Articles tagged with Toxicity
Partners of colorectal cancer survivors experience long-term financial toxicity leading to worse health-related quality of life. Multilevel interventions are needed to address individual and systemic factors affecting both patients and their partners.
Human macrophages use Siglec-14 receptors to recognize and engulf carbon nanotubes, leading to inflammation. The discovery could pave the way for developing safer carbon nanotubes and therapies to prevent inflammatory diseases.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
Researchers at Ritsumeikan University have made a breakthrough in understanding how macrophages recognize microplastics, discovering an interaction between aromatic rings that drives this process. The study suggests that while microplastics may not induce acute inflammation, chronic exposure could lead to autoimmune diseases.
A recent study found that polymeric PFAS used in food packaging break down into toxic smaller molecules, contaminating food and the environment. The research contradicts claims that polymeric PFAS are harmless and poses a risk to human health.
A new study suggests that climate change could lead to increased pesticide toxicity on bee populations and their pollination services. Environmental temperature can influence the degree to which pesticides affect bees' behavior, with certain temperatures causing a 'tipping point' in their ability to tolerate pesticide exposure.
A study by Columbia University's Mailman School of Public Health reveals that Industrial Bio-Test Laboratories produced fraudulent reports on PCB products, claiming they were not carcinogenic. The researchers also found that test conditions were compromised, leading to the indictment and conviction of employees involved.
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
Researchers from Swansea University and Université Grenoble Alpes demonstrate the effectiveness of selenium nanoparticles in killing ovarian cancer cell models. The study reveals a novel biological mechanism underlying the anti-cancer effect, involving histone methylatransferases and epigenetic processes.
Researchers at the University of Virginia have identified a promising approach to delay aging by detoxifying glycerol and glyceraldehyde, harmful by-products of fat. By activating an enzyme called AMAR, they found that microscopic worms lived longer and healthier lives, and similar effects were seen in other lab models.
Scientists at Gladstone Institutes have discovered how excess oxygen changes proteins in our cells, triggering a cascade of events that damage cells and tissues. The findings have implications for conditions such as heart attacks and sleep apnea, revealing that hyperoxia is not solely caused by reactive oxygen species.
A US FDA mandate to limit acetaminophen dosage in pills combining it with opioids significantly reduced hospitalizations and acute liver failure cases. Researchers found a persistent decline in yearly rates of these cases after the mandate was implemented in 2014.
A new study by Weill Cornell Medicine found that the FDA's mandate to limit opioid-acetaminophen combinations resulted in significant reductions in liver injuries. The mandate, implemented in 2014, limited the dosage of acetaminophen in these drugs, leading to a decline in hospitalizations and acute liver failure cases.
Scientists at St. Jude Children's Research Hospital demonstrate a framework to develop solutions to evade detoxification networks in drug development, potentially reducing side effects. By altering the structure of a small molecule, they found a way to stretch out binding regions, making it energetically unfavorable for drugs to bind a...
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
Researchers developed new spiro-pyrazolo quinazoline derivatives with reduced bee toxicity without compromising insecticidal activity. The compounds showed promising results, including one compound with an LD50 value three to four orders of magnitude lower than fipronil.
A new study from Oregon State University found that both cotton and synthetic microfibers have negative impacts on the behavior and growth of aquatic organisms. The research, published in Frontiers in Marine Science, suggests that increasing awareness and control over fiber release can help mitigate these effects.
Researchers developed a translational step forward in treating brain tumors using intraventricular immunovirotherapy, which has shown safety and efficacy in recent clinical trials. This approach uses oncolytic herpes simplex virus type-1 to target high-grade glioma with promising results.
Researchers investigated micro-sized polyethylene's toxicity on human colorectal cancer cells, finding decreased cell viability and increased reactive oxygen species production. Exposure to high doses caused cell death and oxidative stress responses.
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
Researchers have improved the FDA's equation for predicting drug interactions by addressing fundamental limitations and incorporating new models. The modified equation has shown a significantly increased accuracy of about 80%, which is expected to contribute to increasing the success rate of new drug development.
Researchers at KAUST developed a high-efficiency metal-free battery using ammonium cations as charge carriers, outperforming existing analogues with a record operation voltage of 2.75 volts. This breakthrough provides potential for lowering battery costs and enabling large-scale applications.
KAUST researchers have designed and built novel organic scintillator materials for detecting X-rays at low doses, overcoming stability issues with existing ceramic or perovskite materials. The new approach uses heavy atoms to improve X-ray absorption capability and exciton utilization efficiency.
A team of researchers has identified a protein called hemopexin that may help protect the heart from damage caused by anthracycline chemotherapy. Levels of hemopexin in the blood were associated with increased cardiac toxicity, but administering hemopexin prevented the development of cardiac dysfunction in mice.
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
Researchers at Memorial Sloan Kettering Cancer Center discovered that common cancer treatments cause long-term damage to heart tissue by activating a key inflammatory signaling pathway. Inhibiting this pathway may reduce the risk of cancer survivors developing heart disease later in life.
Researchers discovered that microplastics can transform chromium metal into a more toxic form when attached to UV filters, potentially harming aquatic life. The study suggests that microplastics may not just accumulate contaminants, but also interact with them to increase environmental toxicity.
Researchers discovered how enzymes metabolize chiral PCBs, leading to neurodevelopmental issues. The study found that mirror-image isomers are metabolized differently, causing selective toxicity in humans and animals.
A recent study found that MRI-guided adaptive radiation therapy, also known as SMART, has shown promising safety and patient outcomes data for treating locally advanced and borderline resectable pancreatic cancer. The study, led by Henry Ford Health, reported no incidence of acute grade 3 or higher gastrointestinal toxicity, with preli...
A systematic review and meta-analysis of ADC clinical trials found that 91.2% of patients experienced treatment-related adverse events, with serious side effects including neutropenia, hypoesthesia, and thrombocytopenia. The study highlights the need for clinicians to address these toxicities in ADCs' use.
A special issue of Frontiers in Toxicology highlights diverse approaches to assess chemical toxicity without animal use. Non-animal tests have been used to replace animal tests for respiratory and skin effects, but remaining challenges remain.
Researchers have introduced novel ZnSe/ZnS quantum dots that efficiently drive challenging organic transformations with low toxicity. The secret to their success lies in their core/shell structure and variable coatings that can store light energy.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
A recent study found that patients treated with the combination of chemoradiation therapy and immunotherapy in a phase 3 clinical trial did not experience significant safety concerns. The treatment regimen showed no significant increase in toxicity compared to standard trimodality therapy alone.
Particle radioactivity from radon in air pollution increases toxicity and risk of death from cardiovascular disease, especially from heart attack and stroke. Researchers used spatiotemporal predictions to estimate exposure and found that higher gross beta-activity levels increased the risk of death from these conditions.
Scientists successfully inhibited cancer cell growth using a modified pyrrolizidine alkaloid that avoids liver damage. The approach uses 'on-site synthesis' near cancer cells to limit toxicity.
A study by Colorado State University found that indoor air contains more known human toxins than outdoor air, particularly when cooking or cleaning. The research, called HOMEChem, identified compounds like benzene, formaldehyde, and acrolein as potential health risks.
A peer-reviewed study detected PFAS in all 'stain-resistant' school uniforms tested from nine popular brands, with concentrations as high as those in outdoor clothing. The presence of PFAS in school uniforms poses a risk to children's health through skin absorption and inhalation.
Researchers analyzed four pesticides' effects on earthworms and springtails in Northern, Central, and Southern Europe. They found varying risks depending on soil compartment and pesticide characteristics. The study highlights the need to consider regional variability when regulating agricultural practices.
Researchers at IRB Barcelona have found that CRISPR/Cas9 gene editing can trigger cell toxicity and genomic instability, particularly in regions near the tumour suppressor protein p53. The study identified 3,300 targeted spots with strong toxic effects, highlighting the need for safer CRISPR reagents.
A study by Washington State University found a 37% drop in poisoning reports for illicit synthetic cannabinoids in states with legal recreational or
The study investigated the effects of combined endocrine-disrupting chemicals (EDCs) on liver function and metabolic homeostasis in mice models. Significant changes were observed at high EDC exposure levels, including liver weight increase, lipid buildup, and elevated blood glucose levels.
The levels of per- and polyfluoroalkyl substances (PFAS) in environmental media have dramatically decreased over the last 20 years due to new insights into their toxicity. However, due to the global spread of PFAS, environmental media everywhere will now exceed guidelines designed to protect human health.
A study by ETH Zurich researchers shows a sharp increase in opioid poisoning cases and sales in Switzerland between 2000 and 2019, with oxycodone being the second most common cause. The rise is similar to that seen in other European countries, but per capita sales are higher in Switzerland.
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
A study published in Annals of Internal Medicine found that Medicare could save up to $3.6 billion by purchasing generic drugs at the same prices as the Mark Cuban Cost Plus Drug Company. The researchers compared the price of 89 generic drugs sold by MCCPDC to the price Medicare paid in 2020 and estimated potential savings of up to $3....
High concentrations of disinfection byproducts in tap water are linked to adverse health outcomes. Researchers suggest adopting solutions such as advanced water treatment and sourcing water from less polluted areas to reduce the risk. Additionally, nanofiltration is proposed as an effective household treatment to improve water quality.
Researchers at the University of Birmingham have identified a 'cellular brake' protein that may help prevent autoimmune responses in lung cancer patients undergoing immunotherapy treatment. This finding could enable clinicians to closely monitor high-risk patients and develop preventative strategies.
Researchers have discovered a way to create devices that mimic natural photosynthesis, producing fuels like hydrogen instead of sugars. The breakthrough uses bismuth oxyiodide, a non-toxic semiconductor material that can produce clean hydrogen from water over weeks.
A new analysis found over 10 million tonnes of PCB-containing materials remain globally, posing public health and environmental threats. The Stockholm Convention's deadline for elimination is nearing, but most countries are not on track to meet it.
Researchers evaluated the toxicological effects of BaP on bay scallops, finding increased immune response-related parameters with time at higher concentrations. The study suggests that BaP dampens the immune response of scallops and decreases their capacity to respond to oxidative stress.
Researchers found that maintaining hard water reduces zinc accumulation and oxidative stress in goldfish, mitigating toxic effects. This study provides an eco-friendly approach to address aquatic ecosystem pollution caused by heavy metal contamination.
An analysis found that government websites often understate PFAS health risks, failing to address the needs of highly exposed populations. The study recommends improved communication from agencies and non-governmental organizations to provide accurate and practical guidance for those affected.
Researchers at University of Texas M.D. Anderson Cancer Center identify IL-6 as a key player in immunotherapy toxicity. A novel strategy combining IL-6 blockade with immune checkpoint blockade shows promise in reducing autoimmune side effects while preserving antitumor efficacy.
A new project led by INRS will assess how living organisms respond to reduced pesticide use, focusing on soil and water health. The study aims to provide a clear understanding of the benefits and limitations of reducing pesticide use in sustainable farming.
Scientists discovered that intermittent dosing of PI3Kδ inhibitors can reduce toxicity while maintaining anti-tumor immunity in patients with head and neck cancers. This finding holds promise for improving treatment outcomes and saving lives.
The ESMO Breast Cancer Congress 2022 event will present more than 200 studies on various aspects of breast cancer, including new treatments and innovative clinical practices. The congress will be held onsite in Berlin, Germany, and online, offering a platform for breast cancer specialists to share knowledge and improve patient outcomes.
A new study found that opioid-related mortality rates in Ontario, Canada, have shifted downward to peak in the mid-30s among males and females. The study analyzed high-frequency data from 2003 to 2020 and hypothesizes that opioid-related mortality among younger adults will continue to grow.
The CodeBreaK 100 trial demonstrated prolonged tumor responses and favorable safety profiles in patients treated with sotorasib. Long-term treatment was well-tolerated, with a two-year overall survival rate of 32.5%.
Researchers have identified avocado meal as a safe and palatable fiber source for dogs, rivaling industry standards in digestibility and energy intake. The study found that persin levels were undetectable in processed meal, contradicting long-held concerns about avocado toxicity in pets.