Articles tagged with Toxicity
Researchers created a Liver-Chip using Organs-on-Chips technology to predict liver toxicity across species. The platform accurately assesses the liver-specific effects of various drugs on liver cells from rat, dog, and human sources.
A new study links common bladder medication Elmiron to a vision-threatening eye condition, finding that about one-quarter of patients with significant exposure show signs of retinal damage. The research highlights the potential for long-term use of the drug to masquerade as other known conditions.
Research from Georgia Institute of Technology found that consumer-grade 3D printers emit particles that can negatively impact indoor air quality and respiratory health. The study suggests measures such as better ventilation, lower nozzle temperatures, and using low-emission filaments to minimize harm.
A team of US and Chinese scientists, led by UCI Professors Xiangmin Xu and Rozanne Sandri-Goldin, will develop a new brain mapping tool using genetically engineered herpesviruses. The tool aims to enhance signal outputs and generate variants carrying different functional payloads.
Researchers found that dual PPARα/γ agonists cause heart dysfunction in diabetes patients due to mitochondrial biogenesis and energy production issues. Activating SIRT1 with resveratrol reduced heart toxicity in mice treated with tesaglitazar, maintaining its therapeutic benefits.
Researchers discovered over 1,400 substances in plastics but only identified 260 of them, highlighting the challenge of assessing their safety. The study found that three out of four everyday products contained toxic chemicals, with PVC and PUR being the most toxic.
The NRG-HN002 trial found that reduced-dose intensity-modulated radiotherapy (IMRT) with cisplatin achieved acceptable progression-free survival (PFS) rates and swallowing-related quality of life for p16-positive oropharyngeal cancer patients. Patients who received IMRT and cisplatin reported higher acute toxicities, but similar late t...
A Phase 1 study demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation. The therapy, AMG 510, showed encouraging anti-tumor activity with no dose-limiting toxicities or adverse events leading to discontinuation.
A team of evolutionary biologists found that diversity exists even when expecting otherwise, as rare warning colors in poison frogs persist alongside stronger signals. The research suggests that predators learn to avoid more distasteful yellow frogs and generalize this avoidance to white frogs.
Researchers at Massachusetts General Hospital found that the timing of HD onset is determined by a property of the expanded CAG repeat in an individual's DNA, not its length. The study also identified multiple genes involved in DNA maintenance and repair as modifiers of HD onset, offering potential targets for treatments.
A molecule called GM1 ganglioside has been shown to inhibit the toxic effects of alpha-synuclein, a protein that forms clumps in Parkinson's disease. This discovery supports GM1 as a potential treatment for slowing disease progression and improving motor symptoms.
Researchers at Beth Israel Deaconess Medical Center found that metabolites associated with energy powerhouse mitochondria changed differently in patients who developed heart dysfunction compared to those who did not. Citric acid and aconitic acid levels differentiated the two groups of patients.
Researchers found that smaller silver nanowire diameters reduce toxicity to cells, with wires adopting crumpled forms within endolysosomes for containment. This could lead to increased transparency and device performance without compromising safety.
Researchers developed a slow-release formulation of tetrodotoxin that efficiently penetrates nerves, providing a safe and highly targeted nerve block for up to three days. The toxin was paired with a chemical penetration enhancer to increase safety and effectiveness.
A new study confirms grapefruit juice prolongs the QT interval, posing a risk to patients with congenital long QT syndrome and those taking QT-prolonging medications. The findings call for stronger warnings to protect these patient groups.
Researchers at Rutgers University have developed a low-cost, high-speed algorithm to test chemical toxicity without animals. The algorithm uses massive amounts of data from PubChem and achieves a 62-100% success rate in predicting oral toxicity for several groups of chemicals.
Processed aconite root relieves neuropathic pain in murine models, with neoline emerging as the active compound. Neoline is stable and shows promise for pain alleviation.
Research from Oregon State University found that microplastic capsules encasing insecticides increased toxicity in water fleas, highlighting the need for reevaluation of encapsulation's environmental impact.
Researchers have developed a human-on-a-chip model that can mimic the effects of chronic drug exposure, overcoming limitations of previous organ-on-a-chip systems. This breakthrough technology allows for realistic replication of system responses to compounds, enabling more accurate prediction of toxicity and efficacy.
A new study reveals significant venom variation among Florida pygmy rattlesnakes, with individual snakes having varying effectiveness against lizard prey. The research suggests that the toxicity of snake venom may be adapted to specific prey species.
Research at Montana State University reveals that the gut microbiome plays a crucial role in protecting against acute arsenic toxicity. The study found that certain microorganisms in the human gut can neutralize arsenic, reducing its toxic effects.
A new Australian study has provided direct evidence that zinc oxide nanoparticles do not penetrate human skin or cause cellular toxicity after repeated application. The findings support the use of ZnO nanoparticle sunscreens, outweighing perceived risks and improving consumer confidence in these products.
A new study led by the University of Queensland and University of South Australia found that zinc oxide nanoparticles used in sunscreen do not penetrate the skin or cause cellular toxicity after repeated applications. The research refutes widespread claims about the safety of nanoparticulate-based sunscreens.
A study published in the Journal of Thoracic Oncology found that elderly patients with limited-stage small cell lung cancer (LS-SCLC) can benefit from concurrent chemo-radiotherapy, similar to younger patients. The analysis showed comparable survival rates and toxicity between older and younger groups, providing robust evidence for tre...
A team of researchers at inStem has developed a nucleophilic polymer-based topical gel that can deactivates pesticides on the skin through nucleophilic-mediated hydrolysis, preventing pesticide-induced toxicity and lethality. The gel shows broad-spectrum activity against commonly used pesticides in India.
Patient-reported outcomes from NRG-RTOG 0232 show that brachytherapy alone is the superior treatment for men with intermediate risk prostate cancer, with less toxicities. The study found significant differences in clinician and patient-reported late toxicity profiles between arms.
A pooled analysis of four UK randomised controlled clinical trials found significant differences in chemotherapy side-effects between men and women with oesophagogastric cancer. Women experienced higher rates of nausea and vomiting, diarrhoea, mouth ulceration, and hair loss compared to men.
Acetaminophen's breakdown product activates glutathionylation, affecting mitochondrial energy production and leading to metabolic dysfunction. This discovery explains the drug's toxicity at high doses and may apply to other drugs with similar structures.
Dream Tech LLC is developing a methodology to reduce animal use in chemical toxicity studies of food, pharmaceuticals, pesticides and other products. The project aims to enhance dose-response assessment efficiency and effectiveness.
Researchers at Ben-Gurion University found that artificial sweeteners like aspartame and sucralose can harm gut microbes, leading to potential health issues. The study used bioluminescent bacteria to detect toxicity and may help regulate the use of these additives in food products.
Researchers have identified two protein domains that mediate toxicity in ALS and FTLD, revealing a key role for stress granules in disease progression. The study provides new insights into the molecular mechanisms underlying these neurodegenerative diseases.
A study published in Toxicological Sciences suggests that computer algorithms can predict toxic properties of chemicals more accurately than standard animal tests. The researchers developed a large database of known chemicals and used machine-learning algorithms to create a map of chemical structures and their associated toxic properties.
Researchers at University of Oregon and Oregon State University found that biocompatible gold nanoparticles and surfactants become toxic when combined in a synergistic way, causing 88% mortality rate in zebrafish embryos. The study's new delivery system could serve as an early screening method to detect toxicity and ensure product safety.
Researchers at Boston University School of Medicine discovered that flavored electronic cigarettes contain additives that can decrease blood flow and increase inflammation in blood vessels, similar to combustible cigarettes. The study's findings suggest a potential link between flavored e-cigarette use and cardiovascular disease.
Researchers have made significant progress in developing computational models, human tissue-based assays, and other advanced systems to assess the toxicity of inhaled materials without using animals. These novel approaches aim to improve safety and regulatory compliance in industries such as pharmaceuticals and personal care.
Silver nanoparticles have been found to be highly toxic to Danio fish embryos, with flat particles being more toxic than spherical ones. The research suggests that the toxicity of nanosilver is due to the presence of nanoparticles themselves, not just silver ions.
Researchers at HKU and Chinese Research Academy of Environmental Sciences have developed a novel scientific method to derive water quality criteria (WQC) of metals for protecting different marine ecosystems. The new approach considers variable temperature and salinity regimes, improving protection for tropical marine organisms.
A recent study published in Communications Chemistry found that tungsten accumulates in specific regions of the bone, particularly in bone marrow and cancellous bone tissue. This accumulation raises concerns over the element's safety for human exposure, especially among young individuals.
A new study found that e-liquid ingredients can vary widely in toxicity, with some being more toxic than nicotine alone and propylene glycol and vegetable glycerin. The researchers developed a system to rapidly evaluate e-liquid toxicity using plastic plates with tiny wells containing human cells exposed to different e-liquids.
Researchers developed a new screening technique to evaluate e-liquid toxicity, finding that some ingredients are more toxic than others. The study suggests that even small doses of propylene glycol and vegetable glycerin can significantly reduce cell growth rates, highlighting the need for further regulation of e-liquid ingredients.
A comprehensive review of gaps in risk assessments for adjuvants in commercial pesticides highlights the need for new regulations to protect people and the environment. The review found that exposure to environmental levels of some adjuvant mixtures can affect non-target organisms and even cause chronic human disease.
A recent study by UL and Johns Hopkins University found that artificial intelligence (AI) is superior to traditional animal testing in detecting toxic substances. The AI-powered software, REACHAcross™, can predict chemical toxicity with high accuracy and speed, reducing the need for animal testing.
Researchers found liver and neuronal toxicity with high doses of gene therapy delivered using an adeno-associated virus (AAV9) vector. The study warns about the importance of prioritizing patient welfare in gene therapy research.
A new report recommends steps toward achieving global regulatory acceptance of non-animal testing approaches for acute inhalation toxicity. The report highlights the need for more efficient and human-relevant methods that don't use animals, with working groups formed to gather reference data and conduct testing.
Researchers have created a simple, fast and sensitive test system to determine the toxicity of carbon nanomaterials. The system uses a unique enzymatic system called Enzymolum, which reacts differently to various additives.
A team of scientists from UC Santa Barbara tested the effect of sulfurized nano-zero-valent iron on a common freshwater alga and found that it picked up cadmium and alleviated toxicity. Organic material produced by the algae mitigated the nanoparticle's toxicity, allowing for greater remediation.
The study found a near doubling of median overall survival (27.8 months) and no grade 3 or higher toxicities for patients receiving higher radiation doses with adaptive MR guided radiation therapy, compared to those receiving lower doses via non-adaptive treatments.
The publication marks a significant milestone in aquatic toxicology with the release of the first generation of annotations for the fathead minnow genome. The data will enhance the utility of this species for ecotoxicology research and open up new avenues for studying its effects on ecosystems.
Researchers at NC State University have developed a high-throughput technique that can determine the potential toxicity of chemicals in seconds, enabling prioritization for in-depth testing. This approach accelerates the identification of environmentally hazardous chemicals and could significantly expedite screening.
A big data approach can predict the toxicity of chemicals without animal tests, saving time, money, and lives. PETA India will present this method at a national conference, suggesting its adoption by governments and regulatory agencies.
A new study published in PLOS ONE demonstrates a single molecule microRNA technology that can detect liver toxicity with high accuracy and specificity. The method, developed by Quanterix, uses a PCR-free approach to measure miR-122, a promising biomarker for drug-induced liver injury.
A team led by the Department of Energy's Oak Ridge National Laboratory has discovered a novel microbial process that can break down toxic methylmercury in the environment. This process could reduce mercury toxicity levels and support health and risk assessments, particularly in fish consumption.
Researchers found that age-dependent protein aggregates can induce Aβ aggregation, leading to Alzheimer's disease. The study identified proteins like PAR-5 as potential therapeutic targets, offering new avenues for preventative research.
Researchers from the University of Leicester and University Hospitals of Leicester NHS Trust have reported outstanding results from a long-term follow-up study on patients with CLL. The study, which used a selective BTK inhibitor, showed durable remissions without new toxicities in most patients.
A recent genetic study of clinging jellyfish populations has discovered unexpected connections between communities in the Pacific and Atlantic oceans, challenging previous assumptions about their origins. The research suggests that there may be more than one species of Gonionemus, with different variants found in various locations.
The use of stem cells in predictive toxicology screening holds promise in reducing animal testing. However, standardizing methods, identifying optimal cell types, and defining measures is essential. The journal Applied In Vitro Toxicology explores the benefits and limitations of this approach.
Researchers found that after reirradiation with intensity modulated proton therapy (IMPT), the majority of patients were free from local recurrence one year following treatment and few experienced severe side effects. Patients who received a higher dose of radiation had fewer local recurrences and improved progression-free survival.
Google's Perspective AI system can be bypassed by manipulating language, resulting in false low toxicity scores for abusive phrases. Researchers suggest techniques to improve robustness, including spellchecking and training with adversarial examples.
Researchers found that rapamycin treatment reduced proinflammatory cytokine release and toxicity without decreasing HIV-1 reactivation in T cells. The treatment did not impair the immune system's ability to recognize infected T cells, making it a potential strategy for targeting latent HIV-1 reservoirs.
An international expert workshop has outlined a strategy for reducing and replacing animal use in acute systemic toxicity testing. The report, published in Toxicology In Vitro, presents recommendations including gathering high-quality reference data and global harmonization.