Articles tagged with Antibiotic Resistance
Researchers developed a 'scanning and direct derivatization' method to target polymyxin, an antibiotic of last resort, for treating diseases resistant to conventional drugs. The method generated hundreds of peptide derivatives with varying effects, accelerating drug development.
Researchers at Duke University have created a new approach to controlling cellular biochemical processes by building synthetic compartments that isolate biomolecules. This technique has the potential to be used to understand and fight disease, including the spread of antibiotic-resistant pathogens.
A global analysis of pharmaceutical sales data reveals that as COVID-19 cases rose, so did antibiotics prescribed to patients, averaging less than 10% bacterial coinfection rates. This study emphasizes the importance of responsible antibiotic use during pandemic treatment.
Scientists discovered a new hexameric structure of RepB protein, which initiates DNA replication for antibiotic resistance plasmids. The study highlights the importance of developing new antibiotics and understanding how resistance spreads.
A study by Dartmouth College researchers found that bacteria can form protective clusters with rival species, making it harder to kill harmful bacteria. This discovery highlights the importance of studying multispecies biofilm structures and may impact the development of bacteriophages and predatory bacteria as antimicrobial alternatives.
A study published by Ruhr-University Bochum found a significant increase in multidrug-resistant Klebsiella pneumoniae in German hospitals since the Ukraine war. Patients from Ukraine are at risk and should be screened prior to hospital admission, researchers recommend.
A new study predicts global antimicrobial use in food-producing animals will increase by 8% by 2030 if stronger regulations are not implemented worldwide. The findings highlight the need for stricter controls on antimicrobial use, which has raised concerns over antimicrobial resistance.
Researchers at the University of Florida have found that silver nanoparticles and aminoglycosides work together synergistically to combat antibiotic-resistant bacteria. The combination reduces the amount of antibiotic needed by 22-fold, making it more potent and potentially reducing side effects.
A genomic study of the Seattle 2017-2022 Shigella outbreak revealed its origin as international travelers from areas where Shigella was common. The study also found that multi-drug resistant Shigella has become a growing global health concern, primarily affecting men who have sex with men and those experiencing homelessness.
Researchers found that carriers of a specific hidden bacteria have a 14% chance of developing an antibiotic-resistant infection within 30 days of hospitalization. The study highlights the significant risk of infections from multidrug-resistant Gram-negative bacteria, particularly in patients undergoing 'dirty' surgery.
Researchers successfully treated a young man with recurrent non-gonococcal urethritis caused by Mycoplasma genitalium using chloramphenicol. The patient showed improvement after 14 days of treatment, despite initial failure with first and second-line antibiotics.
Research suggests that a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant strains. The FDA-approved BPaL regimen is not effective in treating TB meningitis because bedaquiline and linezolid cannot penetrate the blood-brain barrier.
Researchers from UC San Diego and Yale University are exploring the therapeutic potential of
Researchers at Ben-Gurion University of the Negev discovered a new compound derived from marine red microalga that exhibits effective antimicrobial activity against bacteria and fungus. The compound's unique structure, featuring long and dense spikes, allows it to poke holes in bacterial membranes and kill off infections.
Scientists at Umea University found a new transporter controlling bacterial cell wall integrity and resistance to antibiotics. The discovery sheds light on muropeptide recycling and its role in bacteria's ability to thrive.
A new antibacterial spray and coating can kill antibiotic-resistant bacteria, reducing the risk of infection in wounds and medical devices. The innovative material has been shown to be effective against MRSA and other resistant bacteria, offering a promising solution to combat antibiotic resistance.
Researchers have clarified relationships between numerous Enterobacter species and optimised resistance testing. Using genome-based taxonomic studies, they found that Enterobacter xiangfangensis accounted for 68.7% of all detected isolates worldwide.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
Researchers at Aston University have created the world's first computer reconstruction of a virus, including its complete native genome. This breakthrough could lead to the development of targeted treatments to kill bacteria that are dangerous to humans, reducing the threat of antibiotic resistance.
Researchers at the University of Cologne discovered that bacterial membrane potential changes during biofilm formation, correlating with increased antibiotic tolerance. The study found characteristic patterns of polarization that evolve in space and time, which are linked to a change in oxygen availability.
Researchers have designed a treatment that uses a modified bacterium to target and dissolve biofilms caused by Pseudomonas aeruginosa, a leading cause of hospital mortality. The treatment has shown significant efficacy in mice, reducing lung infections and doubling survival rates.
A new study published in Evolution, Medicine, and Public Health found that proper hand hygiene in clinical work can reduce the spread of antibiotic-resistant bacteria. The researchers developed a mathematical model to predict how good or poor hygiene affects resistance evolution, and tested it against data from 691 long-term care facil...
A Phase 2 clinical trial found that a probiotic reduced S. aureus colonization by 96.8% in the stool and 65.4% in the nose. The probiotic Bacillus subtilis was administered orally, surviving passage through the stomach, and did not harm gut microbiota.
Researchers at University of Galway outline a potential new treatment option for MRSA infections using purine nucleosides. The study shows that these sugar versions of DNA building blocks can interfere with bacterial signaling systems, making bacteria more susceptible to penicillin-type antibiotics.
Researchers at UConn have identified a protective bacterial culture, Hafnia alvei B16, that can prevent infection by two strains of Salmonella, including those resistant to multiple antibiotics. The culture works by inhibiting the growth of pathogens and reducing their virulence, potentially providing a new path forward in combating su...
Research from Karolinska Institutet found high levels of antibiotic residues in waterways, including wastewater and drinking water, in regions such as China and India. The study suggests these residues contribute to antibiotic resistance, a global threat to human health.
Researchers at Hokkaido University have developed a new class of antibacterial compounds targeting MraY, effective against MRSA and VRE. The findings provide a promising lead for the development of more effective antibiotics against multidrug-resistant bacteria.
Composite wastewater samples taken over 24 hours reveal a more accurate representation of antibiotic-resistant genes, with levels 10 times higher than 'snapshots'. Chlorination can negatively impact water quality, highlighting the need for improved treatment protocols.
Researchers from Florida International University have patented a synthetic antibiotic, arsinothricin (AST), which is effective against antibiotic-resistant bacteria. The team aims to produce large quantities of the drug to combat the growing number of infections that have become resistant to current antibiotics.
A new project aims to develop a method for producing antimicrobial peptides, which have shown promise in overcoming antibiotic resistance. The peptides' ability to delay microbial resistance development makes them an attractive alternative to conventional antibiotics.
YgaV plays a crucial role in regulating the expression of anaerobic respiratory genes and managing ROS levels in response to external H2S. This helps bacteria fine-tune their metabolism and increase antibiotic tolerance.
A new study at the University of Tokyo has mapped the evolution and process of natural selection in Escherichia coli bacteria, creating fitness landscapes that help understand drug resistance and potential treatments. The researchers hope their results will be useful for predicting and controlling E. coli and other bacteria.
Caulobacter crescentus uses a toxin-antitoxin system to regulate programmed cell death in response to oxygen limitation, releasing DNA that promotes sibling dispersion. This mechanism helps maintain biofilm balance and prevents overcrowding.
A global study reveals that antimicrobial resistance genes in bacteria are driven by various factors, including geographic regions and hosts. The research identifies key genes conferring resistance to critically important drugs, shedding light on the mechanisms of transmission and the need for collaborative interventions.
Researchers identified a strong association between beneficial bacteria and estrogen hormone therapy in postmenopausal women. The study found that estrogen may play a role in reducing susceptibility to recurrent UTIs by promoting the growth of good bacteria such as Lactobacilli in the bladder. Conversely, women with recurrent UTIs had ...
A recent study found that livestock systems are a significant source of antimicrobial-resistant (AMR) bacteria and genes, which can spread to humans through contaminated manure. The researchers recommend ecosystem-wide surveillance and improved manure disposal practices to combat AMR on a global scale.
A new study finds that areas with high levels of arsenic contamination in drinking water have a higher prevalence of antibiotic-resistant Escherichia coli in both water and child stool samples. The study highlights the potential for environmental drivers like arsenic to contribute to antimicrobial resistance.
New research reveals that healthy newborn babies' gut bacteria do not contain multi-drug resistant strains of common hospital pathogens. The study found multiple synergistic relationships between different bacteria, which could potentially be harnessed to outcompete resistant or harmful bacterial strains.
A new study maps the global landscape of antimicrobial resistance, revealing surprising transmissions in Sub-Saharan Africa and highlighting the need for tailored strategies to combat resistance. The research, which analyzed sewage samples from 243 cities in 101 countries, found that resistance genes are more frequently transmitted acr...
A post-pandemic outbreak of a drug-resistant fungus in Brazil was linked to the misuse of medications and full ICUs. The study found that 90% of infected patients had strains resistant to fluconazole and echinocandins, leading to high mortality rates.
Researchers have uncovered a new mechanism of antibiotic resistance in Group A Streptococcus bacteria, making antibiotics ineffective and potentially leading to poor outcomes. The discovery highlights the complexity of understanding AMR and emphasizes the need for rapid diagnostic tools and therapeutics.
A collaborative research team led by Dr Philip Li from HKUMed has pioneered a new nurse-led penicillin allergy triage and testing strategy, which demonstrated its effectiveness and safety compared to traditional allergy testing. The study found that 90% of penicillin allergy labels in Hong Kong are incorrect, leading to potential letha...
Researchers discovered antibiotic-resistant bacteria can travel from the gut to the lungs in a patient, highlighting the importance of preventing pathogenic bacteria from translocating to vital organs. The study's findings suggest eliminating resistant bacteria from the gut microbiome could help prevent serious infections.
A recent study found that superbugs in the environment rarely transmit to humans, contrary to previous fears. The researchers discovered high levels of antimicrobial-resistant bacteria in livestock, pets, and environmental samples, but surprisingly little overlap between hospital and environmental strains.
Climate change is expanding the geographic range of endemic fungal diseases, such as Valley fever, blastomycosis, and histoplasmosis, which can mimic pneumonia. Physicians are often misdiagnosing these conditions due to a lack of training and limited testing options.
The number of Candida auris cases in the EU/EEA nearly doubled between 2020 and 2021, with 11% of cases having no available information on carriage or infection. Early detection is crucial to prevent the spread of this healthcare-associated pathogen.
Researchers developed a technique to measure long-term effects of antibiotic combinations, finding some combinations may reduce treatment effectiveness. Specific combinations were found to prevent resistance development and protect patients from aggressive bacteria.
A new label indicating responsible antibiotic use (RAU) in dairy milk could entice conventional farmers to minimize antibiotics, with half of US adults willing to buy RAU-labeled milk. The price point would need to be competitive with conventional milk, but consumers are more willing to pay for the label.
A new treatment option for multi-resistant bacteria has been identified by a UNIGE team, which uses the drug edoxudine to weaken the defence mechanisms of Klebsiella pneumoniae, making it easier to eliminate. This approach could be a game-changer in the fight against antibiotic resistance.
A new study by Ochsner pharmacist Kevin Lin suggests that oral cephalosporins are as safe and effective as fluoroquinolones for treating acute kidney infections. The study's findings support the use of narrower-spectrum antibiotics to reduce antimicrobial resistance, a growing concern in healthcare.
Researchers at Osaka University have discovered the spatial characteristics of an efflux pump that helps bacteria resist antibiotics. By analyzing a specific inhibitor's binding site, they found bulky mutations can prevent the inhibitor from working, offering hope for developing new countermeasures to combat antibiotic resistance.
A study by University of Portsmouth researchers reveals how hydroquinine kills Pseudomonas aeruginosa, a type of bacteria resistant to many antibiotics. The compound alters the expression levels of virulence factors and interferes with bacterial movement, making it an effective weapon against drug-resistant infections.
A randomized clinical trial found that applying topical antibiotics to the upper digestive tract can improve survival rates in mechanically ventilated intensive care patients. The study, published in JAMA, also showed a significant reduction in new hospital-acquired infections.
A new drug combination of cefepime and enmetazobactam has been found to be more effective in treating complicated urinary tract infections and acute pyelonephritis than a standard treatment. The study showed that the new combination was successful in treating 79% of patients, compared to 58.9% for the conventional treatment.
A recent study by University of Gothenburg researchers found that nearly twice as many Swedes are willing to obtain antibiotics without prescriptions than previously thought. Trust in healthcare plays a significant role in this behavior, with low trust linked to increased prescription without a doctor's order.
Researchers have developed a novel method for antibiotic resistance testing that can analyze bacterial cells in real-time, allowing for faster identification of susceptible and resistant bacteria. This breakthrough technology has the potential to transform microbial screening in clinical and research labs.
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
Research by the University of Exeter found high levels of antibiotic ciprofloxacin in UK wastewater, posing a significant risk to human health. The study suggests that antibiotic pollution from human waste can increase resistance to antibiotics, even in countries with well-established sanitation infrastructures.
A new platform has been created using 214,000 microbiome samples to track antibiotic-resistant bacteria globally. The data can be used to tailor guidelines on combating resistance in different regions.
The WHO European Region sees high mortality rates due to antimicrobial resistance, with countries implementing national actions plans showing lower AMR burden. Developing new treatments and improving hygiene are crucial strategies to combat this growing health threat.