Research on how bacteria evade antibiotics. Covers adaptive metabolism, water-source resistance, drug-efflux pumps, and microplastic pollutant shuttles.
Researchers at ETH Zurich have developed a rapid test that detects bladder infections using bacteriophages, which can identify the pathogenic bacteria in under four hours. The test also allows for tailored phage therapy, predicting patient response and increasing treatment effectiveness.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
A team of researchers led by Laura-Isobel McCall and Zhibo Yang is using single-cell mass spectrometry to investigate the role of intracellular drug concentration in antimicrobial treatment failure.
Researchers developed a novel metal-derived complex to treat Avian Pathogenic Escherichia coli (APEC), a serious respiratory infection resistant to antibiotics. The treatment, manganese carbonyl, showed protective effects in chickens with APEC, reducing bacterial shedding and killing.
A combination of far UVC and blue LED light has been shown to be effective in inactivating a wide range of microorganisms, including antibiotic-resistant ESBL-Ec bacteria. The coupling of these two light wavelengths increases their effectiveness through different mechanisms of microorganism inactivation.
A scorpionfish protein has been found to effectively kill antibiotic-resistant bacteria from patients with cystic fibrosis, escaping an immune response that renders the human version of the protein ineffective. This discovery may provide new therapeutic options for treating chronic bacterial infections in people with cystic fibrosis.
The study identified significant differences in antibiotic resistance trends and associated factors depending on bacterial species and antibiotic resistance to certain antibiotics. High health system quality was linked to low levels of resistance, while high temperatures were associated with increased resistance in Enterobacteriaceae.
Researchers have developed a new method to detect antibiotic resistances in Proteus mirabilis, enabling faster identification of potentially resistant strains. The algorithm uses cutting-edge molecular biology methods and can determine whether a bacterial strain is susceptible to carbapenem antibiotics.
A study published in the Journal of Hospital Infection reveals that pharmacist-led multi-faceted interventions can optimize antimicrobial prescriptions in dental clinics, reducing the incidence of serious infectious diseases. The intervention increased penicillin usage and decreased the use of broad-spectrum antimicrobials.
Researchers discovered that combining honey and vinegar can effectively kill bacteria in biofilms, making it a potential treatment for persistent infections. The study found that using both honey and acetic acid was more effective than using either substance alone.
Researchers found that antimicrobial resistance emerges from selection for pre-existing resistant clones, not new mutations. Infections with multiple pathogen clones show increased resistance to antibiotics, but also potential for faster loss of resistance when no antibiotics are present.
Researchers have discovered a new target for antibiotics that could treat multi-drug resistant superbugs. The antibiotic AMC-109 affects the cell membrane of bacteria by disordering its organization, leading to the death of the bacterium. This approach may also break down resistance to old-fashioned antibiotics.
Researchers found that viruses can insert genes into bacteria to help them adapt and survive in nutrient-depleted man-made environments. The study also identified novel immune systems against viruses in bacteria and detected antibiotic resistance genes in viruses on human skin and surfaces.
A recent study found that Kenyan patients who spend more than three days in hospitals are more likely to harbor antibiotic-resistant bacteria. The research team identified three risk factors associated with colonization, including hospitalization for extended periods and intubation.
Scientists have gained high-res structural insights into a key bacterial enzyme to develop new drugs that target its weaknesses and suppress disease-causing bacteria. The enzyme Lnt is not found in humans and has huge potential as a therapeutic target with fewer side effects for patients.
Researchers discovered high levels of antibiotic resistance among war-wounded patients in Ukrainian hospitals, with nearly 10% resistant to colistin. The study highlights the challenges posed by resistant bacteria in times of war, particularly the highly resistant Klebsiella pneumoniae bacteria.
Researchers discovered how two new compounds attack TB-causing bacteria, providing insights into future therapies. The study found that one compound binds better to ATP synthase than existing treatment, while another targets a previously unknown site.
Researchers at Baylor College of Medicine have discovered a drug called DEQ that significantly reduces the ability of bacteria to develop antibiotic resistance. The study shows that DEQ works by slowing down genetic mutations in bacteria, thereby prolonging the effectiveness of antibiotics.
A 'poo transplant' trial provides evidence that faecal microbiota transplants can improve gut health in patients with cirrhosis, reducing the likelihood of infections. The PROMISE trial aims to deliver FMT capsules via oral administration, offering a potential breakthrough for patients with advanced liver disease.
A recent study found that seven per cent of Aspergillus fumigatus samples from the Three Parallel Rivers region in Yunnan, China were drug resistant, capable of propagating quickly and taking over local populations.
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
Researchers at the University of California - Riverside have developed a low-cost technology using biochar to remove harmful compounds from reclaimed water, making it safe for agricultural reuse. The biochar-based polishing systems have shown promising results in removing antibiotics and resistant bacteria, potentially reducing the spr...
Researchers found that intravenous treatment with MK-3402, a metallo-beta-lactamase inhibitor, can effectively fight antimicrobial resistance in certain bacteria. The studies suggest that dosing three times per day provides adequate blood levels to block bacterial enzymes.
Bioactive glasses with ionic silver show improved antimicrobial activity and can retain effectiveness against antibiotic-resistant bacteria. The study demonstrates the potential for this combination to deliver more effective wound protection than conventional alternatives.
A global observational study found high mortality among infants with culture-positive sepsis, highlighting the need for effective antibiotics. The study developed tools to identify at-risk newborns and inform WHO guidelines on treatment.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
A global analysis of national action plans to tackle antimicrobial resistance reveals a significant gap in preparedness. The study found that many countries lack adequate funding and monitoring mechanisms, hindering effective implementation of policies.
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
Researchers at the University of Zurich have developed a new class of antibiotics that target novel targets in bacterial metabolism, effectively fighting resistant bacteria. The peptides are highly effective, safe, and immune to resistance, offering hope for treating bacterial infections in patients.
Researchers discovered that oxalic acid helps create a sticky, gel-like extracellular matrix in fungi and bacteria. The more oxalic acid present, the more viscous the matrix becomes, allowing microbes to control nutrient uptake and resistance to antibiotics.
Researchers at the Center for One Health Research have found that antiviral drugs can make antifungals work again by blocking efflux pumps in Candida auris. This approach may be a key treatment strategy against the deadly fungal pathogen, which has a 60% mortality rate.
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
A new gene editing tool exploits a bacterial immune system to target and eliminate antibiotic-resistant genes. The tool has shown early promise in laboratory experiments by protecting host cells from developing resistance and reversing it in resistant hosts.
A team from the University of Tsukuba has discovered characteristics of proteins in bacteria that convey antibiotic resistance, providing insights into their function and role. These proteins, known as ARE-ABCFs, work in synergy with other resistance mechanisms to convey extremely high levels of antibiotic resistance.
A new international clinical trial is evaluating new antibiotic combinations for newborn babies with sepsis, which affects up to 3 million babies globally. The NeoSep1 trial will assess the safety and efficacy of three new antibiotic treatments against existing standard regimens.
Researchers developed a new method combining palmitoleic acid, gentamicin, and non-invasive ultrasound to improve drug delivery in chronic wounds infected with S. aureus. The strategy reduced bacterial burden by 94% and successfully sterilized wounds in diabetic mice.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers at Macquarie University have discovered how superbug A. baumannii survives harsh environments and resists antibiotics by exploiting its strong drug pumps to expel essential metals from the cell. Disrupting this master regulatory protein, DksA, breaks the pumping system and allows for control of the bug.
A neglected 80-year-old antibiotic, nourseothricin, has been found to be effective against multi-drug resistant bacterial infections. The improvement in purification of the streptothricins has overcome original toxicity concerns, making it a promising agent for treating difficult-to-treat infections.
Researchers at Beth Israel Deaconess Medical Center have found an effective treatment for multi-drug resistant bacteria, a major concern in the fight against superbugs. The newly discovered antibiotic, streptothricin, has shown potency against several drug-resistant strains of bacteria and may deserve further exploration as a potential...
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
Researchers tracked antimicrobial resistance in E. coli isolated from swine between 2013 and 2019, finding an increasing trend of resistance to ceftriaxone. The study highlights the need for surveillance systems to monitor microbes and develop mitigation strategies to address this growing concern.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
Researchers developed a biocide-coated polymer that effectively kills MRSA, Covid-19, and resistant bacteria, reducing hospital-acquired infections. The new material can be added to plastic products during manufacture or used as a spray, offering an effective solution to combat antimicrobial resistance.
The use of quaternary ammonium compounds (QACs) in disinfectants has been linked to asthma, dermatitis, and inflammation. The scientists recommend using safer alternatives and monitoring their levels in people and the environment.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Researchers identify OmpU protein variants associated with antimicrobial resistance in Vibrio cholerae bacteria. Understanding the evolutionary origins of AMR can inform the development of effective therapeutics against resistant infections.
Updated guidelines recommend discontinuing antibiotics immediately after a patient's incision is closed. Continuing antibiotics increases risk of C. difficile infection and antimicrobial resistance, but does not prevent surgical site infections.
A research team from Université Laval and Université Clermont Auvergne has shown that clouds harbor antibiotic resistance genes of bacterial origin. The concentrations vary widely, ranging from 330 to over 30,000 bacteria per milliliter of cloud water.
Researchers found that agricultural antimicrobial peptide use can generate broad cross-resistance to the human innate immune response. This has major implications for the design and use of therapeutic antimicrobial peptides.
Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.
Researchers developed a bioengineered drug candidate that counteracts <em>Staphylococcus aureus</em> infections, including MRSA. The mAbtyrins treatment targets multiple disease-causing mechanisms without killing the bacteria.
Researchers developed a novel gene deletion method called SLICER, allowing seamless modification of Deinococcus radiodurans. The technique enables the efficient deletion of multiple genes, potentially leading to improved strains with various applications.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
A study by Florida Atlantic University researchers found a significant 'antibiotic culture' in US hospital ICUs, with up to 70% of patients receiving unnecessary antibiotics. The preference for antibiotics is driven by urgency, hierarchy, and uncertainty, leading to increased use despite antimicrobial stewardship guidelines.
Researchers at Aalto University developed a drug that undercuts antibiotic resistance by blocking key toxins involved in the infection process. The treatment sequesters toxins and disrupts biofilms, making bacteria more vulnerable to antibiotics. Initial results show promising protection against bacterial infections.
A study from Lund University reveals how antibiotic-resistant bacteria acquire resistance through two molecular mechanisms. The researchers identified a novel protein that conveys resistance to specific antibiotics, and found that certain antibiotics induce the production of this factor, providing clues for designing new medicines.
Rapid metagenomics can provide accurate results within just 6 hours of knowing bacteria are growing in a blood sample, allowing for effective treatment 18-42 hours earlier than conventional laboratory tests. Metagenomic sequencing has the potential to save lives and better manage the use of antibiotics by rapidly identifying antimicrob...