Articles tagged with Insulin
Disturbances in the internal clocks of pancreatic cells are linked to type-2 diabetes. Researchers successfully restored clock function using a natural compound, improving insulin secretion and providing new hope for diabetes care. The study shows that synchronizing the internal clocks can help regulate blood sugar levels.
Scientists have developed a non-fibrillating form of human insulin called glycoinsulin, which demonstrates the same glucose-lowering effects as native insulin without fibril formation. This discovery presents a promising solution for patients relying on insulin pumps and could improve the shelf life of insulin products.
The FDA has approved an artificial pancreas system that automatically monitors and regulates blood glucose levels in people with type 1 diabetes. The system, developed by the University of Virginia, uses a continuous glucose sensor and insulin pump to provide seamless integration and automatic insulin dose adjustment.
The global diabetes epidemic is reaching epidemic levels, with 425 million people affected and projected to increase to over 600 million. The book 'Traveling with Sugar' examines the havoc diabetes has caused in Belize, highlighting the need for improved infrastructure for treating the condition.
A team of researchers at Wayne State University is developing a novel oral insulin delivery system to address the issues of low absorption and bioavailability. The goal is to create a safe and efficient treatment that can enhance the quality of life for diabetes patients.
A common insulin signaling pathway has been found across cancer and diabetes, revealing the importance of protein TRAP-alpha in maintaining protein homeostasis. Deleting TRAP-alpha triggered a 90% reduction in insulin content in pancreatic beta cells, highlighting its role in insulin biogenesis.
A genetic screen in worms reveals TRAP-alpha as a crucial component of the insulin synthesis pathway, affecting both early and late steps. The findings support the idea that defects in insulin synthesis contribute to Type 2 diabetes, and may lead to new approaches for prevention and treatment.
A new Tel Aviv University study finds that consuming a starch-rich breakfast early in the morning and a small dinner may improve glycemic control among type 2 diabetics, reducing the need for insulin injections. The researchers' 3M-diet was shown to have significant benefits, including weight loss and improved sugar levels.
Researchers have solved a critical piece of the puzzle by showing how insulin interacts with its receptor at a second binding site. This new understanding will allow researchers to design improved treatments for insulin-related disorders, such as diabetes.
Researchers at Stevens Institute of Technology developed a meal-detection system that can accurately calculate carbohydrate intake in real-time, allowing for faster insulin administration. The system's estimates are remarkably accurate, outperforming previous systems by up to 17 grams.
A WSU study published in Cell Reports demonstrates that mammalian insulin activates an antiviral immunity pathway in mosquitoes, increasing their ability to suppress flavivirus infections. This discovery has the potential to inhibit the spread of West Nile virus and other diseases such as dengue and Zika.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
A new project aims to create a smartphone app that helps manage life-saving devices for people with diabetes, focusing on the senior citizen population. The app will consider factors such as visual setup, font size, and user experience to make it easy to use, potentially improving quality of life.
Scientists develop optogenetic approach to control glucose levels in diabetic mice, achieving improved tolerance and regulation of glucose without pharmacological intervention. The light-switchable cells can produce more than two- to three-fold the typical level of insulin in response to glucose levels.
A new study by Lund University researchers has identified a key mechanism in insulin release by a cholesterol metabolite. The receptor GPR183 plays a major role in stimulating insulin secretion in human cells and rats.
A multicenter randomized clinical trial found that the new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, outperforming existing treatments. The system significantly increased time with target blood glucose levels and showed improvements in other diabetes control measurements.
A six-week study found that exercising before breakfast increased fat burn by 100% compared to after breakfast. This shift allowed for better insulin control, potentially lowering diabetes and heart disease risk.
A new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, reducing the risk of low blood sugar levels. The system's advanced algorithms and safety features enabled users to achieve near-normal blood sugar levels every morning.
A new artificial pancreas system has been shown to improve blood glucose control throughout the day and overnight, offering a significant advantage over existing treatments for people with type 1 diabetes. The system, which automatically monitors and regulates blood glucose levels, was more effective than traditional therapies in achie...
Researchers at UNIGE identified a protein called S100A9 that regulates blood glucose and lipids, improving glucose management and reducing harmful side effects in diabetic mice. A clinical trial is underway to test the safety and efficacy of this new therapy in humans.
Researchers developed a new oral delivery device that can carry insulin and other protein drugs, protecting them from the acidic environment of the stomach. The capsule contains microneedles that attach to the intestinal wall and release the drug for uptake into the bloodstream, enabling fast and pain-free delivery.
Advances in medications, lifestyle changes, and technologies can help manage post-meal blood sugar levels, but more research is needed to pinpoint a target range and improve clinical outcomes. Small lifestyle changes, such as eating protein and vegetables before carbohydrates, can also lower blood glucose levels.
A study found that patients with poor health were more likely to continue taking insulin after age 75, despite guidelines recommending reduced treatment intensity. Discontinuing insulin may outweigh its benefits for older adults, especially those with multiple health conditions.
This observational study found that insulin treatment was used less frequently among older adults (75-79 years) in poor health compared to those in good health. The study also revealed higher discontinuation rates of insulin treatment among those in poor health, suggesting potential implications for diabetes management.
Researchers at Uppsala University have identified a previously unknown protein, Sac2, that regulates insulin secretion from β-cells. Lowering Sac2 levels leads to reduced insulin secretion, highlighting the importance of fat composition on secretory granule function.
Researchers at UNIGE found that the liver can produce glucose independently of hormonal signals, challenging the long-held belief about its role in glucose regulation. This autonomous glucose production may contribute to the development of type 2 diabetes in patients with a fatty liver syndrome.
Researchers have developed an 'Islet-on-a-Chip' device that integrates organ-on-a-chip and stem-cell technologies to screen insulin-producing cells, test insulin-stimulating compounds, and study the fundamental biology of diabetes. The device makes it easier to monitor islet function and study cell therapies for diabetes.
Researchers confirm known genomic variants and identify a novel ZRANB3 gene linked to T2D susceptibility in sub-Saharan Africans. The study's findings also suggest the gene may influence T2D development in other populations.
Researchers at Ohio University are investigating the pulsatility of pancreatic islets in an effort to prevent or reverse type 2 diabetes. By forcing exhausted beta cells to pulse, they aim to restore their healthy functioning and improve health prospects for patients with pre-diabetes and diabetes.
Researchers found that intranasal insulin delivery improves performance on memory tasks and increases brain connectivity in adolescents with high BMI. The study suggests that obesity-related cognitive impairment can be reversed by intranasal insulin.
Researchers found that intermittent fasting reduced pancreatic fat in mice, a key finding in the development of type 2 diabetes. The study suggests that excess weight-induced fat accumulation in the pancreas contributes to the onset of diabetes.
A study from Joslin Diabetes Center found that a minority of patients treated for decades with type 1 diabetes may have monogenic diabetes, which can be treated with oral drugs. The research suggests screening for genetic mutations in young people diagnosed with type 1 diabetes to identify potential treatment options.
A team of researchers has identified highly-connected cluster of 'leader' cells in the pancreas that coordinate insulin response and help understand how diabetes develops. By selectively deleting these leader cells, they disrupted the level of coordination in subsequent responses to glucose.
A randomized clinical trial found that patients taking IDegLira achieved and maintained lower blood glucose levels for longer periods compared to those taking insulin only. The study showed improved outcomes without the need for additional therapy, reducing side effects often associated with insulin-only treatment.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
A 10-week pilot study integrated health coaching and incentives into standard treatment for pediatric patients with type 1 diabetes, lowering A1c levels by an average of .5%. Health coaches received greater empathy and engagement, while families benefited from personalized feedback and support.
A newly discovered immune cell, the 'X cell', has been found to be a major driver of the autoimmune response believed to cause type 1 diabetes. The X cell can act as both a B cell and a T cell, amplifying the autoimmune response.
Scientists uncover how light influences insulin sensitivity and metabolic homeostasis, shedding light on the circadian rhythms' impact on diabetes. The study suggests that taking into account time of day can help patients better manage their treatment and reduce risks associated with daily insulin injections.
Researchers at the University of California, Davis have discovered that metals can subtly affect the structure of C-peptide, a hormone involved in insulin production. The study found that certain metals, such as copper and chromium, prevent cells from taking up C-peptide, while others like zinc do not.
A new type of insulin called i-insulin was developed by UCLA researchers to help regulate blood sugar levels and prevent hypoglycemia. The smart insulin works like a 'smart key,' allowing glucose to enter cells while blocking excessive entry when blood sugar is normal.
Researchers from George Washington University have successfully used ultrasound therapy to increase insulin levels in mice, providing a potential alternative to current treatments. The study found significant increases in blood insulin levels after exposure to ultrasonic pulses, but did not see the corresponding drop in glucose levels.
Researchers have discovered that transplanted islets in the anterior chamber of the eye exhibit early signs of inflammation before type 1 diabetes symptoms appear, suggesting a potential biomarker for predicting disease development. Early intervention with immunosuppressive treatments may halt disease progression, and future studies ai...
Researchers at the UPV/EHU-CIBER BBN have developed a new system for treating type 1 diabetes mellitus that reduces the technical problems associated with microencapsulating pancreatic islets. The innovative approach uses magnetic nanoparticles and a microfluidic chip to separate empty microcapsules from purified islets, resulting in a...
A new study found that hospitalizations for diabetic ketoacidosis (DKA) surge in the US among young adults, but remain relatively low in Canada. The disparity is attributed to differences in healthcare systems and access to insulin, with the US experiencing a significant increase in DKA rates as teenagers become young adults.
A pilot study found that Montmorency tart cherry juice reduced systolic blood pressure and lowered insulin levels in adults with metabolic syndrome. The study also showed improvements in arterial stiffness after consumption of the juice.
A study by the University of Exeter found that 38% of patients with type 1 diabetes over 30 were initially treated as type 2. Half of those misdiagnosed remained so 13 years later. Insulin treatment is crucial for type 1 diabetes diagnosis.
Researchers identified insulin as a primary signal that helps communicate meal timing to the body clock, driving daily physiological rhythms. This discovery could lead to new therapies targeting insulin signaling and emphasize the importance of meal timing for maintaining healthy body clocks.
A study found that a high-calorie diet combined with stress leads to more weight gain than the same diet without stress. The researchers discovered a molecular pathway controlled by insulin and the NPY molecule, which drives additional weight gain. This highlights the importance of being mindful of food intake when stressed.
Researchers at Harvard Medical School discovered an unexpected mechanism by which insulin triggers changes to thousands of genes. The insulin receptor is physically transported to the cell nucleus and helps initiate the expression of insulin-related genes, providing new avenues for diabetes research and potential therapeutic targets.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
Researchers developed a simple and inexpensive way to measure C-peptide, allowing clinicians to accurately diagnose type of diabetes and tailor treatment. The test has been used on over 750 patients with Type 1 diabetes diagnosis and shown that some have other types of diabetes, enabling them to stop insulin treatment.
A new study suggests that glucagon can help regulate insulin action and prevent blood sugar levels from becoming too high. By activating a protein called PGC1A, glucagon can prepare the liver to respond quickly to insulin signals after meals.
A plant-based meal has been shown to increase the postprandial secretion of insulin and incretin hormones, particularly GLP-1, in individuals with type 2 diabetes. This improvement in beta-cell function parameters suggests a potential solution for managing and treating the condition.
Researchers have shown that human cells can differentiate into different cell types, changing their original function. This breakthrough may lead to new treatments for diabetes by influencing glucagon-producing cells in the pancreas to produce insulin instead.
A collection of 27 papers has been compiled to better understand the pathophysiology of endocrinopathic laminitis in horses. The research highlights the key role of insulin dysregulation and equine metabolic syndrome in driving the condition.
Researchers at UNIGE show that human pancreatic cells can be converted to produce insulin in a sustainable way, potentially compensating for lost or dysfunctional cells. The conversion was successful in both diabetic and non-diabetic donors, with modified alpha cells showing improved resistance to autoimmune diabetes.
Researchers have made significant progress with UVA's artificial pancreas, a device that automates blood-sugar level monitoring and insulin injection. The International Diabetes Closed Loop Trial has provided early results from its nationwide clinical trial, examining the algorithm's use in smartphone apps and embedded devices.
A new capsule has been developed to deliver oral doses of insulin, potentially replacing injections for people with type 2 diabetes. The capsule contains a small needle that releases insulin in the stomach, and its design allows it to orient itself to ensure contact with the stomach lining.
Researchers have created an oral formulation of insulin using a pill-sized device that can deliver a microinjection from within the stomach. The device, called SOMA, uses a spring and sugar disc to trigger the injection, and has shown promising results in animal trials with a marked decrease in blood glucose levels.
A new ingestible device, inspired by a tortoise's shell, can inject drugs through the stomach wall, overcoming challenges of oral delivery. The device has been shown to achieve similar insulin plasma levels as traditional subcutaneous injections in animal studies.