Articles tagged with Insulin
A new drug capsule developed at MIT may be able to replace injections for biologic drugs by tunneling through the mucus barrier in the small intestine. The capsule's robotic cap spins and displaces mucus, allowing drugs to pass into cells lining the intestine.
A bionic pancreas, which automatically delivers insulin based on blood glucose levels, was more effective than standard care at maintaining normal blood sugar levels. The study, funded by NIDDK and conducted at Nemours Children's Health, Jacksonville, found the device to require less user input and provide more automation.
Researchers at Brigham and Women's Hospital and MIT have developed RoboCap, a robotic capsule that delivers drugs to the gut by clearing mucus and churning to enhance absorption. In preclinical models, RoboCap increased drug permeability by over 10-fold for insulin and vancomycin.
Researchers found that knocking out TXNIP in alpha cells improves diabetes-associated hyperglycemia and hyperglucagonemia. This discovery suggests a new potential treatment for Type 1 diabetes.
A new study found that placing a monthly cap on out-of-pocket costs for commercially insured patients could lower their highest monthly healthcare bills by 50-60%. A $500 monthly limit would affect about 25% of enrollees and reduce in-network OOP costs over a year by 46%, while a $250 limit would show a 51% reduction.
A new study estimates that up to 17.5 million people worldwide will live with Type 1 Diabetes by 2040, with the highest burden in low- and middle-income countries. The modeling study predicts a significant increase in global deaths due to T1D, highlighting the need for improved surveillance, diagnosis, and care.
The need to reduce diabetes care product waste is a pressing issue, with disposable devices generating enormous amounts of plastic. Experts, including Professor Lutz Heinemann, are exploring strategies to increase recycling and sustainability in the industry.
Research at Karolinska Institutet shows that people with diabetes have lower levels of psoriasin, a key peptide that weakens the bladder's protective barrier function. This increases the risk of urinary tract infections. Oestrogen therapy may help regulate the immune response to UTIs in patients with diabetes.
A study by the University of Geneva team shows that disrupted circadian clocks lead to a rigidity in the membrane of pancreatic endocrine cells, affecting their function. The researchers also found that lipid profiles oscillate more during the day than previously thought, particularly in phospholipids and sphingolipids.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
A new study reveals that ant queens implement a dual-control system for insulin to promote egg development while slowing down the aging process. This unique mechanism allows ants to live longer and reproduce more effectively, unlike other animals.
Queen ants live much longer than workers by generating an anti-insulin protein that blocks aging pathways. This protein enables pseudoqueens, female worker ants that become queens, to reproduce and live longer without aging.
A study by University of Basel researchers found that insufficient insulin production contributes to overweight, challenging the long-held belief that poor nutrition and lack of exercise cause weight gain. The research revealed a key enzyme's role in hormone activation, leading to severe hunger and obesity.
Researchers at CeMM have discovered that targeting SMNDC1 in alpha cells can induce insulin production, a potential new approach for treating diabetes. The study identified a key molecular mechanism regulating insulin hormone production and its essential role in the treatment of diabetes.
A study published in Nature Communications suggests that better glucose control can improve brain structure and function in youth with Type 1 diabetes. The findings indicate that participants using a hybrid closed-loop insulin delivery system showed significant improvement in key brain metrics compared to those receiving standard care.
Researchers at the University of British Columbia have made a breakthrough in developing an oral insulin tablet that is absorbed by the body in the same way as injected insulin. The tablet is designed to dissolve when placed between the gum and cheek, releasing all the insulin into the liver without wasting or decomposing it.
Mutations in EnhP disrupt a non-protein coding gene, causing pancreatic malformations and diabetes. The study sheds light on the hierarchical operation of enhancers in gene regulation.
Researchers determined the cryo-EM structure of IGF Ternary complex and its assembly & activation mechanism. The study reveals how IGFBP3 and ALS form a stable complex with IGF1, regulating its activity. The findings provide new insights into growth-related diseases such as growth hormone deficiency and ALS deficiency.
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
A team of MIT engineers and collaborators have devised a way to overcome the foreign body response, forming a thick layer of scar tissue that blocks insulin release. The device is repeatedly inflated and deflated for five minutes every 12 hours, preventing immune cells from accumulating around it.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
A new study published in JAMA Oncology has found a significant association between daily insulin dose and increased cancer risk in patients with type 1 diabetes. The research, led by Yuanjie Mao, investigated the relationships between various risk factors and cancer incidence in this population.
Individualized, comprehensive treatment approaches and risk stratification of patients are crucial for effective treatment of MAFLD. Lifestyle modifications and pharmaceutical therapeutics combining to treat the condition.
Researchers at Joslin Diabetes Center identified a human gut bacterium that makes a protein mimicking the insulin peptide targeted by the immune system in type 1 diabetes. The presence of this bacterium accelerates the onset of diabetes in a mouse model and is linked to its development in children at genetic risk.
Researchers have found that infusing glucagon-like peptide-1 (GLP-1) hormone can improve impaired islet cell function in the pancreas of cystic fibrosis patients, potentially improving blood sugar control and treatment burden. The study suggests a new therapeutic approach for treating cystic fibrosis-related diabetes.
Researchers at UNIGE have found that the S100A9 protein can significantly improve insulin metabolism in diabetic patients, reducing the risk of severe side effects associated with insulin therapy. The protein's anti-inflammatory effect may also help to normalize ketone production and prevent life-threatening conditions.
A long-term high-fat diet has been shown to cause significant weight gain and metabolic disorders in mice, leading to anxiety, depression, and worsening Alzheimer's disease. The study suggests a clear link between chronic obesity and diabetes with cognitive decline.
Researchers at University of Basel found that the sight and smell of a meal stimulate an inflammatory response in the brain, which affects insulin secretion. In overweight individuals, this response is excessive and can impair insulin function.
Researchers found that factory-calibrated continuous glucose monitors are sufficiently accurate for estimating blood-sugar levels in patients with end-stage renal disease on hemodialysis. The devices showed 'clinical reliability', with almost 99% of readings accurate enough to be used without confirmatory fingerstick blood sugar readings.
Researchers at Beth Israel Deaconess Medical Center have identified a key enzyme involved in producing a new class of lipids with therapeutic effects for patients with diabetes. The discovery, published in Nature, could pave the way for new treatments to protect insulin-producing cells and improve blood sugar control.
Researchers at Karolinska Institutet describe a new way of generating insulin-producing cells using a molecule that stimulates protein synthesis and boosts insulin production. The study shows promise for treating type 1 and 2 diabetes, potentially increasing the number of insulin-producing pancreatic β cells.
Research found that patients using insulin have a higher risk of fractures compared to those using metformin, particularly in non-obese and well-controlled diabetic patients. Routine fracture risk assessments are recommended for these individuals.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
Research describes how breast cancer cells impair pancreatic islet function to suppress insulin production, leading to diabetes and increased tumor growth. The study identifies microRNA-122 as a key player in this process.
A new systematic review and meta-analysis published in The BMJ provides a comprehensive understanding of the adverse outcomes associated with gestational diabetes mellitus during pregnancy. The study found that women with gestational diabetes had increased odds of caesarean section, preterm delivery, and infant complications.
A large Japanese trial found that daily vitamin D supplements had no clinically meaningful effect on preventing type 2 diabetes in people at high risk of the condition. However, results suggested a potential benefit for those with insufficient insulin secretion, warranting further research.
The Edmonton Protocol team has reported that islet transplantation is an effective therapy for patients with difficult-to-control Type 1 diabetes, with a high rate of graft survival and insulin independence. The procedure has been shown to stabilize blood sugar levels and improve quality of life for patients.
Researchers at University of Missouri, Georgia Tech and Harvard University have successfully demonstrated a new Type 1 diabetes treatment in large animal models. By transplanting pancreatic islet cells with a molecule called FasL, they prevent rogue immune cells from destroying the transplanted cells.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
A new study at Stellenbosch University identified significant knowledge gaps among medical specialists regarding the emergency management of hyperkalaemia. The researchers recommend starting therapy when potassium levels reach 6 mmol/L or higher, performing an ECG on all patients, and monitoring for hypoglycaemia.
A phase 2 randomized controlled clinical trial found that intranasal insulin increased walking speed, cerebral blood flow, and improved decision making and verbal memory. The treatment also showed promise for preventing or slowing the progression of Alzheimer's disease-related dementias in older adults.
A novel therapy using sustained release of nitric oxide has been shown to ameliorate obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy was found to decrease body weight, improve glucose tolerance, and stimulate the browning of adipose tissue.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Children of exceptionally long-lived parents and their spouses experience lower risk of type II diabetes compared to the general population. The study found that low BMI, high HDL cholesterol, and certain hormones in the blood protect against developing diabetes II.
A new study found that Black people with diabetes were more likely to develop life-threatening complications like diabetic ketoacidosis during the pandemic. The disparity persisted even before the COVID-19 pandemic and was present in 45% of Black people, compared to 16% of White people.
Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves beta cell activity and prevents high blood glucose in mice. This approach may prevent the exhaustion of beta cells and improve long-term diabetes treatment.
A new study suggests that people with type 1 diabetes who have high levels of psychological resilience are more likely to manage their condition successfully. The research found that those with low resilience also had poorer blood sugar control after two years.
Researchers at Lund University have found a link between microRNA levels and insulin secretion in type 2 diabetes. By reducing the levels of miR-200c, they were able to increase insulin secretion in human cells.
Researchers developed a compound consisting of insulin bound to an antioxidant group, improving glucose consumption and brain function in mice with type 1 diabetes. The combination therapy showed better cognitive performance than individual treatments alone.
A large cohort study found that babies born to men who took metformin during sperm development were at increased risk for genital defects in boys. Diabetes control affects sperm quality, so men should discuss alternative treatments with their doctors before conception. The findings suggest a need for further study on treatment of prosp...
Researchers discovered a new venom compound in deep-water cone snails, similar to the hormone somatostatin, with possible pharmaceutical applications for treating chronic pain and other human maladies. The study highlights the rich biochemical diversity of animal venoms and the need to explore new compounds.
Researchers have designed a fast-acting injectable insulin based on the venom of the Conus kinoshitai marine snail, which doesn't form clusters like human insulin. The new hybrid insulin holds promise for better diabetes control with faster action and reduced clustering.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
A new study from Northwestern University finds that even moderate light exposure during sleep harms cardiovascular function and increases insulin resistance. Closing blinds and using dim lighting before bed can help mitigate these effects.
A rigorous randomized controlled trial found that adding a 300-calorie serving of French fries to one's diet daily for a month did not result in differential weight gain or biomarker changes compared to an isocaloric daily serving of almonds. The study measured body composition, blood sugar, and insulin levels, finding no clinically si...
Researchers developed genetic modifications to increase stress resistance and immune evasion in stem cell-derived beta cells, leading to improved survival rates. The study suggests a potential breakthrough for treating type 1 diabetes through transplantation of these cells.
Researchers found that verapamil treatment delayed disease progression, lowered insulin requirements, and preserved some beta cell function in patients with Type 1 diabetes. The study used proteomics analysis and RNA sequencing to examine changes in circulating proteins in response to verapamil treatment.
Researchers found that many newly diagnosed patients with diabetes had less severe blood sugar levels and more severe COVID-19. After hospital discharge, roughly half reverted to normal blood sugar levels, and only 8% required insulin after one year.