Articles tagged with Hypermethylation
A study found that RNA methylation plays a pivotal role in TDP-43-related neurodegeneration in ALS. The researchers observed highly abundant RNA methylation in the end-stage tissues of patients with ALS. This discovery opens up new avenues for research into the disease, which is linked to environmental exposure.
Researchers developed an electrochemical platform to measure DNMT1 activity, a protein linked to cancerous transformation, in crude tissue samples. The technique shows promise for early detection of colorectal cancer with high sensitivity and minimal invasion.
Researchers at Penn Medicine have discovered hypermethylation of the C9orf72 gene may protect against certain neurodegenerative diseases. Patients with hypermethylation showed more dense grey matter in affected brain regions, suggesting a potential neuroprotective target for drug discovery.
Researchers found that serum RASSF1A promoter hypermethylation is a promising biomarker for diagnosing gastric and colorectal cancer. The study detected higher rates of this abnormality in tumor tissues and patient sera compared to benign disease or healthy individuals.
Researchers identified DNA hypermethylation in E-cadherin, p16, and RAR-B2 genes as common in breast tumors. The study found that these alterations were more frequent in ER-negative and PR-negative tumors, but not associated with other clinicopathological features.
Researchers found that the GSTP1 gene is temporarily inactivated through hypermethylation, increasing the risk of prostate cancer in African-Americans compared to Caucasians. The study suggests that GSTP1 hypermethylation may serve as a potential biomarker for prostate cancer diagnosis and treatment.
Fox Chase Cancer Center researchers have identified hypermethylation of BRCA1 and RASSF1A genes as a potential target for detecting ovarian cancer in blood. The study found that 82% of patients with ovarian cancer had hypermethylated genes in their blood DNA, making it a promising diagnostic tool.