Articles tagged with Insulin
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This observational study found that insulin treatment was used less frequently among older adults (75-79 years) in poor health compared to those in good health. The study also revealed higher discontinuation rates of insulin treatment among those in poor health, suggesting potential implications for diabetes management.
Researchers at Uppsala University have identified a previously unknown protein, Sac2, that regulates insulin secretion from β-cells. Lowering Sac2 levels leads to reduced insulin secretion, highlighting the importance of fat composition on secretory granule function.
Researchers at UNIGE found that the liver can produce glucose independently of hormonal signals, challenging the long-held belief about its role in glucose regulation. This autonomous glucose production may contribute to the development of type 2 diabetes in patients with a fatty liver syndrome.
Researchers have developed an 'Islet-on-a-Chip' device that integrates organ-on-a-chip and stem-cell technologies to screen insulin-producing cells, test insulin-stimulating compounds, and study the fundamental biology of diabetes. The device makes it easier to monitor islet function and study cell therapies for diabetes.
Researchers confirm known genomic variants and identify a novel ZRANB3 gene linked to T2D susceptibility in sub-Saharan Africans. The study's findings also suggest the gene may influence T2D development in other populations.
Researchers at Ohio University are investigating the pulsatility of pancreatic islets in an effort to prevent or reverse type 2 diabetes. By forcing exhausted beta cells to pulse, they aim to restore their healthy functioning and improve health prospects for patients with pre-diabetes and diabetes.
Researchers found that intranasal insulin delivery improves performance on memory tasks and increases brain connectivity in adolescents with high BMI. The study suggests that obesity-related cognitive impairment can be reversed by intranasal insulin.
Researchers found that intermittent fasting reduced pancreatic fat in mice, a key finding in the development of type 2 diabetes. The study suggests that excess weight-induced fat accumulation in the pancreas contributes to the onset of diabetes.
A study from Joslin Diabetes Center found that a minority of patients treated for decades with type 1 diabetes may have monogenic diabetes, which can be treated with oral drugs. The research suggests screening for genetic mutations in young people diagnosed with type 1 diabetes to identify potential treatment options.
A team of researchers has identified highly-connected cluster of 'leader' cells in the pancreas that coordinate insulin response and help understand how diabetes develops. By selectively deleting these leader cells, they disrupted the level of coordination in subsequent responses to glucose.
A randomized clinical trial found that patients taking IDegLira achieved and maintained lower blood glucose levels for longer periods compared to those taking insulin only. The study showed improved outcomes without the need for additional therapy, reducing side effects often associated with insulin-only treatment.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
A 10-week pilot study integrated health coaching and incentives into standard treatment for pediatric patients with type 1 diabetes, lowering A1c levels by an average of .5%. Health coaches received greater empathy and engagement, while families benefited from personalized feedback and support.
A newly discovered immune cell, the 'X cell', has been found to be a major driver of the autoimmune response believed to cause type 1 diabetes. The X cell can act as both a B cell and a T cell, amplifying the autoimmune response.
Scientists uncover how light influences insulin sensitivity and metabolic homeostasis, shedding light on the circadian rhythms' impact on diabetes. The study suggests that taking into account time of day can help patients better manage their treatment and reduce risks associated with daily insulin injections.
Researchers at the University of California, Davis have discovered that metals can subtly affect the structure of C-peptide, a hormone involved in insulin production. The study found that certain metals, such as copper and chromium, prevent cells from taking up C-peptide, while others like zinc do not.
A new type of insulin called i-insulin was developed by UCLA researchers to help regulate blood sugar levels and prevent hypoglycemia. The smart insulin works like a 'smart key,' allowing glucose to enter cells while blocking excessive entry when blood sugar is normal.
Researchers from George Washington University have successfully used ultrasound therapy to increase insulin levels in mice, providing a potential alternative to current treatments. The study found significant increases in blood insulin levels after exposure to ultrasonic pulses, but did not see the corresponding drop in glucose levels.
Researchers have discovered that transplanted islets in the anterior chamber of the eye exhibit early signs of inflammation before type 1 diabetes symptoms appear, suggesting a potential biomarker for predicting disease development. Early intervention with immunosuppressive treatments may halt disease progression, and future studies ai...
Researchers at the UPV/EHU-CIBER BBN have developed a new system for treating type 1 diabetes mellitus that reduces the technical problems associated with microencapsulating pancreatic islets. The innovative approach uses magnetic nanoparticles and a microfluidic chip to separate empty microcapsules from purified islets, resulting in a...
A new study found that hospitalizations for diabetic ketoacidosis (DKA) surge in the US among young adults, but remain relatively low in Canada. The disparity is attributed to differences in healthcare systems and access to insulin, with the US experiencing a significant increase in DKA rates as teenagers become young adults.
A pilot study found that Montmorency tart cherry juice reduced systolic blood pressure and lowered insulin levels in adults with metabolic syndrome. The study also showed improvements in arterial stiffness after consumption of the juice.
A study by the University of Exeter found that 38% of patients with type 1 diabetes over 30 were initially treated as type 2. Half of those misdiagnosed remained so 13 years later. Insulin treatment is crucial for type 1 diabetes diagnosis.
Researchers identified insulin as a primary signal that helps communicate meal timing to the body clock, driving daily physiological rhythms. This discovery could lead to new therapies targeting insulin signaling and emphasize the importance of meal timing for maintaining healthy body clocks.
A study found that a high-calorie diet combined with stress leads to more weight gain than the same diet without stress. The researchers discovered a molecular pathway controlled by insulin and the NPY molecule, which drives additional weight gain. This highlights the importance of being mindful of food intake when stressed.
Researchers at Harvard Medical School discovered an unexpected mechanism by which insulin triggers changes to thousands of genes. The insulin receptor is physically transported to the cell nucleus and helps initiate the expression of insulin-related genes, providing new avenues for diabetes research and potential therapeutic targets.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
Researchers developed a simple and inexpensive way to measure C-peptide, allowing clinicians to accurately diagnose type of diabetes and tailor treatment. The test has been used on over 750 patients with Type 1 diabetes diagnosis and shown that some have other types of diabetes, enabling them to stop insulin treatment.
A new study suggests that glucagon can help regulate insulin action and prevent blood sugar levels from becoming too high. By activating a protein called PGC1A, glucagon can prepare the liver to respond quickly to insulin signals after meals.
A plant-based meal has been shown to increase the postprandial secretion of insulin and incretin hormones, particularly GLP-1, in individuals with type 2 diabetes. This improvement in beta-cell function parameters suggests a potential solution for managing and treating the condition.
A collection of 27 papers has been compiled to better understand the pathophysiology of endocrinopathic laminitis in horses. The research highlights the key role of insulin dysregulation and equine metabolic syndrome in driving the condition.
Researchers have shown that human cells can differentiate into different cell types, changing their original function. This breakthrough may lead to new treatments for diabetes by influencing glucagon-producing cells in the pancreas to produce insulin instead.
Researchers at UNIGE show that human pancreatic cells can be converted to produce insulin in a sustainable way, potentially compensating for lost or dysfunctional cells. The conversion was successful in both diabetic and non-diabetic donors, with modified alpha cells showing improved resistance to autoimmune diabetes.
Researchers have made significant progress with UVA's artificial pancreas, a device that automates blood-sugar level monitoring and insulin injection. The International Diabetes Closed Loop Trial has provided early results from its nationwide clinical trial, examining the algorithm's use in smartphone apps and embedded devices.
Researchers have created an oral formulation of insulin using a pill-sized device that can deliver a microinjection from within the stomach. The device, called SOMA, uses a spring and sugar disc to trigger the injection, and has shown promising results in animal trials with a marked decrease in blood glucose levels.
A new ingestible device, inspired by a tortoise's shell, can inject drugs through the stomach wall, overcoming challenges of oral delivery. The device has been shown to achieve similar insulin plasma levels as traditional subcutaneous injections in animal studies.
A large clinical study found that intensive glucose management after stroke did not improve functional outcomes and increased the risk of low blood sugar. The results provide a clear answer to the long-held debate on blood sugar control after stroke.
A new capsule has been developed to deliver oral doses of insulin, potentially replacing injections for people with type 2 diabetes. The capsule contains a small needle that releases insulin in the stomach, and its design allows it to orient itself to ensure contact with the stomach lining.
A multicenter trial of 1,151 patients found that IV insulin intensive glucose control did not improve functional outcomes at 90 days compared to standard subcutaneous insulin injections. Intense glucose therapy also increased the risk of hypoglycemia and required more resources.
Researchers found that bariatric surgery triggers the release of higher levels of gut hormones, particularly GLP-1, leading to increased insulin production and improved glucose control. The study suggests a new mechanism for weight loss and diabetes management after surgery.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
Researchers found a small increase of 0.14 percent in hemoglobin A1c levels after switching from analogue to human insulin, which falls within expected biological variation. The switch was not associated with serious hypoglycemic or hyperglycemic events and improved economic outcomes for patients.
The discovery of glucose-regulated protein GRP94 as a chaperone assisting proinsulin folding has significant implications for understanding insulin production. Removing GRP94 from beta cells impaired insulin secretion, suggesting its specialized function in maintaining cellular response to misfolded proinsulin.
A recent study found that insulin deprivation in mice resulted in decreased ATP production in brain regions critical for memory, similar to previous findings in skeletal muscle. Intranasal insulin treatment reversed this decline, suggesting insulin's role in maintaining brain mitochondrial function.
Researchers at Washington University School of Medicine have developed a new method for producing insulin-producing beta cells from human stem cells, which are more responsive to fluctuating glucose levels. The resulting cells were transplanted into diabetic mice and effectively controlled blood sugar for several months.
A study from the University of Pittsburgh found that rising drug costs are driven by both new and existing medications. While new drugs contribute to price increases, existing products explain most of the cost rises, particularly for brand-name drugs with multiple patents preventing competition.
Scientists at the University of Bergen found that glucagon-producing cells in the pancreas can change identity and adapt to produce insulin for damaged or missing cells. This discovery may lead to new treatments where the body produces its own insulin with minimal assistance.
A Northwestern Medicine study found that sulfonylureas and basal insulin increase the risk of heart attack, stroke, and amputation in patients with Type 2 diabetes. The study suggests a paradigm shift in treatment, recommending newer diabetes medications with more favorable cardiovascular profiles.
Researchers have discovered a new therapeutic avenue for treating type 2 diabetes by targeting the interaction between hormone-sensitive lipase (HSL) and a transcription factor responsible for fatty acid synthesis. Decreasing HSL expression leads to improved insulin sensitivity, which may help prevent or manage the disease.
Scientists from the Diabetes Research Institute renewed their original theory that pancreatic progenitor cells exist and can regenerate in humans. The study's findings could potentially address a major challenge in type 1 diabetes by regrowing patients' own insulin-producing cells.
One in four patients with type 1 or 2 diabetes have reported using less insulin than prescribed due to high costs. This underuse of insulin is often accompanied by poor glycemic control and difficulty affording other diabetes management equipment.
A small survey of patients with diabetes found that 1 in 4 reported underusing insulin due to cost concerns. Poor glycemic control was a common result of this underuse. The study emphasizes the importance of making insulin more affordable.
Research finds that socio-economic conditions in regions affect T1 diabetes treatment, with disadvantaged areas having higher blood glucose levels, lower use of pump therapy and CGMS, and better outcomes for severe hypoglycemia. Frequent use of pump therapy and CGMS could improve treatment outcomes in these regions.
A global study predicts a 20% increase in insulin use by 2030 due to rising type 2 diabetes cases. Without improved access, nearly half of the 79 million adults with type 2 diabetes will not receive insulin.
Scientists from the University of Bristol have designed a new synthetic glucose binding molecule platform that brings us closer to developing the world's first glucose-responsive insulin. This innovation could eliminate hypoglycemia and provide better metabolic control for people living with diabetes.
A new streamlined method by the Endocrine Society helps people with diabetes use CGM data to refine insulin doses and improve blood glucose control. The approach, based on trend arrows in Abbott FreeStyle Libre systems, provides simplified calculations for users.
A recent pilot study by kinesiologists at UMass Amherst found that pedaling while working improved insulin responses to a test meal, with lower insulin levels observed when using a pedal desk compared to a standard desk. The study suggests that pedal desks could be a feasible solution for sedentary work environments.
Eating daily servings of nuts has been associated with lower risk of weight gain and obesity, as well as improved glucose and insulin responses. A one-ounce serving of nuts or peanut butter can be substituted for less healthy foods to prevent slow weight gain over time.
Researchers at the Walter and Eliza Hall Institute have produced the first definitive 3D image of how insulin binds to its receptor on the surface of cells. This image could inform the design of faster-acting and longer-lasting insulin therapies, potentially benefiting millions worldwide.
Researchers at UNIGE discovered that α and δ cells can take over insulin production when β cells are damaged, leading to a phenomenon of cell plasticity. This finding opens the door to new treatments by harnessing the body's regenerative capacities.