A team of researchers from Saitama University has discovered a natural peptide aptamer called Calmodulin-binding peptide (CBP) that can selectively recognize two structurally distinct proteins, calmodulin and human midkine. CBP binds to calmodulin in the presence of calcium ions and to human midkine in the presence of sodium ions.
New research suggests that ocean turbulence and horizontal stirring will dramatically increase in the Arctic and Southern Oceans due to human-induced Global Warming. The study uses ultra-high-resolution simulations to investigate how mesoscale horizontal stirring (MHS) responds to warming, revealing a pronounced future intensification ...
Researchers design a high-throughput approach to create novel polypeptides with diverse chemical properties, leading to the discovery of hundreds of unique low-energy repeating structures. The study paves the way for broader applications in materials design and biotechnology.
Researchers found that folded peptides are more electrically conductive than their unfolded counterparts due to the formation of a specific secondary structure called the 3_10 helix. This discovery has implications for the design and development of molecular electronic devices.
Researchers developed an improved method for G4 landscape determination, revealing that sequence property-specific constraints in the nuclear environment mitigate G4 formation. The technique, AbC G4-ChIP, captures G4s efficiently without bias, showing that depletion of a repeat-binding protein enhances net G4 capture at specific sites.
A Tokyo University of Science study found that fluoride nanoparticles enhance β-sheet formation in amyloid β proteins, a common feature of Alzheimer's disease. The researchers also discovered that surrounding ions can control this process, paving the way for targeted treatments.
Researchers from Skoltech identified the role of distant RNA regions in regulating gene expression, revealing their impact on splicing and gene regulation.
Researchers at Purdue University have developed a new software called Emap2sec that can identify secondary structures in proteins from lower-resolution cryo-EM maps. This technique has the potential to speed up protein structure analysis and improve accuracy, enabling researchers to develop more effective drugs for various diseases.
A new infrared spectroscopy technique called nano-FTIR has enabled researchers to map the secondary structure of proteins on the nanometer scale. The technique, which combines scanning near-field optical microscopy and FTIR spectroscopy, allows for nanoscale-resolved protein spectroscopy and identification of single protein complexes w...
Researchers have developed a new method for analyzing the spatial conformations of biomolecules like proteins and DNA, minimizing interactions with pore materials. The approach enables the prediction of translocation dynamics of nucleic acids with varying sequences.
A study at UNC Chapel Hill found that specific genetic variants of the COMT gene can affect pain processing by altering messenger RNA secondary structure. The discovery may lead to more effective treatments for TMJD and other chronic pain conditions.