Articles tagged with Microrna
Researchers have developed a new method to detect microRNA targets at the level of single cells, allowing for detailed study of gene regulation. This breakthrough enables researchers to follow microRNA targeting of thousands of RNAs during biological processes, revealing surprising complexity in each cell.
Researchers at the University of Alabama at Birmingham have developed a modified messenger RNA that can temporarily induce cardiomyocyte cell division, leading to reduced infarct size and improved heart function. The treatment has shown promise in mouse and pig models without increasing the risk of deadly arrhythmias.
Researchers found that cold exposure increases the secretion of miR-378a-3p by brown adipose tissue, which stimulates hepatic gluconeogenesis. This process is essential for regulating whole-body glucose homeostasis during cold stress.
Researchers developed a targeted microRNA therapy that slowed cancer tumor growth in a 21-day study. The therapy, which combines a delivery system with modified microRNA-34a, suppressed the activity of genes driving cancer and resistance to other therapies.
HSE biologists explain how coronavirus evolves from Wuhan variant to Omicron, highlighting the crucial role of microRNA molecules in the process. The study found that substitutions in the viral genome disrupted microRNA binding regions, leading to the emergence of more contagious and resilient strains.
A new gene therapy study has identified microRNA-22 as a potential treatment for liver cancer, achieving better survival outcomes and reducing inflammation compared to the current FDA-approved drug lenvatinib. The treatment was administered via a single intravenous injection and showed no observable toxicity.
Researchers examine translational studies on peripheral surrogates of tumor burden, including circulating tumor DNA, miRNA, and HPV-specific antibodies, to inform chemotherapy and immunotherapy strategies. These biomarkers show promise as prognostic and predictive markers of response to treatment.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
Gray mold is a fungus that causes billions of dollars in crop losses each year, but researchers have discovered a way to control it without using toxic chemicals. The discovery reveals that gray mold uses lipid 'bubbles' to deliver RNA molecules that silence plant immune systems.
A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Researchers discovered microRNA-132 can impact different brain cells, including microglia, which are key players in neuroinflammation. The study suggests increasing microRNA-132 levels may be a therapeutic strategy for Alzheimer's disease.
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
Researchers at NYU Abu Dhabi identified microRNAs associated with a weakened immune response and ICU admission. The study provides new insights into how patient genetic makeup affects disease severity and offers potential biomarkers for disease monitoring.
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.
Scientists discovered that inhibiting microRNA-141-3p can reduce chronic inflammation, muscle loss, and bone degradation in aged mice. By blocking this tiny RNA, researchers found improvements in the spleen's immune response, lower levels of pro-inflammatory proteins, and a more youthful profile in bones and muscles.
A study with 116 participants found associations between microRNAs in extracellular vesicles and mental health disorders such as depression and ADHD. While no biomarkers were identified, the results suggest genetic material can be non-invasively accessed through blood samples.
Researchers at MIT have created a vaccine printer that can produce hundreds of vaccine doses in a day, using microneedle patches that can be stored long-term at room temperature. The printer can be deployed anywhere vaccines are needed, providing on-demand vaccine production.
Researchers have created a new method for fast miRNA amplification and detection that reduces the time required to detect micro-RNAs. The technique combines rolling circle amplification (RCA) with CRISPR-Cas12a, resulting in improved sensitivity and specificity, and can be completed in just 70 minutes.
A simple blood test for ALS has been developed using microRNA analysis, which can accurately identify patients with the disease. The test uses a unique protein called L1CAM to concentrate diagnostic particles from extracellular vesicles in the bloodstream.
James Chappell, a Rice University bioscientist, has won a National Science Foundation CAREER Award to create RNA programming methods for microbial communities in natural habitats. His research aims to improve human health and the environment by genetically manipulating microbial communities.
Scientists at UC Riverside identify microRNA as a key player in plant temperature responses and growth, revealing its essential role in sensing environmental changes. The discovery has significant implications for increasing crop yields in diverse environments and adapting to climate change.
Researchers found that miR-145 suppresses cervical cancer cell growth and inhibits aerobic glycolysis. Targeting miR-145 is expected to be an effective strategy for cervical cancer treatment, according to the study.
A study by Tokyo Medical and Dental University reveals that chronic kidney disease promotes vascular calcification by altering signaling molecules in blood vessel walls. The researchers identified four microRNAs that target a key pathway driving calcification, providing potential biomarkers and therapeutic targets for both diseases.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Researchers at Rice University aim to create genetically encoded antibiotics that selectively kill pathogenic bacteria while sparing beneficial microbes. The goal is to develop targeted, tailored RNA antibiotics to combat antibiotic resistance and improve treatment outcomes.
A study has identified new microRNA biomarkers for the partial remission phase of type 1 diabetes and linked one of these microRNAs to immunoregulatory processes. The findings suggest a unique microRNA signature expression during this phase, which modulates regulatory T cell expansion and PD-1 expression.
A new study from WashU Medicine identified a possible treatment strategy for poikiloderma with neutropenia, a rare bone marrow failure syndrome. Researchers found that inhibiting an enzyme called PAPD5 can restore normal blood cell formation by stabilizing microRNA molecules.
A large-scale genetic analysis identified microRNAs in human pancreatic cells strongly associated with type 2 diabetes. The study found specific microRNAs different in people with the condition, which may chart its course or inform drug therapies.
A new study published in the Proceedings of the National Academy of Sciences has identified 14 pancreatic islet miRNAs associated with human type 2 diabetes. The study used a large sample size of nearly 65 human pancreatic islets to uncover these miRNAs, revealing potential mechanisms for disease development and novel therapeutic targets.
Researchers developed a novel CRISPR system to detect small amounts of cancer-related molecules in exosomes in plasma, effectively distinguishing between malignant and benign samples. The method has the potential to make cancer diagnosis and monitoring quicker and easier by analyzing blood samples.
Researchers from Nagoya University have identified two microRNAs that are downregulated in systemic lupus erythematosus, a disease where the immune system attacks itself. The study found that these miRNAs regulate the same set of genes through 'seed overlap' co-targeting, which negatively regulates inflammatory cytokine production.
Researchers discovered that non-vascular bryophytes like Marchantia polymorpha adapt their architecture in response to shade, using phytochromes to regulate branching. The study found a liverwort-specific microRNA and SPL gene controlling meristem function, differing from vascular plants.
Researchers at HKUST mapped out the fundamental mechanisms of C.elegans Microprocessor (cMP), revealing its distinctive molecular mechanism. The study suggests that cMP's two subunits, cDrosha and Pasha, determine cleavage sites using distinct methods, differing from human MP in multiple aspects.
Researchers developed predictive models using serum microRNAs to identify patients at risk of requiring early palliative care. The study used serum samples from 178 patients with various types of cancer and found that miRNA-based models had higher accuracy than clinical models in predicting referral to a palliative care unit.
Smidt Heart Institute researchers have identified a way to control the natural 'fight back' response of heart cells against RNA therapies, leading to increased effectiveness. By targeting specific microRNAs, they were able to stabilize the heartbeat and boost gene expression.
Researchers at the University of Tokyo have developed artificial DNA that can target and kill cancer cells by binding to microRNA molecules. The DNA triggers an immune response that not only kills cancer cells but also prevents further growth of cancerous tissue.
The discovery of microRNAs in octopus species reveals a common role in advanced brain development and cognition, linking the evolution of intelligent life. MicroRNAs regulate protein expression, diversifying cell function and enabling complex organisms to perform specialized tasks.
Researchers from IIT have discovered a correlation between small RNA molecules, piRNAs, and brain inflammation. The study lays the groundwork for new diagnostic technologies to detect neurodegenerative diseases, such as Alzheimer's and Parkinson's, at an early stage.
Research reveals that octopuses have a massively expanded repertoire of microRNAs in their neural tissue, similar to vertebrates. This finding suggests that miRNAs play a fundamental role in the development of complex brains.
A new microfluidic multiplexed chip uses CRISPR technology to detect SARS-CoV-2 and monitor antibiotic levels, offering a rapid and sensitive solution for managing COVID-19 patients. The test omits nucleic acid amplification and can be easily adapted to new virus mutations.
Researchers discovered a microRNA biomarker, miR-145, can predict which breast cancer patients are at high risk of recurrence and death. This finding has the potential to identify tailored treatment options for these patients.
A new study explores the value of 'trash data' from cancer genome sequencing, identifying new strategies to uncover previously unexplored information. The researchers found that genomic and transcriptomic data contain relevant information that can help elucidate carcinogenesis and discover putative biomarkers with clinical applications.
A new study published in ACS Central Science finds that some microRNAs can upregulate specific genes, increasing protein production in both normal and cancer cells. This discovery expands our understanding of how microRNAs function and has implications for the development of miRNA-based therapeutics.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
A recent study found that microRNA-145 can identify breast cancer patients at lower risk of recurrence and those who may need additional therapy. The biomarker was measured in patients' blood samples during chemotherapy and predicted long-term oncological outcomes.
Researchers have identified microRNA-7 as a non-classic genetic risk factor for hereditary obesity. The molecule affects energy balance and appetite regulation in humans and mice, highlighting the need to examine non-genetic factors in gene-based studies. This discovery may lead to new therapeutic approaches for treating obesity.
A chemically modified microRNA, miR-143#12, has been developed to target KRAS mutant cancers, demonstrating potent antiproliferative activity against colon cancer cell lines and significant tumor growth inhibition in mouse models. The microRNA suppresses the expression of key genes in the KRAS signaling network, inducing cell death at ...
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
A study by IMIBIC and UCO found that brain-regulated microRNAs influence reproductive capacity in males and females. The researchers discovered that microRNAs are crucial for Kiss1 neurons, essential for proper pubertal activation and adult reproduction.
A new study has found associations between plasma miRNAs and cognitive function among cognitively normal men, including those with higher MMSE scores and slower rates of cognitive decline. These findings suggest that extracellular microRNAs may play a role in the early stages of cognitive decline.
Researchers have developed a new labeling technique to analyze exosomes from specific cell types, providing insights into their role in both health and disease. The technique allows for the identification of protein cargo and RNA in exosomes, enabling the study of cellular communication and potential monitoring of response to treatment.
Researchers at Brain Chemistry Labs have developed a new blood test for ALS using microRNA sequences, which accurately discriminated between patients and healthy individuals. The test works even with varying environmental conditions, offering hope for rapid diagnosis and improved patient outcomes.
A study by Osaka University researchers comprehensively analyzed mRNA and microRNA expression patterns in the blood of patients with severe COVID-19, revealing specific mRNAs and microRNAs associated with the immune response pathway. The findings suggest that interferon-β plays a crucial role in COVID-19 severity.
A study published in eLife identified three microRNAs that may impair healing in venous ulcers, a common type of chronic wound. The findings suggest that drugs targeting these microRNAs could help facilitate healing in patients, offering new approaches for treating this painful and slow-to-heal condition.
Researchers at the University of Copenhagen have developed a new method to detect biliary tract cancer and other serious cancers by analyzing changes in microRNA molecules in patient blood. This approach enables early diagnosis and has potential for targeted treatments.
Researchers have developed a new method to produce RNA chips, which can help elucidate the functions of RNA molecules in cells. The method allows for quick and easy conversion from commercially available DNA chips, paving the way for further applications in disease diagnosis and treatment.
Researchers at Moffitt Cancer Center discovered that gains in chromosome 1q stimulate a network of competitive endogenous RNA molecules that promote melanoma metastasis. These RNA sequences act as 'ceRNAs' that sponge miRNA molecules, driving tumor growth and development.
A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
The June issue of SLAS Discovery focuses on the role of microRNAs in cancer progression, particularly Kaposi’s sarcoma-associated herpes virus-derived miRNA K12-1. Researchers have also developed a new software workflow called Screener to automate data analysis from automated patch clamp electrophysiology platforms.