Articles tagged with Antibiotic Resistance
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A new genomics study has helped guide the development of vaccines against Shigella, a leading cause of severe diarrhoea in children. The research revealed the extent of genomic diversity among Shigella species, highlighting challenges to current vaccine approaches.
Scientists discovered that surviving bacteria share a common feature: they accumulate acid in their cells, shutting down protein synthesis. This leads to increased survival and can be exploited to develop new antimicrobial treatments.
Decision-making tools, including a double-sided document and video training, were ineffective in reducing antibiotic prescription rates for acute respiratory infections. Despite this, general practitioners' knowledge of relevant evidence increased significantly after the intervention.
Researchers at TTUHSC developed novel hydrophilic nanoparticles that target bacterial membranes, killing pathogens while sparing mammalian cells. The nanoantibiotics' size-dependent activity reveals a new blueprint for developing non-toxic and environmentally friendly antibiotics.
A new report estimates that antibiotic-resistant bacterial infections caused over 1.27 million deaths worldwide in 2019, with the greatest impact on lower respiratory and bloodstream infections. The study highlights the urgent need to combat antimicrobial resistance and provides immediate actions for policymakers to save lives.
Rice University researchers developed a microfluidic platform to analyze how infectious bacteria evolve resistance to antibiotics. The platform allows for controlled environments and fine-tuning of conditions, revealing previously unknown pathways to resistance.
Researchers developed a mathematical model that can predict resistance outcomes for various drug pairs. The model, called JDFE, characterizes mutations available to bacteria and allows for classification of drug pairs into those that facilitate or hinder multi-drug resistance.
A new EU-funded project, MUSIC, will investigate how bacterial defences influence the spread of mobile genetic elements (MGEs) between bacteria. MGEs can change key traits of bacteria, including antibiotic resistance and virulence.
Researchers have pinpointed a gene in E. coli ST131 that makes it highly resistant to antibiotics, leading to new treatment strategies and improved tracking of emerging resistance. The study aims to create better treatments to stop deadly E. coli infections.
Researchers at Sanford Burnham Prebys have received a $3.6 million grant to study antibiotic resistance, employing an innovative approach known as the 'evolution machine.' This project aims to shed new light on how bacteria develop resistance and inform more precise antibiotic prescribing practices.
A study published in Nature found that a type of MRSA called mecC-MRSA originated in hedgehogs over 200 years ago, long before the clinical use of antibiotics. The researchers believe that the bacteria evolved as an adaptation to living on the skin of hedgehogs with a fungus that produces its own antibiotics.
Researchers at Rockefeller University have discovered a novel compound called macolacin that is highly potent against multidrug-resistant bacteria, including those resistant to colistin. The compound was discovered using an evolutionary approach to antibiotic discovery and has shown promising results in lab experiments.
A new species of antibiotic-resistant bacteria, Enterococcus innesii, has been discovered by researchers at the John Innes Centre. The strain is resistant to vancomycin and may cause hospital-acquired infections.
New research combines antibiotics and phage therapy to cure infections more effectively and reduce antibiotic use. The study found that bacteriostatic antibiotics trigger CRISPR-Cas adaptive immunity in bacteria, increasing the chances of treatment efficacy.
Scientists have discovered a new potential treatment to reverse antibiotic resistance in bacteria causing sepsis, pneumonia, and urinary tract infections. The indole carboxylates class of enzyme blockers can stop MBL resistance enzymes from working, allowing antibiotics like carbapenems to effectively target bacteria.
A new study reveals widespread prescribing of clarithromycin-based regimens for H. pylori infection, defying increasing resistance and suboptimal eradication rates. Talicia, a rifabutin-based therapy, offers an alternative with higher eradication rates and fewer concerns over resistance.
Scientists have developed an enzyme that degrades the capsule surrounding the bacterium that causes anthrax, reducing virulence and protecting mice from infection. The treatment, known as PEG-CapD-CPS334C, is a promising avenue for treating multidrug-resistant anthrax and other bacterial infections.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
Researchers at USC developed a new peptide that stimulates the host's immune response to fight bacterial infections, offering an alternative to antibiotics. The peptide, MTD12813, is highly effective in clearing infections and modulates inflammation, reducing the risk of complications.
A new study led by Rice University engineers finds that microplastic pollution contributes to the spread of antibiotic-resistant genes. The researchers discovered that aging polystyrene breaks down into microplastics with high surface areas, trapping microbes and leaching chemicals that enhance gene transfer.
A new white paper shares practical strategies to inform stewardship efforts and ensure appropriate use of antibiotics, citing the public health crisis of antibiotic resistance leading to 23,000 preventable deaths each year. Implementation science principles can bridge the evidence-practice gap.
Researchers from the University of Manchester have discovered a new way to manipulate key assembly line enzymes in bacteria using CRISPR-cas9 gene editing. This approach could lead to the production of improved antibiotics with potentially improved properties, addressing the growing threat of antimicrobial resistance.
Researchers from Trinity College Dublin investigate the epidemiology and population biology of Enteroccocus faecium, a high-priority pathogen. They found that Irish isolates have evolved independently and are diverse, with a unique genetic transposon element encoding vancomycin resistance.
A recent study found that antibiotic resistance rates for Helicobacter pylori are decreasing in European countries. The use of three antibiotics over 10-14 days resulted in success rates of over 90%. The researchers hope to reduce antibiotic consumption to prevent further resistance.
Researchers have found that ultrashort-pulse lasers can inactivate antibiotic-resistant bacteria and bacterial spores, reducing their numbers by over 1,000 times. The technology has the potential to be used to sterilize wounds and disinfect blood products, and may also be used to treat bloodstream infections.
A study led by New York University researchers found that the FDA-approved hepatitis C treatment telaprevir can increase bacterial sensitivity to antibiotics and reduce antibiotic resistance. The antiviral blocks the function of essential proteins in bacteria, revealing an opportunity to repurpose the drug to use alongside antibiotics.
Researchers at the University of Texas at Dallas have developed a vaccine method against recurrent urinary tract infections (UTIs) using metal-organic frameworks. The new approach produces substantially enhanced antibody production and significantly higher survival rates in mice compared to standard vaccine preparation methods.
The European Union and European Economic Area saw a significant decline in antibiotic consumption in 2020, with a 18% decrease compared to 2019. This decline was largely attributed to the COVID-19 pandemic, which led to reduced primary care consultations for mild infections.
Researchers at Karolinska Institutet have discovered a new group of small antibacterial compounds that inhibit the formation of bacterial cell walls, showing promise against antibiotic-resistant strains. The molecules work by binding to lipid II, a crucial molecule for bacterial cell wall construction.
Researchers have identified compounds that interfere with fungal enzymes required for fatty acid synthesis, potentially overcoming resistance to current treatments. These compounds show promise as antifungal agents, effective even against drug-resistant strains of fungi.
A study by Anglia Ruskin University has identified potentially dangerous Pseudomonas bacteria in 21% of wild bird faeces collected from locations near the River Cam. The bacteria, which can be passed on to humans through cross-contamination, were resistant to multiple antibiotics.
A rapid same-day test has been developed to identify secondary infections in COVID-19 patients on intensive care, allowing for targeted antibiotic treatment and reduced risk of antimicrobial resistance. The test uses nanopore sequencing technology to analyze bacterial and fungal pathogens present in patient samples.
Research identifies way of using nanoparticles to target and disrupt bacterial cells, making them more susceptible to standard antibiotic treatments. Laboratory studies show a strong effect in killing a range of bacteria, including some linked to hospital-acquired infections.
Scientists used computational strategies to evaluate antibiotic candidates, identifying a promising new variant that is up to 56 times more active than existing antibiotics. This approach enables faster and more affordable development of new antibiotics, helping to combat resistance.
A new study found that most pregnant women with a penicillin allergy label are not allergic, but rather have Group B Strep or need antibiotics for labor. Testing for penicillin allergy can help reduce antibiotic exposure and ensure safer treatment options.
A new technique measures bacterial metabolic activity with an electric probe to identify antibiotic resistance in less than 90 minutes. This rapid method enables doctors to quickly determine which antibiotics will or won't work for a patient's infection, improving treatment decisions and potentially saving lives.
The need for new antibiotics is critical due to rising antibiotic resistance, which kills over 35,000 people annually in the US. Research by Harvard Medical School aims to develop better antibiotics by targeting essential bacterial proteins.
Researchers have made a giant leap in fighting antibiotic resistance by using supercomputers to redesign existing antibiotics. The new approach shows that the redesigned antibiotic is up to 56 times more active than two existing antibiotics on the World Health Organisation's list, and potentially effective against three top-ranked bact...
Researchers at Karolinska Institutet discovered that interleukin-26 plays a critical role in bacterial pneumonia by directly killing bacteria and modulating the immune system. This finding positions IL-26 as a new potential target for biological treatment of pneumonia, an increasing global health threat.
A study published in The Lancet Infectious Diseases found that temocillin was effective in treating febrile urinary tract infections with fewer resistant bacteria. Temocillin acts specifically against E. coli and other intestinal bacteria, reducing the risk of treatment failure.
A new study reveals that iboxamycin effectively fights both gram-negative and gram-positive drug-resistant bacteria in mouse models. The researchers discovered the molecular mechanism that allows this drug to overcome resistance, which is important for developing new antibiotics.
A study found that infant formula is associated with a 70% higher occurrence of antibiotic resistance genes in newborns. Breastfeeding, on the other hand, reduces the proliferation of opportunistic pathogens, potentially lessening the risk of difficult infections.
Researchers have recorded the sharpest images of living bacteria, revealing a complex architecture that makes them harder to kill by antibiotics. The study found that bacteria with protective outer layers may have stronger and weaker spots on their surface.
Researchers revealed that β-lactam antibiotics like penicillin kill MRSA by forming small holes in the cell wall, which gradually enlarge and lead to bacterial death. This discovery provides new avenues for treatment developments against antibiotic-resistant superbugs.
Researchers at Cornell University used machine learning to predict the spread of antibiotic resistance genes among bacteria, identifying potential networks of exchange and driving factors. The approach could help control the spread of antibiotic resistance and develop new targets for novel antibiotics.
Researchers at the University of Bonn discovered a novel resistance mechanism in Staphylococcus aureus, which protects the bacteria from vancomycin. By binding vancomycin to its cell wall, the strain prevents the antibiotic from reaching the membrane and killing the bacteria.
Researchers have developed new qPCR assays to quantify the transmission of antimicrobial resistance (AMR) using water and wastewater samples. These methods provide a more exact way to determine AMR by measuring DNA in wastewater samples.
Researchers identified a bacterium on healthy cats that produces antibiotics against severe skin infections in humans and pets. The discovery may lead to new treatments for MRSP infections in dogs and potentially other inflammatory skin diseases.
A new study suggests that a novel treatment involving the administration of an enzyme that degrades neutrophil nets may prevent brain swelling and improve waste clearance in rats with bacterial meningitis. The treatment could be combined with antibiotics if needed.
A new hydrogel treatment kills drug-resistant bacteria, including MRSA, and induces the expression of naturally-existing antimicrobial peptides in human skin cells. The gel is non-toxic, biodegradable, and scalable.
Researchers at the University of Oklahoma have contributed to a study on a new antibiotic that may cure Lyme disease and eradicate its occurrence from the environment. The antibiotic, hygromycin A, targets the ribosomes of the bacteria Borrelia burgdorferi and shows promise in treating the disease.
The cost of establishing laboratories to track antimicrobial resistance in Southeast Asian hospitals is substantial, making it challenging for many countries to implement such programs. Financial support is crucial to overcome these costs and provide effective antimicrobial resistance monitoring.
Researchers at the University of Exeter develop a new method to mimic microenvironments in the human body, overcoming a major obstacle to using phage therapy. The study finds that phage can effectively kill bacteria in these environments without promoting genetic resistance.
A new study by Oxford academics found that approximately 20% of flies and cockroaches carry carbapenem resistance, while 70-80% carry extended spectrum cephalosporin resistance. Climate change could lead to a doubling of insect populations and an increase in the global spread of antibiotic resistance.
A large trial found that antibiotic amoxicillin has little effect on relieving symptoms in children with uncomplicated chest infections. The study also highlights the need for 'safety-netting' advice to parents, explaining illness course and when re-attendance may be necessary.
A new study from Cornell University has found that the antimicrobial properties of certain stem cell proteins can effectively reduce the viability of methicillin-resistant Staphylococcus aureus (MRSA) in skin wounds. The treatment also stimulates the surrounding skin cells to build up a defense against the bacterial invader.
Scientists have developed a new therapy that combines bacteriophages with antibiotics to treat antibiotic-resistant infections, specifically targeting Mycobacterium abscessus. The treatment, using the bacteriophage 'Muddy', showed significant improvement in survival rates and severity of infections when paired with rifabutin, demonstra...
A team of researchers characterized different bacterial populations isolated from the International Space Station's potable water system, exploring their functional properties and long-term interactions. The study aimed to improve microbial risk assessments for human-built environments in space and on Earth.
A whole genome analysis of a Staphylococcus aureus collection recovered from Cape Verde reveals high genetic variability among isolates. The study identifies three primary genetic clusters associated with lineages ST152, ST15, and ST5, commonly found in S. aureus infections worldwide.
A research team at HKU has developed a framework to evaluate the risks of antibiotic resistance genes (ARGs) based on three factors: human-associated environments, gene mobility, and host pathogenicity. The framework provides a risk hierarchy for ARGs, allowing for informed decision-making on tackling environmental ARGs.