Articles tagged with Toxicity
Researchers at University of Texas M.D. Anderson Cancer Center identify IL-6 as a key player in immunotherapy toxicity. A novel strategy combining IL-6 blockade with immune checkpoint blockade shows promise in reducing autoimmune side effects while preserving antitumor efficacy.
A new project led by INRS will assess how living organisms respond to reduced pesticide use, focusing on soil and water health. The study aims to provide a clear understanding of the benefits and limitations of reducing pesticide use in sustainable farming.
Scientists discovered that intermittent dosing of PI3Kδ inhibitors can reduce toxicity while maintaining anti-tumor immunity in patients with head and neck cancers. This finding holds promise for improving treatment outcomes and saving lives.
A new study found that opioid-related mortality rates in Ontario, Canada, have shifted downward to peak in the mid-30s among males and females. The study analyzed high-frequency data from 2003 to 2020 and hypothesizes that opioid-related mortality among younger adults will continue to grow.
The ESMO Breast Cancer Congress 2022 event will present more than 200 studies on various aspects of breast cancer, including new treatments and innovative clinical practices. The congress will be held onsite in Berlin, Germany, and online, offering a platform for breast cancer specialists to share knowledge and improve patient outcomes.
The CodeBreaK 100 trial demonstrated prolonged tumor responses and favorable safety profiles in patients treated with sotorasib. Long-term treatment was well-tolerated, with a two-year overall survival rate of 32.5%.
Researchers have identified avocado meal as a safe and palatable fiber source for dogs, rivaling industry standards in digestibility and energy intake. The study found that persin levels were undetectable in processed meal, contradicting long-held concerns about avocado toxicity in pets.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Researchers developed a two-step synthesis route for NK0238, an amino acid-derived pesticide, with high atom economy and yield. The compound exhibited broad antiviral activity against multiple plant viruses, outperforming existing agents in terms of efficacy.
Researchers found that exposure to 6PPD-quinone at environmentally relevant levels can be deadly for rainbow and brook trout, but not for Arctic char or white sturgeon. The study suggests possible non-lethal effects on the latter species, warranting further examination.
Researchers at University of Copenhagen find that pharmaceutical residues in sewage sludge and cattle manure do not harm soil organisms, despite concerns over environmental risks. Organic fertilizers like sludge and manure provide better soil quality than conventional mineral fertilizers.
A new study by Tel Aviv University researchers found that microplastics absorb and concentrate toxic organic substances, increasing their toxicity by a factor of 10. This may lead to severe impact on human health due to contaminated food and drink.
Researchers aim to eliminate respirable coal mine dust toxicity with chemical additives, targeting ultrafine particles and quartz. The project will investigate particle surface chemistry and aging effects on toxicity, with potential applications in metal, non-metal mining, and construction.
A new study examines the toxic impact of bio-based substances and innovative technologies on the environment, finding both biosurfactants and microgels as highly promising candidates for use in sustainable products. The results highlight the importance of integrating green toxicology into bioeconomy strategies.
A recent study found that women have a 34% higher risk of severe toxicity than men in cancer treatment, with higher risks for immunotherapy and targeted therapies. The analysis of over 20,000 patients from more than 200 clinical trials supports the idea that sex may independently modulate drug toxicity.
Researchers at the University of Copenhagen found hundreds of chemical substances in tap water stored in reusable plastic bottles, including some potentially harmful to human health. The study revealed that machine washing and dishwasher use can increase the leaching of toxic substances from the plastic.
Researchers found that rural areas have similar levels of oxidative potential as urban areas, challenging the misconception that air pollution is more toxic in urban settings. The study also showed that summertime agricultural activity can produce PM2.5 particles that are just as toxic as those from urban settings.
A new study by the University of North Carolina at Chapel Hill and an international team finds that triclosan triggers gut inflammation in mice. The researchers identified specific bacteria and enzymes that drive this damage, but also developed a microbiome-targeted inhibitor to block triclosan processing, preventing colitis.
Researchers found high levels of per- and polyfluorinated alkyl substances (PFAS) in anti-fogging sprays and cloths sold on Amazon. The products contained fluorotelomer alcohols and fluorotelomer ethoxylates, which are associated with impaired immune function, cancer, and other health disorders. The study highlights the need for more r...
The combination of relatlimab and nivolumab doubled progression-free survival benefit compared to nivolumab alone, with significant benefits across pre-specified subgroups. The treatment was associated with a lower risk of disease progression or death.
A new post-surgery approach for treating HPV-related throat cancer uses low-dose radiation and spares the majority of patients from chemotherapy. The trial found high survival rates and quality of life in patients at medium risk for recurrence.
Researchers from South Korea have demonstrated that applying an electric field during air stripping can significantly improve ammonia removal efficiency from wastewater. The study found that electric fields with alternating current of 50 MHz and power of 15 V/cm increase efficiency from 51% to 94%, even under sub-optimal conditions.
A multi-center study demonstrated improved overall survival and quality of life for inoperable pancreatic cancer patients treated with MRIdian SMART, with a median survival of 26 months. The treatment showed low rates of major adverse events and was more effective than standard radiation therapy.
Researchers at Ural Federal University developed an ultra-sensitive sensor to analyze honey for nitrobenzene, a toxic compound. The sensor's exceptional accuracy and low sample requirements make it suitable for on-site analysis.
A Rutgers-led study found that banning right-wing extremists from Twitter significantly reduces the spread of anti-social ideas and conspiracy theories. Removing these individuals from social media platforms leads to a nearly 92% decline in tweets referencing them, as well as a 90% decrease in new users tweeting about them.
Researchers found that combining zinc oxide with small-molecule UV filter ingredients reduced UVA protection by 84.3-91.8% compared to non-mineral sunscreens. The study also showed toxic effects on zebra fish embryos when exposed to sunscreen mixtures containing zinc oxide.
A phase II clinical trial has shown that the DNA alkylation drug DM-CHOC-PEN improved survival in adolescent and young adult patients with central nervous system cancers. The treatment was well-tolerated, with no severe toxicities observed, and showed potential for combination with other treatments.
Patients with certain gene mutations are at high risk of fatal chemotherapy toxicity, with a 25-times increased risk detected in those with uncommon DPYD variants. The study suggests that adding pre-treatment screening may help prevent avoidable deaths without interrupting standard care.
Researchers found that certain nanomaterials break down rapidly when exposed to light but decompose slowly in its absence. This discovery highlights the need for better understanding of nanomaterial behavior under environmental conditions.
The researcher is investigating the inflammatory responses produced by exposure to chemical agents, comparing different chemical exposures at both whole-body and tissue levels. The study aims to develop a common treatment for chemical exposures and diagnose the responsible chemicals.
Researchers at UB aim to reduce unwanted toxicity in cancer treatments by combining antibody-drug conjugates with payload-binding selectivity enhancers. The five-year study may lead to safer and more effective treatments for 1.8 million US cancer patients.
Researchers found that tin fluoride additive traps oxidized tin in solution, reducing instability. Fluoride also improves colloid stability, leading to more homogeneous crystal growth.
Researchers created nano-scale borate bioactive glass, which effectively reduces biological toxicity and promotes skin repair. The material accelerates wound healing by slow-releasing essential elements and promoting collagen deposition.
A study found specific gut microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment. The research identified a potential new strategy to treat toxicity while maintaining response through IL-1R inhibition or manipulation of the gut microbiota.
Researchers developed a nano-scale borate bioactive glass (Nano-HCA@BG) with enhanced biological performance, reducing toxicity and improving biocompatibility. The material accelerates wound cell migration and collagen synthesis, promoting faster healing.
A study found that nearly half of patients with gynecologic cancer experience financial toxicity, which can lead to worsening health outcomes. Younger patients are at a higher risk due to limited financial safety nets and ability to work.
Researchers mapped river ecosystems' responses to remediation efforts, revealing strategies that improved some of the biggest problems of mining contamination. The team's methodology showed that restoration can improve water quality, but regulations need to consider all contaminants together.
Researchers have compiled the most complete library yet of lanthanides and their potential toxicity by exposing baker's yeast to lanthanide metals. The study found that lanthanides interrupt cell-signaling pathways, disrupting calcium-binding sites in endocytosis and ESCRT machinery.
A new study finds that correcting online falsehoods on Twitter can lead to an increase in lower-quality, partisan content and toxicity, as users retweet and share false information after being corrected by others.
Researchers link C9ORF72 mutations to neuronal death in familial ALS patients by discovering a toxic mechanism that blocks cellular processes involving DNA and RNA. The newly identified mechanism reveals how arginine-rich proteins displace essential proteins, leading to cell death.
The review explores recent strategies in surface functionalization, their specific biomedical applications, and comparative toxicities with non-functionalized metallic nanoparticles. It discusses the challenges for metallic NPs to undergo human clinical trials due to their aggregation and toxic nature.
A study published in Science reveals that applied pesticide toxicity has increased substantially between 2004 and 2016, threatening plant and insect biodiversity. The findings apply to genetically modified (GM) crops, challenging the claim of decreasing environmental impact.
New study finds toxicity of commonly used pesticides to nontarget species, including aquatic invertebrates and pollinators, has increased considerably. The use of highly toxic pyrethroid and neonicotinoid pesticides is linked to these impacts.
A new system developed by University of Missouri researchers can automatically prioritize pollutants in landfills based on their toxicity and abundance. The system has the potential to help environmental agencies create more specific and efficient plans to combat leachate, which can cause cancer and other serious harm.
A study by The Endocrine Society finds oral testosterone therapy undecanoate (TU) is an effective treatment for men with low testosterone levels, with a safety profile consistent with non-oral products. TU has minimal effects on cholesterol levels and no liver toxicity was reported.
A new review by the University of Surrey highlights the most effective techniques for collecting airborne pathogens, particularly viruses, using cyclone sampling methods. Harvard impactor samplers are also found to be suitable for capturing fine and ultrafine particles for toxicity assessments.
Researchers found that cigarette smoke affects communication between bacteria, causing a negative effect on the formation of biofilm in lungs. Cigarette filters helped lower toxicity levels, highlighting the need for new filter development to reduce harm.
Researchers have discovered that combining copper-silver ionization with lower amounts of chlorine can decrease disinfection byproducts and cell toxicity in chlorinated pool water. This approach may help mitigate respiratory problems, such as asthma, associated with swimming pool exposure.
Researchers found that commercially available 3D-printable resins leach toxic compounds that can induce severe toxicity in mouse oocytes, potentially affecting reproductive health. The study highlights the need to better understand the impact of these materials on human health.
A global analysis of antibiotic combination use reveals that 80% of commonly prescribed combinations are not recommended by the WHO. The study found that these inappropriate combinations can lead to inefficacy, toxicity, and selection for antimicrobial resistance.
Researchers developed a gene biomarker identification technique to predict liver toxicity in just 24 hours, reducing lengthy animal studies. The method uses machine learning approaches to identify key genes in messenger RNA, enabling accelerated testing for agrochemical and pharmaceutical companies.
Researchers created artificial liver organoids from zebrafish cells, allowing for chronic toxicity testing in a shorter time. This alternative method to animal testing may replace traditional zebrafish tests without ethical issues.
A study published in Journal of the American College of Surgeons found that financial toxicity among breast cancer patients is independently associated with worse psychological well-being. Even small improvements in financial pressure can lead to better mental well-being and higher patient satisfaction with breast reconstruction.
A study found that George's Marvellous Medicine contains 34 toxic ingredients, including engine oil and antifreeze, which can cause nausea, vomiting, diarrhoea, heart rhythm problems, kidney injury, convulsions, and stomach damage. Researchers advise parents to be cautious and check medicinal ingredients for potential toxicity before use.
Researchers have developed a new approach to prevent toxicity seen in sensory neurons of dorsal root ganglia after gene therapy to treat neurological disorders. The approach involves modifying a transgene with a microRNA target, which reduces transgene expression and eliminates toxicity.
Quat-containing disinfectants have raised concerns over potential toxicity, with links to fertility and developmental problems found in animal and cell experiments. However, industry experts argue that skin irritation is the biggest concern, and typical exposures in people are unlikely to pose significant health risks.
Dream Tech LLC will develop a more comprehensive and reliable modeling and library system for chemical risk assessment using its BBMD system. The grant will allow the startup to analyze diverse types of dose-response data from various studies, providing effective solutions to practical dose-response assessment.
A recent report of two children's deaths in a gene therapy trial for X-linked myotubular myopathy has sparked concerns over the safety of gene therapy vectors. The editorial emphasizes the need for iterative development and cooperation among scientists to ensure safe and effective treatments for rare genetic diseases.
Researchers recommend avoiding all per- and polyfluorinated substances (PFAS) for nonessential uses, citing their extreme persistence and toxicity. Studied PFAS have been linked to various serious health problems, including cancer and endocrine disruption.
Researchers identified chloro-perfluoro-polyether-carboxylate compounds (ClPFPECAs) in soils across New Jersey, suggesting the use of these compounds as PFAS substitutes. The discovery provides insight into the environmental impact and toxicity of next-generation PFAS substitutes.