Articles tagged with Proteolysis
A new study suggests that stalled amyloid protein production contributes to the development of Alzheimer's disease. Researchers found that rare familial genetic mutations linked to early-onset dementia cause deficiencies in multiple APP processing steps, leading to neurodegeneration.
Researchers at the University of Arizona Health Sciences are studying the molecular mechanisms of coagulation factor XII as a contributor to heart failure with reduced ejection. The goal is to develop better preventive and treatment options for this irreversible condition, which affects millions of Americans.
Jianhua Zhao's five-year, $2.4 million grant will focus on proteolysis, the process cells use to break down and recycle unused proteins, with implications for cancer treatment. Cryogenic electron microscopy (Cryo-EM) will be used to study protein recycling and its structures, opening new avenues for cancer research.
A research team led by Prof. ZHANG Kaiming uncovered a previously unrecognized mechanism for processive substrate degradation by the Lon protease. The study reveals that the protein degradation occurs at each individual proteolytic active site, following a C-to-N processive cleavage mechanism.
A study published in Nature Communications reveals the mechanisms of SARS-CoV-2 proteolysis and identifies key cellular substrates with therapeutic potential. The research provides a powerful resource for developing targeted strategies to inhibit the virus, which has caused over 227 million infections and 4.6 million deaths worldwide.
The proteasome complex has been found to regulate DNA packing in the nucleus, influencing gene expression. In yeast cells, the proteasome can induce heterochromatin formation but prevent its spread, suggesting an alternative mechanism of action beyond proteolysis.
Researchers from RIKEN found that a subtle change in the Lon enzyme allows bacteria to quickly adapt between low-oxygen gut environments and high-oxygen outside conditions. This discovery could lead to new therapeutic targets for enteric diseases.
Scientists at Scripps Research Institute mapped two essential cellular processes, revealing their cooperation during apoptosis. The study provides insights into programmed cell death and opens a new approach to cancer treatment.
Researchers discovered that RING Finger proteins play a crucial role in targeting cellular molecules for proteolysis during the cell cycle. This process is essential for regulating cell growth and preventing cancer. The study provides new insights into how cells recognize which proteins to eliminate and when.