Articles tagged with Dendrites
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Researchers from Kyushu University found that the brain forms new, high-density clusters of synapses on specific segments of dendrites during adolescence, challenging the 'adolescent synaptic pruning' hypothesis. This discovery may offer new hope for understanding the biological basis of schizophrenia and other neurodevelopmental condi...
A new AI model developed by Tokyo University of Science's researchers predicts dendritic growth in thin films, offering a powerful pathway for optimizing thin-film fabrication. The model analyzes morphology using persistent homology and machine learning with energy analysis, revealing conditions that drive branching behavior.
Researchers created a computational method to track brain cell development over time, capturing unlabeled cells and fine structures in live cultures. The algorithm achieved high precision rates for detecting individual neurons, paving the way for studying neurological diseases and developing therapies.
Researchers discovered that a network of subcellular structures similar to those responsible for muscle contraction are also present in brain cells. These structures, called contact sites, play a crucial role in transmitting calcium signals that regulate neuronal signaling. The study provides new insights into the molecular mechanisms ...
Researchers found that glial cells accumulate excess extracellular matrix proteins and alter gene expression when detecting damaged cilia. This discovery may have implications for treating diseases caused by defective cilia, such as polycystic kidney disease.
Researchers found that neurons establish 'mini-computers' in dendrites to process information early in life. These computational subunits are clustered according to the information they transmit, increasing a neuron's computational power.
Scientists at Kyushu University created QDyeFinder, an AI pipeline that untangles the dense neuronal networks in the brain. The system uses a super-multicolor labeling protocol to tag neurons and then automatically identifies their structure by matching similar color combinations.
Researchers at University of Cologne's CECAD Cluster of Excellence discovered that mitochondrial fusion boosts new neuron plasticity. The study found that as new neurons mature, their mitochondria fuse to acquire elongated shapes, sustaining synaptic plasticity and refining brain circuits.
A new study led by Dr. Richard Naud of the University of Ottawa's Faculty of Medicine tackles the mystery of neuronal response variability, controlling output with dendrites' inputs to the core and little antennas
A team of researchers, including York University, used a mouse model to test how the brain learns new sensory input patterns. They found that the brain's response to image patterns that violate expectations evolves differently over time, suggesting a distinct role in sensory learning.
Researchers characterized changes in cognitive behaviors, neuronal morphology and gene expression in a tauopathy mouse model. The study found significant decreases in dendritic arborization and synaptic gene upregulation over time.
A team of researchers from Okayama University found that short-chain fatty acids produced by intestinal bacteria trigger elongation of dendrites in dendritic cells, capturing intestinal pathogens and enhancing immune responses. This discovery may lead to the development of new treatments targeting dendritic cells to prevent diseases.
Researchers found that nearly all Purkinje cells in the human cerebellum have multiple primary dendrites, which contradicts the traditional understanding of a one-to-one relationship between climbing fibers and Purkinje cells. This discovery was made possible by analyzing thousands of cells from both human and mouse tissue using immuno...
The study reveals that spontaneous waves of neurotransmitter glutamate facilitate dendrite pruning, while a unique protection/punishment machinery strengthens certain connections and eliminates others. Proper pruning is critical for neural development, with insufficient or excessive connections linked to neurophysiological disorders.
A new high-speed two-photon microscope was developed with an unprecedented line scanning frequency of 400 kHz, achieving up to 10,000 frames per second. This allowed for precise observations of complex biological processes in living tissues, including calcium signal propagation and blood flow measurements.
In a breakthrough study, researchers at Münster University revealed that mechanical tearing is the primary mechanism behind neurite pruning in sensory nerve cells of fruit flies. This process, which occurs during development, involves strong body contractions causing stress on fragile neurites, leading to their severance and removal.
Researchers at Kyoto University found that a poor, low-yeast diet causes fruit flies' larvae to grow dendrites in an unexpected way. The hyperarborization phenotype is triggered by a simultaneous deficiency in vitamins, metal ions, and cholesterol, which increases the production of Wingless signaling molecules from body wall muscle.
Researchers at the University of Bonn discovered that people with chronic epilepsy may have impaired dendritic integration, leading to less specific place cell firing and reduced ability to distinguish familiar from unfamiliar places. Administering a sodium ion channel inhibitor improved memory in animal models.
Researchers at MIT have discovered that the adult brain contains millions of silent synapses, which may explain how the brain forms new memories without modifying existing connections. These inactive connections can be recruited to help form new memories when important new information is presented.
Researchers at MIT discovered that mechanical stresses can prevent dendrites from forming in solid-state lithium batteries. The team developed a way to apply controlled pressure to divert the growth of dendrites, making lightweight batteries safer and more efficient.
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
Researchers discovered that each neuron performs complex calculations within its branches, enabling precise movements. This understanding may lead to new treatments for neurodegenerative disorders like Parkinson's disease and autism.
Researchers found that primates and non-primates have distinct axonal origins, with axons emerging from dendrites more common in non-primates. This difference may influence neocortical information processing, but the exact function of axon-carrying dendrites remains unknown.
Researchers at the University of Chicago Medicine Comprehensive Cancer Center and the University of Amsterdam have identified a new mechanism that prompts T cell responses, including MHC-I cross-dressing. This discovery may lead to improved vaccine design and targeted cancer treatment strategies.
Researchers at the University of Bern have identified how the brain processes emotions during dream sleep. During REM sleep, the brain favors the discrimination of safety versus danger in the dendrites, but blocks the over-reaction to emotion, particularly danger. This decoupling is essential for optimizing survival and stability.
Researchers found that vitamin E boosts immunotherapy responses by stimulating dendritic cell activity, leading to improved antigen presentation and enhanced antitumor immunity. Vitamin E treatment also showed promise in combining with cancer vaccines and immunogenic chemotherapies.
Ira Mellman, PhD, is being honored with the 2022 AACR-CRI Lloyd J. Old Award in Cancer Immunology for his seminal work on dendritic cell function and its impact on atezolizumab and neoepitope vaccines. His research has made a major impact on cancer immunology and has the potential to stimulate new directions.
A team of researchers at MedUni Vienna's Center for Physiology and Pharmacology has discovered a key building block in immune cells that promotes immunotolerance and prevents T-cell attacks on the body's own tissues. The study suggests a potential new cell-based therapeutic approach to slow down autoimmune disease progression.
Researchers at MIT found that different types of dendrites process incoming information in distinct ways before sending it to the neuron's body. This specialization enables neurons to integrate various inputs and generate an appropriate response, particularly in navigation and planning movements.
Nagoya University researchers have discovered how bird brains compute time differences between sounds reaching each ear to determine their location. This process relies on the clustering of nerve junctions in specialized dendrites dedicated to low-frequency sounds.
Researchers at the University of Texas at Austin have developed a new sodium-based battery material that overcomes the dendrite problem in earlier sodium batteries. The new material recharges as quickly as a traditional lithium-ion battery and has a higher energy capacity than existing sodium-ion batteries.
Researchers identified a subset of dendritic cells that can cloak themselves in tumor proteins and trigger a strong T cell response. Stimulating these dendritic cells may enhance the effectiveness of cancer immunotherapy by slowing the growth of melanoma and colon tumors.
A study involving Drosophila found that a constant and precisely regulated energy supply is essential for nerve development, particularly during the degradation of nerve connections. Malnutrition was shown to intensify defects in this process.
A new hydrogel treatment kills drug-resistant bacteria, including MRSA, and induces the expression of naturally-existing antimicrobial peptides in human skin cells. The gel is non-toxic, biodegradable, and scalable.
The living retina achieves sensitivity and efficiency that human engineers can only dream about, with optimized mosaics of different sensitivities parsing 40 visual features. The retinas adapt to current conditions and conserve energy by tuning out noise, making them orders of magnitude less power-hungry than smartphone sensors.
Researchers at Helmholtz-Zentrum Berlin have achieved a new world record in materials research by using X-ray microscopy to create 1000 three-dimensional images per second. This allows for the non-destructive study of fast processes in materials, enabling researchers to gain insights into material properties and behavior.
A study published in the British Journal of Ophthalmology found nerve fibre damage and an increase in dendritic cells on the eye surface may be identifying features of 'long COVID'. Patients with neurological symptoms showed greater corneal nerve fibre loss and higher dendritic cell density compared to those without symptoms.
Scientists identify BMPR-2 as a key regulator of selective stabilization of neuron branching, strengthening connections only when received signals from other neurons. Glutamic acid is also found to activate the process, demonstrating simultaneous control necessary for selective branch stabilization.
A recent study published in Cell Reports found that KIF5C plays a critical role in long-term memory formation by transporting RNA cargo to synapses. The research suggests that impairments in KIF5C could contribute to neurological disorders, such as intellectual disability and autism.
Researchers identified a protein that interferes with the immune system's response to cancer, allowing tumours to evade killer T-cells. Lower levels of this protein in tumours have been linked to improved survival rates in patients with specific types of cancer, such as liver, head and neck, and stomach cancers.
Research found that activating plasmacytoid dendritic cells with interferon-beta increases CD40 expression and induces CD38 upregulation on AML cells, leading to antibody-mediated killing. This mechanism may provide a novel therapeutic approach for acute myeloid leukemia.
Researchers discovered that type 1 dendritic cells (cDC1) promote progression of non-alcoholic steatohepatitis (NASH) by inducing inflammatory and aggressive behavior in T cells. Blocking or genetically modifying cDC1 alleviates symptoms in mice, suggesting a potential new approach to prevent serious liver damage.
Researchers at ETH Zurich have discovered that dendritic cells can migrate more quickly to lymph nodes via a newly found pathway during inflammation. This route allows them to bypass the slow and energy-intensive process of entering capillary vessels, enabling faster immune activation and response.
Moffitt researchers found that inhibiting TIM-3 enhances immune cell activity and prevents tumor growth in mice. The study suggests targeting TIM-3 to activate the STING pathway in dendritic cells as a potential therapy for certain types of cancer.
A new study reveals that skin's epidermis layer is comprised of an army of immune cells that station themselves at regular intervals across the skin. When necessary, these cells reposition themselves to protect vulnerable areas, forming a dynamic surveillance system.
Scientists discovered that elite controllers' myeloid dendritic cells display traits of trained innate immune cells, which enhance their ability to control HIV. The study also found a specific long-noncoding RNA, MIR4435-2HG, that may be an important driver of this enhanced state.
A recent study found that c-Jun and JunB proteins play a crucial role in the development of Type 1 dendritic cells, which are essential for defending against bacteria and viruses. The discovery could lead to new therapeutic approaches for cancers and viral infections.
Researchers at the Walter and Eliza Hall Institute have discovered a critical immune cell type called cDC1 that helps control cancer and infections. The study highlights the importance of DC-SCRIPT, a new regulatory protein, in producing effective dendritic cells.
A multidisciplinary project between NAU and ASU aims to create a secure identification system for food traceability throughout the supply chain. Dendritic tags, which offer unique identities, could enable real-time tracking of contaminated products and reduce economic losses.
A new study implicates a type of immune cell in the development of chronic lung disease following viral infection. Measuring dendritic cells may help doctors identify high-risk patients.
WEHI researchers have uncovered a process cells use to fight off infection and cancer that could pave the way for precision cancer immunotherapy treatment. The study found how the Flt3L hormone increases dendritic cell numbers, helping the immune system fight off cancer and infection.
Dendritic cells, key immune responders, can reprogram their genes to enhance immune response by changing epigenetic marks on DNA. This new mechanism could lead to improved vaccination and immunotherapy strategies.
A new study from the University of Bern has developed a simplified computational model to accelerate brain research. The approach uses a mathematical relation to reduce complexity while retaining accuracy, allowing for easier characterization and simulation of large neural networks.
Researchers have found that dendritic cells in young animals are capable of triggering effective immune reactions, challenging the conventional view on their immaturity. These findings suggest new ways to boost the efficacy of vaccines for young children.
Researchers at the Francis Crick Institute discovered that dendritic cells present proteins from dead cells to T-cells by bursting phagosomes, a process involving receptor DNGR-1. This mechanism is fundamental to the immune system and could lead to new ways to exploit natural defenses against infection and cancer.
A study published in Cell Reports identified a protein called SHP-1 as a key player in the Leishmania parasite's evasion of the human immune system. By activating SHP-1, the parasite can limit the capacity of dendritic cells to present antigens, thereby preventing autoimmune disorders and protecting itself from an immune response.
Scientists have found that surface diffusion of proteins is more effective at providing proteins to distal dendritic sites, reducing the need for protein production. By optimizing dendritic radii, neurons can reduce their protein synthesis cost by several orders of magnitude.
Researchers found a vaccine created to prevent melanoma recurrence is about twice as effective when patients receive two immune-boosting components, Flt3L and poly-ICLC. This combination nearly doubled the vaccine's efficacy in promoting antibodies and T cells that can later fight melanoma.
A study published in Science Immunology reveals that the activity of IL-33, an immune signaling molecule, depends on which cell type releases it. This discovery opens up a new direction for understanding its involvement in various health conditions such as obesity, inflammatory bowel disease, and asthma.
A breakthrough discovery has revealed a new pathway for the development of allergy treatments by identifying the release of neuropeptide Substance P by sensory neurons upon detection of allergens. This finding suggests that interrupting this pathway could potentially stop allergic immune responses.