Articles tagged with Microrna
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A set of microRNAs, known as C19MC, was found to be specific to infantile hemangiomas and detectable in patient plasma. These microRNAs may serve as biomarkers for IH diagnosis and treatment monitoring, with levels decreasing before tumor regression but rebounding upon re-growth.
A team of University of Houston researchers has identified novel regulators of heart formation, including microRNAs, which can convert human fibroblasts into heart muscles. These findings hold promise for treating human heart attack and subsequent heart failure within the next five to 10 years.
Researchers at The Scripps Research Institute (TSRI) found that members of a cluster of microRNAs work together throughout the stages of immune cell generation. Different miRNAs dominate different stages as disease-targeting immune cells develop, guiding the development of therapies against autoimmune diseases.
A new study by TSRI scientists identifies microRNA-155 as a key player in regulating protein levels and combating disease. The researchers found that miR-155 works by repressing a protein called Peli1, promoting normal T cell proliferation and antibody production.
Researchers designed an engineered protein to repress a specific cancer-promoting message within cells, paving the way for precise treatments with fewer side effects. The protein, Rbfox2, was modified to bind to microRNA miR-21, which is present in high levels in many tumors.
Scientists have developed a new technique to selectively block the disease-causing protein in mice with spinocerbellar ataxia type 6 (SCA6). The method uses a modified virus to deliver micro RNA that prevents SCA6 from developing, offering a potential treatment for other diseases caused by mutations in bicistronic genes.
Researchers discovered a previously unknown interaction between metabolic pathways in two tissues, triggering a key step in maturation and regulating the transport of lipids from storage to reproductive cells. This intertissue dialogue is a remarkable strategy to precisely choreograph the transition to adulthood.
Researchers have identified various miRNAs that can predict the response of metastatic renal cancer patients to anti-angiogenic agents. These biomarkers have been shown to be stable and detectable, allowing for personalized treatment. The study provides a promising tool for improving patient outcomes.
Scientists at Salk Institute discovered that microRNA miR-19 regulates new neuron placement in adult brains and is disrupted in schizophrenia patients. The study paves the way for understanding how adult brains control new neuron growth and its potential link to neuropsychiatric disorders like schizophrenia.
Researchers found that measuring specific microRNAs in blood can improve risk prediction for myocardial infarction by 15-20% compared to traditional risk factors alone. The study, published in Journal of Molecular and Cellular Cardiology, identified five key microRNAs that can help identify individuals at high risk for heart disease.
Research reveals five major ways microRNAs contribute to chemoresistance in epithelial ovarian cancer (EOC). Targeting cell cycle regulation, apoptosis, drug transporters, tumor suppressor roles, and signaling pathways can help reverse resistance. This knowledge highlights the therapeutic potential of miRNAs.
Researchers found that microRNA-181b targets Card10, a protein that helps activate inflammation. In preclinical studies, the delivery of miR-181b reduced blood clot formation and prolonged time to artery blockage by up to 1.6 fold.
Researchers at Helmholtz Munich have developed a new method to predict disease progression in glioblastoma patients. By analyzing four specific miRNAs, they can identify patients who are at high risk of poor treatment outcomes and may benefit from alternative or intensified treatments.
Researchers at EPFL have found a way to reclaim corrupted immune cells and turn them into signals for the immune system to attack tumors. They identified a molecular switch that can convert hijacked macrophages into cells stimulating the immune system to fight cancer growth and spread.
Researchers at UC Santa Barbara have pinpointed a specific long non-coding RNA that regulates neural development and drives human brain expansion. The lncRNA, called lncND, binds to microRNAs and regulates the expression of Notch proteins, which are critical for cell differentiation and development.
A research team at Georgia Institute of Technology identified a specific miRNA molecule that controls the genes governing chemotherapy resistance in human pancreatic cancer cells. Increasing this miRNA's level restored sensitivity to the drug in vitro, suggesting a potential therapeutic approach for battling chemotherapy resistance.
A study by Jeremy Sanford's lab at UC Santa Cruz identified an extensive malignancy-associated gene expression circuit regulated by IGF2BP3 in pancreatic cancer cells. The protein drives metastasis by influencing the expression of genes involved in cancer biology, including cell migration and proliferation.
A study found that human-specific variants of four microRNAs may have altered expression levels and gene targets compared to other great apes. The variations were linked to neural functions and development, suggesting a possible role in shaping human-specific traits.
Researchers at TGen and ASU have discovered three microRNAs associated with the regeneration of tails in green anole lizards. These tiny RNA switches may play a role in regenerating muscles, cartilage, and spinal columns, potentially leading to new therapies for humans.
MicroRNAs play a crucial role in controlling fertility and puberty by regulating the expression of gonadoliberin or GnRH, a neurohormone that stimulates sexual maturation. Failure to produce microRNAs leads to infertility and sterility in adults.
Scientists have identified 91 novel microRNAs in the dog genome, which can help understand their role in regulating gene expression and potentially lead to breakthroughs in human diseases. The discovery provides a significant opportunity for future studies on biomedicine, evolution, and animal domestication.
A team of scientists from the Scripps Research Institute is studying the role of microRNAs in memory, sleep and synapse function. The five-year study will use Drosophila fruit flies to answer key questions about microRNA mechanisms in the brain.
A powerful genetic regulator, miR-9, has been identified as a risk factor for schizophrenia, controlling the activity of hundreds of genes involved in fetal brain development. The study, led by Kristen Brennand and Gang Fang, found that miR-9 was under-expressed in brains of schizophrenic patients, leading to miswiring of neurons.
Researchers at Penn State College of Medicine have identified new asthma biomarkers in blood that can predict asthma with 91% accuracy. The discovery may lead to the development of a diagnostic blood test and more targeted treatments for asthma.
Researchers identified microRNA-146a in osteoclast-derived extracellular vesicles, which regulate bone cell function. The study suggests that miR-146a-rich EVs may act as a potential biomarker for osteoclast presence and regulate target cells.
Researchers developed a novel RNA-based hairpin molecule to inhibit microRNA activity in cells and mice. The plasmid-based microRNA inhibitor system effectively knocks down endogenous miRs, revealing roles for miRs in developmental pathways and cellular processes.
Researchers discovered a microRNA called miR-181b that controls the function of vessels in adipose tissue, improving insulin sensitivity and glucose levels. The study found that reconstituting this microRNA in obese mice reduced inflammation in adipose tissue, suggesting potential new targets for obesity and diabetes treatment.
Researchers have found that the RNA virus bovine viral diarrhea virus relies on host miRNAs, specifically miR-17 and let-7, to replicate. Inhibiting this interaction may provide an effective target for developing new drugs to control BVDV.
A novel Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease (EVD). This fragment was found to be detectable in the blood of patients before the development of viremia, suggesting its potential to advance the diagnosable window for EVD.
A fully sequenced seagrass genome reveals insights into marine ecosystem adaptation to climate warming and salt tolerance. The study provides a valuable resource for advancing research on carbon sequestration and plant breeding.
Researchers from Scripps Research Institute have identified microRNA miR-148a as a cause of autoimmune diseases like lupus. Elevated levels of this molecule allow self-reactive immune cells to escape and attack the body's own tissues.
Researchers have discovered two microRNAs, miR-155 and miR-184, that are directly related to the severity of inflammation in trachoma. The study found that increased expression of miR-155 and decreased expression of miR-184 are associated with higher levels of conjunctival inflammation.
Researchers developed a new technology to detect disease biomarkers in nucleic acids, which can be used as indicators of what's going on inside cells and tissue. The approach uses nanotechnology to identify specific target sequences and quantify them through electronic signatures.
Researchers at Scripps Florida identified a memory suppressor microRNA called miR-980, which regulates neuronal excitability and inhibiting it improves memory. The study found links between miR-980 and autism spectrum disorder, suggesting that the microRNA may contribute to the development of the condition.
A team from Ludwig-Maximilians-Universität München has discovered that the enzyme Dicer promotes the development of atherosclerosis by activating endothelial cells. Inhibition of Dicer using a specific microRNA reduces inflammation and atherosclerotic plaque formation.
Scientists at the University of Michigan have developed a polymer sphere that delivers microRNA molecules to bone wounds, instructing cells to repair damage. This technology can help grow bone in patients with conditions like oral implants or osteoporosis, offering a new therapy for treating bone loss and associated functional problems.
Researchers found that mice and humans produce microRNAs to control bacterial gene activity and shape the gut microbiome. These microRNAs can protect against intestinal diseases by regulating the composition of gut microbes.
Scientists at IBS Center for RNA Research have elucidated the three-dimensional image of DROSHA, one part of the Microprocessor complex. This discovery confirms previous findings and reveals unique physical characteristics of DROSHA, including a 'bump' that may act as a measuring guide for cleaving pri-miRNA.
Research reveals tiny genetic molecules called microRNAs play crucial role in controlling muscles, with dysfunction linked to devastating neurodegenerative diseases such as ALS and SMA. The findings open new avenues for treating these disorders by correcting dysfunctional microRNAs.
Researchers at Arizona State University have created a worldwide resource to explore genes' deep and hidden messages, specifically the untranslated elements (UTRs) of the human genome. The UTRome library contains over 1,400 human 3'UTRs and is freely available for researchers to study gene regulation and disease.
Mount Sinai researchers developed a synthetic vector to rapidly eliminate total cellular miRNA populations, revealing the limited role of microRNAs in modulating cell biology over long periods. This tool enables manipulation of miRNA responses for potential treatment of diseases like cancer.
Researchers have developed an innovative approach to treat drug addiction using RVG-exosome delivered RNAi against the opioid receptor mu (MOR). This method successfully down-regulates MOR in mouse brain and rescues opioid relapse. The study demonstrates the potential of this therapy for treating CNS diseases.
Researchers at Thomas Jefferson University discovered that both strands of a tiny microRNA are active in suppressing genes in triple negative breast cancer cells. This breakthrough enables the design of specific blockers of one microRNA strand without imitating the opposite strand, opening a pathway to new treatments.
Researchers at IUPUI developed a nanotech-based sensor to detect microRNAs in blood, enabling early cancer diagnosis and potentially improving treatment outcomes. The sensor's ultrasensitivity allows for the detection of minute changes in microRNA concentrations.
Researchers have identified four microRNAs that play critical roles in controlling cholesterol and triglyceride levels, including miR-128-1 and miR-148a. These microRNAs regulate genes involved in lipid metabolism and may hold promise for treating cardiovascular disease.
A team of researchers at the University of Sussex has discovered a novel link between genetics and movement control in fruit flies. The study found that specific microRNAs play a crucial role in regulating precise movements, which could have significant implications for understanding human disorders like Parkinson's disease.
Researchers identified abnormal miRNA levels in patients with myeloma, detectable in peripheral blood, suggesting a potential biomarker for disease progression. Analysis revealed unique miRNA signatures indicative of myeloma, including the let-7 family members.
A research team led by Dr. Saumya Das will investigate microRNA-30d as a potential biomarker to predict patient outcomes in heart disease. They aim to use microRNA-based tests to identify patients at risk of complications and intervene with medications or implantable devices.
A recent study has found that microRNAs, previously thought to be digested and absorbed by the body, are actually broken down in the small intestine, rendering them ineffective for modifying physiological functions.
A first-of-its-kind study identified a potential gene target, FOX03, strongly associated with nonalcoholic fatty liver disease-related liver damage due to miR-182 regulation. The study found suppressed FOX03 protein levels in damaged livers, suggesting its role in the initiation of liver disease.
Researchers at Rockefeller University identified a protein that recognizes a chemical instruction tag on RNA molecules. This 'reader' molecule determines the fate of RNA by recognizing m6A tags, influencing gene expression and splicing processes.
Researchers at Mayo Clinic have discovered a way to potentially reprogram cancer cells back to normalcy by restoring the expression of specific microRNAs. This finding represents an unexpected new biology that provides the code for turning off cancer, offering a potential strategy for cancer therapy.
Researchers have developed a strategy for genome-wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse. This study sheds light on the mechanisms of regulation of microRNA gene expression, including novel regulatory mechanisms and alternative promoters.
A new serum miRNA panel has been identified as a potential biomarker for diagnosing non-small-cell lung cancer (NSCLC) in ethnically diverse patients. The panel, consisting of five serum microRNAs, was found to have high sensitivity and specificity for detecting NSCLC in both Chinese and American cohorts.
A study has identified a novel microRNA, miR-181a-5p, as a potential diagnostic breast cancer biomarker in the blood. The use of Droplet Digital PCR technology enabled the accurate quantification of this miRNA, which showed significant downregulation in the serum of patients with breast cancer.
Scientists from Scripps Research Institute have identified five microRNAs that are necessary for memory formation, while others decrease it, affecting neuronal physiology and nervous system development. The study provides valuable insights into the complex mechanisms of learning and memory.
A study published in the Journal of Clinical Investigation found that microRNA-132 plays a critical role in regulating the transition from inflammation to proliferation during wound healing. The researchers identified miR-132 as a therapeutic target for promoting healing and developing new treatments for chronic skin wounds.
Researchers have discovered how Microprocessor, a complex of DROSHA and DGCR8, precisely determines cleavage sites on miRNA-containing primary transcripts. This process allows faithful initiation of microRNA biogenesis.
Researchers at NYU have found that microRNA can serve as a decoder ring to understand complex biological processes, highlighting the potential for miRNA to shed light on diseases such as coronary artery disease and cleft palates. By analyzing miR-200, the team identified a trio of glycans critical to cell movement and tumor metastasis.
Researchers have developed a new technology that uses synthetic microRNA switches to purify live human cells with improved efficiency. The method, which involves identifying unique miRNAs for each cell type, shows promise for clinical applications and could lead to more homogeneous cell pools and better cell therapy outcomes.