Articles tagged with Microrna
Researchers discovered pancreatic beta cells secrete miR-29 family members to promote insulin resistance and enhance hepatic glucose output. This finding reveals a new mechanism linking obesity-induced insulin resistance in type 2 diabetes's pathogenesis.
Researchers identified pancreatic β cell-derived exosomal miR-29 family as a new mechanism that regulates glucose homeostasis through liver. Exosomal miR-29s negatively regulate insulin signalling pathway via targeting p85 α, attenuating the suppression of insulin on glucose output.
Researchers have identified microRNA biomarkers that play a role in brain damage caused by traumatic brain injury, and are also associated with Alzheimer's disease. The study found coordinated miRNA dysregulation followed by increased amounts of BACE1, a key enzyme in neurodegenerative disease pathology.
A new study by ISGlobal has identified six microRNAs that may be used as biomarkers to predict disease severity in children with severe malaria. The findings provide a potential breakthrough in understanding the mechanisms underlying severe malaria and improving treatment outcomes.
A new study identified a molecule that reduces inflammation during mechanical ventilation, but isn't enough to prevent lung damage. Delivering high levels of the molecule with nanoparticles was effective in fending off ventilator-related lung damage in mice.
Researchers identified a circular RNA, circ2082, and an RNA-binding protein, RBM3, that form a complex with the enzyme DICER to disrupt microRNAome regulation in glioblastoma cells. This leads to increased survival rates in mice and longer lifespans in human patients with circ2082-dependent signatures.
Researchers discover new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as microRNAs. The study found that 110-120 miRNAs modulate circadian rhythms, with tissue-specific impacts on human health.
Georgetown University researchers successfully used RNA molecules to suppress SARS-CoV-2 protein production, potentially leading to an inhalable drug that mitigates viral chaos. The approach targets viral machinery within cells via siRNA, degrading messenger RNA and reducing infection spread.
Researchers found a ubiquitin ligase complex that degrades miR-7 and other miRNAs in cells. This discovery sheds light on how cells dispose of genetic molecules regulating protein production.
Researchers from Tokyo Medical and Dental University identify TruB1 as a regulator of the microRNA let-7, which has significant implications for cancer development and suppression. The study reveals that TruB1 promotes maturation of let-7 and suppresses cell growth and division.
Scientists have discovered a new RNA-centric mechanism that regulates the creation of a crucial cancer microRNA. The findings reveal that environmental stimuli can activate a 'hidden' layer of regulation, enhancing the efficiency of miR-21 processing and potentially leading to disease.
Researchers at HSE University have discovered microRNA molecules that can bind to coronavirus genomes, slowing down their replication and potentially allowing the virus to delay an active immune response. The study found four families of human miRNAs with binding sites for all seven types of human coronaviruses, including SARS-CoV-2.
Researchers found that a genetic mutation in SIDT1 protein reduces the absorption of MIR2911, a key component in SARS-CoV-2 treatment, leading to reduced antiviral effects. People carrying this mutation had lower serum levels and exosome levels of MIR2911 compared to those without the mutation.
Researchers at the University of Bonn discovered a protein that influences cell communication in vascular cells. The study found that an RNA-binding protein acts as a gatekeeper, controlling the release of microRNAs that promote regeneration. This breakthrough offers new hope for treating diseases like arteriosclerosis.
A new study reveals that the mammalian stomach absorbs dietary miRNAs via SIDT1, a transmembrane family member. This finding uncovers a novel physiological function of the stomach and sheds light on orally delivered small-RNA therapeutics.
The COVID-19 virus acts as a microRNA sponge, depleting specific miRNAs that regulate cell metabolism and stress responses. This depletion promotes infected cell survival, allowing the virus to replicate and evade the host's immune system.
A new study finds that endurance exercise induces changes in sweat biomolecule levels, potentially creating a non-invasive exercise monitoring system. Sweat extracellular vesicles contain microRNA molecules, which regulate biological processes and are essential mediators in exercise adaptations.
A new study found that absorbed plant miRNA MIR2911 in honeysuckle decoction can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking the decoction accelerates negative COVID-19 patient conversion, suggesting a potential therapeutic strategy for treating SARS-CoV-2 infection.
Researchers found that certain microRNAs can decrease the expression of ACE2 and TMPRSS2 enzymes, which are crucial for SARS-CoV-2 entry into human cells. This discovery could lead to new approaches for fighting the virus.
Researchers found that absorbed miRNA MIR2911 in honeysuckle decoction can directly target SARS-CoV-2 genes, inhibit viral replication, and accelerate the negative conversion of infected patients. Drinking the decoction accelerates the recovery process.
A team of researchers at North Carolina State University has identified a microRNA, miR-218-5p, that enhances the molecular pathway responsible for promoting hair follicle growth. The study found that increasing miR-218-5p promoted hair regrowth in mice treated with 3D cultured dermal papilla cells.
Researchers at Duke University have developed a new optical sensing platform that can detect genomic cancer biomarkers in tissue samples using silver-plated gold nanostars. This technique has the potential to provide fast and reliable diagnostic results for cancer and other diseases, simplifying testing processes.
Researchers developed nanoparticles that can deliver a localized cancer treatment by inhibiting tumor growth in mice. The nanoparticles use a specific chemistry to attach a microRNA that prevents cancer cells from producing proteins, leading to cell death.
Researchers at Brain Chemistry Labs have developed a new blood test that can diagnose ALS earlier than current methods, using brain exosomes and microRNA. The test, based on genetic material shed by different tissues, distinguishes between ALS patients and healthy controls with high accuracy.
Researchers explore direct reprogramming as an alternative to cell therapy-based strategies for cardiac regeneration after myocardial infarction. They identify microRNAs and biomaterials like electrospun scaffolds and nanoparticles as potential non-viral vectors for safe delivery of genetic reprogramming.
A novel intracellular biopsy technique developed by City University of Hong Kong isolates targeted miRNAs from living cells within 10 minutes using diamond nanoneedles. This technique simplifies the experimental operation, reducing processing time from hours to minutes and enabling quasi-single-cell miRNA analysis.
Researchers discovered a microRNA named miR-126-5p that protects endothelial cells from damage and reduces atherosclerosis risk. By inhibiting caspase-3 activity, miR-126-5p maintains vascular integrity and prevents the development of atherosclerotic lesions.
A study published in Oncotarget found that physical activity can modulate miRNAs involved in breast cancer progression, leading to reduced cancer cell viability. The researchers identified two specific miRNAs, miR-206 and anti-miR-30c, which showed promising results as non-invasive biomarkers for breast cancer prevention.
Researchers at Karolinska Institutet have discovered a new mechanism by which microRNAs regulate protein production, potentially leading to new cancer treatments. The study focused on miR-34a, a microRNA that plays a key role in cancer by regulating the activity of the p53 protein.
A new study published in Cell Reports reveals how microRNAs regulate the immune system by acting as a release for the
Glioblastoma cells acquire radiation resistance by dumping exosomal microRNA miR-603, leading to increased protein production and insensitivity to radiation. This study reveals a new therapeutic strategy for overcoming cancer cell resistance.
Researchers found that tiny RNAs that target the SARS-CoV-2 virus are associated with over 72 biological processes and decline with age and underlying medical conditions. The study suggests that replenishing these microRNAs could help restore immunity against the virus.
Researchers have found that genes associated with female hormone synthesis and ovarian follicle development play a more complex role in oocyte maturation. The study reveals new information on the ovarian function, which can improve diagnosis and treatment options for female infertility.
Researchers discovered multiple RNA elements in the upper stem of pri-miRNAs crucial for regulating miRNA expression. These elements affect miRNA processing, leading to dysregulation and abnormal cell activities. The study's findings may help interpret miRNA-related human diseases and develop clinical diagnostics.
Researchers at Moffitt Cancer Center identified potential therapeutic targets for cutaneous squamous cell carcinoma by studying the activity of protein TAp63 and microRNAs. The study found that miR-30c-2* and miR-497, which are normally expressed in normal skin, are underexpressed in cuSCC tumors and inhibit growth when reintroduced.
Researchers found that micro RNAs, like miR399, play a crucial role in regulating stomatal pore development and density in response to environmental cues. The study could lead to strategies for improving crop productivity by adjusting stomatal pore density.
A team of scientists has developed a cancer diagnostics method that amplifies microRNA in live tumor cells using synthetic DNA and nanoparticles. This allows for the detection of tumor cells with high sensitivity, potentially leading to earlier diagnosis and improved treatment outcomes.
A recent study published in Oncotarget found that microRNA (miR) dysregulation is associated with immune cell activation, gastric inflammation, and carcinogenesis. Specifically, miR-155 upregulation is considered a key marker of chronic gastric inflammation and predisposes patients to gastric carcinogenesis.
The Obesity Society's latest research explores the pathophysiology of obesity, therapeutic goals, and differential risk. A new coding system is proposed to address suboptimal efforts in prevention and treatment, offering a personalized approach to care.
Researchers found that both strands of microRNA coordinate to act on the same cancer pathways, driving aggressiveness and growth. MicroRNAs miR-30a and miR-145 were identified as key players in keeping cancers in check, impacting patient survival.
Scientists at St. Jude Children's Research Hospital have identified two critical microRNAs driving ventricular enlargement in models of schizophrenia. Reduced expression of these microRNAs leads to increased motile cilia movement and brain ventricle enlargement, highlighting a potential target for future treatments.
Researchers developed a method to capture and count cancer-associated microRNAs in blood or serum with single-molecule resolution. This approach could enable low-concentration cancer-related molecules to be detected for diagnostic purposes.
Dodder parasitic plant avoids genetic evolution arms race with host plants by sending microRNAs that shut down defense genes. The parasite targets conserved host genes and creates multiple versions of its genetic weaponry to ensure effectiveness.
Researchers developed a biochemical model that reveals novel insights into microRNAs and enables accurate prediction of their effects on genetic expression. The model explains nearly half the variability in miRNA-mediated silencing and greatly surpasses correlative models.
A new study published in Gastroenterology reports that prostaglandin E2 (PGE2) promotes metastasis of colorectal cancer through the microRNA MIR675-5p, which silences the expression of p53. Researchers found that mice treated with PGE2 had increased metastases compared to controls, and tumor cells expressed more MIR675-5p and less p53.
A team of investigators from Brigham and Women's Hospital has identified a specific microRNA, miR-30d, that increases during peak disease in MS patients. Orally administering a synthetic version of the microRNA prevented disease in a preclinical mouse model.
A team of scientists at the University of Freiburg has created a microfluidic chip that recognizes small RNA fragments, enabling faster and more precise disease diagnosis. The CRISPR biosensor can detect increased levels of miRNA in blood samples from patients with brain tumors.
Research reveals that adolescent binge drinking can lead to altered gene expression, increasing susceptibility to anxiety and alcohol use disorders in adulthood. Targeting specific microRNAs may be a new approach to undoing the damage of early-life alcohol exposure.
Researchers from MIPT explored microRNA interactions with mRNA in two human cell lines, finding that microRNA does not strongly regulate all genes and its regulation potential does not directly depend on its expression level. The study also identified differences between microRNA interactions in the two cell lines.
Researchers at Thomas Jefferson University used a new sequencing method to identify a sea of previously invisible RNA molecules that may play a role in aging processes. The study found that these cyclic-phosphate containing RNAs (cP-RNAs) are abundantly expressed throughout the body and change in number as tissues age.
A recent study by Goethe University Frankfurt identified 17 microRNA families that play a crucial role in the interface between the immune and neuronal systems, showing sex-specific differences in gene expression. These findings may lead to new therapeutic approaches for psychiatric diseases.
Researchers identified specific microRNAs that predict pneumonia complications, enabling early detection and intervention. The study found correlations between microRNA profiles and sepsis and respiratory failure in pneumonia patients.
Researchers developed a new approach to diagnosing melanoma using microRNA biomarkers, achieving high sensitivity and specificity rates. The method overcomes challenges of tumor heterogeneity and improves diagnostic accuracy, potentially leading to earlier detection and better patient outcomes.
Researchers at the Center for Cell-Based Therapy identified microRNAs involved in pluripotency maintenance and cell differentiation. The study found that these molecules play a crucial role in regulating ESC behavior, with some miRNAs contributing to both pluripotency and differentiation.
Researchers identified microRNAs that regulate plant reproduction in ancient liverwort species, also found in modern crops. The discovery may lead to new applications for predicting harvest times and improving crop yields.
UTSW researchers identified a novel mechanism regulating fat creation in mammals. The miR-26 family of microRNAs strongly protects against weight gain and metabolic issues by controlling FBXL19 protein levels.
The bioMILD trial demonstrated that a blood microRNA assay, combined with low-dose CT screening, is safe and effective in enhancing lung cancer prevention. Preliminary analysis showed a significantly higher lung cancer incidence and overall mortality in subjects with positive LDCT and/or miRNA at baseline.
The bioMILD trial demonstrated that combining low-dose CT screening with a microRNA blood test reduces lung cancer mortality and incidence in high-risk individuals. The study found that participants with positive LDCT and/or miRNA at baseline had a significantly higher lung cancer incidence and overall mortality.
Researchers from Osaka University found that microRNA methylation levels can discriminate cancer patients from healthy individuals with high sensitivity and specificity. The study suggests that methylation of specific mature microRNAs could be a more powerful indicator of early-stage pancreatic cancer than existing biomarkers.
A recent study found that boosting levels of tiny RNA miR322 can reduce heart muscle death by 40% after a heart attack. The research suggests that miR322 regulates the enzyme FBXW7, which tags cells for elimination, and its overexpression can protect the heart from damage.