Researchers at HKUST have identified novel molecular targets for Alzheimer's drug development, focusing on endothelial cells and microglia. The study reveals a link between blood vessel dysregulation and AD pathogenesis, as well as potential therapeutic interventions through the cytokine IL-33.
SourceHong Kong University of Science and Technology·JournalProceedings of the National Academy of Sciences·DateNov 5, 2020
Scientists have discovered a novel mechanism to increase arterial diameter by selectively increasing endothelial cell size, allowing for rapid increases in blood flow. This approach has significant advantages over conventional angiogenesis methods, enabling faster restoration of blood flow and oxygen delivery.
SourceKarlsruher Institut für Technologie (KIT)·JournalNature Communications·DateOct 28, 2020
Researchers found that exosomes secreted by cardiac cells derived from human induced pluripotent stem cells improved myocardial recovery and reduced arrhythmia in pigs. The treatment showed regenerative benefits equivalent to injecting living cells, without increasing the risk of tumorigenesis.
SourceUniversity of Alabama at Birmingham·JournalScience Translational Medicine·DateSep 29, 2020
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at North Carolina State University developed a prototype vascular graft that combines synthetic fibers and collagen filaments to aid in regeneration of the coronary artery lining. The design showed improved strength, flexibility, and biological response compared to previous models.
SourceNorth Carolina State University·JournalMaterials Science and Engineering C·DateSep 29, 2020
Recent studies suggest COVID-19 may cause a range of cardiovascular problems, from mild cell damage to life-threatening cardiogenic shock. The causes of these heart issues are still unknown, with factors such as inflammation response and autoimmune phenomena being investigated.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateSep 23, 2020
A new bioengineering technique called CardioCluster has shown promise in improving heart function after a heart attack by reducing scar tissue. The clusters of mesenchymal stem cells, endothelial progenitor cells, and cardiac interstitial cells persist in the heart walls for up to five months.
SourceSan Diego State University·JournalNature Communications·DateSep 15, 2020
Scientists have identified new genes that are overexpressed in endothelial cells of people with Down syndrome, increasing their risk for leukemia. The study suggests these genes could be therapeutic targets for developing novel treatments and prevention strategies.
SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalOncoTargets and Therapy·DateSep 8, 2020
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A University of Houston researcher has identified sphingomyelinase as a key player in the development of obesity-induced cardiovascular disease. The study aims to develop therapeutic strategies for treatment or prevention of this condition, which affects millions worldwide.
Scientists have identified new points to calm frenzied energy production in the retina, enabling recovery. The excessive byproducts of glycolysis initiate a vicious loop of crosstalk between endothelial cells and microglia, promoting inflammation and dysfunctional blood vessels.
SourceMedical College of Georgia at Augusta University·JournalScience Translational Medicine·DateAug 10, 2020
Researchers developed a novel two-step targeting strategy to selectively deliver therapies to the brain by exploiting the high impermeability of the BBB. This approach allows for specific brain targeting with minimal accumulation in peripheral organs, paving the way for increased clinical translation of nanoparticle-based therapies.
SourceInnovation Center of NanoMedicine·JournalProceedings of the National Academy of Sciences·DateJul 26, 2020
A new optical coherence tomography (OCT) instrument has been developed to image the curved layers of the cornea with cell-level detail, enabling improved monitoring of eye diseases and general health conditions. The device provides a large viewing area, allowing for more precise counting of cells and nerves.
Researchers identify a protein called BafA produced by bacteria that induces angiogenesis in human endothelial cells, leading to the formation of new blood vessels and lesions. The discovery opens new possibilities for studying angiogenesis and developing diagnostic and therapeutic strategies for bartonellosis.
SourceFujita Health University·JournalNature Communications·DateJul 16, 2020
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers found that mice with a common genetic mutation in autism spectrum disorder had delayed and weaker blood vessel responses, which led to neuronal dysfunction and autistic traits. The study suggests that problems with blood vessels begin early in life and can contribute to the development of autism.
SourceThe Ottawa Hospital·JournalNature Neuroscience·DateJul 13, 2020
miR-151a regulates endothelial cell motility and angiogenesis, with Slug expression required for these functions, providing new insights into the processes in the lung niche environment. The study highlights the potential of miR-151a as a therapeutic target against lung cancer.
SourceImpact Journals LLC·JournalOncotarget·DateJun 10, 2020
Researchers discovered a microRNA named miR-126-5p that protects endothelial cells from damage and reduces atherosclerosis risk. By inhibiting caspase-3 activity, miR-126-5p maintains vascular integrity and prevents the development of atherosclerotic lesions.
SourceLudwig-Maximilians-Universität München·JournalScience Translational Medicine·DateJun 4, 2020
Scientists at Temple University Health System discovered a novel mechanism between mitochondrial fission and endothelial cell inflammation. Salicylate reduces mitochondrial fragmentation, inflammation, and oxidative stress in the cardiovascular system.
Researchers developed a miniature human vein device called Vein-Chip to study changes in vein wall cells and blood flow that lead to DVT. The technology allows for testing various factors such as gender and ethnicity to predict DVT risk, paving the way for personalized therapies.
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at CNIC have identified an inflammatory regulatory circuit controlled by endothelial cells in the eye, which may regulate retinal vascular diseases and inflammatory disorders. The discovery provides new perspectives on treating conditions like age-related macular degeneration (AMD).
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalJournal of Experimental Medicine·DateMar 20, 2020
A team of scientists at Hong Kong University of Science and Technology develops a novel optical technique to label single hemogenic endothelium cells in zebrafish embryos and track their descendants. The technology uses infrared laser-evoked gene operator (IRLEGO) to achieve precise single-cell labeling, overcoming previous limitations.
SourceHong Kong University of Science and Technology·DateMar 12, 2020
A study has created a database on endothelial cells, which may enhance our understanding of the complex network of blood vessels in the mammalian body. The research team identified 78 endothelial cell subclusters, including unexpected subtypes, that can inform the development of new treatments for diseases.
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at the University of Illinois Chicago have identified distinct genetic profiles for endothelial cells in various organs, including heart, brain, and lungs. These findings suggest that targeting specific blood vessels could lead to more effective treatments for vascular diseases, such as Alzheimer's disease.
Researchers developed an advanced blood vessel model to study progeria, a devastating genetic disease. The model shows that the endothelium, not just smooth muscle cells, plays a crucial role in progeria symptoms, and dynamic 3D models are necessary to understand its effects.
SourceDuke University·JournalStem Cell Reports·DateFeb 6, 2020
Researchers propose evaluating vascular function in women starting in middle age to detect early signs of vascular aging and reduce heart disease risk. This approach could help establish a baseline of vascular health, measure effectiveness of lifestyle changes and clinical treatment for cardiovascular disease.
SourceMayo Clinic·JournalMayo Clinic Proceedings·DateFeb 5, 2020
Scientists create a bilayer platform that can alter surface topographies using shape-memory polymers and gold nanorods to promote cell polarization and collective migration of vascular endothelial cells. This approach enables dynamic manipulation of cell functions, mimicking the native ECM-mediated effects in the human body.
SourceScience China Press·JournalNational Science Review·DateFeb 5, 2020
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A new vasculogenic niche contributes to cardiac lymphatic system development, with cells originating from different tissues. The coronary lymphatic vessels have varied origins and functions.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalDevelopmental Cell·DateJan 9, 2020
Researchers at Osaka University discovered that ESAM, a surface marker for hematopoietic stem cells and vascular endothelial cells, is crucial for the development of definitive hematopoiesis, especially adult-type erythropoiesis. The study found that ESAM-deficient mice had impaired hematopoiesis-supporting ability.
SourceOsaka University·JournalStem Cell Reports·DateDec 26, 2019
Researchers developed a remote-controlled 'smart' platform to mimic natural extracellular matrix-mediated endothelialization. The platform uses shape-memory polymers and gold nanorods to direct programmed vascular endothelium remodeling in a temporally controllable manner, offering new possibilities for treating cardiovascular disease.
SourceChinese Academy of Sciences Headquarters·JournalNational Science Review·DateDec 3, 2019
Researchers at Wyss Institute for Biologically Inspired Engineering developed an AAV-based gene therapy that targets leaky lung cells by overexpressing the CD98hc protein. This approach shows great promise in reducing vascular leakage and improving lung function, offering a new hope for treating pulmonary edema.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalAPL Bioengineering·DateDec 2, 2019
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin complete with blood vessels. The advancement brings researchers closer to creating grafts that are more like the skin our bodies produce naturally, which can accelerate wound healing and improve patient outcomes.
Scientists fabricate multilayer blood vessels with unique biomolecules that transform into functional blood vessels when implanted. The result is a fully functional blood vessel with enhanced strength and anti-thrombosis functions.
SourceAmerican Institute of Physics·JournalApplied Physics Reviews·DateOct 22, 2019
Researchers link high glucose levels to impaired circadian clock function in obesity, which may drive cardiovascular disease. Intermittent fasting and clock repair drugs show promise in restoring normal circadian rhythms and improving cardiovascular health.
SourceMedical College of Georgia at Augusta University·DateOct 22, 2019
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Research reveals how breast cancer cells use exosomes to bypass the blood-brain barrier and spread to the brain. Exosomes trick endothelial cells into taking them up, allowing cancer cells to metastasize, and can also manipulate astrocytes to facilitate tumor growth.
A Yale-led study reveals that transforming growth factor beta (TGFß) proteins trigger inflammation in endothelial cells, leading to plaque buildup and atherosclerosis. Disrupting TGFβ receptors with RNAi drug reduces inflammation and plaque effectively.
SourceYale University·JournalNature Metabolism·DateAug 26, 2019
Researchers develop a high-resolution printing method to create complex tissue shapes in a biocompatible hydrogel containing stem cells. The resulting tissue can be vascularized by adding endothelial cells, enabling the creation of functional bioprinted organs with unprecedented speed and design freedom.
SourceEcole Polytechnique Fédérale de Lausanne·JournalAdvanced Materials·DateAug 23, 2019
A new mathematical model reveals that breast cancer cells can change shape to facilitate spreading to other parts of the body. The researchers also found that these cells can cross the endothelium barrier with greater ease, which is a critical step in metastasis.
SourceBeth Israel Deaconess Medical Center·JournalScientific Reports·DateJul 17, 2019
Scientists at the University of Edinburgh have developed a system to study endothelial cells, which line blood vessel walls. This breakthrough could lead to therapies that promote new blood vessel growth and help treat conditions like heart disease.
SourceUniversity of Edinburgh·JournalEuropean Heart Journal·DateJun 26, 2019
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new microfluidic organ chip model of the human blood-brain barrier has been developed, allowing for in vivo-like transport of drugs and therapeutic antibodies. The model recapitulates the physical barrier functions and transport abilities of the human BBB, offering a significant advance in drug development.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Communications·DateJun 13, 2019
Research reveals pressure-sensing protein piezo 1 plays a key role in lung edema development. Suppressing its activity or bolstering adherens junctions may prevent fluid entry into the lungs.
SourceUniversity of Illinois Chicago·JournalProceedings of the National Academy of Sciences·DateJun 11, 2019
Researchers used stem cells to investigate the impact of e-liquids on cardiovascular disease, revealing that cinnamon and menthol flavors are the most toxic. The study found that acute exposure to flavored e-liquids worsens endothelial dysfunction, which often precedes cardiovascular diseases.
SourceUniversity of Arizona Health Sciences·JournalJournal of the American College of Cardiology·DateMay 28, 2019
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new study found that exposure to flavored e-cigarette liquids and e-cigarette use exacerbate endothelial cell dysfunction, a key risk factor for heart disease. The researchers observed pro-inflammatory markers and toxic effects on cells from various e-liquids.
SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·DateMay 27, 2019
A Stanford-led study found that e-cigarette flavorings may increase the risk of cardiovascular disease when inhaled. The researchers discovered that certain flavors, such as cinnamon and menthol, were particularly harmful to endothelial cells, which line the interior of blood vessels.
SourceStanford Medicine·JournalJournal of the American College of Cardiology·DateMay 27, 2019
Researchers at Wake Forest Institute for Regenerative Medicine have successfully engineered vascularized functional renal tissues using a novel biomimetic scaffold. The study's findings suggest that this approach may be a more feasible and practical treatment strategy for patients with chronic kidney disease.
SourceAtrium Health Wake Forest Baptist·JournalActa Biomaterialia·DateMay 22, 2019
Researchers found that cancer cells can capitalize on temporary gaps in endothelial cell layers caused by physical forces and mechanical stresses, allowing them to migrate through and colonize new organs. This opportunistic approach complements chemical signaling and enables cancer cells to spread more efficiently.
SourceUniversity of Birmingham·JournalPLOS Computational Biology·DateMay 2, 2019
Researchers discovered that tumors subvert endothelial cells' ability to form new blood vessels, using microRNA to control gene expression. Delivering this microRNA to endothelial cells in mice slowed tumor growth and reduced blood vessel formation.
SourceUniversity of Virginia Health System·JournalJournal of Clinical Investigation·DateMay 1, 2019
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at UT Southwestern have found that SR-B1 and DOCK4 proteins ferry LDL particles into and across endothelial cells, driving the development of atherosclerosis. Deleting these proteins from endothelial cells reduces LDL entry and atherosclerotic plaque formation.
SourceUT Southwestern Medical Center·JournalNature·DateApr 24, 2019
A Kanazawa University study reveals that RAGE binds to oxytocin, facilitating its transport through the blood-brain barrier and central nervous system. The findings show that oxytocin plays a crucial role in maternal nurturing behaviors, with reduced survival rates observed in offspring when mothers lack functional RAGE.
SourceKanazawa University·JournalCommunications Biology·DateApr 3, 2019
Researchers at UVA Health System found that perivascular cells are essential for complete blood vessel formation. The discovery offers new direction for treating conditions like diabetes and heart attacks by growing functional blood vessels.
SourceUniversity of Virginia Health System·JournalNature Communications·DateMar 13, 2019
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers created a 3D vascularized proximal tubule model to study renal reabsorption outside the human body. The model exhibited functional epithelial and endothelial cell morphologies and transported glucose effectively, allowing for the testing of drugs and modeling of diseases.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalProceedings of the National Academy of Sciences·DateMar 4, 2019
Researchers at Florida State University have discovered that a natural immune system response can cause further harm after a spinal cord injury. The study found that the process of clearing myelin debris from the injury site can lead to inflammation and the formation of abnormal blood vessels, inhibiting recovery.
SourceFlorida State University·JournalNature Neuroscience·DateJan 21, 2019
A study published in Developmental Cell reveals that TAK1 preserves endothelial cell survival in an inflammatory environment, suggesting its potential as a target for anti-angiogenic therapy. The researchers used a unique mouse model to show that TAK1 is essential for endothelial cell survival during inflammation and injury.
SourceOsaka University·JournalDevelopmental Cell·DateJan 17, 2019
Aging endothelium displays reduced vasomotor functions and angiogenic capabilities due to increased oxidative stress. Lifestyle factors like exercise and omega-3 intake influence Endothelial Progenitor Cells (EPCs), which support endothelial health and function.
SourceBentham Science Publishers·JournalCurrent Cardiology Reviews·DateDec 27, 2018
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A recent study discovered a non-coding genetic variant, rs17114036, that enhances endothelial response to blood flow, reducing the risk of coronary artery disease. This variant is associated with increased expression of phospholipid phosphatase 3 (PLPP3), which promotes vascular health.
SourceUniversity of Chicago Medical Center·JournalProceedings of the National Academy of Sciences·DateNov 14, 2018
Researchers are creating three-dimensional models of blood vessels using pig arteries and human endothelial cells to study fibroblast behavior. This could provide a powerful tool for diabetes basic research and drug screening systems.
Research suggests that leptin levels play a crucial role in protecting the cardiovascular system from damage. When leptin levels are optimal, they help restore balance to the body's physiological processes, reducing inflammation and oxidative stress.
SourceMedical College of Georgia at Augusta University·DateOct 29, 2018
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at the University of Nottingham have discovered a characteristic of the Descemet membrane that can cause difficulties for surgeons performing corneal transplants. The study found that elastin, an elastic-like fiber, governs the direction of the membrane's roll and may be responsible for its unidirectional behavior.
SourceUniversity of Nottingham·JournalAmerican Journal of Ophthalmology·DateSep 30, 2018
A UCI research team found that brain endothelial cells can engulf and deposit red blood cells outside of blood vessels without a blood vessel tear. This discovery could lead to new efforts to eliminate brain bleeding and its consequences.
SourceUniversity of California - Irvine·JournalFrontiers in Cellular Neuroscience·DateSep 25, 2018
Dr. Ming-Hui Zou's research focuses on how high glucose affects mitochondria, leading to atherosclerosis and endothelial dysfunction in diabetes. The study aims to understand the cellular mechanisms behind these complications and explore potential self-defense mechanisms.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers at the University of Basel have found that endothelial cells can migrate within vessel sprouts while remaining firmly attached to each other. This process allows for the formation of a complex network of blood vessels that pass through the body from head to toe.
SourceUniversity of Basel·JournalNature Communications·DateSep 3, 2018
Researchers identified three key proteins that determine blood vessel growth and behavior, which may become new therapeutic targets. A novel approach focusing on endothelial cell metabolism could outperform current anti-VEGF therapies in efficacy.
SourceVIB (the Flanders Institute for Biotechnology)·JournalNature·DateAug 30, 2018
Researchers discovered that endothelial cells instruct neurons on their correct positioning in the cerebral cortex through laminin secretion. This finding highlights the importance of neurovascular communication in brain development and may hold key to treating dementia and mental illness.
SourceGoethe University Frankfurt·JournalScience·DateAug 23, 2018