follows a two-phase pattern: an initial exponential fall and a subsequent stable phase. This discovery suggests that people with Type 1 diabetes may retain some working beta-cells for seven years after diagnosis.
A recent study found that infants with diabetes can maintain excellent blood glucose control for up to ten years using sulfonylurea tablets, offering a promising alternative to insulin injections. The treatment has been shown to be safe and effective in children worldwide.
A 20-year longitudinal study found clear predictors of rising A1C levels in young persons with type 1 diabetes, including sex and weight status. Insulin dose data and glycemic control were assessed over time to identify clinical factors associated with glycemic changes.
A decade-long study has shown that sulphonylurea tablets are a safe and effective treatment option for babies with neonatal diabetes, providing excellent blood sugar control over the long-term. The treatment has been hailed as a 'miracle cure' by patients and their families, offering improved quality of life.
Researchers found that obese children who consume at least two servings of cow's milk daily have better blood sugar control and lower fasting insulin levels. In contrast, those consuming less than recommended amounts had higher insulin levels, indicating increased risk of metabolic syndrome.
New research finds that obese children who drink at least two cups of low-fat milk daily have lower fasting insulin levels and better blood sugar control. The study's authors recommend encouraging children with obesity to consume the recommended amount of milk to protect against metabolic syndrome.
Fasting every other day impairs insulin function, leading to potential long-term health risks, including type-2 diabetes. This study found that even in normal-weight rats, intermittent fasting diets can cause damage to the pancreas and increase insulin resistance.
Researchers have developed a new method for synthesizing insulin using self-assembly of polypeptide chains, achieving a 40% efficiency rate. This approach enables the production of customized insulin compounds without relying on genetic engineering, which could lead to the development of novel insulin preparations.
Researchers at Oregon State University have developed transparent transistors that can be fabricated onto curved surfaces, paving the way for improved diabetes therapy. This innovation is a key step towards creating an artificial pancreas, which can detect blood sugar levels and transmit information to a wearable insulin pump.
Diabetes UK has committed £2.6 million to 19 new research projects investigating medieval remedies for foot ulcers, sleep disturbances as a predictor of Type 2 diabetes, and other forms of diabetes. The funding aims to reduce amputations, sepsis cases, and improve treatment options.
A new implantable device could help insulin-producing cells live longer after transplant and improve treatment of type 1 diabetes. The device, developed by MIT researchers, supplies oxygen to transplanted islet cells, allowing them to remain viable for several months and maintain normal blood glucose levels.
Researchers discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduces insulin effectiveness and glucose uptake in cells. In SDF-1 knockout mice, insulin-induced glucose uptake increased and insulin efficacy improved.
A phase I clinical trial enrolls adults with type 1 or 2 diabetes to test the accuracy of a non-invasive tattoo sensor that measures glucose levels through sweat. The technology has the potential to break down barriers to regular blood glucose monitoring, improving patient management and quality of life.
A review of 41 trials involving over 1000 people with type 1 diabetes found that artificial pancreas systems provided almost two and a half extra hours of normal blood glucose levels per day. The treatment also reduced time spent in both hyperglycaemia and hypoglycaemia compared to other types of insulin-based therapy.
A new study by The Endocrine Society shows that an insulin pump system can improve glycemic outcomes in children with type 1 diabetes starting from age 7. The MiniMed 670G system also demonstrates effectiveness in adults and adolescents, leading to significant improvements in time spent within target glucose ranges and reduced A1c levels.
Researchers created a biomaterial that can be seeded with insulin-producing beta cells, reversing diabetes in a mouse model. The study found normalized glucose levels and increased survival in treated mice, without triggering an immune response.
A new study from Israel found that a diet with three meals per day, including a high-energy breakfast, promotes weight loss and improves diabetes control in obese type 2 diabetes patients. The study showed significant reductions in glucose levels, insulin dosage, and hunger.
Scientists have identified progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes.
A Stanford University School of Medicine study found that cutting carbs or fats results in similar weight loss, with no association between individual biological factors and diet success. Participants followed either a low-fat or low-carb diet for one year, showing that the fundamental strategy for losing weight is to eat whole foods.
Researchers from Helmholtz Munich successfully visualize insulin receptor activation for the first time, revealing a structural change that propagates across the plasma membrane to initiate signaling cascades. This breakthrough sheds new light on insulin's biological actions and has implications for understanding diabetes and cancer.
A peptide called catestatin has been shown to improve glucose and insulin tolerance and reduce body weight in obese mice. CST treatment also inhibited liver inflammation and reduced fatty liver.
A study by Uppsala University researchers reveals that a vesicle attachment defect is the root cause of insulin secretion problems in type-2 diabetes. The defect leads to slowed arrival of new insulin-containing vesicles at the cell membrane, resulting in insufficient insulin release.
A comprehensive data analysis found no significant effect of 100% fruit juice on fasting blood glucose, insulin resistance, or glycemic control. The study supports previous research indicating that 100% fruit juice is not linked to an increased risk of Type 2 Diabetes.
A study at Queen Mary University of London reveals a new gene, MAFA, that affects insulin-producing cells, leading to rare genetic forms of diabetes and insulinomas. The research found that the same gene defect can cause both high and low blood sugar levels in the same family.
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
Researchers from Ural Federal University and Russian Academy of Sciences developed new methods to treat type 1 diabetes by using anti-diabetic chemical compounds. The study showed that these compounds can help reduce glucose levels and increase insulin production in lab rats with diabetes.
Research published in the Lancet Diabetes & Endocrinology found that over 40% of type 1 diabetes cases occur after age 30, and many adults are initially misdiagnosed with type 2. Type 1 diabetes requires insulin treatment to control blood sugar levels, while type 2 can often be managed with diet and medication.
A daily insulin pill did not slow down or prevent type 1 diabetes development among individuals with a higher risk of developing the disease. The trial involved 560 participants who received either oral insulin or a placebo, and found that time to diagnosis was not significantly different between groups.
Scientists at University of Basel find feedback mechanism to maintain insulin production in overweight patients, using ILC2 immune cells and retinoic acid. The study highlights the complex interactions between endocrine and immune cells in regulating insulin release.
Experts developed a streamlined approach to using Dexcom G5 Mobile Continuous Glucose Monitor (CGM) trend arrow data. The new tool helps individuals with diabetes adjust insulin doses more accurately, reducing dangerous fluctuations and long-term complications.
Researchers found that inhibiting microRNA-204 could lead to better treatment of diabetes by regulating the cell surface receptor GLP1R. This could result in lower-drug doses and reduced dose-dependent side effects. The study suggests a novel approach to targeting beta-cell function and improving glucose control.
A recent study from UC Davis researchers refutes the use of an anti-malaria drug to create new insulin-producing cells for Type 1 diabetes treatment. The findings highlight the crucial need for reproducibility in scientific research, contradicting a previous report that sparked excitement in the field.
Artificial beta cells mimic the body's natural glucose-controllers and can be subcutaneously inserted into patients or delivered via a painless skin patch. In lab experiments and animal models, they demonstrated rapid responsiveness to excess glucose levels and normalized blood glucose levels in diabetic mice.
Scientists at Columbia University Irving Medical Center have identified several compounds that selectively inhibit FOXO1, improving insulin sensitivity and reducing glucose production in the liver. These findings offer a promising approach to developing new, safer treatments for diabetes.
A new study reveals that up to 97.3% of people with pancreatic disease are misdiagnosed with Type 2 diabetes, instead of the correct condition, Type 3c diabetes. This can lead to delayed treatment and devastating long-term effects for patients.
Researchers developed an engineered protein therapy based on the GDF15 molecule to treat obesity. The treatment successfully lowered body weights, insulin levels, and cholesterol in obese mice, rats, and primates.
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.