Articles tagged with Insulin
A new study found that nearly one-third of individuals adopting healthy diets didn't lose weight but still experienced significant improvements in cardiometabolic markers, including increased HDL cholesterol and reduced visceral fat. The research suggests a healthy diet can have benefits beyond weight loss.
Researchers have discovered a key marker, FXYD2, that identifies functional maturity and heterogeneity of stem cell-derived islet organoids. This breakthrough enables quality control for production of transplantable islets, advancing the field toward safer and more effective islet replacement therapies.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
Researchers found that insulin signaling changes affect both Alzheimer's disease and epilepsy in animal tests. This discovery confirms clinical evidence of increased risk of Alzheimer's in people with epilepsy and highlights the need for a broader therapeutic approach to address the complex nature of Alzheimer's disease.
Researchers at Kyoto University have developed a new non-invasive diagnostic method for insulinomas, which achieved 100% diagnostic accuracy in a Phase II clinical trial. The new method using positron emission tomography (PET) probe successfully detected cases difficult to diagnose through existing methods.
The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.
Researchers discovered a key step in the hepatic ERK pathway that triggers insulin production in response to colonic inflammation caused by obesity. The study reveals a novel role of the gastrointestinal tract in regulating glucose homeostasis.
Researchers at Pennington Biomedical found that mitochondrial fragmentation can bypass defects in mitophagy to sustain skeletal muscle quality control in patients with Type 2 Diabetes. This adaptation helps maintain mitochondrial function despite impaired mitophagy.
Research in mice suggests that antibiotics during infancy can stunt insulin-producing cell growth and boost diabetes risk. Specific microorganisms, such as Candida dubliniensis, may help promote pancreatic cell development and improve metabolic function.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A new study from the University of Surrey found that healthcare professionals face difficulties in recognizing and addressing disordered eating in people with type 1 Diabetes due to lack of support and limited confidence. This can lead to delays in diagnosis and potentially life-threatening complications for patients.
Pacific children are not meeting daily recommended intakes for key micronutrients, leading to associations with childhood obesity and acanthosis nigricans. The study highlights excessive sodium intake across the region, posing cardiovascular health risks.
A new study published in Nutrients found that eating two cups of mango daily can help lower insulin concentration levels and improve insulin sensitivity in overweight or obese adults. The study, conducted at the Illinois Institute of Technology, showed significant reductions in insulin resistance and improved beta-cell function.
A dynamic signaling network plays a crucial role in regulating insulin action in human muscle cells. The study reveals previously unknown mechanisms that could be used to treat type 2 diabetes, including the stimulation of specific enzymes and protein kinases.
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
A recent study reveals that intermittent fasting can impair beta-cell function and maturation in young mice, potentially leading to diabetes. Researchers found that adolescent mice showed a decline in insulin production after prolonged fasting, with defective beta cells resembling those of type 1 diabetes patients.
A study by University of Gothenburg researchers found that consuming sulforaphane from broccoli sprouts improved blood sugar levels in people with prediabetes. The compound had a significant effect on fasting blood sugar levels, particularly in those with certain pathophysiological and microbiome characteristics.
A study comparing hybrid closed-loop and open-loop systems in young people with type 1 diabetes found that hybrid closed-loop systems offered improved long-term blood sugar values, a lower risk of hypoglycemic coma, but a higher rate of diabetic ketoacidosis. The results suggest that hybrid closed-loop therapies may be beneficial for i...
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
A new clinical trial at UVA is testing an innovative AI-powered device designed to improve automated insulin delivery, aiming to simplify diabetes management. The trial will evaluate the 'Bolus Priming System with Reinforcement Learning' technology in adult participants with Type 1 Diabetes.
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.
A Brazilian researcher at Harvard identified serotonin as the central role in postprandial hypoglycemia, a common complication of bariatric surgery. The study found that serotonin levels increase significantly after meals in affected individuals, unlike those without symptoms.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
Lantidra is the only FDA-approved treatment for brittle type 1 diabetes, a more severe form of the disease. The therapy involves pancreatic islet cell transplantation and has shown promising results in clinical trials, with most patients no longer requiring insulin one year after the procedure.
Researchers developed an ingestible capsule that releases a burst of drugs into the stomach or other organs, eliminating the need for injections. The capsule uses compressed carbon dioxide or tightly coiled springs to propel liquid drugs out, targeting specific parts of the digestive tract.
The American Heart Association has awarded $75,000 to local entrepreneurs to develop innovative solutions addressing health inequities in their communities. The EmPOWERED to Serve Business Accelerator program supports social entrepreneurs and organizations focused on improving health outcomes.
Researchers at Brown University have found a way to extend the lifespan of flies by suppressing a hormone that regulates insulin secretion. The study suggests that certain medications used to treat human obesity and diabetes may also impact aging, making it a promising area of research for future studies.
A new treatment strategy combining ReCET and semaglutide has been shown to eliminate insulin therapy in 86% of type 2 diabetes patients, improving sensitivity to endogenous insulin. The novel procedure, which employs electroporation, is compliance-free and disease-modifying, addressing ongoing patient adherence issues.
Researchers developed glucose-responsive micelles that encapsulate and protect glucagon, releasing it when blood sugar levels drop below a certain threshold. The micelles prevented hypoglycemia in mouse trials, achieving normal blood sugar levels within 40 minutes.
Researchers at University of Gothenburg propose inhibiting somatostatin to restore glucagon release and prevent dangerous blood sugar levels. This approach has the potential to save lives and is supported by experimental results in mice with type 1 diabetes.
A recent study published in Diabetes, Obesity and Metabolism reveals that intensive diabetes treatment can positively impact periodontal inflammation. The research found improvements in glycoalbumin levels and Periodontal Inflamed Surface Area, indicating reduced blood glucose levels and periodontal disease.
A new class of weekly insulin, efsitora alfa, has been shown to be non-inferior to daily injections in managing blood sugar levels in patients with type 1 diabetes. However, the study found higher rates of hypoglycaemia, highlighting the need for vigilance in dose initiation and optimization.
A new class of once-weekly insulin, efsitora, is noninferior to daily insulin injections in controlling high blood sugar levels. The study found that efsitora reduced Hb1Ac by 1.26% and was associated with a lower rate of hypoglycaemia compared to daily insulin.
A new study published in Health Affairs found that the Colorado insulin price cap law resulted in a 40% reduction in out-of-pocket costs for insulin prescriptions. The law, which caps monthly costs at $100 for state-regulated health insurance plans, had the largest impact on children and adults aged 18-34, as well as rural patients.
Researchers found that altitude changes during flights may cause slight increases and decreases in insulin delivery, potentially leading to blood glucose fluctuations. Individuals using insulin pumps should be aware of these effects and consider temporarily disconnecting their pumps before take-off.
A UCL-led research team has crystallized the first alternative DNA structure from the insulin gene, revealing its shape and structure. The discovery suggests that different variants in the insulin gene can form different DNA structures, which could affect insulin function and potentially play a role in diabetes development.
Researchers found that adult mice with only beta cells have better glycaemic balance and insulin sensitivity than standard animals. Non-beta cells are not essential for maintaining blood sugar levels, contradicting the prevailing conception.
Researchers used genetic method Mendelian randomization to show high levels of fasting insulin cause reduction in Lp(a), rather than the other way around. Low Lp(a) is unlikely to be a risk factor for type 2 diabetes, independent of pre-existing hyperinsulinaemia and insulin resistance.
Scientists discovered the highest natural blood sugar levels in mammals, found in a species of bats that can survive on a diet rich in sugars. The study's findings suggest that these bats have evolved unique strategies for glucose regulation, which may hold potential for managing metabolic diseases in humans.
A clinical trial found that consuming Mankai after meals can significantly lower blood sugar levels in patients with type 2 diabetes. The study showed a 20% reduction in post-meal blood sugar levels and faster return to baseline levels in about two-thirds of participants.
Researchers led by Ayyalusamy Ramamoorthy find that insulin, zinc and pH levels work together to inhibit the buildup of protein clumps contributing to Type 2 diabetes. The study offers promising avenues for innovative treatments and may revolutionize treatment approaches.
Scripps Research scientists discovered a molecule produced by roundworm intestines that signals the brain to slow fat loss when food is not available. The discovery sheds light on why fasting has benefits independent of calorie intake and may lead to new treatments for obesity and diabetes.
A deadly marine cone snail's venom contains a toxin that interacts with human cells in a specific manner, regulating blood sugar levels and hormone balance. This discovery may lead to the design of more effective drugs for treating diabetes and endocrine disorders.
A study found that state-level insulin cost caps do not significantly increase insulin claims for patients with Type 1 or Type 2 diabetes. Most commercial enrollees were already paying out-of-pocket costs below the mandated caps.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
A recent study found that long-term use of sulfonylureas increases the risk of impaired awareness of hypoglycemia in patients with type 2 diabetes. The longer the patient uses sulfonylureas, the higher the risk. Researchers suggest using newer classes of medications to reduce this risk.
Researchers from Mount Sinai and City of Hope demonstrate a combination treatment that increases human insulin-producing beta cells by 700% in mice with diabetes. This breakthrough could lead to new treatments for the hundreds of millions of people with diabetes worldwide.
Researchers found GLP-1 receptor agonists lower risks of certain obesity-associated cancers in patients with type 2 diabetes, suggesting potential benefits for cancer prevention in high-risk populations. The study provides preliminary evidence supporting further preclinical and clinical studies to prevent specific obesity-linked cancers.
A study led by UPF describes the mechanism behind insulinoma formation, a rare type of pancreatic beta cell tumor. The research reveals that a change in the epigenetic pattern of beta cells leads to the accumulation of mutations and excessive insulin production.
Researchers found that individual responses to proteins and fats can drive insulin production, challenging the long-held belief that fats have negligible effects on insulin release. This study has implications for tailored dietary guidance to manage blood sugar and insulin levels in individuals with diabetes or those at risk.
A study of almost 400,000 live births found that paternal use of metformin monotherapy was not significantly associated with major congenital malformations. However, researchers noted that fathers prescribed metformin had higher rates of cardiovascular and metabolic conditions, which could affect reproductive health.
Researchers have made a breakthrough in understanding the GIP hormone's role in regulating insulin levels and weight loss. The study, involving over 500,000 individuals, found that inhibiting the GIP receptor may result in weight loss, while activating it without arresting its signal is crucial.
Researchers developed an antioxidant gel to preserve islet function after pancreas removal, significantly improving survival and preserving normal blood sugar levels in animals. The new approach could enable patients to live pain-free without complications of diabetes.
Researchers at the University of British Columbia have developed oral insulin drops that can be easily absorbed by the body, potentially replacing insulin injections. The drops contain a unique cell-penetrating peptide that helps insulin navigate through cells and reach the bloodstream quickly.