Articles tagged with Endothelial Cells
Scientists have discovered a new relationship between the enzyme PDIA1 and Drp1 that drives endothelial cell damage in diabetes. Restoring a healthy balance of PDIA1 and Drp1 may provide new treatment targets for diseases associated with endothelial cell senescence.
Researchers found that stabilizing dysfunctional endothelial cells with approved drugs reverses cellular dysfunction in a rat model of cerebral small vessel disease. The study suggests a potential new treatment for vascular dementia, which is a major cause of cognitive disability in the elderly.
Researchers have identified a new gene-activation pathway caused by lipids associated with coronary artery disease, which could help identify new directions in research and drug development. The study found that exposure to lipids activates the MTHFD2 gene in the walls of blood vessels.
Researchers at the University of Helsinki have identified a monoclonal antibody that inhibits capillary leakage in sepsis. The antibody targets β1-integrin, a key molecule in endothelial cells, and improves junctions between endothelial cells, decreasing vascular leakage and protecting against sepsis-induced heart failure.
Researchers found that e-cigarette flavorings impaired nitric oxide production in endothelial cells, leading to increased inflammation and oxidative stress. The study suggests that flavoring additives may have serious health consequences, particularly for youth tobacco users.
A novel scaffold enables programmed deformation of 2D cell-laden structure to 3D tubular shape, facilitating facile 3D endothelialization. The study offers a new method for creating tissue-engineered vascular grafts and a potential in vitro model for screening cardiovascular drugs.
Researchers at Goethe University Frankfurt found that single cells in the innermost layer of blood vessels proliferate after injury and contribute to the formation of new vessels. This process, known as clonal expansion, is thought to play a significant role in tissue damage repair, such as in diabetes or heart attacks.
A new biomarker identified a 'window of opportunity' for cancer chemotherapy timing, optimizing the effectiveness of anti-angiogenic and anticancer drug combinations. The biomarker, CD109 expression in vascular endothelial cells, correlates with tumor cell growth and enables the visualization of proliferating blood vessels.
Scientists at Johns Hopkins Medicine have made significant breakthroughs in understanding the underlying biology behind pulmonary hypertension. By studying endothelial cells, they discovered that KLF15 protects these cells from damage caused by low oxygen levels, which can lead to blood vessel damage and progression of the disease.
Researchers discovered a glitch in muscle-blood vessel communication that causes vascular aging, which they reversed using NAD+ and SIRT1-boosting treatments. The findings have implications for therapies targeting humans with vascular aging disorders.
Researchers developed nanoparticles to target liver sinusoidal endothelial cells with miR-20a, restoring normal behavior and reducing tumor growth. The study found an 80% reduction in liver metastasis caused by colon cancer, highlighting a potential complementary treatment strategy.
A team of researchers from Osaka University has identified adult endothelial stem cells capable of generating fully functional blood vessels. The discovery was made by isolating a population of endothelial cells expressing the glycoprotein CD157 and testing their ability to form new blood vessels in injured mice.
Researchers created an organ-on-a-chip model of the human gut to mimic radiation damage and tested a potential radioprotective drug, DMOG. The study found that DMOG significantly reduced cell damage, apoptosis, and intestinal permeability in both epithelial and endothelial cells.
Researchers created Organ Chips to overcome limitations of organoids, enabling the study of dynamic processes and interactions with the microbiome. The innovation allows for highly personalized investigations into nutrient transport, digestion, and disease-related processes.
Scientists at IIT fabricated an artificial device reproducing the blood-brain barrier, a structure protecting the central nervous system. The device is composed of artificial and biological components and will be fundamental for studying new therapeutic strategies to overcome the blood-brain barrier.
Scientists have detailed the normal human blood-nerve barrier transcriptome for the first time, revealing 12,881 RNA transcripts that define its structure and function. This comprehensive guide will help physicians understand how to keep nerves healthy and design targeted treatments for peripheral nerve disease.
Researchers have developed a method to selectively mark multipotent stromal cells in mice using the CD73 gene, allowing for the analysis of their distribution pattern and function in living organisms. This breakthrough enables the study of these stem cells in their original state, providing insights into their role in regenerative medi...
Researchers have developed a microfluidic device that emulates the human blood-retinal barrier, allowing for the study of its structure and physiological conditions. The device enables cells to communicate and interact with each other like in a living organ, making it an essential tool for boosting in vitro experimentation.
Researchers discovered synthetic APC-mimicking small molecules called 'parmodulins' provide anti-inflammatory and anti-thrombotic protection on par with APC, but without interfering with blood clotting. Parmodulins activate PAR1, triggering protective pathways in endothelial cells.
A new stem cell method creates human arterial endothelial cells from cord blood and adult bone marrow, revealing two distinct states: healthy and compromised. The compromised state is linked to arteriosclerosis and can be used to study a major risk factor for heart disease.
Researchers have developed an organ-on-a-chip device that accurately models atherosclerosis, allowing them to study inflammatory responses in cells lining blood vessels. The device can also be used to diagnose early immune responses in patients, providing a more accurate assessment of blood health.
In diabetes, copper excess hinders angiogenesis, leading to impaired blood flow and increased risks of heart attacks and nerve death. Researchers are exploring ATP7A's therapeutic potential to restore healthy copper balance and improve vascular repair functions.
Scientists discovered a new cell signaling pathway governed by Notch signaling protein that keeps blood vessels intact, which could lead to better drug development and reduce side effects of cancer and cardiovascular treatments. The new pathway operates through a different mechanism than the protein's known transcription-based pathway.
A study found that corneal donor tissue can be preserved for up to 11 days without affecting graft success rates. The researchers analyzed data from over 1,000 individuals and found that longer preservation times did not significantly impact the success of corneal transplantation.
Researchers from UW-Madison detail a defined process to make an exact mimic of the human blood-brain barrier in a laboratory dish. This breakthrough allows for more robust exploration of cells and their properties, paving the way for new therapeutic strategies.
Scientists identify protein disulfide isomerase (PDI) as a key therapeutic target to improve blood vessel health in diabetes. PDI regulates angiogenesis, wound healing and mitochondrial function, offering new potential treatments.
Scientists at Emory University School of Medicine have developed a method for generating endothelial cells from human induced pluripotent stem cells, which can survive for over 10 months when surrounded by a supportive gel. This breakthrough could lead to new treatments for peripheral artery disease.
Researchers have identified adenosine receptor A2a as a potential target for reducing dysfunctional blood vessel development in the eye. Blocking this receptor has been shown to inhibit pathological angiogenesis and promote healthy blood vessel formation, offering new hope for treating diabetic retinopathy.
Researchers have identified a gene that may provide potential therapy for cerebral cavernous malformations (CCMs), a condition characterized by enlarged and irregular blood vessels in the central nervous system. The study suggests using angiogenesis inhibitors, such as TSP1, to treat or prevent CCMs.
Researchers at IBS and KAIST found that YAP/TAZ promotes cytoskeleton remodeling and junction formation in endothelial cells, essential for normal as well as pathological angiogenesis. Overexpression of YAP/TAZ leads to excessive blood vessel growth, while removal results in vision impairment and internal bleeding.
Researchers designed a therapeutic fusion protein that triggers increased S1P receptor activity, recovering blood vessel health in mice with various vascular diseases. The combination of ApoM-Fc and S1P reduced blood pressure and mitigated tissue damage.
Scientists at the University of Würzburg discovered differences in gene expression between embryonic endothelial cells of the central nervous system and other organs, shedding light on the blood-brain barrier's development and maturation. The study also identified transcription factors involved in this process.
Researchers found that a receptor called Notch is crucial in the process of artery formation, directing sprouting cells into developing arteries. The study provides new insights into how vascular networks are established and may lead to identifying new therapeutic approaches to stimulate growth of new arteries after organ injury.
A recent study published in the International Journal of Radiation Biology found that low doses of radiation can cause permanent alterations in coronary artery endothelial cells, leading to reduced nitric oxide production and increased oxidative stress. This damage can result in long-term premature dysfunction and an increased risk of ...
Researchers from Rice University and Baylor College of Medicine have demonstrated a key step in generating implantable tissues with functioning capillaries. They used human endothelial cells and mesenchymal stem cells to initiate tubulogenesis, crucial for blood-transporting capillary formation.
Researchers have successfully produced functional arterial cells using new techniques, exhibiting key functions required by the body. Mice treated with these cells showed an 83% survival rate, compared to 33% for controls, and demonstrated improved artery formation and survival.
Researchers discovered that endothelial cells lining blood vessels are not as effective at removing invading bacteria via xenophagy, a process used by epithelial cells. The study suggests that targeting the ubiquitination pathway could lead to new approaches for fighting infections like GAS.
Ca2+ plays a crucial role in arteriolar function by triggering vasodilation through endothelial cells. The magnitude of these signals depends on IP3 receptors.
A laboratory study reveals that e-cigarette vapour has no effect on wound healing, whereas cigarette smoke completely prevents it at concentrations over 20%. The test used the scratch test to compare the effects of smoke extract and vapour extract from two commercial e-cigarettes.
Scientists developed an organ-on-a-chip model that mimics human retinal cells and vascular endothelial cells. The model replicates neovascularization in wet-type age-related macular degeneration, offering a potential alternative to animal models for disease modeling and drug screening.
Rice University scientists have discovered a way to selectively open gaps in blood vessel barriers, allowing large molecule drugs to reach targeted tissues. The technique uses magnets to manipulate nanoparticles and alter the endothelial cell's structure, creating temporary 'leakiness' that can be controlled.
New research at Karolinska Institutet reveals the role of Endoglin protein in vascular formation and malformation, leading to potential treatments for vascular diseases. The study also found that reducing vascular malformation can be achieved by manipulating endothelial cells.
A new biomarker has been identified that can predict the risk of lung disease and death in extremely preterm infants. The biomarker is related to endothelial mitochondrial function, which can be measured using umbilical cord cells collected at birth.
A collaborative research group found that histone code changes and a transcription factor group essential for blood vessel differentiation play key roles in vessel formation. They also discovered that the regulatory genomic region of the transcription factors has gradually switched from suppressing to activating transcription.
Researchers at Weill Cornell Medicine have developed a method to generate healthy blood-forming stem cells from readily available cells lining blood vessels. This breakthrough enables the creation of an unlimited supply of new, healthy blood cells for transplantation, which may help cure patients with genetic and acquired blood diseases.
Dr. Michael A Gimbrone, Jr has made significant contributions to the field of vascular biology through his research on endothelial cells and the development of methods for culturing these cells. His work has led to a paradigm shift in our understanding of vascular diseases and has paved the way for countless studies and discoveries.
Researchers have determined that fluorescent granular perithelial cells, which protect the brain against diseases, arise from endothelial cells in the circulatory system. This finding may contribute to understanding cognitive decline of aging and HIV infection of brain cells.
Researchers at St. Jude Children's Research Hospital have identified trunk neural crest cells as key players in the development of blood-forming stem cells, which can produce any type of blood cell. This discovery may lead to new avenues for investigating stem cell biology and improving access to bone marrow transplantation.
White blood cells use their nuclei to exert force and insert themselves between endothelial cells, creating large holes in the blood vessel walls. This discovery sheds light on the movement of immune cells and may aid in cancer research.
Scientists at Lund University have developed a new understanding of how human blood cells form during embryonic development, showing that endothelial cells undergo dramatic changes to become blood cells. The research provides critical insights into the origins of blood and its regulation in development.
Researchers found that non-toxic amounts of ammonia increase the production of heme oxygenase-1 (HO-1), which protects endothelial cells and prevents plaque buildup. Glutamine, an amino acid supplement, triggers this natural response.
Researchers discovered that human umbilical endothelial cells are more susceptible to Zika infection, allowing it to access the fetal bloodstream. The virus uses a cell surface molecule called AXL to exploit a secret passage, enabling it to cause birth defects such as microcephaly and eye damage.
Researchers discovered that immune cells use an active process to create gaps in blood vessel walls, involving the breakage of thin filaments and rapid reassembly. This process allows immune cells to squeeze through and survey organs for problems or join the fight against pathogens.
Scientists have discovered that a man-made version of soluble gp130, or sgp130, can inhibit inflammation in the eye and prevent retinal destruction associated with diabetes. The new molecule, called sgp130-Fc, has been shown to reduce inflammation and improve vision in mouse models of diabetic retinopathy.
Researchers developed a microfluidic device that overcomes previous models of the blood-brain barrier, allowing for study of brain inflammation and its link to neurodegenerative conditions. The device was successfully tested with flying colors, paving the way for use in testing new drugs and compounds.
Scientists have discovered PIEZO1, a cation channel in the inner layer of blood vessel walls, which translates mechanical stimuli into molecular responses controlling vessel diameter. This finding could lead to the treatment of high blood pressure by activating PIEZO1 pharmacologically.
Researchers at the University of Strathclyde are developing miniature optical techniques to visualize the endothelium, a complex sensory system that monitors blood pressure and flow rates. The technology aims to revolutionize our understanding of vascular disease, including hypertension and atherosclerosis.
Researchers discovered that a protein called SPARCL1 can prevent the formation of new blood vessels, inhibiting tumor growth in patients with a good prognosis. In contrast, tumors with poor prognoses lack this protein, leading to continued tumor growth.
For the first time, researchers have identified rapidly proliferating cells in the corneal endothelium of specimens from normal corneas and those with Fuchs' Endothelial Corneal Dystrophy (FECD). This discovery holds promise for new therapies to be developed using these cells to return normal clearing abilities to patients with FECD.
Cancer cells use DR6 to kill endothelial cells, allowing them to slip through the vascular wall and form metastases. This process is known as necroptosis, which enables cancer cells to overcome an endothelial cell layer in the laboratory and in living organisms.