Articles tagged with Microrna
Researchers identified dysregulation of the gene NEUROG2 as a key factor in the development of focal cortical dysplasia, a common cause of drug-resistant epilepsy. The study found that overexpression of NEUROG2 was linked to reduced expression of microRNA hsa-miR-34a, leading to nerve cell differentiation failure.
Researchers identified a correlation between gut microbial composition and microRNA expression in human colorectal cancer. The study found that dozens of microRNAs are differentially regulated in colorectal cancer tumors and are correlated with the abundance of microbes in the tumor microenvironment.
Researchers found that healthy octogenarians have high cholesterol efflux capacity, a trait linked to reduced early signs of atherosclerosis. Additionally, two microRNAs were identified as drivers of programmed cell death in fat cells, suggesting a potential target for sustainable weight loss.
Researchers found that physical and mental exercise improves learning ability and reduces disease risk in mice, with the effect being passed on to the next generation through epigenetic inheritance. The study identified two microRNA molecules, miRNA212 and miRNA132, as responsible for this inherited learning capacity.
Research at Washington University School of Medicine found that aging immune cells contribute to inflammation and abnormal blood vessel growth in macular degeneration, potentially leading to vision loss. The study identified microRNA-150 as a potential therapeutic target for preventing progression to advanced forms of the disease.
A research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off. The technology could lead to the development of new cancer therapies and other drugs by activating non-toxic cancer prodrugs into their therapeutic forms.
A study published in Circulation Journal identified four microRNA molecules in the bloodstream that could predict the onset of atrial fibrillation. The researchers found that these microRNAs were significantly upregulated in the serum of patients with AF and diseased mice, suggesting their potential use as biomarkers for disease.
Researchers at the University of Sussex have identified a specific molecule that plays a key role in forming long-term memories. By controlling this molecule, a drug could be developed to relieve the block on new memories in dementia patients and help repress painful memories in post-traumatic stress disorder sufferers.
Researchers discover FUS plays a crucial role in the microRNA-mediated gene silencing system, which regulates cellular activity. Disruption of this system may contribute to neurodegenerative diseases like ALS and FTD. The study suggests that FUS facilitates guiding and targeting of messenger-RNAs by microRNAs.
Researchers have identified microRNA 876-3p as a strong predictive biomarker for bronchopulmonary dysplasia in extremely low birth-weight infants. The biomarker is associated with inflammation and impaired lung development, and its presence can help guide targeted therapies to prevent or lessen BPD.
A bioengineering team has designed genetic 'circuits' using living cells to study microRNA expression. This research aims to improve synthetic biology and gene therapy by understanding how microRNAs function in different biological contexts.
Researchers have identified two distinct types of vision-degrading glaucoma and pinpointed key genes associated with the condition. The study also suggests that exercise can help reduce eye pressure and provides a potential new point of intervention for treating glaucoma.
Researchers at Purdue University found that microRNA miR-223 can help control inflammatory disease by regulating the NF-kB pathway, which is critical in human bronchial epithelial cells. Supplementing this microRNA to epithelial cells may provide a new treatment option for asthma and cancer.
Researchers discover that low levels of microRNA miR-125a-5p correlate with high levels of protein TIMP-1 in human lung cancer cells. Increasing miR-125a-5p levels reduces cancer spread and increases cell death. TIMP-1's role is also explored, revealing its dual function in promoting or inhibiting tumor growth.
Researchers have identified 52 microRNAs that are decreased in expression as thyroid cancer becomes more aggressive. Restoring these molecules' levels in tumors may be a novel treatment strategy.
Researchers discovered dodder's sophisticated gene manipulation system, which operates like a computer virus, allowing the parasite to silence specific genes in its hosts. This finding has implications for engineering parasite-resistant plants.
Researchers discovered that a parasitic plant called Dodder can silence the expression of genes in its host plants, including those involved in defense against parasites. By targeting specific regions of the gene sequence, Dodder regulates the flow of nutrients to itself while preventing the host from producing defensive proteins.
Researchers at Boston University School of Medicine discovered a possible biomarker for Huntington's disease, which may help evaluate treatment effectiveness and potentially delay disease onset. The study found altered levels of microRNAs in individuals carrying the HD gene mutation twenty years before symptoms appear.
Researchers at Nagoya University have developed a novel medical device that can efficiently capture extracellular vesicles in urine, potentially leading to early diagnosis of cancer. The device surpasses existing methods and shows promise for non-invasive testing, including a simple urine test.
Kansas State University researcher Anna Zinovyeva is studying microRNAs to understand their role in regulating gene expression, with potential breakthroughs for human health conditions such as cardiovascular disease and cancer. The $1.8 million grant will support her lab's exploration of new leads in microRNA regulatory activity.
Researchers at Ohio State University have developed a novel RNA nanotechnology to decorate exosomes for effective cancer therapy. The technology uses antibody-like RNA nanoparticles to deliver siRNA specifically to cancer cells, overcoming the challenge of delivering therapeutics directly to tumor cells.
Researchers at the University of Pennsylvania have developed an injectable gel that slowly releases microRNAs to stimulate heart muscle regeneration. The gel's unique properties allow it to target specific signaling pathways related to cell proliferation, resulting in improved recovery rates and potentially life-prolonging effects.
Researchers found that certain microRNAs in saliva can accurately identify concussions and predict symptom duration. The study's findings suggest that measuring microRNAs could lead to a more fact-based diagnosis and treatment of concussion patients, ultimately improving care and outcomes.
A recent study published in JAMA Pediatrics found that microRNA levels in the saliva of children with mild traumatic brain injury can accurately identify those with prolonged concussion symptoms. This discovery holds promise for improving concussion management and reducing parental anxiety.
A study at Georgetown University Medical Center reveals distinct molecular signatures in two brain disorders, CFS and GWI, with implications for diagnosis and treatment. The research found changes in miRNA levels after exercise, differing from other conditions like depression and Alzheimer's disease.
Researchers found a previously dismissed genetic mechanism that contributes to nicotine dependence and withdrawal effects. The study identified specific genes and microRNA that play an essential role in how the roundworms develop nicotine dependence and withdrawal responses.
A new blood test has been developed to detect ovarian cancer with high accuracy, using microRNA profiling to distinguish between cancerous and benign tumors. The test shows promise in accurately predicting ovarian cancer, even when other methods fail.
Researchers at Drexel University have identified microRNA miR-34a as the 'master regulator' involved in bronchopulmonary dysplasia (BPD), a chronic lung disease affecting up to 15,000 premature infants annually. Inhibiting miR-34a significantly reduces BPD in mice, suggesting a potential new treatment target.
Researchers at the University of Basel have identified a microRNA that inhibits epithelial-mesenchymal transition (EMT), a process linked to tumor cell spread and metastasis. This discovery may lead to new treatment approaches for breast cancer.
Researchers are exploring the role of microRNAs in brain structure changes associated with neuropsychiatric disorders. The study aims to identify biomarkers in blood and cerebrospinal fluid that correlate with brain variations.
Researchers have identified two microRNAs, miR-294 and miR-721, that are upregulated in macrophages infected with Leishmania parasites, potentially inhibiting the immune system's response. By analyzing the expression of these microRNAs, scientists hope to identify molecular targets for developing new treatments against leishmaniasis.
Researchers at University of California San Diego School of Medicine found exosomes from inflamed adipose tissue macrophages cause metabolic derangements of diabetes. Exosomes carry microRNA that inhibits key proteins, leading to insulin resistance.
Researchers at Salk Institute discover two microRNAs that help cancer cells survive and subvert the immune response by lowering cGAS levels. Inhibiting these microRNAs in tumor cells slowed tumor growth, but their effect was diminished in immune-deficient mice.
Researchers found nine microRNAs in premature breast milk that target metabolic processes, regulating gastrointestinal function and energy use in premature babies. These findings suggest that breast milk may be optimized for premature infants' nutritional needs.
A pilot study found changes in blood-based miRNAs associated with gene regulation in veterans affected with combat-related PTSD. The research suggests that these molecules could serve as candidate biomarkers for screening and understanding trauma-related psychiatric disorders.
Researchers found that honeybees fed plant microRNA supplements developed more slowly and had smaller bodies than those not receiving the supplements. The study reveals a previously unknown function of plant microRNAs in fine-tuning larval development.
Plant miRNAs in beebread/pollen delay honeybee caste differentiation and keep ovaries inactive, inducing sterile worker bees. This study reveals a new mechanism for RNA regulation in insect development.
A new study sheds light on the connection between gut bacteria and anxiety, finding that a significant number of miRNAs were changed in the brains of microbe-free mice. The researchers suggest that targeting the gut microbiome may be a potential therapeutic approach for psychiatric disorders.
The FANTOM5 project has created an extensive atlas of microRNA expression in human primary cells, providing insights into the intricate regulatory network governing cellular function and behavior. The atlas reveals thousands of new genomic loci producing short RNAs, which may constitute a novel class of regulatory short RNAs.
Researchers at UMass Amherst have identified a microRNA molecule called let-7 that serves as a molecular control hub to direct the function of cytotoxic T lymphocytes, enabling them to kill tumors and pathogens. When let-7 levels are low or absent, T cells can become super killers, potentially enhancing immune responses.
Researchers have discovered a circular RNA, Cdr1as, that regulates microRNA levels and modulates synaptic responses in the brain. This finding has significant implications for our understanding of neural function and may hold potential for treating psychiatric diseases.
Researchers have found a close link between early brain developmental events and changes in cognitive function in adulthood. Disruptions to the ability of developing brain cells to form connections were associated with increased fear-related memories.
Researchers at Purdue University have discovered a mechanism to deliver tumor-suppressing microRNAs without toxic delivery vehicles. They conjugated the microRNA to a folate molecule, which targets cancer cells while avoiding healthy cells.
Researchers at Tokyo Medical and Dental University identified two microRNAs that can improve pancreatic cancer response to gemcitabine, a common chemotherapy drug. These findings suggest novel combined treatments for this devastating disease. MicroRNA levels can also predict prognosis in pancreatic cancer patients.
A study by Tufts University researchers found significant changes in miRNA expression levels in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure. The study identified new genomic biomarkers, including exosomal miR-181c and miR-495, which could provide insight into diagnosis and therapies for MMVD and human ...
Studies found significant differences in microRNA cargo carried by exosomes in males and females with osteoarthritis, with females showing more altered biological processes. The findings suggest a link between estrogen levels and the development of osteoarthritis, potentially leading to new diagnostic and treatment options.
Researchers have identified a micro-gene called miR-211 that protects the brain from developing epilepsy. Elevated levels of this gene may act as a protective mechanism to reduce the risk of epileptic seizures.
Researchers at Karolinska Institutet have found that a small RNA molecule in sensory neurons regulates how touch is perceived, leading to increased pain sensitivity after nerve damage. The study's results suggest that microRNA-based drugs could be a promising treatment option for chronic nerve pain.
Researchers at Texas A&M AgriLife Research have discovered two new proteins, RICE1 and RICE2, that play a crucial role in regulating plant structure and resisting crop stresses like drought. The study sheds light on the mechanism of RNA silencing, which can be used to help plants overcome environmental challenges.
Researchers at Goethe University Frankfurt have developed light-inducible microRNA inhibitors that can target specific genes involved in slow-healing wounds. By injecting these inhibitors into the skin of mice, they were able to improve wound healing by blocking a particular microRNA that is frequently found in diabetes patients.
Researchers have identified a microRNA biomarker that shows a strong association with atrial fibrillation incidence. The study found that low levels of miR 21 are strongly linked to the development of atrial fibrillation, which can increase stroke risk and negatively impact quality of life.
A recent study reveals that microRNA-223 plays a crucial role in regulating intestinal inflammation in inflammatory bowel disease. Synthetic versions of this microRNA can reduce inflammation in mice and may hold promise as a future therapy for IBD patients.
Research suggests a simple saliva test can predict which children will experience prolonged concussion symptoms, providing a more accurate prognosis than standard survey questions. The study found that salivary miRNA levels were significantly more effective in predicting prolonged concussion symptoms than SCAT-3 surveys.
Researchers developed fCLIP-seq to analyze DROSHA's impact on miRNA fragments, revealing hundreds of new cleavage sites and alternative processing patterns. The study uncovers additional end modifications important for miRNA biogenesis, shedding light on its regulation in diseases like cancer.
Researchers discovered that microRNA-210 reduces plaque instability and improves fibrous cap stability, potentially reducing the risk of stroke. Local application of microRNA-210 is being explored as a safer alternative to systemic administration, which could minimize side effects.
Researchers have restored nerve insulation and improved limb mobility in mice with multiple sclerosis by treating them with a microRNA called miR-219. The treatment reinvigorated the function of damaged cells that produce myelin, allowing it to reform and reinsulate nerves.
Researchers at Intermountain Medical Center Heart Institute have identified three microRNA molecules linked to AFib recurrence after ablation therapy. These molecular markers hold promise as screening tools to help determine which patients will benefit from various therapies.
Researchers have created a pioneering nanobiodevice that can isolate cancer biomarkers quickly with high resolution. The device separates microRNA from DNA/RNA mixtures in under 100ms, promising faster and more reliable isolation of microRNA for cancer detection.
Researchers at CNIC discovered that miR-28 regulates the terminal differentiation of B lymphocytes, blocking the growth of B cell lymphomas. This finding highlights the potential of synthetic miR-28 analogs to inhibit tumor growth in Burkitt lymphoma and diffuse large cell lymphoma.
A team of scientists at UC Riverside has identified five major microRNA expression peaks in the Aedes aegypti fat body following a blood meal. By disrupting these miRNAs, researchers hope to control mosquito reproduction and prevent the spread of diseases transmitted by these mosquitoes. The study provides insight into the regulatory g...