Articles tagged with Cells
Research reveals Alzheimer's disease genomic changes occur primarily in non-neuronal brain cells, rather than neurons. The study found a number of new genes not previously implicated in dementia, which could be targets for future drug development.
A University at Buffalo-led study suggests the huntingtin protein is involved in neuronal injury and regeneration. The research found that HTT moves from the injury site to the cell body, carrying components necessary for survival.
Researchers at UNSW Sydney have made significant discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors. Two studies have emerged from UNSW researchers in this area that shine new light on how precursors to blood stem cells occur in animals and humans, and how they may be i...
Researchers at UBC develop new process to produce T cells, the most essential human immune cells, in the lab with improved efficiency. The breakthrough could lead to cost-effective production of cancer-fighting cells for CAR T therapy, a treatment with an efficacy rate of close to 50%.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers at The University of Texas at Austin are developing controllable synthetic cells with the goal of improving cancer treatment and regenerative medicine. By controlling these cells, they aim to eliminate exhaustion and targeting errors, making them more effective.
Researchers at UC San Francisco have discovered how to shift damaged brain cells from a diseased state into a healthy one using CRISPR technology. The study found that reprogramming microglia cells can help remove protein plaques and protect synapses, potentially treating Alzheimer's and other forms of dementia.
A mutated zebrafish eye provides a glimpse into the role of banp in preventing cell death and regulating the cell cycle. The study found that banp promotes the expression of 31 genes involved in DNA repair, tumor suppression, and cell duplication.
A new study by Tokyo University of Science researchers reveals that dendritic cell immunoreceptor (DCIR) plays a crucial role in the development of colorectal tumors. Blocking DCIR may prevent ulcerative colitis and colon cancer, offering a potential therapeutic target for treating these diseases.
Researchers discovered that liver cancer cells modify their metabolism to leave them susceptible to disruptions in arginine supply, a key molecule. A three-pronged approach targeting tumor metabolism, blocking survival-promoting responses, and starving tumors of arginine can induce senescence, making cancer cells killable.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
A new statistical method called Association Plot facilitates the determination and analysis of marker genes in single-cell data. This allows researchers to trace back RNA molecules to their cell of origin, providing insights into cell-type specific genes.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
Researchers studied ant brains using single cell technology, revealing functional specialization and complementary brain cell composition differences among individuals. The study found specialized neurons for learning and memory in worker ants and optic lobe cells in male ants.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
Researchers from China have developed a novel bioconjugate that can suppress the growth of K-Ras mutant pancreatic tumors. The conjugate, which targets folate receptors and macropinocytosis, was found to be highly cytotoxic and effective at suppressing tumor growth.
Researchers have identified new biomarkers to detect non-small cell lung cancer in its early stages through a blood test, offering improved survival chances. The approach can also identify potential drug resistance, allowing clinicians to choose alternative treatment options.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Researchers at Gwangju Institute of Science and Technology have developed a new bioinformatics pipeline, CRESSP, to investigate the mechanism underlying autoimmune diseases following SARS-CoV-2 infection. The tool identified potential epitopes responsible for COVID-related autoimmune diseases and predicted cross-reactive epitopes of di...
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
Researchers at the University of Illinois have successfully engineered artificial photosynthetic life-forms through endosymbiosis between cyanobacteria and yeast. The engineered chimera can survive and reproduce under optimal conditions, shedding light on the evolutionary origins of eukaryotic cells.
A study by Tokyo University of Science researchers has demonstrated that a computationally-light model can simulate complex brain cell responses, including periodic and quasi-periodic responses. The Izhikevich neuron model was found to be capable of reproducing both types of responses at lower computational cost.
Researchers discover medusavirus undergoes four stages of maturation within host cells, with unique particle structures and DNA-protein exchange mechanisms. The findings provide new insights into giant viruses' biology and behavior.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
Researchers at Albert Einstein College of Medicine found that increasing chaperone-mediated autophagy activity can prevent atherosclerosis by protecting macrophages and smooth muscle cells from damage. The study suggests that boosting CMA could be an effective strategy for curbing atherosclerosis and halting its progression, particular...
Researchers at Northwestern University developed an AI-assisted Nanofountain Probe Electroporation system to engineer stem cells. The new method reduces cell loss and increases throughput, enabling selective manipulation of individual cells in micro-arrays.
Researchers develop novel therapeutic approach for treating tuberculosis using phosphatase inhibitors, offering potential benefits for TB research and basic biology exploration. The discovery provides a promising alternative to traditional antibiotic-based treatments and has significant implications for combating antimicrobial resistance.
The newly developed KANPHOS database provides comprehensive information on kinase-associated protein phosphorylation, facilitating research into neural signaling pathways. The database contains information on phosphoproteins, phosphorylation sites, and participant kinases, allowing for searches based on various parameters.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
A new University of Copenhagen study reveals that well-functioning fat tissue is crucial for overall health and may help prevent diseases such as type 2 diabetes, cancer, and obesity. High levels of lifelong exercise have been shown to improve mitochondrial function in fat cells, reducing oxidative stress and damage.
A study led by A*STAR's Genome Institute of Singapore has identified the gene KCNJ15 as a key player in helping the immune system fight tuberculosis. The research found that TB patients have altered acetylation levels at thousands of DNA regions, which helps to reduce the ability of bacteria to reproduce inside cells.
Scientists analyzed over 100,000 cells from 15 human brain metastases and identified two functional archetypes of metastatic cells, each containing both immune and non-immune cell types. These archetypes work together within single cells to shape inflammatory and proliferative processes co-existent in each metastatic tumor.
A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.
Researchers have developed a machine learning framework called dynamo that can predict a cell's path over time, including its fate and genetic changes. The tool uses data from individual cells to create mathematical equations describing the cell's trajectory.
Researchers at University of California San Francisco have catalogued over 40 previously unknown cell types in the human brain's blood vessels. These findings connect hemorrhagic stroke with novel immune cells, offering new targets for therapies.
Researchers discovered that yeast cells can actively regulate temperature-dependent phase separation in their membranes. This process is crucial for membrane function and cell division. By adjusting the temperature, yeast cells can maintain a consistent state of phase separation, which may be essential for optimal cellular performance.
A meta-analysis of 4280 samples found cell phone use associated with reduced sperm motility, viability, and concentration. The study suggests male users should limit daily cell phone use to protect their fertility.
Researchers have created PicoShells, microscopic particles that can speed up the growth and analysis of microorganisms, including algae. This new tool enables faster identification of cell strains suitable for mass production, potentially shortening R&D timelines by months.
Scientists have identified a new tool to control the movement of motor proteins in neurons, which could lead to new treatments for cancer and neurodegenerative diseases. The study found that the GSK3β enzyme can act as a stop switch for kinesin 1 motors, preventing them from detaching from microtubule tracks.
Researchers at UCSF have identified a new potential drug target, BRD2, which regulates the ACE2 receptor, a key entry point for SARS-CoV-2. Blocking production of BRD2 prevents virus from infecting various human cell types.
Researchers have discovered a new mechanism for regulating organelle contacts, essential for producing specific lipids in nerve cells. The study reveals that phosphorylation of a protein at the peroxisomes can block interaction with the endoplasmic reticulum.
Researchers at IST Austria find that a specific gene, Fos, regulates macrophage infiltration into surrounding tissue by creating an actin shell, making it easier for immune cells to invade. This discovery raises hopes for new targets in treating cancer and understanding the immune system.
Researchers at UCSF identify unique immune microenvironments in different types of cancer, paving the way for personalized immunotherapies. The study categorizes tumors into 12 groups based on their immune profile, suggesting that some cancers share similar characteristics despite being from different types.
Researchers discovered that human lung stem cells can undergo abnormal differentiation in response to injury from diseases like COVID-19 and pulmonary fibrosis. This aberrant process prevents the restoration of normal lung function, but the study also identified a potential therapeutic target for reversing damage.
A new study reveals that SARS-CoV-2 limits viral particle release and instead spreads through cell-to-cell transmission, enabling efficient infection without the need for antibodies. This stealthy transmission method makes it challenging for the host immune system to target and neutralize the virus.
Researchers at Goethe University and the Max Planck Institute of Biophysics have gained new insights into how mitochondrial complex I facilitates proton transfer through water molecules. The study's high-resolution structure data enabled computer simulations that shed light on the protein's dynamics during its catalytic cycle.
Researchers discovered that mechanical forces guide cell development, influencing gene expression and potentially leading to pathologies like heart disease. The findings could inspire advances in engineering authentic artificial tissue for medical applications.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
Scientists have developed a technology called LUX-MS to study the organisation of cell surface molecules, revealing that proteins work together to fulfil cellular functions. The method can detect the proximity of molecules on the cell surface with nanometer-scale precision.
Researchers at the University at Buffalo have created model protein-RNA droplets with properties similar to those of viscoelastic Maxwell fluid and Silly Putty. These droplets exhibit dual behavior, acting like both elastic solids and viscous liquids, depending on the timescale.
Researchers found that cells form transcription factories through phase separation, similar to liquid condensation. This process enables rapid and reliable gene activation, advancing cancer treatment and DNA-based data storage systems.
Researchers have discovered a new type of skin cell, TIFFs, that may play a role in inflammatory skin diseases such as scleroderma. These cells were found to interact with immune cells and expand in response to inflammation, leading to an exaggerated response and fibrosis.
Researchers at UT Southwestern Medical Center have identified a protein called Xbp1 that plays a crucial role in halting the cell cycle in response to stressful events. The study uses innovative techniques to track proteins in individual cells over time, revealing a previously unrecognized function of Xbp1 in regulating the cell cycle.
Researchers at MIT develop a method to decode images of cells in a tissue to determine its phase, which can indicate its developmental stage or cancer progression. The technique uses triangular order parameters to characterize tissue states, allowing for quicker and less invasive diagnoses.
Researchers have created a human disease model of FCMD using stem cells from a patient, which successfully mimicked the disorder's brain defects. The study found that a small compound called Mannan-007 can restore αDG glycosylation and reduce FCMD-related defects.
A new study predicts that climate change will cause a sudden shift in algae distribution pole-wards over the next 100 years, affecting marine ecosystems. The UK is among the areas most likely to be severely impacted due to its warm waters, with changes potentially occurring before previously thought.
Researchers at Kyushu University successfully reconstitute the ovarian follicle from mouse stem cells, generating functional egg cells and growing viable mice. This breakthrough could lead to new treatments for infertility and help conserve endangered animals through egg cell production.
A new study proposes that protocells, the putative ancestors of modern living cells, used temperature differences to divide. This simple mechanism could underlie the growth and self-replication of these early cells.