Articles tagged with Antibiotic Resistance
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Researchers found that human antibiotic use increased resistance to antibiotics in bears' bacteria, affecting even those far from civilization. The study suggests that reducing antibiotic use can help decline resistance rates.
A virulent Salmonella Enteritidis strain has been sequenced from two consecutive poultry flocks in North Carolina State University. The strain, SE_TAU19, exhibits seven antimicrobial resistance genes and 120 virulence genes, posing a threat to human health. Genome sequencing provides valuable data for tracing outbreaks and preventing f...
A CDC analysis of National Healthcare Safety Network data revealed a significant increase in four types of healthcare-associated infections in U.S. hospitals during the COVID-19 pandemic, with central line infections rising by 46-47% compared to pre-pandemic rates.
Scientists detect early resistances to new antibiotic combination in Germany, limiting its potential as a treatment option for carbapenem-resistant pathogens. The study highlights the importance of genome-based surveillance for early detection of new resistance developments and emerging pathogens.
Researchers have identified a unique sequence essential for efficient multidrug efflux function of the MtrD protein in Neisseria gonorrhoeae, a key mechanism for antimicrobial resistance. This discovery could lead to the development of new antibiotic treatments.
Using sequential antibiotic treatment with similar but swapped antibiotics slows down bacterial adaptation to drugs, reducing cross-resistance. The study used Pseudomonas aeruginosa and found that fast switching between antibiotics constrained bacterial evolution.
A study found that commercial composts contain more airborne pathogens than backyard composts, while immature compost samples have high levels of antibiotic resistance genes. The researchers hope to improve their detection method to assess the threat to humans.
Researchers analyzed oral bacteria of wild brown bears to track history of human antibiotic use and find significant decrease in antibiotic resistance after national policies were implemented. The study highlights the effectiveness of governmental policies in mitigating a major health threat on a national level.
Scientists have developed stable peptide mimics called peptoids to treat viruses and prevent infections. Peptoids, such as those tested against SARS-CoV-2 and HSV-1, could one day cure or prevent many kinds of infections, including COVID-19.
Researchers discovered that human milk oligosaccharides can prevent GBS infections in cells and tissues, and in mouse models. The sugars may act as anti-adhesives and prebiotics to support good bacteria growth, making them a potential substitute for antibiotics.
A study found that COVID-19 restrictions led to a 36% drop in antibiotic dispensing rates in Australia, primarily for respiratory tract infections. The decline continued into winter and was seen across all age groups, suggesting it was not due to reduced access to healthcare.
A recent study published in Clinical Infectious Diseases documents the person-to-person transmission of antimicrobial-resistant pneumonic plague in an outbreak in rural Madagascar. The AMR strain was resistant to streptomycin but susceptible to co-trimoxazole, and all patients treated with antibiotics survived.
A study by Duke University researchers found antibiotic-resistant bacteria in the guts of lemurs living close to humans. The closer the contact, the more resistant bugs were found. Proximity to humans determined the type and abundance of resistance genes acquired.
A six-month observational study found significant MRSA shedding during outpatient visits and appointments, with 38.5% of carriers shedding MRSA to the environment. The presence of a culture-positive wound was the only factor significantly associated with shedding.
Dr. Jitender Mehla has received a National Institutes of Health Grant to study small molecule-based inhibition of multidrug efflux pump in Pseudomonas aeruginosa, a serious threat to hospital-acquired infections. The proposed research aims to develop antibacterials effective against multidrug-resistant Gram-negative pathogens.
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
Researchers found that over 60% of US residents infected with antibiotic-resistant salmonella Kentucky while abroad were resistant to fluoroquinolones. The bacteria is more likely to cause disease and evade antibiotics when acquired in Europe, Asia, and parts of Africa.
A new study by researchers at Massachusetts General Hospital found that preoperative urinalysis screening for asymptomatic patients undergoing surgery has little or no benefit. However, the test may lead to unnecessary antibiotic prescriptions and exposure to potential harms, including Clostridium difficile infection.
Bacteria use lipoproteins, which contain a soft, unstructured 'spaghetti' segment, to protect themselves from invaders. Removing or altering this segment weakens the bacteria, making it an important target for new antibiotic treatments.
A new model using simple changes in microbe growth curves can predict how antibiotic resistance evolves in response to different treatment combinations, doses and sequences. The model helps explain counterintuitive behavior observed in past experiments, such as slowed evolution when combining two antibiotics.
A team of researchers from HKU has developed a transferrable and integrative type I CRISPR-based platform that can efficiently edit Pseudomonas aeruginosa, a superbug capable of infecting various tissues and organs. The technique enables rapid identification of resistance determinants and development of novel anti-resistance strategies.
Researchers at the University of Exeter have developed a novel method to measure bacterial acidity, which could help reduce antimicrobial resistance. The study found that certain bacteria can survive antibiotic treatment by maintaining an acidic pH, and the team is working on developing new antibiotics that target these persisters.
Research finds that giant tortoises on the Galapagos Islands with human contact have higher bacterial resistance to antibiotics, posing a threat to public health. The study suggests that human activities are facilitating the dispersal of antibiotic resistance into the environment.
A new study found that antibiotic-resistant bacterial infections are killing children in Bangladesh, with 77% of pneumonia cases caused by gram-negative bacteria. Children with resistant infections were 17 times more likely to die than those without.
A new study in mSystems finds human waste contaminating urban lakes, rivers, and surface water in Bangladesh is driving the spread of antibiotic-resistant bacteria. The research highlights the importance of improving access to clean water, sanitation, and sewerage infrastructure to reduce antimicrobial resistance.
Scientists investigate how bacteria develop resistance to silver nanoparticles, identifying a key genetic mutation and differences in motility. The findings suggest that silver nanoparticles may be effective against certain strains of bacteria, but caution is needed to prevent resistance.
The mcr-1 gene, providing resistance to last-resort antibiotic colistin, has been detected in humans and pets worldwide since its first report in China in 2015. Research finds that household pets may be acting as reservoirs of the gene, aiding its spread in the community.
A study found that raw dog food in European supermarkets and pet shops contains antibiotic-resistant bacteria, including 'superbugs' found in hospital patients. The researchers concluded that dog food is a source of bacteria resistant to last-resort antibiotics and could potentially spread to humans.
Research suggests that common prescription drugs like proton pump inhibitors, beta-blockers, and antimetabolites can increase the risk of developing antibiotic-resistant infections. These non-antibiotic medications are commonly used to treat various conditions but can also contribute to drug resistance.
A study analyzing over 1,200 VA outpatient clinics found a 3.9% annual decline in total antibiotic prescriptions between 2011 and 2018. The largest decrease was seen for ciprofloxacin, while outpatient use of doxycycline, azithromycin, and amoxicillin/clavulanate remained high.
A WHO-sanctioned panel will discuss the need for more warnings before it's too late to address antimicrobial resistance. The world is facing a growing threat to modern medicine, with patients paying high prices for antibiotics due to a weak market and lack of access.
A new study found that one in ten veterinary workers in the Netherlands carries strains of antibiotic-resistant bacteria, including ESBL-producing bacteria. The study suggests that occupational contact with animals may be a key factor in transmitting these resistant bacteria to humans.
Researchers have developed a new technique, native state mass spectrometry, to identify effective inhibitors against antibiotic-resistant bacteria. This approach analyzes the behavior of metallo-beta-lactamase inhibitors and could lead to the development of novel treatments for resistant infections.
Researchers at HKU have identified 38 authentic Ag+-binding proteins in Staphylococcus aureus, revealing silver's molecular targets and mode of action. The study shows that silver-based antimicrobials can potentiate the efficacy of antibiotics, resensitize MRSA to antibiotics, and slow down antibiotic resistance evolution.
Researchers developed a new framework to establish safe thresholds for antimicrobial release into the environment, addressing the global health threat of antibiotic-resistant bacteria. The framework provides guidance on risk assessment and could inform policy to reduce antimicrobial levels in water systems, helping to mitigate resistance.
Researchers have discovered that pre-trained phages can increase their ability to fight bacterial infections, delaying the onset of antibiotic resistance. This breakthrough uses evolutionary training to improve phage potency against deadly bacteria.
A study found that travellers who returned from abroad acquired and spread destination-specific antimicrobial resistance genes in their gut microbiome. The diversity of these genes increased significantly after travel, with high-risk genes resistant to common antibiotics identified.
Researchers found numerous novel genes promoting microbial resistance in international travelers' gut microbiomes. The study highlights the global spread of antimicrobial resistance through travel and emphasizes the need for broader surveillance.
A global metagenomic study of urban microbiomes found distinct microbial signatures in cities across six continents, with over 4,200 known species identified. The research also discovered a core set of 31 species present in 97% of samples and highlights the potential for new discoveries related to microbial diversity.
A new study from the University of Copenhagen reveals that Danish one-year-olds carry several hundred antibiotic resistant genes in their bacterial gut flora. The presence of these genes is partly attributable to antibiotic use among mothers during pregnancy, and well-developed gut flora may reduce the incidence of resistant bacteria.
A mathematical model predicts how bacterial mutations impact antibiotic success. The study suggests measuring mutation levels is crucial for determining treatment failure and informs novel strategies. Multiple mutations limit drug resistance evolution substantially, depending on drug type and administration route.
A new study found that organic-certified meats are 56 percent less likely to be contaminated with multidrug-resistant bacteria compared to conventionally produced meat. The research analyzed data from the US National Antimicrobial Resistance Monitoring System and covered over 39,000 meat samples.
Researchers found that earthworm guts have lower numbers and relative abundances of antibiotic-resistance genes compared to surrounding soils. The earthworms' unique gut environment may destroy ARGs or outcompete bacteria hosting them, suggesting a potential role in natural bioremediation.
A portable, rapid testing platform can detect gonorrhea infections and determine antibiotic resistance in under 15 minutes. The platform's speed and low cost could combat the spread of drug-resistant strains and improve timely diagnoses for patients with gonorrhea or other STIs.
A randomized controlled trial found that brief educational videos can reduce patients' expectations for antibiotic treatment of upper respiratory tract infections. However, the doctors' actual prescribing habits showed no significant change.
A component of bacteria's cell walls, cardiolipin, may hold the key to fighting antibiotic-resistant microbes. Without it, the outer membrane becomes penetrable, making bacteria vulnerable to antibiotics.
Researchers tracked antibiotic resistance in E. coli over 16 years, finding rapid increase in multi-drug resistant strains. The study highlights the importance of tracking resistant bacteria to prevent their spread and improve treatment options.
The Mfd protein's dual role in repairing bacterial DNA and promoting mutations has been discovered, offering new avenues for fighting antibiotic resistance. This phenomenon could also lead to a better understanding of cancer cell resistance to chemotherapy.
Researchers found high levels of antimicrobial resistance in water from the Hua Krabue canal, but low levels in aquaculture ponds. The study highlights the urgent need to improve urban sanitation in Thailand's coastal region. Safely managed sanitation is crucial for combatting antibiotic resistance.
A new study found that microplastics in wastewater treatment plants can host antibiotic-resistant bacteria and pathogens, leading to a significant increase in resistance by up to 30 times. The microplastics form a biofilm that allows the bacteria to attach and exchange genes, posing risks to human health.
Researchers discovered how bacterial colonies form multilayered biofilms when exposed to antibiotics, which can contribute to antibiotic resistance. The study's findings suggest that breaking up the formation of these biofilms could be an effective strategy for treating infections.
The study found enormous differences in the availability and use of antibiotics between African and Asian countries, with Asia having more readily available antibiotics. Self-medication is a significant problem, with high rates in some countries, and context plays a crucial role in combating antibiotic resistance.
The summit aims to discuss how individual behaviour and organisational norms can be changed to slow down the development of antimicrobial resistance. Key findings include the need for strong political leadership and communication strategies to address misconceptions about antimicrobial resistance.
Scientists have pinpointed a critical mechanism allowing deadly bacteria to resist antibiotics, and discovered a potential new target for effective treatment. The study identified quinolone antibiotic resistance mechanisms, including the production of pentapeptide repeat proteins, and revealed how they inhibit bacterial enzymes.
A study found that multidrug-resistant Staphylococcus aureus strains are spreading between pigs, farmworkers, and community residents in North Carolina, raising concerns about a potential emerging public health threat. The strains were closely related and carried genes conferring resistance to multiple antibiotics.
A new model links bacterial metabolism and growth to mechanisms of antibiotic resistance, enabling predictions of mutation types and levels. The study suggests a previously unobserved connection between nutrient uptake and resistance development, which can inform strategies for slowing resistance emergence.
A new model can predict the evolution of antibiotic resistance in bacteria by analyzing growth rates and resistance levels at different drug concentrations. This knowledge can help identify optimal treatment protocols, drug targets, and new antibiotic candidates to combat resistant bacteria that threaten global health.
Researchers found that travelers to the tropics are exposed to a wide range of superbacteria, including 83 different strains, during their trip. Daily stool samples revealed that all participants contracted superbacteria within the first week abroad, with some carrying multiple strains over time.
A recent study reveals that international travellers are highly susceptible to virulent strains of drug-resistant bacteria, often acquiring multiple types during a single trip. Researchers found that 70% of European volunteers colonised with MDR-GN bacteria, highlighting the need for improved infection control measures.
Research found fidaxomicin is more effective than existing TB medication at preventing growth of M. tuberculosis, including resistant strains. Fidaxomicin's in vitro activity was compared to rifampicin and showed promise as a potential new treatment for TB.