Articles tagged with Antibiotic Resistance
Scientists at the University of Bath have discovered a novel polyamine that destroys MRSA superbug Staphylococcus aureus by disrupting its cell membrane, rendering it susceptible to antibiotics. The compound is also effective against biofilm and has shown promise as a potential new treatment option for antibiotic-resistant infections.
Researchers have identified a new antifungal antibiotic named solanimycin produced by a pathogenic potato bacterium. The compound shows efficacy against various fungi, including Candida albicans, and has potential for both agricultural and clinical applications.
A clinical trial is underway to evaluate the safety and efficacy of bacteriophage therapy in adults with cystic fibrosis who carry Pseudomonas aeruginosa. The trial aims to reduce bacterial load in the lungs using a phage cocktail that targets specific bacteria, providing a potential new treatment for difficult-to-treat infections.
Researchers found that Carbapenemase-producing Enterobacteriaceae (CPE) colonizes the gut without symptoms, depleting key bacteria and leaving tell-tale marks. Rebalancing gut bacteria may help promote CPE decolonization and prevent antibiotic resistance transmission.
A new single-cell functional tool has been developed to screen and sequence active antibiotic-resistant bacteria (ARB) in native soils. The study found that the percentage and activity of ARB in soils were elevated with human activity, highlighting the need for control technologies.
A new study by the University of Bern has discovered 21 highly-active metal compounds that demonstrate good activity against various resistant fungal strains. These compounds were up to 30,000 times more active against fungi than human cells.
Researchers used Raman spectroscopy to identify and analyze Escherichia coli persister cells, finding they have enhanced metabolic activities despite being in a dormant state. This new understanding could lead to the development of novel therapeutic strategies.
A new project will explore the defence mechanisms of bacterial cells to stop the spread of drug-resistant genes. The team, led by Professor Edze Westra, will use a range of methods to understand how bacteria defend against mobile genetic elements (MGEs) that contribute to antimicrobial resistance.
Researchers found that poor infrastructures, low awareness, and unstable funding hinder efforts to implement global guidelines for antimicrobial resistance. The study highlights the need for tailored interventions responsive to local needs.
The Society for Healthcare Epidemiology of America highlights the need to strengthen antibiotic stewardship programs to address overuse of antibiotics in early stages of viral epidemics. The guidance provides strategies for hospitals and healthcare personnel to improve antibiotic prescribing and diagnostic testing.
Researchers used E. coli as an indicator of antimicrobial resistance in Canadian turkey flocks. They found that antimicrobial use in feed and injection into eggs were main drivers of resistance. The study suggests that disease treatment also contributes to the development of resistance.
Researchers at Imperial College London discovered a 'silent' mutation in bacteria that helps them evade antibiotics. The mutation alters the structure of an mRNA intermediate, preventing ribosomes from producing protein, and has arisen independently several times globally.
Scientists found that weedy rice has developed herbicide resistance through gene flow from crop rice, with most fields showing resistant plants within 20 years of herbicide-resistant rice cultivation. This rapid evolution is due to the close proximity of weedy and crop rice in the same fields, allowing for pollen transfer and outcrossing.
Scientists at Aston University developed a new treatment combining manuka honey with the widely used antibiotic amikacin to treat drug-resistant lung infections. The study found that this combination improved bacterial clearance and reduced side effects, benefiting patients with cystic fibrosis.
A new study from MIT reveals that computer models predicting molecular interactions, like AlphaFold, need improvement to help identify drug mechanisms of action. Researchers improved the performance of these models using machine-learning techniques, but more work is needed.
A novel method developed by Brazilian researchers can analyze bacterial samples without isolating live bacteria, making it easier to detect antibiotic resistance in Streptococcus pneumoniae. The technique was tested on 873 samples and found that 51% were sensitive to antibiotics, while 17% were resistant.
Researchers have found hydroquinine, an organic compound found in tree bark, has potent antibacterial properties against several microorganisms. The study suggests it may be a potential candidate for future clinical investigation to combat antibiotic-resistant infections.
A study by Taiwanese researchers found that patients with atherosclerosis are at higher risk for life-threatening vascular infections from non-typhoidal Salmonella bacteremia. The study suggests the use of a scoring system to predict infection risk and identifies interleukin-1 beta as a potential biomarker.
Researchers developed a light-based therapy, photodynamic therapy (aPDT), to combat antibiotic-resistant bacteria. The treatment showed promise in weakening bacteria, allowing lower doses of current antibiotics to effectively eliminate them.
A new class of light-activated hemithioindigo molecules developed by Rice University scientists kill specific Gram-positive bacteria and their biofilms. The molecules induce reactive oxygen species that chemically attack and destroy drug-resistant cells, offering a safer alternative to conventional antibiotics.
Researchers identified four categories of antimicrobial stewardship programs: Collaborative Model, Centrally Coordinated Model, Centrally Led Model, and Collaborative, Consultative Network Model. The study aims to enhance patient care and reduce antibiotic resistance by understanding best practices in these models.
A new oral drug candidate, JSF-2659, has been developed to eradicate the bacteria causing gonorrhea. It works by simultaneously targeting two molecular targets, making it effective against resistant strains and reducing the risk of drug resistance.
Researchers have discovered a new molecule, fabimycin, that effectively treats over 300 drug-resistant bacteria in lab experiments and mice with pneumonia and urinary tract infections. The compound reduces the amount of drug-resistant bacteria to pre-infection levels or below, outperforming existing antibiotics at similar doses.
A massive analysis of over 10,000 Mycobacterium tuberculosis isolates revealed new genes associated with resistance to 13 antibiotics. The study provides a comprehensive framework for understanding the genetic mechanisms of resistance and identifying diagnostic gaps.
A new biosynthesis method has been developed to produce antibiotics from natural substances with added fluorine, which can strengthen bonding and improve accessibility. This technology has huge potential for optimizing polyketides, a gigantic substance class used in various medicines.
A new study published in Nature Microbiology reveals high prevalence of antibiotic resistance genes in mothers and neonates from 7 LMICs. The researchers found that ARGs were present in neonates within hours of birth, indicating initial colonization with antibiotic-resistant bacteria.
Researchers at TUM have developed a cell-free production method for bacteriophages, which can be used to target and combat specific types of antibiotic-resistant bacteria. The new technology has the potential to produce personalized therapeutic phages for clinical trials, addressing multi-resistant germ infections.
Researchers have discovered a new mechanism that some bacteria use to evade rifamycin antibiotics, showing antimicrobial resistance is more complex and evolved than previously recognized. The discovery has implications for finding new antibiotics and combating the growing global health threat of antimicrobial resistance.
Researchers at Texas A&M University's Center for Phage Technology have completed a study on phage therapy, identifying potential applications to fight multidrug-resistant bacterial infections. The study showed promise in treating Acinetobacter baumannii, a deadly pathogen found in hospital settings and the Middle East.
Researchers used a new tool to capture hundreds of undiscovered mechanisms of gene regulation in MRSA, revealing a previously unknown layer of gene regulation. The study identified a regulatory RNA that promotes an enzyme involved in cell wall thickening, potentially identifying new targets for antibiotic treatment.
Two studies found that dogs fed on a diet of raw meat were more likely to excrete antibiotic-resistant E. coli in their faeces. The research suggests that not feeding raw meat to dogs may help reduce the circulation of critically important antibiotic-resistant bacteria.
NC State researchers discovered a new way to make the difficult-to-characterize gut bacterium Bifidobacterium more responsive to antibiotics. They also found tiny changes in different strains that reflect large differences in their characteristics, highlighting the need for individualized CRISPR-based genome engineering approaches.
A new report highlights the importance of acknowledging antimicrobial resistance (AMR) in regulatory frameworks for accelerated drug approval. The analysis provides recommendations to improve access to new antibiotics in Brazil, India, and South Africa, where antibiotic development is hampered by regulatory hurdles.
Researchers at Ben-Gurion University have found a phytochemical derived from broccoli that breaks down biofilms protecting antibiotic-resistant pathogens, enabling eradication rates of up to 94% when combined with antibiotics. The compound also accelerates wound healing and is being further developed for commercialization.
Scientists have found that prior exposure to Staphylococcus aureus prevents effective vaccination due to immune response memory. To overcome this, the research suggests targeting only the protective component of the protein IsdB, generating a more effective vaccine against MRSA.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
A new study found that the O139 cholera variant lost antimicrobial resistance and changed toxin production, leading to its unexpected decline. The findings suggest continuous monitoring of genetic changes is key to preventing future outbreaks.
Researchers explore the emergence of antibiotic resistance genes in bioaerosols, including sources and detection strategies. The study highlights the need for monitoring and understanding the relationship between human, animal, and environmental microbiomes to counter the spread of AR.
A machine learning model has been developed to predict TB resistance to fluoroquinolones, which could speed up treatment. The model uses demographic and clinical factors to estimate the probability of resistance, allowing clinicians to optimize treatment regimens before test results are available.
Researchers have deciphered the exact bacterial adhesion mechanism using Bartonella henselae, revealing a key role for trimeric autotransporter adhesins and their interaction with fibronectin. Experimental blocking of these processes almost entirely prevents bacterial adhesion.
A highly antibiotic-resistant strain of MRSA has emerged in livestock over the past 50 years, primarily due to widespread antibiotic use in pig farming. The CC398 strain has maintained its resistance and is capable of rapidly adapting to human hosts, posing a significant threat to public health.
New research shows a decrease in antibiotic use, treatment within 48 hours, and broad-spectrum antibiotics among patients with signs of systemic inflammatory response syndrome (SIRS). The study found improvements in mortality rates and development of multi-drug resistant bacteria without increasing antibiotic overuse.
Bacteria's extreme lifestyle change during UTI infection cycles may hold clues to combating antimicrobial resistance and damage. Researchers used advanced microscopy to study the reversal of filamentation, shedding light on a previously unknown mechanism.
Researchers at University of Southern Denmark discover that certain fatty acids can neutralize disease-causing bacteria by turning off their ability to infect and spread. The discovery has potential implications for developing new treatments for antibiotic-resistant infections.
A study published in The Lancet Microbe reveals that typhoid-causing bacteria have developed resistance to critical antibiotics, spreading globally since 1990. This rise threatens the effectiveness of antibiotics for treating typhoid fever infections.
Scientists detect a highly resistant strain of Neisseria gonorrhoeae in Austria, causing treatment failure with current antibiotics. The discovery highlights the urgent need for enhanced antimicrobial surveillance and development of novel treatments to combat this growing public health concern.
The study reveals that the 16th-century E. coli acquired novel genes and antibiotic resistance over time, posing a significant threat to human health despite not causing pandemics. The reconstructed genome provides valuable insights into its evolution and potential role as an opportunistic pathogen.
Gram-negative bacteria rely on cell wall to synchronize outer membrane building, but a new study identified 'old' peptidoglycan as the key factor controlling this process. Disrupting this mechanism makes Gram-negative bacteria vulnerable to targeted antibiotics.
A state health department's swift action halted a nursing-home outbreak of drug-resistant Acinetobacter baumannii. Improved hand hygiene, enhanced environmental cleaning protocols, and colonization screening helped contain the spread of the organism, with no additional cases detected after implementation of infection control recommenda...
Researchers have discovered proteins that mediate intimate contacts between bacteria, enabling DNA transfer and resistance to antibiotics. Understanding this process can help develop new approaches to slow the spread of antimicrobial resistance.
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
A study found that Pseudomonas bacterium rapidly develops resistance to Colistin due to a gene called pmrB, which mutates at an extremely high rate. This allows the bacteria to adapt to changing immune system conditions and survive antibiotic treatment.
A study published in eLife has shown that fast-growing bacteria can resist antibiotics by displaying higher ribosome expression, allowing them to avoid macrolide accumulation. This finding highlights a new survival strategy for bacteria and offers potential avenues for developing improved antibiotic compounds.
A new class of antibiotics has been discovered that is highly effective against drug-resistant tuberculosis, with low toxicity and a high level of safety. The new drugs, called PPs, are targeted at the PE_PGRS57 gene and show promise as an alternative to current treatments.
A new platform and genomic database has been developed to monitor and control multidrug-resistant bacteria, with over 500 human pathogens already available. The database aims to provide strategic information on microorganisms classified as a “critical priority” by the World Health Organization.
A new study found that unnecessary antibiotic prescriptions for nonhospitalized children resulted in 2.8 million cases of avoidable infections, costing the US at least $74 million. Children prescribed inappropriate antibiotics were up to eight times more likely to develop complications such as diarrhea and skin rashes.
Researchers at Aston University have developed a new antibiotic combination that successfully treated a cystic fibrosis patient's deadly lung infection. The combination of imipenem/relebactam with amoxicillin eradicated the infection, enabling the patient to receive a lifesaving lung transplant.
A new study by the University of Exeter found that antibiotic-resistant plasmid molecules can spread quickly through bacterial communities, making them more resistant to antibiotics. This raises concerns about the potential for antimicrobial resistance to spread in environmental settings and impact human health.
New data analyses from RedHill's Talicia H. pylori eradication clinical trials program showed high eradication rates and favorable safety and efficacy profiles in patients with diabetes. The study found that Talicia maintained high eradication rates of 91.7% and 84.1% in patients with and without diabetes, respectively.
A study by Flinders University researchers reveals how hospital bacteria adapt and resist antimicrobial medications, including colistin. The findings provide potential new therapies for treating multi-drug resistant bacterial infections, highlighting the growing threat of antibiotic resistance.