Articles tagged with Chemokines
Researchers reveal that specific physical and chemical cues guide CD8+ T cells to sites of activation in the lymph node. This discovery provides insight into the fundamental behavior of the immune system and suggests new approaches to vaccine strategies.
Researchers found that bird flu virus H5N1 induces higher levels of pro-inflammatory proteins in human lung cells compared to the human flu virus H1N1. This imbalance can lead to severe lung inflammation and may explain the severity of avian flu virus infections.
Researchers found that chemokines CCL19 and CCL21 induce DC maturation and enhance T-cell proliferation. Mice lacking these chemokines showed partially activated DCs, highlighting their crucial role in full maturation and proper T-cell activation.
A study at University College London found that macrophage inflammatory protein-1a plays a crucial role in allergic responses. Drugs blocking MIP-1a's binding to its receptors could help treat ocular allergy and other diseases.
Researchers at Medical College of Georgia are using an animal model of cerebral palsy to identify the most effective way to transplant stem cells. They aim to determine whether transplanted stem cells work best when injected directly into the brain along with natural chemicals called chemokines.
Researchers found that GBV-C infection slows HIV growth and increases survival in HIV patients. The harmless virus boosts immune proteins, which prevent HIV from infecting cells.
Researchers have determined the mechanism that draws immune system's B cells toward T cells, needed to launch an antibody response after exposure to foreign antigen. The discovery highlights the role of chemokine receptors in guiding B cell movement, which may underlie a range of cellular movements in embryonic development.
Researchers at UC Riverside have identified a chicken chemokine, cCAF, that plays a critical role in wound healing and may help accelerate the process in humans. The discovery has potential for treating wounds in diabetics, people with pressure ulcers, and those with bedsores.
Researchers have discovered that chemokine expression plays a crucial role in enhancing antibacterial immunity. This finding is significant for the development of novel therapeutic strategies against bacterial infections.
Human microvascular endothelial cells express CXCR3 receptor in response to cell cycle regulation, leading to antiproliferative effect. This mechanism provides an additional pathway for controlling angiogenesis, potentially blocking tumor growth.
Researchers at UCSF and Compugen identified a new chemokine CXCL16 that recruits immune cells to sites of infection. The novel molecule binds to the CXCR6 receptor, which is exploited by HIV viruses for entry into human cells.
Researchers from MGH discover that a protein called SDF-1 not only attracts but also repels T cells at high concentrations. This finding opens up potential new ways to manipulate the immune system for treatment of autoimmune diseases and organ transplantation.
Researchers have discovered a naturally occurring chemokine antagonist, vMIP-II, which can block both CCR5 and CXCR4 receptors used by HIV to infect human cells. This breakthrough may lead to novel approaches for HIV therapy, including prevention of initial infection and slowing disease progression.