Articles tagged with Dendrites
Researchers have developed novel dual solidification mechanisms for a ternary Fe47.5Cu47.5Sn5 peritectic-type alloy, enabling the effective synthesis of advanced materials. The mechanisms involve peritectic solidification at moderate undercoolings and macroscopic phase separation at greater undercoolings.
A combination therapy of dendritic cell implants and radiotherapy was found to be effective in inducing tumor-specific immune responses in 52.9% of trial patients with high-risk soft tissue sarcomas. The treatment resulted in dramatic increases in immune T cells in the tumors, leading to significant clinical benefits.
A new model of aggressive ovarian cancer reveals that dendritic cells actively support tumor progression, but can be restored to suppress it. Researchers propose targeting dendritic cells to control metastatic ovarian cancer.
Researchers have developed a new therapeutic vaccine that uses a person's own dendritic cells to stimulate an improved immune response against HIV. The vaccine showed virtually no side effects and significantly enhanced the body's ability to suppress the virus, but did not eliminate it entirely.
Researchers at Arizona State University investigate the coordination of a particular type of immune response involving the release of IFN-λ, a cell-signaling protein molecule. They found that antigen-independent production of IFN-λ by memory T cells relies on splenic dendritic cells and NOD-like receptors.
Researchers at the University of Texas Medical Branch at Galveston identified key molecular mechanisms by which implanted human neural stem cells aid recovery from traumatic axonal injury. The study found that stem cell transplantation prevents further axonal injury and promotes axonal regrowth through the secretion of glial derived ne...
Researchers found that high levels of dendritic cells in the pancreas can alleviate cellular stress caused by severe inflammation, while low levels are associated with exacerbated pancreas injury. Dendritic cells play a critical protective role in pancreatic organ survival.
Tiago Branco's research focuses on how single neurons process information from the outside world to generate behaviors. He discovered that dendrites actively filter and transform this information, enabling single neurons to solve complex computational tasks.
Researchers found that specific receptor variants determine the development of nerve cells' dendrites, a crucial mechanism for communication. Different cell classes use these variants to grow dendrites in unique ways.
Centenary Institute researchers have identified a set of immune cells in the outer layer of the skin that prevent the immune system from attacking friendly bacteria. This discovery opens up new possibilities for treating inflammatory bowel disease and other immune-mediated disorders.
Neuroscientists at CSHL develop genetic 'GPS' system to comprehensively label GABA neurons, enabling real-time tracking and manipulation. The system uses Cre-Lox recombination to create cell-type specific markers, allowing for the study of inhibitory modulation in living brains.
A study in worms has yielded clues about how nerves grow by identifying the molecular mechanisms that prompt dendrite development. The QBI team discovered that a ligand and receptor work together to coax certain neurons to extend dendrites towards their targets.
Researchers discovered dendritic cells play a protective role in the liver against acetaminophen-induced acute liver failure. High levels of dendritic cells are associated with protection, while low levels exacerbate liver damage and death.
Scientists at WashU Medicine reveal that CD8 alpha+ dendritic cells (CD8a+ DCs) help fight infections, but can also be hijacked by bacteria like Listeria to cause harm. The trait that makes these cells both an asset and a liability is the way they alert other immune cells.
The research identified phosphatase MKP-1 as a crucial regulator of immune balance and a bridge between innate and adaptive immune responses. The findings suggest that MKP-1 controls the production of specialized T cells, including Th1, Th17, and regulatory T cells.
A new study reveals that subsets of dendritic cells in the skin can promote unique and opposite immune responses against the same type of infection. The research highlights the critical role of dendritic cells in initiating an effective immune response.
Researchers have created a uniform, controllable core-shell nanoparticle that can be made-to-order with precise shape and size. This nanoparticle testbed enables the study of controlled variations in biological systems, facilitating the development of better nanomaterials.
U-M researchers found that attacking specific microRNA molecules can reduce deaths from sepsis. The approach also holds promise for other inflammatory diseases like juvenile rheumatoid arthritis and graft-vs.-host disease.
A study found that dendritic cells release CCL17, which drives atherosclerosis by restraining regulatory T-cell homeostasis. The researchers used transgenic mice to demonstrate the role of CCL17 in promoting atherosclerosis.
A McGill research team identified two distinct disease-causing mutations in the IRF8 gene, which causes severe immunodeficiency and disseminated BCG infection. These findings led to a successful stem cell transplant that saved the life of a three-month-old baby girl.
UCLA researchers have discovered a novel method to stimulate the immune system against lung cancer by delivering an immune-stimulating protein via nanoscale containers called vaults. The approach showed potent inhibition of cancer growth in pre-clinical studies and has the potential to be a game-changer in cancer immunotherapy.
A personalized dendritic cell vaccine has been shown to increase median survival time in patients with glioblastoma, a deadly form of brain cancer. The vaccine was found to be effective in patients with the mesenchymal subtype of glioblastoma, which accounts for about one-third of all cases.
Researchers have discovered that retinal ganglion cells receive visual information from amacrine cell dendrites running along the null-direction, allowing for directional selectivity. This mechanism relies on asymmetric synapses and inhibitory influences between neighbouring amacrine cells.
Scientists identified a class of RNAs called CIRTs that target genetic building blocks to guide protein synthesis in nerve cell dendrites. This discovery provides clues for understanding brain disorders and highlights the potential impact of viral infections on normal cellular function.
A new Scripps Research study has mapped the dynamic changes in brain connectivity during development, revealing that connections are constantly forming and dissolving. The research highlights the importance of understanding these mechanisms to better comprehend conditions such as autism and schizophrenia.
Researchers have discovered how a key viral gene helps viruses evade early detection by the immune system, providing new insights into chronic infection treatments. Dendritic cells, critical for immune response, are compromised by this gene, allowing viruses to establish chronic infections.
A team of scientists led by Melissa Rolls has discovered a key protein controlling the layout of microtubules in dendrites, allowing neurons to regenerate after severe injury. The research provides new insights into the process of nerve cell regeneration and potential avenues for treating neurodegenerative diseases.
A novel form of splicing in the cytoplasm of nerve cells dictates a special form of a potassium channel protein in the outer membrane, essential for coordinating electrical firing of nerve cells. This discovery highlights the importance of introns in regulating protein diversity and has implications for brain diseases such as epilepsy.
Scientists at Rockefeller University have discovered a new class of dendritic cells, called monocyte-derived dendritic cells, that can be derived from blood monocytes. These cells have been shown to have the same functional properties as classical dendritic cells and are promising for therapeutic uses in humans.
Researchers have developed a new method to explore the olfactory system in mammals, revealing that there are many more information output channels leaving the olfactory bulb than previously thought. This complexity may help the brain rapidly make accurate odor distinctions.
Researchers at Walter and Eliza Hall Institute have identified a protein called PU.1 as essential for the development of dendritic cells, which are key players in the immune response. By regulating PU.1 expression, Flt3 can control DC development, revealing a crucial role for this protein in immune system function.
Researchers found a sensor in dendritic cells that recognizes HIV, sparking a more potent immune response. The ability to stimulate this protective response is critical for developing therapeutic vaccines against HIV.
Researchers have identified dendritic cells in zebrafish, opening up new possibilities for studying the complexities of the human immune system. The discovery provides another model for investigating the mammalian immune system, particularly with regard to humans.
Researchers found that people with allergic asthma are more susceptible to respiratory viruses like the flu due to impaired immune response. Elevated IgE levels in dendritic cells may interfere with antiviral proteins, worsening asthma symptoms.
Researchers at Medical College of Georgia have identified a rare hybrid cell that can switch the immune system on or off, expressing indoleamine 2,3 dioxygenase to turn off T cells. This unique cell has properties of both dendritic and B cells, with potential implications for cancer and rheumatoid arthritis therapies.
Dendritic cells produce higher levels of α-defensins 1-3, associated with slower HIV disease progression and potential therapeutic implications. The findings open a new line of investigation for treating HIV/AIDS.
Researchers discovered a magnetometer system in the upper beak of birds, composed of over 500 dendrites that encode the magnetic field information. This system helps birds create a magnetic map for spatial orientation, contradicting previous myths about iron-based magnetoreception.
Researchers have discovered a molecular process that controls the growth of nerve cells, allowing them to form complex extensions for signal transmission. The study highlights the importance of Nedd4-1 enzyme in regulating cytoskeleton structure and ensuring normal dendrite growth.
A signaling protein, GM-CSF, plays a vital role in fighting bacterial infections and inflammation in the intestinal tract. Its deficiency is linked to increased susceptibility to persistent gut infection, severe inflammation, and disease duration.
A new study identifies thymic stromal lymphopoietin (TSLP) as a molecule that directs immune cells to develop an allergic response. The signaling molecule is involved in the development of allergic diseases such as asthma, atopic dermatitis and food allergy.
Researchers used a classic staining method to observe how semaphorin regulates the creation of synapses and their distribution in the brain involved in conscious thought. The discovery could have an impact on understanding early origins of neurological disorders like autism, schizophrenia, and epilepsy.
A recent study by Michigan Medicine has found that dendritic cells, a type of immune cell, are more active in patients with severe COPD, leading to increased inflammation and disease progression. This research suggests that targeting dendritic cells may be a potential strategy for preventing COPD from worsening.
Researchers have discovered that fruit fly neurons can rebuild themselves after injury, with a structurally and functionally different component replacing the damaged part. The study reveals a dynamic microtubule response, where dendrites convert to axons, offering potential avenues for understanding axon regeneration.
Researchers discovered that dendritic cells in the lung provoke destructive T-cells that attack elastin, causing lung tissue death and emphysema. The study found a link between systemic inflammation and cardiovascular diseases associated with smoking.
Researchers have discovered a method to deliver a natural suppressor of the immune response, HLA-G, directly to dendritic cells using microscopic beads. This approach shows promise in creating 'designer' immune cells that can tolerate transplanted organs. The therapy could potentially replace current anti-rejection drugs and improve pa...
Researchers at UC Davis have visualized the formation of a new synapse using neuroligin, a protein linked to autism. The study reveals the dynamic process of molecule recruitment, showing how neuroligin stabilizes adhesion between neurons and recruits other proteins important for synapse function.
Scientists identified a protein that regulates mitochondrial movement in brain cells, shedding light on how the brain recovers from stroke. Understanding this mechanism may help identify novel approaches for preventing and treating neurological disorders.
Scientists have discovered a novel signaling pathway in dendritic cells that can be activated by bacterial fragments, leading to the activation of NFAT and triggering an immune response. This discovery has identified potential new therapeutic targets for diseases such as sepsis and chronic heart failure.
Researchers have developed a new computer simulation model that captures the human immune response to influenza type A, predicting treatment design and pandemic preparedness. The model reveals that drugs and vaccines targeting dendritic cell presentation of antigens have a significant impact on patient outcomes.
Researchers discovered a new mechanism that affects the immune system's ability to respond to certain vaccine components. The study found that low-stability peptide:MHC class II complexes support initial T cell expansion, but competitive responses to immunodominant peptides stall the response.
Preclinical studies highlight PS-targeting antibodies' ability to reverse immune suppressing effects of tumors, change tumor microenvironment, and mobilize immune cells. These findings suggest that PS-targeting antibodies facilitate a cytokine shift in the tumor environment, encouraging multiple types of immune system cells to mount an...
Researchers discovered a sorting mechanism that filters proteins into dendrites and axons, enabling finer control over neurons. The study's findings may enable more precise targeting of neurological disorders and basic research applications.
Researchers used microscopy to study neuron growth in Caenorhabditis elegans and found that certain neurons work backward from their destination. The discovery suggests that the brain is wired based on connectivity rather than absolute distance, providing an explanation for how the brain grows in proportion to the organism.
Research suggests that dendritic cells are essential for generating and maintaining immunological tolerance. Without these cells, the immune system fails to distinguish between self and foreign substances, leading to autoimmune responses. This study highlights the critical role of dendritic cells in protecting against autoimmune diseases.
Scientists have discovered a compound called zymosan that can respond to two different receptors in dendritic cells, sending both stimulatory and calming messages. This finding could guide the development of vaccines against infectious agents and potentially boost the immune system's ability to fight chronic infections.
Duke researchers found that a blood-derived lymph node dendritic cell type plays a key role in developing acute T-cell responses. This discovery challenges traditional views on dendritic cell function and has implications for vaccine science and autoimmune disease therapy development.
Scientists at North Carolina State University have found that Lactobacillus acidophilus can deliver vaccines into the small intestine, where they trigger an immune response. The approach could potentially be used to create oral vaccines for other viruses and pathogens.
Researchers aim to teach the immune system to ignore insulin-producing cells by boosting IDO levels. By enhancing this natural mechanism, they hope to slow or prevent disease progression in high-risk children. A new treatment approach could provide a breakthrough in preventing type 1 diabetes.
Researchers identify eotaxin as a novel target for new class of allergy medications, which may help alleviate symptoms of asthma and other allergies. The study's findings could lead to breakthroughs in understanding the severity of allergic reactions and developing effective treatments.
Researchers at Cedars-Sinai Medical Center developed a gene therapeutic approach that results in tumor regression and long-term survival. The approach uses proteins to draw dendritic cells into the brain tumors, stimulate an anti-tumor response, and increase survival time by six months.