Articles tagged with Insulin
Research reveals that faster placental growth increases the risk of preeclampsia and shorter pregnancy duration. Genetic variations affecting placental size also influence baby weight and mother's health.
A new study published in Diabetologia found that hybrid closed-loop technology improved maternal blood sugars during pregnancy complicated by type 1 diabetes. The technology, which adjusts insulin doses every 10-12 minutes, helped reduce maternal blood sugar levels and weight gain, while also improving baby health outcomes.
A phase 1/2 study shows that a stem cell-derived islet therapy has improved blood sugar control in all six adult patients with type 1 diabetes. Three patients achieved insulin independence and showed sustained improvements in blood glucose levels.
Research suggests that universal screening for type 1 diabetes at two ages could predict most cases of T1D by age 15. Dr. Emily K. Sims emphasizes the importance of identifying individuals with early, presymptomatic stages of disease to prevent life-threatening episodes and improve outcomes.
A new clinical trial has found that administering metformin to pregnant women with gestational diabetes does not increase adverse neonatal outcomes or maternal health risks. The study provides hope for expectant mothers and healthcare providers seeking a safe alternative to traditional insulin-based treatments.
A randomized clinical trial found that early metformin treatment did not improve insulin initiation or fasting glucose levels in pregnant women with gestational diabetes. Further investigation into larger trials is warranted based on prespecified secondary outcome data.
A study of over 1 million Swedish men found that high blood pressure at age 18 was associated with a higher risk of major cardiovascular events, including heart failure, heart attacks, and strokes. Early intervention for hypertension may be critical to reducing later cardiovascular events.
Researchers developed a computational model to analyze glucose-responsive insulin (GRI) performance in human patients. The model predicted that differences in sugar receptor behavior between humans and lab animals led to the drug's poor effect in clinical trials. This breakthrough helps researchers design better GRIs, potentially reduc...
Researchers have designed an implantable device that carries hundreds of thousands of insulin-producing islet cells and has its own on-board oxygen factory, generating oxygen by splitting water vapor. The device was tested in diabetic mice and maintained normal blood glucose levels for at least a month.
A recent study published in the Journal of Diabetes Science and Technology found that HbA1c levels are markedly higher in young black youth compared to whites with type 1 diabetes. This disparity can lead to increased risk of hypoglycemia and long-term complications if primarily used for insulin management.
A comprehensive study reveals that genetics and diet significantly influence insulin signaling in skeletal muscle. The research identified thousands of novel phosphosites associated with insulin regulation and provided a unique tool for assessing phosphorylation in insulin reactions.
A small study found that treating newly diagnosed Type 1 diabetes patients with semaglutide significantly reduced their need for insulin. The medication's ability to stimulate insulin secretion from the beta cells of the pancreas allowed for the elimination of mealtime and basal insulin doses in most patients.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
A new study from the University of Copenhagen reveals that GDF15 improves insulin sensitivity in rodents, particularly in their liver and fatty tissue. This finding raises interesting perspectives for treating type 2 diabetes and high blood pressure, as increased insulin sensitivity is a critical indicator of health.
Researchers at ETH Zurich have developed a gene switch that uses sound waves to trigger insulin release in designer cells. The system works by embedding an ion channel protein from the bacterium E. coli into human cells, which opens in response to sound, causing insulin vesicles to fuse and release insulin.
A recent study by Pennington Biomedical Research Center identifies GDF15 as a protein that acts as a cellular signal to enhance insulin secretion. High-intensity exercise training in patients with type 2 diabetes was found to have elevated levels of GDF15, associated with improved glycemic control.
Researchers found that liraglutide improves associative learning in people with obesity by restoring brain activity to normal-weight levels. The study showed that participants with obesity had reduced ability to associate sensory stimuli and decreased brain activity compared to those with normal weight.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
A recent study found that patients with type 1 diabetes using insulin pumps for extended periods do not exhibit significantly more pathology in their skin compared to short-term users. Despite this, researchers still struggle to understand the underlying causes of skin damage and inflammation at infusion sites.
A new study found that snacking on high-quality foods can improve blood fat and insulin responses, while late-night snacking may have unfavorable effects. The researchers analyzed data from over 1,000 people in the UK and found no association between snack frequency or calories consumed and health measures.
Researchers at UC Berkeley discovered that deep-sleep brain waves can regulate the body's sensitivity to insulin, improving blood sugar control. The study found that synchronized brain waves during deep sleep predict next-day glucose control, even after controlling for other factors.
A study published in Nature Communications reveals the controlled release of mucins and insulin by cells, with tetraspanin-8 acting as a gatekeeper. The regulated secretion is biphasic, involving rapid and slower releases of granules, which can be targeted to reset deregulated mucin and insulin secretion.
A recent meta-analysis of 29 studies found that intranasal insulin treatment can boost cognition in individuals with mild cognitive impairment or Alzheimer's Disease. The analysis suggests potential benefits for this treatment approach, which may be worth further investigation.
Once-weekly Icodec demonstrated superior HbA1c reduction compared to once-daily Degludec after 26 weeks, but no difference was found in weight change. However, Icodec showed a higher rate of combined level two or three hypoglycemic events
A randomized phase II study found that adding metformin to androgen deprivation therapy did not reduce the risk of metabolic syndrome or improve PSA response in patients with advanced prostate cancer. Metformin showed some antitumor effects through mTOR inhibition, but these were not significant.
Researchers have found a hidden mechanism connecting cancer and diabetes, where cancer cells don't respond well to insulin, leading to faster cancer growth. Insulin resistance can also cause muscle loss and strength decline in cancer patients.
A plant-based, oral delivery of proinsulin regulated blood sugar within 15 minutes similar to naturally secreted insulin in diabetic mice. This method eliminates the need for expensive laboratory equipment and results in a shelf-stable product, making it more affordable and accessible.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A study of over 55,000 people identified new genetic variants associated with insulin resistance after eating, which may help inform future treatments of type 2 diabetes. The discovery highlights the importance of understanding how glucose regulation works in the body, particularly in the fed state.
Researchers have discovered molecules in 3,000 diabetic patients that could help predict and monitor disease progression. The study identified 20 biomarkers associated with rapid disease progression, including a protein called NogoR.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
Researchers have developed an algorithm that accounts for individual patient differences and validated a pump control algorithm that does not require meal announcement. This innovation simplifies the control problem, reduces delays, and increases the accuracy of insulin delivery, making diabetes management less burdensome for patients.
Rice University scientists developed a screening technique to identify high-performing biomaterials for encapsulating insulin-secreting cells, providing long-term blood sugar level control in diabetic mice. The study's findings have the potential to open the door to a more sustainable and self-regulating way to treat Type 1 diabetes.
A new study has identified a metabolic enzyme called FBP1 that acts as a safety valve to prevent insulin shock. Researchers found that FBP1 inhibits protein kinase AKT, which is the primary conduit of insulin activity, and developed a peptide derived from FBP1 that can reverse insulin resistance and restore normal glycemic control.
Researchers at RMIT University have designed a new oral capsule that can deliver insulin and other protein drugs in a pain-free manner. The technology has shown promising results in pre-clinical studies, with good absorption rates for slow-acting insulin and potential for dosing over specific time periods.
A recent analysis of three clinical trials found that the UVA-developed artificial pancreas improved blood sugar control by 13 percentage points and decreased hemoglobin A1c levels. The device spent an average of 2.8 more hours per day in target blood sugar range, benefiting both kids and adults with diabetes.
Researchers have developed a novel insulin formulation that can be switched on by glucose, offering improved regulation of blood sugar levels in patients with type 1 diabetes. The new formulation uses biocompatible lipid nanoparticles and achieves precise control of insulin release in response to fluctuations in blood sugar.
Researchers at the University of Gothenburg discovered that insulin can be stored at room temperature for four weeks, quadrupling its previous storage period. This finding has significant implications for global health, particularly in developing countries where insulin is often in short supply and expensive.
Two new subtypes of insulin-producing beta cells, ß <sub> HI </sub> and ß <sub> LO </sub>, have been identified with distinct characteristics. The study suggests epigenetic dosage as a driving force behind the decision of ß cells to become these subtypes, offering a new target for potential diabetes treatments.
A team of researchers at ETH Zurich has created an implantable fuel cell that uses excess blood sugar to generate electrical energy. The device powers artificial beta cells that produce insulin, effectively regulating blood glucose levels.
A new study by Weill Cornell Medicine investigators found four distinct types of beta cells in the pancreas, with cluster 1 beta cells producing more insulin than others and appearing better able to metabolize sugar. The loss of these high-functioning beta cells may contribute to type 2 diabetes development.
A study published in Communications Biology reveals that a large portion of an insulin dose may not be effective, providing a tool for developing more precise medications. The discovery could lead to improved treatment outcomes for millions of people worldwide.
Dr. David McDougal's research project aims to find better therapies to prevent hypoglycemic episodes in people with type 1 diabetes, focusing on the role of leptin in regulating blood sugar responses. The grant-funded study seeks to identify novel treatments for preventing low blood glucose in these patients.
A new clinical trial has shown safety and tolerability of oral GABA and reduced serum glucagon levels in children with recent onset Type 1 diabetes. The study focused on the potential of GABA and GAD to preserve insulin-secreting beta cells and attenuate excessive glucagon release.
Researchers reveal Akt2's role in insulin-regulated metabolism, initiating energy production and nucleic acid synthesis. The study provides new insights into metabolic disorders like diabetes, paving the way for targeted therapeutics.
A recent study published in the Journal of Clinical Investigation found that PAX5 is strongly associated with impaired insulin secretion in type 2 diabetes. The research team identified 94 previously known genes and discovered many new genes differently expressed in individuals with type 2 diabetes.
A survey of primary care clinicians revealed that 44% of patients experience cost-related insulin underuse, with those experiencing poor diabetes control not being more likely to report underuse. Clinicians can address this issue by using empathy to discuss cost barriers and increase the likelihood of changing insulin prescriptions.
Researchers at the University of Cambridge developed an artificial pancreas that can help maintain healthy glucose levels in type 2 diabetes patients. The device doubled the time spent in the target range for glucose and halved the time spent with high glucose levels, reducing average glucose levels and glycated haemoglobin levels.
Researchers have developed an orally administered tablet powered by chemical micromotors that deliver insulin to the colon, reducing blood glucose levels for over five hours. The mini-tablets protected from stomach acid and used hydrogen gas bubbles as micromotors to propel insulin into the bloodstream.
Researchers found that people with higher levels of Coprococcus tended to have higher insulin sensitivity, while those with Flavonifractor had lower insulin sensitivity. The study aimed to understand the relationship between microbiome composition and diabetes development.
Researchers discovered that physical activity suppresses insulin-producing cells in fruit flies, allowing for efficient energy replenishment. This finding has implications for human health, as reduced insulin activity is linked to healthy ageing and longevity.
A wafer-thin device called NICHE has been developed to treat Type 1 diabetes by delivering islet cells and immunotherapy directly into the body. The device restored healthy glucose levels and eliminated symptoms for over 150 days, avoiding severe adverse effects of anti-rejection therapy.
Over three decades, glycemic control stagnated among US adults with diabetes, exacerbating racial and ethnic disparities. Improved insulin access may optimize glycemic control and reduce disparities in this population.
WEHI researchers have visualized how a non-insulin molecule can mimic the role of insulin, opening new avenues for an oral insulin pill. The study confirms alternative molecules can be used to turn on blood glucose uptake, bypassing insulin needs.
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.
Researchers found that individuals with CYP8B1 loss-of-function mutations have improved insulin sensitivity and better glucose regulation, reducing the risk of developing Type 2 diabetes. The study suggests a potential new treatment approach using bile acid modulators to target this gene.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that pancreas transplantation can provide up to 90% of recipients with diabetes freedom from insulin therapy and glucose monitoring. Despite high success rates, transplant numbers have declined due to lack of consensus criteria, education, and resource ...
A novel HNF1A gene variant has been found to cause monogenic diabetes, affecting almost seven percent of all cases in Greenland. This discovery may pave the way for precision treatment using tablet therapy with sulphonylurea, offering a simpler and cheaper alternative to insulin.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...