Articles tagged with Insulin
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Salk Institute scientists develop transplantable human insulin-producing pancreatic cell clusters that evade the immune system, providing sustained blood glucose control without immunosuppressants. The cells were created using stem cell technology and a protein called WNT4 to induce a genetic switch that makes them functional.
Researchers develop a new mouse model of permanent neonatal diabetes using the Kuma mutation, which exhibits severe insulin-deficiency and beta-cell dysfunction in an immune deficient background. The study successfully reverses hyperglycemia with insulin implants, making it suitable for islet transplantation research.
A national cost-sharing cap on insulin can help reduce the financial burden on families of children and young adults with type 1 diabetes. The study found that approximately 60% of patients would benefit from a $25 cap, with average savings of almost $480 per year.
Case studies published by Physicians Committee for Responsible Medicine found that plant-based diets rich in whole carbohydrates improved health markers in individuals with type 1 diabetes. The diets led to decreased insulin needs, stabilized blood sugar control, and reduced cholesterol levels.
A study in Journal of Biological Chemistry describes a new way to determine the age of insulin-storage parcels and sheds light on how their age affects their release into the bloodstream. This finding could help experts better understand diabetes and fine-tune therapies for it.
Stanford researchers developed a new ultrafast insulin formulation that stabilizes monomeric insulin for over 24 hours, allowing it to take effect almost immediately upon injection. The formulation could potentially reduce the time it takes for insulin to reach peak activity by four-fold.
A new ultra-rapid insulin formulation, UFAL, reached peak activity in pigs with diabetes twice as fast as Humalog, a commercially available option. This could lead to faster quality-of-life improvements for diabetic patients by allowing quicker blood sugar level management during mealtimes.
Diabetic ketoacidosis is a common and severe complication in hospitalized patients with COVID-19, causing dehydration and breathing difficulties. A new clinical perspective outlines simpler methods of management to protect healthcare providers and keep ICU beds available for severe cases.
A Phase 2 study led by UB pediatric endocrinologist Teresa Quattrin shows that golimumab, an anti-TNF therapy, preserved beta-cell function and reduced injected insulin required in children and young adults with newly diagnosed Type 1 diabetes. The study demonstrated a higher C-peptide level in patients treated with golimumab compared ...
Researchers at Oregon Health & Science University have developed an AI algorithm that uses data from continuous glucose monitors and wireless insulin pens to provide guidance on adjustments. The algorithm, paired with a smartphone app called DailyDose, generated recommendations in agreement with physicians 67.9% of the time.
The study shows that the FreeStyle Libre 14 day system is estimated to save roughly 50% in average costs associated with severe hypoglycemia for people with type 1 and type 2 diabetes. Annual cost savings are 61% and 63% lower compared to traditional fingerstick testing.
A new study finds that people with Type 1 diabetes spend an average of $2,500 a year on healthcare costs, with diabetes-related supplies costing more than insulin. The study also highlights the importance of automating glucose monitoring and insulin delivery for young children and adolescents with Type 1 diabetes.
Researchers created a mini-insulin molecule that combines human insulin's potency with the fast-acting potential of cone snail venom, potentially improving blood sugar control. The hybrid insulin has the same potency as human insulin but acts faster, making it a prime candidate for new diabetes treatments.
Researchers at ETH Zurich create implant that uses electrical signals to stimulate insulin production in diabetic mice, offering potential breakthrough for real-time glycemic control. The system is designed to be connected to the internet and controlled via an app, paving the way for a more integrated approach to diabetes management.
Researchers have developed a wearable device that uses external electric fields to trigger insulin release from bioengineered cells, stabilizing blood glucose levels in mice. The approach opens the door for remote-controlled diabetes therapies and represents an expansion of electrogenetic toolboxes for human therapeutics.
A study revealed that insufficient insulin action in adipocytes leads to the development of diabetes and NASH by hyperactivating the protein FoxO1. This finding could serve as a potential target for new drug development for these conditions.
Researchers developed a novel approach to decontaminate single-cell RNA seq data, allowing for accurate quantification of cell-specific drug effects in pancreatic islets. The method revealed species-specific and cell-type-specific responses to drugs, including the induction of insulin production in alpha cells.
A study funded by JDRF, ADA, and Helmsley found all human and analog insulins in US pharmacies contained the expected amount of active insulin, posing no safety risks for people with diabetes.
Researchers at Stanford University have developed a way to combine insulin with amylin, a second hormone that plays a synergistic role in controlling blood sugar levels. The new technique involves a protective coating that allows the two hormones to coexist in a single shot, enabling patients to take a double-acting injection.
Researchers found that patients with type 2 diabetes have blood vessels resistant to insulin, leading to elevated oxidative stress and vessel dysfunction. A new therapy combining insulin treatment with DPP4 inhibitors shows promise in reversing damaging vascular effects.
Two case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in adults and infants during the pandemic. The technology showed improved outcomes with increased time-in-range, as patients received virtual management and dose adjustments.
Type 2 diabetes patients exhibit elevated glucagon levels due to α-cell resistance to insulin. Glucagon counteracts insulin's effects, exacerbating high blood sugar levels.
A new study finds that a wearable device called V-Go can safely deliver regular human insulin (RHI) to patients with type 2 diabetes, achieving good blood sugar control. The study, which compared RHI to rapid acting insulin (RAI) analogs, showed improvements in hemoglobin A1c levels and met its primary endpoint of noninferiority.
A recent study found that technology use by adults with type 1 diabetes is lower among African-American and Hispanic patients. The use of continuous glucose monitors (CGM) and continuous subcutaneous insulin infusion (CSII) devices was significantly lower in these groups, highlighting racial disparities in access to healthcare.
A study analyzing 6 million days of real-world data shows the MiniMed 670G system can maintain target glucose range of 70-180 mg/dL over 71% of the time. The AutoMode feature improves glycemic control, reducing low and high blood sugar episodes.
Researchers at MIT have developed a way to encapsulate therapeutic cells in a flexible protective device that prevents immune rejection while allowing oxygen and nutrients to reach the cells. This technology could lead to long-term treatment of chronic diseases such as diabetes.
A team of international medical experts successfully delivered insulin via a drone to a patient living in a remote community in Ireland, addressing healthcare access issues. The project demonstrated the potential for autonomous drones to deliver life-saving medications and supplies in disaster scenarios.
Researchers at UW-Madison discovered that removing a specific gene from insulin-producing cells can prevent Type 1 diabetes in mice by allowing the cells to disguise themselves from immune cells. This genetic manipulation enabled the cells to evade an autoimmune response, leading to normal glucose levels and insulin production.
Research reveals that children diagnosed with type 1 diabetes under 7 years old have a different form of the condition compared to those diagnosed at 13 or above. The study proposes two distinct endotypes: T1DE1 and T1DE2, which could lead to new treatments and a potential cure for some people.
Researchers developed a mathematical model to predict the behavior of glucose-responsive insulins in humans and rodents. The model identified optimal designs that could work well in both species, with about 13% predicted to be effective in both, and 14% in humans alone.
A team of McGill University researchers has created an artificial pancreas system that significantly improves glucose control, enhancing quality of life for individuals with type 1 diabetes. The system, which combines insulin and pramlintide, has shown promising results in minimizing glucose highs and lows.
Researchers found a truncated receptor called DAF-2B that acts as a decoy to capture insulin molecules, reducing insulin signaling. This discovery may offer new insights into insulin resistance, a feature of type 2 diabetes and aging.
A new study by Brigham and Women's Hospital finds that over 40% of patients refuse insulin therapy, leading to worse blood sugar control and longer time to lower blood sugar levels. Patients who decline insulin therapy had more severe diabetes complications and higher blood sugar levels.
A new study found that people with Type 2 diabetes in the US often receive treatment that is too aggressive or not aggressive enough, with those who are most likely to benefit from intensive therapy being underserved. The study suggests a fine line between effective treatment and increased risk of hypoglycemia.
Boston College biologist Emrah Altindis received a $300,000 grant from the G. Harold and Leila Y. Mathers Foundation to explore the role of gut microbes and viruses in triggering Type 1 diabetes. The research aims to understand molecular mimicry as a potential cause of the autoimmune disease.
A new device can automatically manage glucose levels and deliver needed insulin quickly, eliminating the need for constant blood sugar checks and insulin injections. The adhesive patch, about the size of a quarter, has been successfully tested on mice and pigs, showing promise as a potential diabetes treatment.
Researchers at the University of Illinois found that tasting or consuming sucralose can affect blood glucose and insulin levels, even in healthy individuals. The study suggests that sweetness should be consumed in moderation regardless of calories.
Disturbances in the internal clocks of pancreatic cells are linked to type-2 diabetes. Researchers successfully restored clock function using a natural compound, improving insulin secretion and providing new hope for diabetes care. The study shows that synchronizing the internal clocks can help regulate blood sugar levels.
Scientists have developed a non-fibrillating form of human insulin called glycoinsulin, which demonstrates the same glucose-lowering effects as native insulin without fibril formation. This discovery presents a promising solution for patients relying on insulin pumps and could improve the shelf life of insulin products.
The FDA has approved an artificial pancreas system that automatically monitors and regulates blood glucose levels in people with type 1 diabetes. The system, developed by the University of Virginia, uses a continuous glucose sensor and insulin pump to provide seamless integration and automatic insulin dose adjustment.
The global diabetes epidemic is reaching epidemic levels, with 425 million people affected and projected to increase to over 600 million. The book 'Traveling with Sugar' examines the havoc diabetes has caused in Belize, highlighting the need for improved infrastructure for treating the condition.
A team of researchers at Wayne State University is developing a novel oral insulin delivery system to address the issues of low absorption and bioavailability. The goal is to create a safe and efficient treatment that can enhance the quality of life for diabetes patients.
A common insulin signaling pathway has been found across cancer and diabetes, revealing the importance of protein TRAP-alpha in maintaining protein homeostasis. Deleting TRAP-alpha triggered a 90% reduction in insulin content in pancreatic beta cells, highlighting its role in insulin biogenesis.
A genetic screen in worms reveals TRAP-alpha as a crucial component of the insulin synthesis pathway, affecting both early and late steps. The findings support the idea that defects in insulin synthesis contribute to Type 2 diabetes, and may lead to new approaches for prevention and treatment.
A new Tel Aviv University study finds that consuming a starch-rich breakfast early in the morning and a small dinner may improve glycemic control among type 2 diabetics, reducing the need for insulin injections. The researchers' 3M-diet was shown to have significant benefits, including weight loss and improved sugar levels.
Researchers have solved a critical piece of the puzzle by showing how insulin interacts with its receptor at a second binding site. This new understanding will allow researchers to design improved treatments for insulin-related disorders, such as diabetes.
Researchers at Stevens Institute of Technology developed a meal-detection system that can accurately calculate carbohydrate intake in real-time, allowing for faster insulin administration. The system's estimates are remarkably accurate, outperforming previous systems by up to 17 grams.
A WSU study published in Cell Reports demonstrates that mammalian insulin activates an antiviral immunity pathway in mosquitoes, increasing their ability to suppress flavivirus infections. This discovery has the potential to inhibit the spread of West Nile virus and other diseases such as dengue and Zika.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
A new project aims to create a smartphone app that helps manage life-saving devices for people with diabetes, focusing on the senior citizen population. The app will consider factors such as visual setup, font size, and user experience to make it easy to use, potentially improving quality of life.
Scientists develop optogenetic approach to control glucose levels in diabetic mice, achieving improved tolerance and regulation of glucose without pharmacological intervention. The light-switchable cells can produce more than two- to three-fold the typical level of insulin in response to glucose levels.
A new study by Lund University researchers has identified a key mechanism in insulin release by a cholesterol metabolite. The receptor GPR183 plays a major role in stimulating insulin secretion in human cells and rats.
A multicenter randomized clinical trial found that the new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, outperforming existing treatments. The system significantly increased time with target blood glucose levels and showed improvements in other diabetes control measurements.
A six-week study found that exercising before breakfast increased fat burn by 100% compared to after breakfast. This shift allowed for better insulin control, potentially lowering diabetes and heart disease risk.
A new artificial pancreas system has been shown to improve blood glucose control throughout the day and overnight, offering a significant advantage over existing treatments for people with type 1 diabetes. The system, which automatically monitors and regulates blood glucose levels, was more effective than traditional therapies in achie...
Researchers at UNIGE identified a protein called S100A9 that regulates blood glucose and lipids, improving glucose management and reducing harmful side effects in diabetic mice. A clinical trial is underway to test the safety and efficacy of this new therapy in humans.
A new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, reducing the risk of low blood sugar levels. The system's advanced algorithms and safety features enabled users to achieve near-normal blood sugar levels every morning.
Advances in medications, lifestyle changes, and technologies can help manage post-meal blood sugar levels, but more research is needed to pinpoint a target range and improve clinical outcomes. Small lifestyle changes, such as eating protein and vegetables before carbohydrates, can also lower blood glucose levels.
Researchers developed a new oral delivery device that can carry insulin and other protein drugs, protecting them from the acidic environment of the stomach. The capsule contains microneedles that attach to the intestinal wall and release the drug for uptake into the bloodstream, enabling fast and pain-free delivery.
A study found that patients with poor health were more likely to continue taking insulin after age 75, despite guidelines recommending reduced treatment intensity. Discontinuing insulin may outweigh its benefits for older adults, especially those with multiple health conditions.