Articles tagged with Microrna
Researchers at Stanford University School of Medicine found a way to improve neuron recovery in rats by blocking a molecule that controls genetic instructions. The approach, if applied to humans, may help patients with stroke, cardiac arrest, or major blood loss recover memory functions.
Researchers found a link between microRNA regulation and the rapid evolution of new species in Nicaraguan crater lakes. They analyzed five species of Midas cichlids and identified specific pairs of microRNAs and genes that interact with each other.
Researchers identified thousands of host mRNAs targeted by gammaherpesvirus microRNAs, revealing significant conservation of miRNA targeting among viruses. The study provides new insights into the function of gammaherpesvirus miRNAs and their role in establishing lifelong infections.
Researchers developed a new molecule, HDO-antimiR, that can silence malfunctioning miRNA with heightened efficacy and lowered toxicity. It has been shown to be 12 times more efficient in binding to targeted miRNA and producing enhanced phenotypic effects in mice.
Researchers found that slowing metabolic rates can prevent developmental problems caused by genetic mutations in fruit flies. The study suggests that reducing metabolism by 50% allows for adjustment and correction of errors, thereby preventing detrimental effects.
Scientists have discovered that microRNAs play a crucial role in regulating genes in cell nuclei, not just cytoplasm. MicroRNAs targeting the nucleus can increase gene expression, offering a novel approach to gene therapy.
A study led by Georgia State University researchers found that fecal miRNA can serve as a tool to assess gut microbiota healthiness and provide early clues to intestinal inflammation in mice. The findings offer new hope for diagnosing chronic gut conditions, such as inflammatory bowel disease.
A new study by McGill's Goodman Cancer Research Centre uncovers novel microRNA polycistron functions and their impact on cancer. Researchers discovered a mysterious step in microRNA biogenesis that occurs in cell nuclei, shedding light on the role of microRNAs in cancer.
Researchers identified a key molecule, mir-135b-5p, found elevated in the brain's emotional memory processor that drives PTSD symptoms. Suppressing this molecule enables faster recovery from trauma, and it may also serve as a novel biomarker for treatment.
Researchers at Boston University School of Medicine identified salivary microRNAs that differentiate people with alcohol dependence from healthy controls. The study uses machine learning to predict alcohol dependency with high accuracy, offering potential for early diagnosis and treatment.
A study published in Experimental Physiology found that short-sleepers have lower blood levels of three microRNAs, which influence gene expression and maintain vascular health. This could lead to new tests for sleep-deprived patients concerned about their health.
Researchers at the University of Notre Dame have developed a microfluidics platform using extracellular vesicles containing microRNAs for early-stage disease diagnosis, reducing test time by 13 hours.
Researchers discovered microRNA-like RNAs that regulate the transition from saprophytes to pathogens in Arthrobotrys oligospora. The study provides new insights into understanding fungal adaptation and potential bio-control agents.
Researchers have identified two microRNA family members that can provide both immediate and long-term protection against heart damage. The therapy targets the miR-19a/b microRNAs, which regulate proliferation of cardiomyocytes and reduce inflammation, leading to improved heart function.
A recent study has identified microRNA-like RNAs as key regulators in the lifestyle transition of Arthrobotrys oligospora, a nematode-trapping fungus. The researchers found that these microRNAs are essential for the development of adhesive networks and the capture of nematode prey.
Researchers have identified the lin-41 mRNA as a crucial target of the let-7 microRNA, driving the transition to adulthood and sexual organ formation in C. elegans. This finding may provide insights into human puberty disorders linked to genetic variations affecting let-7 activity.
A human study published in The FASEB Journal suggests a novel type of biomarker to predict atrial fibrillation progression. Researchers found that patients with persistent atrial fibrillation demonstrated the highest expression of five miRNAs associated with signaling pathways and fibrosis involved in AF.
A new method of using multiple microRNAs to weaken cancer cells has shown promising results in preclinical models, increasing survival in a murine model of glioblastoma by five-fold when combined with chemotherapy. The treatment strategy weakens tumor cells but does not directly kill them, making it an advantage for further treatment.
Researchers studied mRNA and microRNA interactions in prenatal human brain cells to understand their role in cell type identification. They found that these interactions are highly cell-type specific, which can lead to overexpression of certain genes and uncontrolled cell production.
Researchers discover microRNAs miR-146a and miR-146b play crucial role in suppressing NF-κB activation, which leads to excessive cell cycle progression and rapid tumorigenesis. The study found differences in cancer outcomes depending on the absent microRNA, offering new insights into cancer development.
This study investigates the role of miRNAs in cardio-protective effects of halogenated anesthetics, a widely used cardiac surgery agent. The expression profile of miRNAs is modulated by perioperative administration of these anesthetics.
A study discovered that a microRNA cluster regulates synaptic strength and is involved in controlling social behavior in mammals. The researchers found that the absence of this microRNA cluster results in increased sociability in mice.
The study investigates the interplay between microRNAs and targeted genes in cellular homeostasis of adult zebrafish, highlighting two types of miRNA unique to each organ. MicroRNAs regulating fundamental processes are common to both liver and gut, while those specific to either organ regulate distinct biological processes.
Researchers identified microRNA-668 as a key player in protecting kidney cells from damage caused by acute kidney injury. By upregulating this microRNA, the protective pathway can prevent most of the damage and allow cells to function ideally until blood and oxygen are restored.
Researchers at UC San Diego School of Medicine developed a method to turn B cells into factories that assemble and secrete vesicles containing tumor-suppressing microRNAs. In mice, breast tumors treated with this approach were significantly smaller than untreated tumors, and the treatment was long-lasting.
In a breakthrough study, researchers successfully delivered a microRNA called miR-126 via a nanocarrier to improve survival rates in a preclinical model of sepsis. The treatment resulted in over 67% of mice being alive at seven days compared to just 25% of untreated mice.
A recent study by Earlham Institute sheds light on the genetic orchestra conductors behind domestication of dogs, cows, horses, pigs, and rabbits. By analyzing microRNAs in their brains, testicles, hearts, and kidneys, researchers discovered that some miRNAs have evolved more recently, playing a crucial role in emerging novel traits.
Researchers at Johns Hopkins Medicine have found a link between low levels of specific microRNA molecules and the development of pediatric brain tumors. Increasing these molecules may potentially treat low-grade gliomas, which affect mostly school-age children and young adults.
Researchers from Osaka University established a new analytical approach, MIGWAS, that integrates genetic and molecular data to reveal tissue-specific features associated with diseases. The study successfully identified novel cellular components linked to traits and diseases.
Researchers developed a novel computational tool called ADmiRE to annotate human microRNA variants and determine their potential contribution to diseases. The tool successfully identified microRNA mutations in miR-142 and miR-21 linked to hematologic cancers and esophageal cancer, respectively.
A new study by UMass Medical School researchers successfully delivers RNAi-based gene therapy to silence SOD1 protein mutations linked to ALS without adverse effects. The therapy, delivered via a viral vector, achieved silencing of over 90% in some motor neurons, suggesting a safe and potentially one-time treatment for humans.
A new Northwestern Medicine study reveals a 'kill code' embedded in every cell that can trigger the self-destruction of cancerous cells. The toxic small RNA molecules can also be triggered by chemotherapy, offering a potential bulletproof treatment against cancer.
Scientists at Newcastle University have found that metformin can reduce the presence of microRNAs that contribute to heart disease in patients with Type 1 diabetes. By decreasing these microRNAs, metformin improves glucose levels and promotes blood vessel repair, opening up new treatment options for this vulnerable patient group.
A Duke University research team has found a way to detect autologous blood transfusions, a method used by athletes to boost oxygen-carrying capacity. By analyzing RNA changes, researchers can identify stored red blood cells and detect self-transfusions.
Researchers found that increasing miR397 levels in domesticated rice plants resulted in traits similar to wild rice, including long stems and few flowering structures. Transgenic expression of the gene encoding miR397 partially de-domesticated rice, boosting grain production and improving resilience.
Researchers at Tokyo University of Agriculture and Technology have developed a simple technique to identify Small Cell Lung Cancer (SCLC) earlier using nanopore technology and DNA computing. The method recognizes specific microRNA patterns associated with SCLC, enabling early detection without invasive cell biopsies.
Researchers discovered that brain-enriched miRNA (miR-124) plays a crucial role in neuronal survival, contrary to previous assumptions. The study identified 98 miR-124 targeted genes that have direct physiological functions, protecting neurons from death.
Researchers found that low colonic miR-31 expression is associated with worse disease outcomes in adults and future development of strictures in children. This discovery has the potential to improve clinical trial designs and develop more personalized therapeutic strategies for Crohn's disease patients.
A new investigational steroid called vamorolone has been found to replicate the benefits of prednisone while reducing its side effects, offering hope for patients with chronic inflammatory diseases. The study identifies nine potential biomarkers for inflammatory diseases that could serve as a fingerprint for chronic inflammation.
A blood test for microRNAs may help predict the likelihood of disease in dairy cows and improve animal welfare. This approach is already being applied to human disease diagnosis.
Researchers at the University of Würzburg have identified viral microRNA molecules that can serve as ideal biomarkers for detecting human herpesvirus 6 (HHV-6) reactivation. The discovery was made using a novel method that allows for early detection of viral activation, potentially leading to improved clinical interventions.
Osaka University researchers successfully delivered microRNAs to immune response cells in inflamed intestinal tracts using a super carbonate apatite (sCA), reducing inflammatory cytokines. The study showed that sCA could be used to treat a wide range of immunity and allergic disorders caused by immune responses.
Researchers have identified a gene variant linked to chronic pain after traumatic injury, specifically the FKBP5 gene, which regulates the stress response and is affected by microRNA miR-320a. Individuals with this variant are more likely to experience increased pain due to altered cortisol levels and nerve sensitization.
Researchers from Brigham and Women's Hospital discovered a neuroprotective microRNA, miR-132, which shows promise in treating tauopathies like Alzheimer's. The study found that miR-132 supplementation reduced toxic forms of tau and glutamate excitotoxicity, providing new avenues for potential treatments.
Researchers at UT Southwestern Medical Center have uncovered the means by which pediatric kidney cancer continues to grow, providing potential targets for more effective treatments. Impairment of miRNA function drives Wilms tumor formation through increased IGF2 production.
A $2 million NIH grant will support research on how herpesviruses contribute to periodontitis and explore the potential of viral microRNAs as biomarkers for oral inflammation. The study aims to identify microRNAs that change in inflamed tissues and understand their impact on host immune cell functions.
A microRNA panel developed by researchers identified 19 microRNAs that can categorize indeterminate thyroid nodule samples into malignant and benign. The panel showed high sensitivity, specificity, and accuracy in diagnosing cancer in patients with suspicious thyroid nodules.
Researchers developed a new technology to identify microRNAs from non-culturable pathogens, discovering five highly probable papillomavirus-encoded microRNAs. These microRNAs regulate viral gene expression and control the papillomavirus life cycle.
Australian researchers have discovered a team of tiny molecules, called microRNAs, that can reverse a 'switch' in cancer cells making them less aggressive. The discovery could lead to safer and more effective cancer treatments by combining the molecules with chemotherapy.
Researchers at Louisiana State University Health Sciences Center have identified miR-27b, a microRNA, as a potential therapeutic target for breast cancer treatment. The study found that suppressing miR-27b enhances the expression of PDHX, a protein involved in cell metabolism, which helps suppress tumor progression.
Researchers at Johns Hopkins Medicine have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice. The contents of the super-small containers were designed to target cancer stem cells, a kind of cellular
Researchers at Columbia University Irving Medical Center found a potential link between microRNAs and sepsis, identifying two molecules that silence inflammatory gene expression. These biomarkers could help diagnose patients at risk of organ failure and death, allowing for faster treatment and potentially saving lives.
A research team has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. Understanding this process may help develop new therapies for cancer treatment.
Researchers at Mount Sinai have discovered two microRNA activity-based biomarkers that can predict patient outcomes and inform treatment decisions for p53-like bladder cancer. The findings hold promise for personalized treatment options, but further research is needed to translate the results into improved patient care.
Scientists found microRNA changes detectable in mice before symptoms of Alzheimer's disease appear. The study suggests microRNA-142 may be a key biomarker for the condition.
A new Penn study finds that microRNAs in the blood can track responses to total sleep deprivation and predict individual differences in cognitive performance. The study identified 14 miRNAs reliably predicting behavioral attention performance, 7 for cognitive throughput, and 10 for memory performance.
A new study found that early life trauma in men is associated with lower levels of two specific sperm microRNAs, which can be transmitted to the next generation. The study suggests a possible link between childhood trauma and increased risk of stress-related disorders.
Researchers uncover the role of SWI2/SNF2 ATPase in microRNA production, revealing a unique gene-editing target to control microRNA levels. The protein has two separate functions: one for its native chromatin and another for the microRNA-producing factory.
Researchers identified dysregulation of the gene NEUROG2 as a key factor in the development of focal cortical dysplasia, a common cause of drug-resistant epilepsy. The study found that overexpression of NEUROG2 was linked to reduced expression of microRNA hsa-miR-34a, leading to nerve cell differentiation failure.
Researchers identified a correlation between gut microbial composition and microRNA expression in human colorectal cancer. The study found that dozens of microRNAs are differentially regulated in colorectal cancer tumors and are correlated with the abundance of microbes in the tumor microenvironment.