Researchers have discovered a new type of skin cell, TIFFs, that may play a role in inflammatory skin diseases such as scleroderma. These cells were found to interact with immune cells and expand in response to inflammation, leading to an exaggerated response and fibrosis.
Researchers at MIT develop a method to decode images of cells in a tissue to determine its phase, which can indicate its developmental stage or cancer progression. The technique uses triangular order parameters to characterize tissue states, allowing for quicker and less invasive diagnoses.
Researchers have created a human disease model of FCMD using stem cells from a patient, which successfully mimicked the disorder's brain defects. The study found that a small compound called Mannan-007 can restore αDG glycosylation and reduce FCMD-related defects.
A new study predicts that climate change will cause a sudden shift in algae distribution pole-wards over the next 100 years, affecting marine ecosystems. The UK is among the areas most likely to be severely impacted due to its warm waters, with changes potentially occurring before previously thought.
Researchers at Kyushu University successfully reconstitute the ovarian follicle from mouse stem cells, generating functional egg cells and growing viable mice. This breakthrough could lead to new treatments for infertility and help conserve endangered animals through egg cell production.
A new study proposes that protocells, the putative ancestors of modern living cells, used temperature differences to divide. This simple mechanism could underlie the growth and self-replication of these early cells.
Researchers found that prostaglandin E2 protects epithelial cells from cell death by binding to EP4 receptors. This activation counteracts intestinal inflammation progression and may prevent bacterial penetration.
A new study reveals that multiple pathways regulate poly(A) tail lengths in yeast, involving poly(A) binding proteins and a self-regulating pathway. This discovery sheds light on the complex control of mRNA tails and their impact on protein production.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
Researchers repurpose cancer drug PLX3397 to combat sarcoma's growth and spread in animal models. The treatment inhibits CSF-1/CSF-1R signaling, reprogramming tumor-associated macrophages and stimulating immune cell infiltration.