Articles tagged with Immunoglobulin Heavy Chains
Researchers at Boston Children's Hospital have identified a mechanism for immune cells to recycle defective or autoreactive antibodies by editing their genes. The new process uses an enzyme called RAG to swap out light chains with nearby new ones, often making them non-defective and functional.
Researchers at UMC Utrecht discovered that converting monoclonal antibodies from IgG to IgM isotype can significantly broaden their ability to recognize and bind multiple human-relevant bacterial pathogens. This finding could guide the future design of antibody therapies against bacterial infections.
Researchers have provided new details on structures resulting from 3D domain swapping in antibody light chains, shedding light on mechanisms of protein aggregation. The study suggests that the formation of tetramers may prevent protein aggregation by decreasing flexibility.
A study found that patients with IgD multiple myeloma have a worse prognosis than other types, with higher mortality rates and more kidney damage. The rare blood cancer produces excessive light chains that can damage the kidneys if left untreated.
Researchers developed an efficient method to produce antibodies that can bind to two different target molecules simultaneously, enhancing cancer immunotherapy. The new approach uses a modified IgG antibody structure with only four key changes, allowing for more versatile formats and improved stability.
Researchers from Penn and Florida developed a plant-based approach to prevent antibodies forming against clotting factor proteins in people with hemophilia. This method, which uses genetically modified plants to induce tolerance, showed promise in preventing inhibitor formation and even reversing it in mice.
Scientists at Joslin Diabetes Center have found that a protein called alpha-myosin heavy chain triggers inflammatory heart disease in people with type 1 diabetes. The discovery could lead to diagnostic and therapeutic tools for this condition, which is often fatal.
Researchers at UC San Diego have created the first 3D image of an antibody gene, shedding light on the human genome's three-dimensional structure. The study uses geometry to resolve the structure of a genetic locus, revealing 'flower-like' structures connected by linkers that generate diverse antibodies.
Researchers at UT Southwestern Medical Center have identified a small RNA molecule that regulates the contractility of the heart under stress. The study found that blocking this molecule might become a way to prevent or treat heart damage.
Clathrin is found to play a role in regulating nuclear morphology and gene expression in plants. The study reveals that clathrin is involved in the formation of nuclear structures and influences gene regulation pathways.
Researchers identified myosin heavy chain as a selective target in cancer cachexia, a condition characterized by muscle wasting. The study found that TNF-a/IFN-g-dependent loss of myosin heavy chain occurred through different mechanisms depending on the model used.