Articles tagged with Microrna
Researchers at UT Southwestern Medical Center have developed a potential drug, RGLS4326, to treat polycystic kidney disease, an incurable genetic disorder. The drug has shown promise in slowing cyst growth and delaying ADPKD progression in preclinical animal testing.
Scientists analyzed microRNAs from Ötzi's skin, stomach, and stomach contents to determine their stability over time. They found some molecules were present predominantly in ancient tissues, while others were not detectable.
Researchers at Joslin Diabetes Center identified a new therapeutic approach by studying the role of microRNAs released from fat cells into the bloodstream. They found that these microRNAs can regulate gene expression in other organs and tissues, potentially leading to new treatments for metabolic diseases and cancer.
Scientists have identified microRNAs as crucial regulators of apoptosis in C. elegans embryogenesis, preserving progenitor cells and ensuring proper nervous system development. By genetically blocking specific microRNAs, researchers observed significant increases in egl-1 mRNA levels, leading to premature cell death.
Researchers at UT Southwestern Medical Center have uncovered a new phosphorylation mechanism involved in controlling microRNA-target interactions, allowing microRNAs to efficiently regulate large sets of target messenger RNAs. This discovery sheds new light on the microRNA pathway and its role in human disease regulation.
A new study found that serum microRNAs are associated with MRI measures of multiple sclerosis severity, suggesting they could serve as biomarkers. The research identified distinct microRNA sets linked to lesions and atrophy, which may help identify underlying disease processes and guide therapeutic decisions.
Researchers at Tohoku University identified two new types of microRNA that improved hyperglycemia in a mouse model of diabetes. These miRNAs were shown to promote insulin-producing cell proliferation and regeneration, offering potential for therapeutic beta-cell regenerative therapies.
Scientists have found a way to reprogram mouse embryonic stem cells to mimic the developmental characteristics of fertilized eggs, also known as zygotes. This breakthrough reveals a novel mechanism regulating totipotency and provides a powerful cell-culture system to further study early embryo development.
Researchers have developed a chemical-biological strategy for microRNA target identification using photo-clickable miRNAs. This approach enables the identification of target genes associated with miRNAs without disrupting their function, revealing new insights into miRNA-involved cellular regulation pathways.
Researchers developed a cost-effective system to detect biomolecules in real-time using spectrally encoded microgels, enabling accurate measurements of microRNAs in blood samples. The system achieved a detection limit of 202 femtoMolars and demonstrated specificity for multiplex measurement conditions.
New research reveals microRNAs play a vital role in regulating gene expression, influencing organismic development and disease. Studies have uncovered a vast network of miRNA families that target disparate gene pathways.
A team of researchers has discovered microRNAs play a critical role in tumor progression and response to radiation therapy in a mouse model. The findings suggest that microRNA biomarkers could be used to predict cancer response to radiation, potentially leading to more effective treatments.
Researchers at St. Jude Children's Research Hospital identified a small RNA that regulates the production of a protein targeted by antipsychotics, providing new clues for quieting the 'voices' of schizophrenia. The microRNA was linked to disruptions in brain circuits and age-related delays in symptom onset.
Researchers at Karolinska Institutet have measured the absolute numbers of short, non-coding, RNA sequences in individual embryonic stem cells, revealing their precise function. The new method could lead to improved IVF treatments by identifying embryos with the best chance of development.
Researchers have discovered a biological link between anxiety and metabolic disorders, revealing microRNAs as key regulators of inflammation and metabolism. This finding offers novel opportunities for innovative diagnoses and treatments, including manipulation of microRNA activity through DNA-based drugs.
Scientists at Helmholtz Zentrum München discovered a mechanism by which EBV virus suppresses alarm signals sent out by infected cells. MicroRNAs made by the virus block production of proteins that would ring the alarm, rendering killer T cells and helper T cells inactive.
A set of microRNAs, known as C19MC, was found to be specific to infantile hemangiomas and detectable in patient plasma. These microRNAs may serve as biomarkers for IH diagnosis and treatment monitoring, with levels decreasing before tumor regression but rebounding upon re-growth.
A team of University of Houston researchers has identified novel regulators of heart formation, including microRNAs, which can convert human fibroblasts into heart muscles. These findings hold promise for treating human heart attack and subsequent heart failure within the next five to 10 years.
Researchers at The Scripps Research Institute (TSRI) found that members of a cluster of microRNAs work together throughout the stages of immune cell generation. Different miRNAs dominate different stages as disease-targeting immune cells develop, guiding the development of therapies against autoimmune diseases.
A new study by TSRI scientists identifies microRNA-155 as a key player in regulating protein levels and combating disease. The researchers found that miR-155 works by repressing a protein called Peli1, promoting normal T cell proliferation and antibody production.
Researchers designed an engineered protein to repress a specific cancer-promoting message within cells, paving the way for precise treatments with fewer side effects. The protein, Rbfox2, was modified to bind to microRNA miR-21, which is present in high levels in many tumors.
Scientists have developed a new technique to selectively block the disease-causing protein in mice with spinocerbellar ataxia type 6 (SCA6). The method uses a modified virus to deliver micro RNA that prevents SCA6 from developing, offering a potential treatment for other diseases caused by mutations in bicistronic genes.
Researchers discovered a previously unknown interaction between metabolic pathways in two tissues, triggering a key step in maturation and regulating the transport of lipids from storage to reproductive cells. This intertissue dialogue is a remarkable strategy to precisely choreograph the transition to adulthood.
Researchers have identified various miRNAs that can predict the response of metastatic renal cancer patients to anti-angiogenic agents. These biomarkers have been shown to be stable and detectable, allowing for personalized treatment. The study provides a promising tool for improving patient outcomes.
Scientists at Salk Institute discovered that microRNA miR-19 regulates new neuron placement in adult brains and is disrupted in schizophrenia patients. The study paves the way for understanding how adult brains control new neuron growth and its potential link to neuropsychiatric disorders like schizophrenia.
Researchers found that measuring specific microRNAs in blood can improve risk prediction for myocardial infarction by 15-20% compared to traditional risk factors alone. The study, published in Journal of Molecular and Cellular Cardiology, identified five key microRNAs that can help identify individuals at high risk for heart disease.
Research reveals five major ways microRNAs contribute to chemoresistance in epithelial ovarian cancer (EOC). Targeting cell cycle regulation, apoptosis, drug transporters, tumor suppressor roles, and signaling pathways can help reverse resistance. This knowledge highlights the therapeutic potential of miRNAs.
Researchers found that microRNA-181b targets Card10, a protein that helps activate inflammation. In preclinical studies, the delivery of miR-181b reduced blood clot formation and prolonged time to artery blockage by up to 1.6 fold.
Researchers at Helmholtz Munich have developed a new method to predict disease progression in glioblastoma patients. By analyzing four specific miRNAs, they can identify patients who are at high risk of poor treatment outcomes and may benefit from alternative or intensified treatments.
Researchers at EPFL have found a way to reclaim corrupted immune cells and turn them into signals for the immune system to attack tumors. They identified a molecular switch that can convert hijacked macrophages into cells stimulating the immune system to fight cancer growth and spread.
Researchers at UC Santa Barbara have pinpointed a specific long non-coding RNA that regulates neural development and drives human brain expansion. The lncRNA, called lncND, binds to microRNAs and regulates the expression of Notch proteins, which are critical for cell differentiation and development.
A research team at Georgia Institute of Technology identified a specific miRNA molecule that controls the genes governing chemotherapy resistance in human pancreatic cancer cells. Increasing this miRNA's level restored sensitivity to the drug in vitro, suggesting a potential therapeutic approach for battling chemotherapy resistance.
A study by Jeremy Sanford's lab at UC Santa Cruz identified an extensive malignancy-associated gene expression circuit regulated by IGF2BP3 in pancreatic cancer cells. The protein drives metastasis by influencing the expression of genes involved in cancer biology, including cell migration and proliferation.
A study found that human-specific variants of four microRNAs may have altered expression levels and gene targets compared to other great apes. The variations were linked to neural functions and development, suggesting a possible role in shaping human-specific traits.
Researchers at TGen and ASU have discovered three microRNAs associated with the regeneration of tails in green anole lizards. These tiny RNA switches may play a role in regenerating muscles, cartilage, and spinal columns, potentially leading to new therapies for humans.
MicroRNAs play a crucial role in controlling fertility and puberty by regulating the expression of gonadoliberin or GnRH, a neurohormone that stimulates sexual maturation. Failure to produce microRNAs leads to infertility and sterility in adults.
Scientists have identified 91 novel microRNAs in the dog genome, which can help understand their role in regulating gene expression and potentially lead to breakthroughs in human diseases. The discovery provides a significant opportunity for future studies on biomedicine, evolution, and animal domestication.
A team of scientists from the Scripps Research Institute is studying the role of microRNAs in memory, sleep and synapse function. The five-year study will use Drosophila fruit flies to answer key questions about microRNA mechanisms in the brain.
A powerful genetic regulator, miR-9, has been identified as a risk factor for schizophrenia, controlling the activity of hundreds of genes involved in fetal brain development. The study, led by Kristen Brennand and Gang Fang, found that miR-9 was under-expressed in brains of schizophrenic patients, leading to miswiring of neurons.
Researchers at Penn State College of Medicine have identified new asthma biomarkers in blood that can predict asthma with 91% accuracy. The discovery may lead to the development of a diagnostic blood test and more targeted treatments for asthma.
Researchers identified microRNA-146a in osteoclast-derived extracellular vesicles, which regulate bone cell function. The study suggests that miR-146a-rich EVs may act as a potential biomarker for osteoclast presence and regulate target cells.
Researchers developed a novel RNA-based hairpin molecule to inhibit microRNA activity in cells and mice. The plasmid-based microRNA inhibitor system effectively knocks down endogenous miRs, revealing roles for miRs in developmental pathways and cellular processes.
Researchers discovered a microRNA called miR-181b that controls the function of vessels in adipose tissue, improving insulin sensitivity and glucose levels. The study found that reconstituting this microRNA in obese mice reduced inflammation in adipose tissue, suggesting potential new targets for obesity and diabetes treatment.
Researchers have found that the RNA virus bovine viral diarrhea virus relies on host miRNAs, specifically miR-17 and let-7, to replicate. Inhibiting this interaction may provide an effective target for developing new drugs to control BVDV.
A novel Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease (EVD). This fragment was found to be detectable in the blood of patients before the development of viremia, suggesting its potential to advance the diagnosable window for EVD.
A fully sequenced seagrass genome reveals insights into marine ecosystem adaptation to climate warming and salt tolerance. The study provides a valuable resource for advancing research on carbon sequestration and plant breeding.
Researchers from Scripps Research Institute have identified microRNA miR-148a as a cause of autoimmune diseases like lupus. Elevated levels of this molecule allow self-reactive immune cells to escape and attack the body's own tissues.
Researchers have discovered two microRNAs, miR-155 and miR-184, that are directly related to the severity of inflammation in trachoma. The study found that increased expression of miR-155 and decreased expression of miR-184 are associated with higher levels of conjunctival inflammation.
Researchers developed a new technology to detect disease biomarkers in nucleic acids, which can be used as indicators of what's going on inside cells and tissue. The approach uses nanotechnology to identify specific target sequences and quantify them through electronic signatures.
Researchers at Scripps Florida identified a memory suppressor microRNA called miR-980, which regulates neuronal excitability and inhibiting it improves memory. The study found links between miR-980 and autism spectrum disorder, suggesting that the microRNA may contribute to the development of the condition.
A team from Ludwig-Maximilians-Universität München has discovered that the enzyme Dicer promotes the development of atherosclerosis by activating endothelial cells. Inhibition of Dicer using a specific microRNA reduces inflammation and atherosclerotic plaque formation.
Scientists at the University of Michigan have developed a polymer sphere that delivers microRNA molecules to bone wounds, instructing cells to repair damage. This technology can help grow bone in patients with conditions like oral implants or osteoporosis, offering a new therapy for treating bone loss and associated functional problems.
Researchers found that mice and humans produce microRNAs to control bacterial gene activity and shape the gut microbiome. These microRNAs can protect against intestinal diseases by regulating the composition of gut microbes.
Scientists at IBS Center for RNA Research have elucidated the three-dimensional image of DROSHA, one part of the Microprocessor complex. This discovery confirms previous findings and reveals unique physical characteristics of DROSHA, including a 'bump' that may act as a measuring guide for cleaving pri-miRNA.
Research reveals tiny genetic molecules called microRNAs play crucial role in controlling muscles, with dysfunction linked to devastating neurodegenerative diseases such as ALS and SMA. The findings open new avenues for treating these disorders by correcting dysfunctional microRNAs.
Researchers at Arizona State University have created a worldwide resource to explore genes' deep and hidden messages, specifically the untranslated elements (UTRs) of the human genome. The UTRome library contains over 1,400 human 3'UTRs and is freely available for researchers to study gene regulation and disease.
Mount Sinai researchers developed a synthetic vector to rapidly eliminate total cellular miRNA populations, revealing the limited role of microRNAs in modulating cell biology over long periods. This tool enables manipulation of miRNA responses for potential treatment of diseases like cancer.
Researchers have developed an innovative approach to treat drug addiction using RVG-exosome delivered RNAi against the opioid receptor mu (MOR). This method successfully down-regulates MOR in mouse brain and rescues opioid relapse. The study demonstrates the potential of this therapy for treating CNS diseases.
Researchers at Thomas Jefferson University discovered that both strands of a tiny microRNA are active in suppressing genes in triple negative breast cancer cells. This breakthrough enables the design of specific blockers of one microRNA strand without imitating the opposite strand, opening a pathway to new treatments.
Researchers at IUPUI developed a nanotech-based sensor to detect microRNAs in blood, enabling early cancer diagnosis and potentially improving treatment outcomes. The sensor's ultrasensitivity allows for the detection of minute changes in microRNA concentrations.