Articles tagged with Microrna
Researchers have discovered a new sleep molecule, microRNA-137 (miR-137), that regulates hypocretin levels for normal sleep. The study found that miR-137 is associated with hypocretin regulation and sleep disorders such as narcolepsy and insomnia.
Researchers from HKUST have identified secondary RNA elements that control DICER's cleavage activity, improving miRNA expression and shRNA design for effective gene silencing. The study provides a foundation for designing accurate and efficient short-hairpin RNAs.
Researchers discovered a novel mechanism for miR-10b activation in high-grade gliomas, implicating topologic reorganization of chromatin and long-non-coding RNAs. This finding suggests new RNA-targeted strategies for glioma therapy and points to the vulnerability of tumor-initiating cells.
Researchers at the University of Eastern Finland have developed a novel nuclear microRNA, miR-466c, that regulates vascular endothelial growth factor A (VEGFA) expression in response to hypoxia. The drug has commercial relevance for treating ischemic cardiovascular disease by increasing VEGFA levels.
Researchers at Brigham and Women's Hospital successfully differentiated vascular smooth muscle cells into endothelial cells using a miRNA cassette. The induced endothelial cells restored blood flow more quickly than conventional ECs in a murine hindlimb ischemia model.
Researchers discovered that Candida albicans stimulates human immune cells to release microRNAs, triggering increased fungal growth. The fungus exploits human immune defenses by releasing signal molecules recognized by special immune cells.
A recent study identified specific RNA biomarkers linked to gastrointestinal symptoms in children with autism. The findings could lead to the development of personalized treatments to ease the pain of these individuals. The research has implications for precision medicine, enabling healthcare providers to track medication effectiveness...
A new study using blood samples from professional soccer players reveals that headers affect brain activity by altering microRNAs, which can serve as biomarkers for brain injury. The research also explores the effects of accidental head impacts and high-intensity exercise on microRNA levels.
Researchers at Brigham and Women's Hospital discovered a new function of miR-10b, interacting with U6 snRNA to alter global splicing in glioma cells. This study highlights the potential for miRNA-based treatments in cancer therapy.
Researchers found that sewer slime can accumulate SARS-CoV-2 RNA, which could decompose or slough off later. The slime's ability to hold onto the viral RNA was linked to the number of diagnosed COVID-19 cases in late fall. Further studies are needed to assess its impact on wastewater epidemiology.
Researchers at the University of Illinois have developed a new approach to detect cancer biomarkers in human serum, reducing the detection time from hours to just one minute. This method uses magnetic-plasmonic nanoparticles and photonic resonator absorption microscopy to achieve high selectivity and rapid sample-to-answer analysis.
Scientists have discovered a new layer of regulation in plant-microbe interactions using peanut studies. An antisense long-noncoding RNA, DONE40, was found to bind to a protein involved in epigenetic control, suggesting a conserved function across plants and animals.
Scientists at the University of Missouri discovered that bisphenol A (BPA) exposure during pregnancy can negatively impact fetal brain development. MicroRNAs in the placenta play a key role in regulating cellular functions, including neural development. Researchers believe that microRNA packages could reach the brain through the placen...
A recent study has identified a new mechanism by which oral cancer cells acquire radioresistance through the transfer of microRNA, specifically miR-503-3p. This discovery brings hope for the development of new treatments for radiation-resistant oral cancer.
Researchers have discovered microRNAs that can detect ovulation and egg quality in fish, and also identify growth signatures. These findings could lead to the development of non-invasive biomarkers for monitoring animal physiological states, enabling cost-effective and accessible information on health.
A Rutgers study found that COVID-19 saliva testing kits with a preservative can accurately measure the oral microbiome, which may lead to new treatments for lung health in people with COVID-19. The study collected saliva samples from participants and compared their ability to measure microbes before and after COVID-19 infection.
A Swedish twin study discovered epigenetic differences in twins with one developing type 2 diabetes. The researchers found lower levels of microRNA-30, a gene that regulates glucose uptake, in the affected twins' fatty tissue.
Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.
Scientists at DZNE and UMG identified three microRNAs in the blood that correlate with mental fitness and cognitive decline. The biomarker is associated with an increased risk of Alzheimer's disease within two years, offering potential targets for therapy and early warning signs.
Researchers discovered a microRNA, miR-766-5p, that targets super-enhancers and reduces MYC expression in cancer cells, inhibiting growth rates. The study suggests this molecule could be used as an anti-cancer therapeutic to fight MYC-driven cancers.
Researchers developed a low-cost sensor that can diagnose heart attacks in minutes by targeting miRNA, distinguishing between acute heart attacks and reperfusion injuries. The technology addresses an unmet clinical need, offering improved diagnosis efficiency and cost-effectiveness.
A research group at Osaka University has developed a new tool for sequencing various types of RNA base modifications, including microRNA modifications. They successfully detected two types of chemical base modifications simultaneously using a single-molecule quantum sequencer.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
This study characterizes the aging-associated miRNA profile in murine cardiac fibroblasts, revealing a significant decrease in miRNAs generated by the Meg3-Mirg locus. The findings suggest that this repression is a common feature of aging across multiple organs, highlighting the robustness of miRNA modulation during this process.
A new study from Salk Institute researchers found that a critical threshold of miR-218 levels determines the development of ALS in animal models. The study sheds light on the complex control of gene expression and its implications for treating neurological disorders.
A study published in Scientific Reports describes the putative molecular regulators of reductive stress — a microRNA network. The researchers identified a subset of miRNAs that appeared to be direct and dose-dependent targets of Nrf2, and thus putative regulators of reductive stress.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
Researchers from HSE University have discovered a nucleotide sequence characteristic of microRNA isoforms, which helps predict errors in microRNA behavior. This discovery has important applications for creating drugs that can detect targets more effectively.
A recent study has identified specific miRNA signatures associated with EGFRI-induced skin rash, suggesting potential treatment-dependent biomarkers for this common side effect. The research found that miR-21 and miR-520e serum concentrations were negatively correlated with the severity of skin rash.
A new study evaluated eight miRNA applications to simplify the process of discovery and characterization. Two programs, sRNAbench and miRExpress, stood out for their high sensitivity and low run times, making them suitable for use in plants with varying genome sizes.
Researchers discovered that SARS-CoV-2 produces microRNAs affecting individuals' respiratory systems and immune responses. Understanding these impacts may provide new insights into COVID-19 pathogenesis and treatment.
The Hackensack Meridian Center for Discovery and Innovation has developed the EV-CATCHER methodology, identifying and capturing tiny pieces of genetic material. This technology shows promise in diagnosing and treating diseases such as cancer early on.
Researchers at Nagoya University have developed a simple urine test that can detect brain tumors with high accuracy, using microRNAs as biomarkers. The new device can extract more microRNAs from just a milliliter of urine than conventional methods, and shows promise for early diagnosis and treatment.
Researchers at Jiangnan University developed a sensing platform to detect microRNA-205, a potential biomarker for radiation-resistant nasopharyngeal carcinoma. The method shows high sensitivity and excellent selectivity, enabling detection of miR-205 with a limit of detection of 4.78 nM.
Researchers discovered that primary miRNA precursor forms are highly expressed in cell-type-specific manner, while mature miRNAs dominate common to all cell types. The study also uncovered microRNA-messenger RNA networks driving cell-type-specific responses.
The study reveals that 1B3, a novel synthetic miR-193a-3p mimic, consistently suppresses several pro-tumorigenic phenotypes in vitro, including reduced cell proliferation, viability, and induced apoptosis. The pleiotropic mechanism of 1B3 action supports its development as a novel therapeutic agent for cancer treatment.
Researchers found that even low levels of lead exposure can cause epigenetic changes, including a decrease in DNA methylation, which may precede cellular disorders. The study suggests that these changes could be an early warning sign of potential health problems, highlighting the need for better public policy to minimize lead exposure.
Researchers have shown that injecting heart muscle cells derived from human induced pluripotent stem cells that overexpress cyclin D2 can aid heart attack recovery. The treatment stimulates proliferation of existing heart muscle cells and promotes angiogenesis, a development of new blood vessels.
A recent study published in PLOS ONE found that low-protein intake during pregnancy can lead to a significant decrease in the number of nephrons in offspring, resulting in hypertensive effects and kidney damage. The researchers discovered this effect by analyzing microRNA expression in rat embryos fed with a low-protein diet during ges...
Researchers have uncovered a molecular reason why faecal transplants are effective in treating C. diff infections, suggesting new therapeutic targets. The study identified specific microRNAs that contribute to disease pathogenesis and protect bowel cells from bacterial toxins.
Scientists identified microRNA-29 as a powerful controller of brain maturation, which was found to be depleted in mice with autism-like symptoms. The study suggests that boosting levels of miR-29 could lead to therapeutic strategies for neurodevelopmental disorders like autism.
Researchers found that liver disease primary biliary cholangitis triggers a signaling cascade in skin cells, leading to the formation of micro-RNA bubbles that signal itching. The discovery could lead to new treatments for severe itching and potential liver disease markers.
Researchers have identified a pair of microRNAs that help maintain breast cancer stem cells and drive tumor growth. Targeting these microRNAs may improve the prognosis of patients with aggressive forms of breast cancer by making cancer stem cells more susceptible to chemotherapy.
Researchers discovered a novel pathway linking T-lymphocyte extracellular vesicles loaded with microRNAs to increased osteoclast formation and bone erosion. The study suggests that these extracellular vesicles act as inflammatory mediators, inducing differentiation of osteoclasts via inhibition of cyclooxygenase 2.
Researchers discovered microRNA-4287 inhibits prostate cancer's progression and metastasis, leading to increased cell cycle arrest. The study found miR-4287 specifically targets SLUG and CD44, suggesting a potential diagnostic and therapeutic tool against advanced prostate cancer.
A team of bioinformaticians at Saarland University have identified microRNAs as potential biomarkers for Parkinson's disease using artificial intelligence methods. They found that the level of these non-coding RNAs in blood samples can track the course of the disease, particularly in the third decade of life and from around age 70.
Researchers found that impaired microRNAs, particularly miR-30c, are responsible for the ineffective function of stem cells in diabetic hearts. Increasing miR-30c levels in the heart improves stem cell survival and growth, offering a novel therapy for treating type-2 diabetic heart disease
A study found associations between urinary miRNAs and cardiorenal outcomes, including blood pressure and eGFR levels, in Mexican children. The researchers identified several miRNAs associated with kidney function, blood pressure, and electrolyte biomarkers.
Researchers have identified how Physarum polycephalum, a single-celled organism, stores and retrieves information about its environment through its network architecture. The slime mold weaves memories of food encounters into the architecture and uses stored information to make future decisions.
A new study found that estrogen deficiency during menopause leads to altered microRNA signalling in skeletal muscle, potentially activating cell death pathways and resulting in muscle wasting. The study suggests resistance training may be beneficial for maintaining muscle mass and power in middle-aged women.
A new study from the University of Eastern Finland has identified two potential biomarkers, miR-9a-3p and miR-136-3p, which could serve as diagnostic biomarkers for mild traumatic brain injury. These microRNAs were found to be elevated in both animal models and human patients, suggesting their potential use in diagnosing the condition....
Researchers discovered pancreatic beta cells secrete miR-29 family members to promote insulin resistance and enhance hepatic glucose output. This finding reveals a new mechanism linking obesity-induced insulin resistance in type 2 diabetes's pathogenesis.
Researchers identified pancreatic β cell-derived exosomal miR-29 family as a new mechanism that regulates glucose homeostasis through liver. Exosomal miR-29s negatively regulate insulin signalling pathway via targeting p85 α, attenuating the suppression of insulin on glucose output.
Researchers have identified microRNA biomarkers that play a role in brain damage caused by traumatic brain injury, and are also associated with Alzheimer's disease. The study found coordinated miRNA dysregulation followed by increased amounts of BACE1, a key enzyme in neurodegenerative disease pathology.
A new study by ISGlobal has identified six microRNAs that may be used as biomarkers to predict disease severity in children with severe malaria. The findings provide a potential breakthrough in understanding the mechanisms underlying severe malaria and improving treatment outcomes.
A new study identified a molecule that reduces inflammation during mechanical ventilation, but isn't enough to prevent lung damage. Delivering high levels of the molecule with nanoparticles was effective in fending off ventilator-related lung damage in mice.
Researchers identified a circular RNA, circ2082, and an RNA-binding protein, RBM3, that form a complex with the enzyme DICER to disrupt microRNAome regulation in glioblastoma cells. This leads to increased survival rates in mice and longer lifespans in human patients with circ2082-dependent signatures.
Researchers discover new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as microRNAs. The study found that 110-120 miRNAs modulate circadian rhythms, with tissue-specific impacts on human health.
Georgetown University researchers successfully used RNA molecules to suppress SARS-CoV-2 protein production, potentially leading to an inhalable drug that mitigates viral chaos. The approach targets viral machinery within cells via siRNA, degrading messenger RNA and reducing infection spread.
Researchers found a ubiquitin ligase complex that degrades miR-7 and other miRNAs in cells. This discovery sheds light on how cells dispose of genetic molecules regulating protein production.