Articles tagged with Tumor Necrosis Factors
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New research suggests that inhibiting tumor necrosis factor (TNF) may improve signs and symptoms of chronic heart failure. Studies using ENBREL, a TNF receptor inhibitor, have shown promising results in patients with moderate heart failure.
Researchers found an immune molecule that kills damaged cells indirectly by closing receptors to a life-saving protein, shedding new insight on neurodegenerative diseases such as Alzheimer's and stroke. The findings could lead to targeted treatments for brain injuries and diseases involving neurodegeneration.
A team of researchers found that tumor necrosis factor (TNF) may have a double-edged effect on brain-injured tissue, with potential benefits in chronic stages but harm in early stages. Blocking TNF in acute phases may be beneficial, while long-term recovery requires natural TNF presence.
A Phase I study published in Circulation demonstrates that ENBREL improves quality of life scores and increases functional status in patients with advanced heart failure. The study found no significant adverse effects from ENBREL treatment, suggesting a potential therapeutic benefit for chronic heart failure patients.
Scientists at Boston University's School of Dental Medicine have discovered a new gene involved in common inflammatory diseases, including Crohn's disease. The researchers identified the gene that controls production of Tumor Necrosis Factor alpha (TNF), a molecule implicated in various inflammatory conditions.
As people age, a protein called TNF helps to destroy diseased cells but also causes the immune system to degenerate. Researchers found that older adults' immune cells became more sensitive to TNF, leading to increased cell death and weakening of the immune system.
Research suggests that high levels of IgE type antibodies can cause an overactive immune response, leading to cerebral malaria. The study found a genetic link between IgE production and the production of TNF, which can be beneficial but also deadly in excessive amounts.
Researchers found high levels of proinflammatory cytokine TNF in individuals with congestive heart failure (CHF), which can damage the heart. Inhibiting TNF through treatment improved patients' signs and symptoms of cardiac failure, including exercise tolerance and heart pumping ability.