Articles tagged with Neurotrophins
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Researchers have successfully used AAV1.NT-3 gene therapy to improve muscle physiology and prevent age-related sarcopenia in mice. The treatment resulted in restored muscle mass, strength, and neural connections, offering a potential new option for managing this debilitating condition.
Researchers found NGF has therapeutic properties for diseases like cutaneous ulcers, glaucoma, and Retinitis Pigmentosa. Early studies led to the development of safe dosages and new treatment routes with NGF-based therapy.
Chemists at Scripps Research Institute invent scalable method for synthesizing jiadifenolide, a plant-derived molecule with potential brain-protecting properties. The new eight-step synthesis yields gram to kilogram quantities, paving the way for further studies and development of a jiadafenolide-derived drug.
Researchers at UNSW Australia have successfully regrown auditory nerves using bionic ear technology and gene therapy, potentially improving outcomes for people with cochlear implants. The technique delivers neurotrophins to cells near the implant electrodes, promoting nerve regeneration.
Researchers tested a drug that acts like growth-promoting protein BDNF and found it reduces degeneration and motor deficits in two mouse models of Huntington's disease. The findings suggest drugs that enhance BDNF action could be effective therapeutics for treating the disorder.
Researchers from University of California have found a way to improve cochlear implant functionality by inducing neurons to extend neurites towards the implant. This study published in Neural Regeneration Research, used soluble neurotrophins and collagen gels to grow cochlear neurites, increasing their numbers and length.
The genome sequence of Daphnia pulex, a small freshwater crustacean, has revealed neurotrophins that suggest the nervous system of crustaceans is more complex than previously believed. This finding may have implications for understanding the impact of climate change on crustacean behavior.
Ohio State University researchers have developed coatings that encourage neurons in the body to grow and connect with electrodes, boosting implant effectiveness. The coatings, which release neurotrophins over time, show promise for treating conditions such as Parkinson's disease and macular degeneration.
A new study found that prenatal drinking has a significant impact on neurotrophins in rats, but environmental enrichment does not mitigate these effects. Researchers discovered that prenatal alcohol exposure generally increased brain neurotrophin levels, which may serve as a compensation for damage to the developing brain.
Researchers at Rutgers University have made a breakthrough in understanding the complex mechanisms behind cochlear implants. By studying the role of neurotrophin proteins, they may be able to develop a new generation of implants that can improve hearing for all patients, regardless of their level of impairment.
Scientists at LSU Health Sciences Center have discovered that NPD1 protects against RPE cell damage by triggering its synthesis and regulating its release. The research also found that NPD1 can counteract the effects of A2E, a toxic component that accumulates in the retina during aging and retinal degenerations.
Studies in mice genetically engineered to mimic Down's syndrome found that increased expression of one gene, amyloid precursor protein (APP), disrupts transport of nerve growth factor (NGF) and leads to neuronal death. Restoring normal cellular levels of a Trk receptor for BDNF rescues neuronal death.
Researchers have identified a potential new treatment strategy for Alzheimer's disease by developing compounds that bind to the p75NTR receptor, preventing neurotrophin-mediated cell death. The study suggests these compounds may inhibit the death of oligodendrocytes and promote neuronal survival.
Researchers found that adding neurotrophins to human embryonic stem cells increases cell survival by 36-fold. This discovery could enable mass production of stem cells for disease treatment and prevent tumor formation.
Researchers at the University of Pennsylvania School of Medicine have shown that neurotrophin signaling is essential for maintaining normal synapse health. The study used a novel gene therapy technique to block neurotrophin activity and demonstrated the disassembly of synapses in adult mice, highlighting the potential therapeutic benef...
Researchers at Duke University have discovered that nerve growth factors can oppose each other in the brain, shaping neural networks in response to experience and learning. This finding has significant implications for the development of therapies for neurodegenerative disorders such as ALS and Alzheimer's disease.
Neurotrophin-4 triggers abnormalities in early brain development in unborn rats, mimicking human conditions such as epilepsy and mental retardation. The study suggests that neurotrophin-4 can cause too many cells to migrate to a specific layer of the cerebral cortex.
Researchers have protected growing brain cells from atrophying by treating them with a protein called NT-4, which fosters brain cell growth. This discovery could offer new treatment options for diseases involving gain or loss of brain cell connections, such as mental retardation and neurodegenerative diseases.