Protein Kinases

Membrane ‘neighborhood’ helps transporter protein regulate cell signaling

Researchers at St. Jude Children's Research Hospital identified a protein network that stabilizes ABCC4 transporters in place to maintain cyclic AMP signaling levels. The discovery reveals a previously unappreciated protein neighborhood and opens new therapeutic opportunities for regulating ABC transporters.

Unveiling a novel AAK1 inhibitor: How chemical proteomics unlocked therapeutic potential

Researchers at Okayama University developed a novel AAK1 inhibitor using Kinobeads technology, shedding light on its inhibitory mechanism and targeting various neurological disorders and viral infections. This breakthrough paves the way for rapid and cost-effective enzyme inhibitors with clinical applications.

CalDigit TS4 Thunderbolt 4 Dock

CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases

Researchers successfully generated viable and heritable knockout mutants for three essential protein kinases using CRISPR/Cas9 genome editing. These mutants displayed severe developmental defects and enhanced disease resistance, providing valuable resources for gene function studies and signaling network regulation.

A new, promising weapon in the fight against HIV

A new molecular compound has been identified that can activate latent HIV-1 in cells, showing promise for HIV treatments. Researchers found that this compound, YSE028, can reactivate latently infected cells and induce cell death, potentially leading to a complete cure for HIV.