Articles tagged with Dendrites
A preclinical study suggests a novel therapeutic immunomodulatory vaccine may slow memory impairment and prevent Aβ oligomer aggregation, with strong immunomodulatory effects without inducing inflammation. The vaccine targets toxic Aβ molecules in the brain, providing a safer alternative to existing anti-amyloid treatments.
Researchers identified Nrp1 as a novel Reelin receptor, essential for superficial-layer neuron dendrite development in the mouse neocortex. The Reelin-Nrp1 interaction regulates apical dendrite formation, suggesting a new mechanism for normal network establishment.
MUSC researchers have identified a new biomarker that may predict which patients are at risk of graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. High levels of plasmacytoid dendritic cells expressing ICOS ligand are associated with increased severity of GVHD and lower survival rates.
Indoximod increases T cell proliferation by modulating CD4+ T cells via the aryl hydrocarbon receptor and reactivating mTOR. It also downregulates IDO protein expression in dendritic cells, opposing the immunosuppressive effects of IDO and TDO.
Heidelberg researchers demonstrate that restoring VEGFD levels can preserve dendritic arborisation and reduce brain damage after a stroke. A treatment using recombinant VEGFD and nose drops achieved similar results in mouse models.
Researchers at Mount Sinai have found a way to regulate special immune system cells in lung cancer tumors, suppressing them and allowing tumors to grow. By blocking this pathway, the immune system can be boosted to prevent tumor formation or growth, offering a potential new treatment for immunotherapy.
Researchers at EPFL have created a prototype vaccine that can travel to the desired location and activate immune cells, overcoming two major obstacles in therapeutic cancer vaccines. The Polycondensate Neoepitope (PNE) combines a patented technique with an algorithm for predicting mutated tumor antigens.
Dendritic action potentials amplify human brain computational power, enabling single neurons to solve complex problems previously thought to require multi-layer neural networks. The investigation reveals a new class of dendritic calcium action potentials in L2/3 neurons.
A research team discovered that dendritic cells play a crucial role in the immune system's response to disease-causing pathogens, which may explain why TNF inhibitors carry a risk of serious infections and cancer. The study suggests that programming dendritic cells could lead to better treatments for persistent infections and cancer.
Researchers at Kyoto University discovered that Purkinje cell dendrites can filter and modulate incoming signals, enabling new learning mechanisms in the cerebellum. This finding provides insight into the brain's ability to modify itself and change signaling properties.
A team led by Chongmin Wang at the Pacific Northwest National Laboratory found that certain compounds in the electrolyte prompt the growth of dendrites and whiskers. By manipulating the battery's ingredients, they hope to prevent their growth and eliminate a major obstacle to widespread use of lithium metal batteries.
This study reveals how sphingosine-1-phosphate positively influences high endothelial venule function and integrity in lymph nodes. Dendritic cell localization and vascular integrity are maintained through S1P-signalling, ensuring proper immune response and tolerance.
The study reveals that ectosomes, tiny vesicles containing key immune messages, can be intercepted and deciphered using super resolution microscopy. This breakthrough understanding of cellular communication has significant implications for developing therapies that shape the immune response to specific diseases.
Research in mice revealed that vaccination led to increased antigen-specific CD8+ T cell proliferation when administered mid-day. The circadian clock influences this response by controlling the cells' transcriptional program and modulating their responsiveness.
Research found that parasitic helminths like Schistosoma mansoni can block HIV-1 interactions with dendritic cells and induce CD4 lymphocytes that down-modulate infection. This could influence disease course in co-infected individuals.
A team of researchers at LMU in Munich has found that messenger RNAs are transported between the cell body and nerve processes like sushi on an endless conveyor belt, allowing them to reach specific synapses. The discovery sheds light on how proteins are delivered to synapses, a crucial process for learning and memory.
Researchers have identified CD11c+ dendritic cells as the first immune cells to interact with HIV, making them key drivers of infection. These newly discovered cells can capture viruses and deliver them to CD4 T cells, which are primary targets for HIV replication.
A recent study from MIT has found that dendrites are nearly always active when the main cell body of a neuron is active, suggesting a larger role in neural computation. The researchers used calcium imaging to measure activity in both soma and dendrites of individual neurons in the visual cortex.
A molecule called LL-37 has been found to boost the function of dendritic cells, which are used in cancer therapy. This improvement could lead to more effective treatments by increasing the success rate of dendritic cell-based therapies.
Researchers found that autophagy in dendritic cells supports T-cell anticancer activity by regulating receptor CD36. This process enhances the phagocytosis of apoptotic tumor cells while restricting T-cell activation.
A Phase 1b clinical trial successfully induces immune tolerance to autoimmune targets in patients with multiple sclerosis and neuromyelitis optica. The treatment involves introducing peptide-loaded tolerogenic dendritic cells, which stimulate the production of IL-10 and promote immune tolerance.
A study published in PLOS Pathogens found that cytomegalovirus (CMV) infection can convert harmless protein antigens into allergens, sensitizing immune cells to cause allergic airway disease. This effect is mediated by activated airway dendritic cells and may contribute to the development of asthma.
Research demonstrates somatosensory cortex, responsible for touch, also participates in reward learning. The findings suggest that learning and memory may permeate the brain, challenging conventional wisdom on brain function.
Researchers found that eliminating protein YTHDF1 boosts dendritic cell activity, leading to better immune response against cancer. This discovery opens new avenues for cancer treatment and may lead to effective combination therapies with checkpoint inhibitors or dendritic cell vaccines.
Researchers at Osaka University found that common bacterial metabolites pyruvate and lactate activate the intestinal immune response, enhancing dendrite protrusion in macrophages. This discovery has multiple clinical applications, including improving oral vaccines and eliminating intestinal pathogens.
Researchers discovered a key brain mechanism that underlies our ability to rapidly focus attention. The cholinergic system plays a crucial role in triggering desynchronization of neurons, allowing individual neurons to respond to sensory information differently. This allows us to focus on specific stimuli while ignoring distractions.
Researchers reveal that dendritic cell partnership with CD4 T cells is crucial for disease development in both diseases, offering new insights into treatment options. The study also highlights the importance of targeting multiple pathways to treat patients with these immunological disorders.
Researchers found that interleukin-6 is involved in the development of severe asthma, a subtype associated with neutrophil accumulation. Blocking this molecule may lead to new treatments for asthma.
Researchers found that anti-PD-1 therapy induces CD8+ T cells to produce interferon-gamma, which activates dendritic cells to produce IL-12, a potent activating signal. This interaction improves the efficacy of anti-PD-1 therapies and offers potential ways to broaden their application.
A research team at Lund University successfully reprograms mouse and human skin cells into immune cells called dendritic cells. This breakthrough enables the development of novel dendritic cell-based immunotherapies against cancer. The process is quick, effective, and opens up possibilities for patient-specific treatment.
Researchers at Ruhr-University Bochum discovered that kainate receptors affect the development of brain cells immediately after birth, causing increased activity and dendrite growth. The discovery sheds light on the role of glutamate receptors in early maturation of nerve cells.
Researchers used mouse models to track the immune cell triggering during anaphylactic shock, revealing a previously unknown mechanism in which dendritic cells mine blood vessels for allergens and rapidly deliver them to mast cells. This finding opens innovative lines of attack against deadly allergic reactions.
Researchers have discovered that human neurons employ highly compartmentalized signaling, unlike those in model organisms. This discovery highlights the potential benefits of human neuron structure for brain computational power.
Researchers discovered that human dendrites have different electrical properties than those in rats, with reduced signal strength as they flow along the longer extensions. This increased electrical compartmentalization could enable single neurons to perform more complex computations.
Researchers at Brigham and Women's Hospital identified CD103+ dendritic cells as a major trigger of skin graft rejection, but found that pre-treating organs with an anti-inflammatory protein can mitigate this effect. This new strategy could offer benefits for organ transplantation, including face transplants.
Scientists have identified a method to grow dendritic cells at scale in the lab, enabling more precise cancer vaccines and potentially improving organ transplant rejection outcomes. This discovery could lead to breakthroughs in cancer treatment and other immunological therapies.
A team of researchers has identified a complex interaction between three cell types that work together to recruit protective NK cells in the lymph node after a viral infection. This collaboration enables the body to mount an effective response against certain viruses, such as mousepox.
Researchers at the University of Münster have discovered a correlation between the spatial organization of a nerve cell and its process degeneration. The study found that specific arrangement of cytoskeleton components influences the direction of dendrite degeneration in fruit flies.
Researchers found that when one synapse strengthens, neighboring synapses weaken due to the action of a crucial protein called Arc. This balance is essential for maintaining healthy neural activity and function. The discovery provides new insights into how brain plasticity works in complex systems.
Researchers at St. Jude Children's Research Hospital have identified a hidden driver, kinases Mst1 and Mst2, that regulates the function of different dendritic cell subsets and primes anti-tumor T cells. This discovery provides clues for new treatment strategies by modulating dendritic cell activity to shape the immune response.
Researchers found that bipolar cells can grow new branches and reestablish selective connectivity with photoreceptors after an injury. This discovery provides hope for therapeutic strategies to replace lost photoreceptors and restore color vision in diseases such as age-related macular degeneration.
A $12M grant from CIRM will fund a phase 1 clinical trial testing pembrolizumab with dendritic cell injections into lung cancer tumors. The goal is to activate a targeted immune response against lung cancer, addressing the challenge of T cells not reaching tumors.
A study found that intelligence is linked to fewer dendrites in the cerebral cortex, allowing for efficient neuronal connections. The research used a neuroimaging technique and IQ tests to confirm the results, shedding light on conflicting findings in previous studies.
A new type of cancer vaccine made from patients' own immune cells has yielded promising results in an initial clinical trial. The vaccine triggers a broad anti-tumor T-cell response, with half of the vaccinated patients showing signs of improved survival and one patient remaining disease-free for five years.
Scientists have discovered a mutation in the catnap2 gene that causes seizures in people with autism spectrum disorder. The mutation shrinks brain neurons' branches, disrupting message delivery and leading to seizures.
A new cellular pathway regulates CD4+ T cell response via mast cells, providing an alternative approach for treating autoimmune diseases, infections, and cancer. NAD+ administration was shown to protect against lethal doses of infection in a pre-clinical model.
Researchers developed a new method to track cell-to-cell interactions, dubbed LIPSTIC, which allows for the identification and counting of specific cells involved in immune responses. This breakthrough enables scientists to better understand how the immune system functions in live animals.
Researchers developed artificial receptors called EVIR that enable dendritic cells to capture antigens from the patient's tumor, amplifying the immune response against cancer. The EVIR technology exploits pro-tumoral exosomes as selective nanocarriers of tumor antigens.
An international research team has discovered that monocyte-derived cells are a diverse mixture, differing from dendritic cells. This diversity affects the immune system's response to tumor cells, impacting cancer immunotherapy success rates.
Researchers have discovered that macrophages form a barrier around kidneys and that dendritic cells communicate with each other to control the magnitude of the immune response. This complex mechanism challenges previous ideas about how the kidney reacts to injury, and may lead to new strategies for protecting individuals' kidney health.
A genetic variation linked to autism spectrum disorders stunts the growth of dendrites in rat cells and a mouse model of autism. This excessive pruning may contribute to differences in neuronal connectivity underlying social and communication deficits observed in autism.
Dendritic cells known as cDC2s are crucial for robust T cell induction and antibody production in vaccination. The study found that intradermal injections may be more efficient than traditional methods, expanding the number of people who can be vaccinated during a pandemic.
A University of Idaho-led team found a way to stimulate the formation of new neural connections in the adult brain, which could help humans fend off memory loss and brain trauma. The study used genetic manipulation in mice to induce axon and dendrite outgrowth, leading to the formation of stable, functional connections.
Researchers have identified a distinctive epigenetic event in immune cells that differentiate in the tumoral microenvironment, making them tolerant to cancer cells. The study found that DNA methyltransferase 3A is responsible for the acquisition of suppressive properties in these cells.
Researchers discovered that activity in dendrites increases during sleep, linked to specific brain waves associated with memory formation. This study could lead to new treatments for learning and memory disorders, such as dementia.
A new study discovered a sugar 'warehouse' in dendritic cells that fuels immune responses, providing a novel regulatory target to regulate immune activity. Enhancing or depleting this sugar warehouse could influence or dampen immune reactions.
A deadly tick-borne virus uses the host neuron's transportation system to move its RNA, resulting in local reproduction of the virus and severe neurological symptoms. The unique virus-host interaction reveals a pivotal non-coding sequence that hijacks the neuronal granule system.
Researchers found that PCSK9 inhibition can reverse the effects of oxidised LDL on immune activation, leading to an anti-inflammatory state that may directly influence atherosclerosis and cardiovascular disease. This new mechanism is independent of lowering LDL cholesterol.
Researchers found that inhibiting the partnership between Tregs and dendritic cells might lead to effective immunotherapy for pancreatic cancer. Blocking this relationship may enable the immune system to target pancreatic tumor cells more effectively, potentially slowing tumor growth.
Two subsets of dendritic cells work together to activate T cells against a virus. CD141+ DCs produce viral fragments from infected CD1c+ DCs, which they then present to T cells.