Articles tagged with Antibiotic Resistance
Researchers found that viruses can insert genes into bacteria to help them adapt and survive in nutrient-depleted man-made environments. The study also identified novel immune systems against viruses in bacteria and detected antibiotic resistance genes in viruses on human skin and surfaces.
A recent study found that Kenyan patients who spend more than three days in hospitals are more likely to harbor antibiotic-resistant bacteria. The research team identified three risk factors associated with colonization, including hospitalization for extended periods and intubation.
Scientists have gained high-res structural insights into a key bacterial enzyme to develop new drugs that target its weaknesses and suppress disease-causing bacteria. The enzyme Lnt is not found in humans and has huge potential as a therapeutic target with fewer side effects for patients.
Researchers discovered high levels of antibiotic resistance among war-wounded patients in Ukrainian hospitals, with nearly 10% resistant to colistin. The study highlights the challenges posed by resistant bacteria in times of war, particularly the highly resistant Klebsiella pneumoniae bacteria.
Researchers discovered how two new compounds attack TB-causing bacteria, providing insights into future therapies. The study found that one compound binds better to ATP synthase than existing treatment, while another targets a previously unknown site.
Researchers at Baylor College of Medicine have discovered a drug called DEQ that significantly reduces the ability of bacteria to develop antibiotic resistance. The study shows that DEQ works by slowing down genetic mutations in bacteria, thereby prolonging the effectiveness of antibiotics.
A 'poo transplant' trial provides evidence that faecal microbiota transplants can improve gut health in patients with cirrhosis, reducing the likelihood of infections. The PROMISE trial aims to deliver FMT capsules via oral administration, offering a potential breakthrough for patients with advanced liver disease.
A recent study found that seven per cent of Aspergillus fumigatus samples from the Three Parallel Rivers region in Yunnan, China were drug resistant, capable of propagating quickly and taking over local populations.
Researchers at the University of California - Riverside have developed a low-cost technology using biochar to remove harmful compounds from reclaimed water, making it safe for agricultural reuse. The biochar-based polishing systems have shown promising results in removing antibiotics and resistant bacteria, potentially reducing the spr...
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
Researchers found that intravenous treatment with MK-3402, a metallo-beta-lactamase inhibitor, can effectively fight antimicrobial resistance in certain bacteria. The studies suggest that dosing three times per day provides adequate blood levels to block bacterial enzymes.
Bioactive glasses with ionic silver show improved antimicrobial activity and can retain effectiveness against antibiotic-resistant bacteria. The study demonstrates the potential for this combination to deliver more effective wound protection than conventional alternatives.
A global observational study found high mortality among infants with culture-positive sepsis, highlighting the need for effective antibiotics. The study developed tools to identify at-risk newborns and inform WHO guidelines on treatment.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
A global analysis of national action plans to tackle antimicrobial resistance reveals a significant gap in preparedness. The study found that many countries lack adequate funding and monitoring mechanisms, hindering effective implementation of policies.
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
Researchers at the University of Zurich have developed a new class of antibiotics that target novel targets in bacterial metabolism, effectively fighting resistant bacteria. The peptides are highly effective, safe, and immune to resistance, offering hope for treating bacterial infections in patients.
Researchers discovered that oxalic acid helps create a sticky, gel-like extracellular matrix in fungi and bacteria. The more oxalic acid present, the more viscous the matrix becomes, allowing microbes to control nutrient uptake and resistance to antibiotics.
A new gene editing tool exploits a bacterial immune system to target and eliminate antibiotic-resistant genes. The tool has shown early promise in laboratory experiments by protecting host cells from developing resistance and reversing it in resistant hosts.
Researchers at the Center for One Health Research have found that antiviral drugs can make antifungals work again by blocking efflux pumps in Candida auris. This approach may be a key treatment strategy against the deadly fungal pathogen, which has a 60% mortality rate.
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
A team from the University of Tsukuba has discovered characteristics of proteins in bacteria that convey antibiotic resistance, providing insights into their function and role. These proteins, known as ARE-ABCFs, work in synergy with other resistance mechanisms to convey extremely high levels of antibiotic resistance.
A new international clinical trial is evaluating new antibiotic combinations for newborn babies with sepsis, which affects up to 3 million babies globally. The NeoSep1 trial will assess the safety and efficacy of three new antibiotic treatments against existing standard regimens.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers developed a new method combining palmitoleic acid, gentamicin, and non-invasive ultrasound to improve drug delivery in chronic wounds infected with S. aureus. The strategy reduced bacterial burden by 94% and successfully sterilized wounds in diabetic mice.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
Researchers at Macquarie University have discovered how superbug A. baumannii survives harsh environments and resists antibiotics by exploiting its strong drug pumps to expel essential metals from the cell. Disrupting this master regulatory protein, DksA, breaks the pumping system and allows for control of the bug.
A neglected 80-year-old antibiotic, nourseothricin, has been found to be effective against multi-drug resistant bacterial infections. The improvement in purification of the streptothricins has overcome original toxicity concerns, making it a promising agent for treating difficult-to-treat infections.
Researchers at Beth Israel Deaconess Medical Center have found an effective treatment for multi-drug resistant bacteria, a major concern in the fight against superbugs. The newly discovered antibiotic, streptothricin, has shown potency against several drug-resistant strains of bacteria and may deserve further exploration as a potential...
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
Researchers tracked antimicrobial resistance in E. coli isolated from swine between 2013 and 2019, finding an increasing trend of resistance to ceftriaxone. The study highlights the need for surveillance systems to monitor microbes and develop mitigation strategies to address this growing concern.
Researchers developed a biocide-coated polymer that effectively kills MRSA, Covid-19, and resistant bacteria, reducing hospital-acquired infections. The new material can be added to plastic products during manufacture or used as a spray, offering an effective solution to combat antimicrobial resistance.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
The use of quaternary ammonium compounds (QACs) in disinfectants has been linked to asthma, dermatitis, and inflammation. The scientists recommend using safer alternatives and monitoring their levels in people and the environment.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Researchers identify OmpU protein variants associated with antimicrobial resistance in Vibrio cholerae bacteria. Understanding the evolutionary origins of AMR can inform the development of effective therapeutics against resistant infections.
Updated guidelines recommend discontinuing antibiotics immediately after a patient's incision is closed. Continuing antibiotics increases risk of C. difficile infection and antimicrobial resistance, but does not prevent surgical site infections.
A research team from Université Laval and Université Clermont Auvergne has shown that clouds harbor antibiotic resistance genes of bacterial origin. The concentrations vary widely, ranging from 330 to over 30,000 bacteria per milliliter of cloud water.
Researchers found that agricultural antimicrobial peptide use can generate broad cross-resistance to the human innate immune response. This has major implications for the design and use of therapeutic antimicrobial peptides.
Researchers developed a bioengineered drug candidate that counteracts <em>Staphylococcus aureus</em> infections, including MRSA. The mAbtyrins treatment targets multiple disease-causing mechanisms without killing the bacteria.
Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.
Researchers developed a novel gene deletion method called SLICER, allowing seamless modification of Deinococcus radiodurans. The technique enables the efficient deletion of multiple genes, potentially leading to improved strains with various applications.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
A study by Florida Atlantic University researchers found a significant 'antibiotic culture' in US hospital ICUs, with up to 70% of patients receiving unnecessary antibiotics. The preference for antibiotics is driven by urgency, hierarchy, and uncertainty, leading to increased use despite antimicrobial stewardship guidelines.
Researchers at Aalto University developed a drug that undercuts antibiotic resistance by blocking key toxins involved in the infection process. The treatment sequesters toxins and disrupts biofilms, making bacteria more vulnerable to antibiotics. Initial results show promising protection against bacterial infections.
A study from Lund University reveals how antibiotic-resistant bacteria acquire resistance through two molecular mechanisms. The researchers identified a novel protein that conveys resistance to specific antibiotics, and found that certain antibiotics induce the production of this factor, providing clues for designing new medicines.
Rapid metagenomics can provide accurate results within just 6 hours of knowing bacteria are growing in a blood sample, allowing for effective treatment 18-42 hours earlier than conventional laboratory tests. Metagenomic sequencing has the potential to save lives and better manage the use of antibiotics by rapidly identifying antimicrob...
A Portuguese study found that six pets in Portugal and one in the UK carried antibiotic-resistant bacteria similar to those found in their owners. The researchers emphasize the importance of including pet-owning households in programs to reduce antimicrobial resistance. Owners can reduce the spread by practicing good hygiene.
A Spanish study found that 40% of supermarket meat samples contained multidrug-resistant E. coli, including strains capable of causing severe infections in people. The study highlights the need for regular assessment and farm-level interventions to reduce the presence of antibiotic-resistant bacteria in food-producing animals.
A Portuguese study found that 19% of surfaces in small animal veterinary practices harboured at least one multidrug-resistant bacterium. These included Staphylococci, such as S. pseudintermedius, and Acinetobacter spp., which are resistant to carbapenem antibiotics.
A multidisciplinary group of experts has reached a consensus on key issues related to molecular prediction of Mycobacterium tuberculosis antibiotic sensitivity or resistance. The document provides guidance for therapeutic regimen design and treatment optimization, aiming to improve clinicians' management of TB patients.
A recent genetic study found that antibiotic resistance is driven by geographic, demographic, diet, and lifestyle factors. Researchers analyzed the microbiome of a large Finnish population sample and discovered associations between food consumption, geographical location, and ARG abundance.
New research at ECCMID 2023 presents 19 gold complexes effective against at least one hard-to-treat bacterium, including MRSA and Pseudomonas aeruginosa. The gold-based drugs use a multimodal mechanism to kill bacteria, preventing antimicrobial resistance from developing.
Researchers at Simon Fraser University are studying the genes of superbugs to develop new and effective treatments for drug-resistant bacterial infections. The team has discovered new genes responsible for causing disease and infection symptoms in humans, which can be targeted by antivirulence drugs.
A new shape-shifting antibiotic has been developed by Cold Spring Harbor Laboratory researchers, offering a potential cure for deadly infections caused by drug-resistant bacteria. The innovative design uses click chemistry to create a molecule with multiple possible configurations, avoiding the development of resistance.
A study from the University of Gothenburg reveals that wastewaters harbor unique characteristics allowing antibiotic resistance genes to evolve. The researchers found key components necessary for gene movement in wastewater samples worldwide, not in human or animal guts.
A global study reveals a bi-directional relationship between antibiotic consumption and antimicrobial resistance (AMR) between humans and animals. The study finds that higher animal antibiotic use increases AMR in human pathogens, while higher human antibiotic use increases AMR in food-producing animals.
Researchers at Baylor College of Medicine discovered crucial steps that promote ciprofloxacin resistance in bacteria, pointing to potential strategies to extend antibiotics' effectiveness. The study found that RNA polymerase plays a major role in regulating DNA repair and identified a key molecule involved in modulating this response.
Researchers discovered that fomepizole, an FDA-approved drug, can significantly reduce disease in mice infected with multidrug-resistant Streptococcus pneumoniae. The combination of fomepizole and erythromycin reduced bacterial burdens by 95% in the lungs and up to 700-fold in other organs.