Researchers at MCG's Vascular Biology Center have identified a new treatment target for age-related macular degeneration (AMD), a leading cause of blindness. Targeting the adenosine receptor 2A (Adora2a) may block excessive blood vessel growth and fibrosis, potentially offering a more efficient treatment than current therapies.
SourceMedical College of Georgia at Augusta University·JournalScience Translational Medicine·DateMay 2, 2024
Researchers from Osaka University found that influenza-associated brain disorders may be caused by the virus entering the brain and producing proteins. Antivirals blocking protein production are unlikely to be effective, but those targeting transcription and translation may offer hope for treatment.
SourceOsaka University·JournalActa Neuropathologica·TypeExperimental study·DateMay 2, 2024
Researchers investigate senescence phenotypes of human corneal endothelial cells upon treatment with ultraviolet (UV)-A. Cells exhibit enlarged morphology, increased β-galactosidase activity and decreased proliferation. UV-A-induced senescent cells show similar gene expression profiles to ionizing radiation (IR)-induced cells.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateApr 30, 2024
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers at Weill Cornell Medicine have discovered a way to boost protective effects of sphingolipids in blood vessels, slowing the development and progression of coronary artery disease. The study suggests revising current views on ceramides' role in the disease, instead finding that their levels remain stable in endothelial cells.
SourceWeill Cornell Medicine·JournalCirculation Research·DateApr 24, 2024
Two anti-inflammatory molecules, TGFβ1 and HpTGM, reduce the inflammatory response within the injured heart and scarring. Treatment with these proteins at the time of reperfusion reduces infarct size and mature scar size.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateApr 4, 2024
Researchers at IBEC have created in vitro models of neuroblastoma vasculature, replicating the tumor's characteristic blood vessel formation and identifying GB3 as a potential therapeutic target. The study uses stiffness-based models and microfluidic chips to explore treatments for this pediatric cancer.
SourceInstitute for Bioengineering of Catalonia (IBEC)·JournalCancers·TypeExperimental study·DateMar 25, 2024
Researchers have mapped the protein composition of brain endothelial cells, revealing dysregulation of key molecules involved in cellular processes. This study provides a framework for understanding endothelial signaling pathways during aging and serves as a data basis for future analyses of brain endothelial function.
SourceLudwig-Maximilians-Universität München·JournalNature Aging·TypeExperimental study·DateMar 22, 2024
A new study found that a viral infection can cause cognitive impairments by damaging the blood-brain barrier, leading to memory loss and learning difficulties. Researchers developed a gene therapy that stimulated the Wnt/beta-catenin pathway to prevent this damage and improve cognitive function in mice infected with SARS-CoV-2.
SourceUniversity of Illinois Chicago·JournalBrain·DateMar 21, 2024
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers have found two proteins, SOX17 and FGF2, that can efficiently mature stem cells into endothelial cells, forming tubular-like vessels. This breakthrough could enable the growth of lab-grown vascular tissue to support heart transplants and develop artificial blood brain barriers for neurological drug testing.
SourcePenn State·JournalStem Cell Reports·TypeExperimental study·DateMar 21, 2024
A study by University of Barcelona researchers reveals that TDP-43 protein is essential for forming stable blood vessels and maintaining the blood-brain barrier, which prevents toxins from reaching the central nervous system. Deficiency in this protein leads to vascular defects and neuroinflammation.
SourceUniversity of Barcelona·JournalJCI Insight·TypeExperimental study·DateMar 13, 2024
Researchers found that FOXO1 translocates to the nucleus specifically in Tip cells upon prolonged VEGF stimulation, guiding vascular branching. This activation triggers the expression of genes determining Tip cell fate and inhibits NOTCH signaling in stalk cells.
SourceKumamoto University·JournaliScience·TypeExperimental study·DateMar 8, 2024
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
SourceLehigh University·JournalJournal of Biomedical Materials Research·DateMar 4, 2024
Researchers have developed a new gene mapping technique that reveals how genetic alterations in cells lining blood vessels contribute to coronary artery disease. The technique, called Variant-to-Gene-to-Program (V2G2P), identifies biological mechanisms driving CAD risk by linking genetic variants to gene expression and function.
SourceBrigham and Women's Hospital·JournalNature·TypeObservational study·DateFeb 7, 2024
A novel reporter cell experimental system enables the visualization of sequential changes during endothelial-mesenchymal transition (EndoMT) induced by transforming growth factor-β. Researchers identified CD40 as a potential partial EndoMT marker, which suppresses the transition from partial to full EndoMT.
SourceTokyo Medical and Dental University·JournalCancer Science·TypeExperimental study·DateFeb 7, 2024
A new study found that nicotine-free vape fluid can increase inflammation and oxidative stress in the lungs, causing damage similar to patients with lung injury. The research identified a protein called ARF6 as a key regulator of this damage.
SourceAnglia Ruskin University·JournalMicrovascular Research·TypeRandomized controlled/clinical trial·DateJan 18, 2024
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A pioneering study published in The American Journal of Pathology reveals the cytoprotective and proregenerative effects of neuropeptide α-MSH in promoting corneal healing after eye injury. The treatment has shown impressive therapeutic potential in reducing the need for corneal transplants.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJan 2, 2024
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
SourceIowa State University·JournalNature Communications·TypeExperimental study·DateDec 19, 2023
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
A Brazilian study found that damage to small blood vessels in the lungs causes severe COVID-19. The researchers observed high prevalence of microscopic blood clots in lung endothelial cells, which led to organ damage and ischemic tissue injury.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Applied Physiology·DateDec 6, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at the Josep Carreras Institute have discovered a crucial protein, PI3K-C2b, that regulates mTORC1 signaling and angiogenic growth in blood vessels. This finding holds promise for developing new treatments for congenital vascular disorders.
SourceJosep Carreras Leukaemia Research Institute·JournalScience Signaling·TypeExperimental study·DateNov 29, 2023
Scientists at St. Jude Children's Research Hospital discovered that a fusion oncoprotein forces cells to become tumor-like, regardless of their original muscle or endothelial cell origin. The study suggests that focusing on the effects of this protein may be a better approach for identifying potential therapeutic interventions.
SourceSt. Jude Children's Research Hospital·JournalNature Communications·DateNov 15, 2023
A study from the University of Wisconsin-Madison and Academia Sinica of Taiwan has successfully combined lab-grown cardiomyocytes with stem-cell-derived endothelial cells to regenerate damaged heart muscle after a heart attack. This combination therapy holds promise for tackling arrhythmia and could lead to improved clinical applications.
SourceUniversity of Wisconsin-Madison·JournalCirculation·DateOct 31, 2023
A collaborative study has developed an agarose spot migration assay to examine the ability of extracellular vesicles to attract other cells in a controlled environment. The assay revealed differences in EVs' recruitment capability for endothelial cells, particularly in highly metastatic cancer cells.
SourceGermans Trias i Pujol Research Institute·JournalBMC Biology·TypeExperimental study·DateOct 31, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateOct 18, 2023
Researchers developed a human in vitro model of radiation-induced lung injury, closely mimicking the complexities of the disease. The Human Lung Alveolus Chip recapitulates hallmarks of RILI, including DNA damage, inflammation, and injury to lung cells and blood vessels.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Communications·TypeExperimental study·DateOct 17, 2023
Researchers have developed a synthetic peptide that could help reduce vascular problems associated with acute respiratory distress syndrome in COVID-19. The peptide, called TIP, works by binding to a subunit of the epithelial sodium channel, which helps maintain barrier function and prevent damage from viral proteins.
SourceMedical College of Georgia at Augusta University·JournalFrontiers in Immunology·DateOct 3, 2023
A new NIH grant will investigate the impact of combined alcohol and e-cigarette use on the blood brain barrier, a cell layer regulating substance passage into the central nervous system. The study aims to identify mechanisms behind damage and potential biomarkers for clinical use.
A study at the Technical University of Munich found that people with long Covid experience altered blood vessels in the eye, which could be used to diagnose the condition. Persistent inflammatory responses were also linked to symptom severity and chronic inflammation.
SourceTechnical University of Munich (TUM)·JournalAngiogenesis·TypeImaging analysis·DateSep 18, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
The study reveals that NO forms a new compound, NO-ferroheme, which significantly expands blood vessels and directly activates guanylyl cyclase. This finding challenges the long-held hypothesis on nitric oxide signalling in blood vessels.
SourceKarolinska Institutet·JournalNature Chemical Biology·TypeExperimental study·DateSep 14, 2023
UTHealth Houston researchers have developed a new mouse model for brain arteriovenous malformations (AVMs) that will be presented at the NIH meeting. The research explored how humoral immune mediators interact with cells surrounding the AVM and found insights into finding therapeutic methods.
SourceUniversity of Texas Health Science Center at Houston·DateSep 12, 2023
Researchers found that dietary AHR ligands from cruciferous vegetables, such as kale and broccoli, maintain a healthy barrier in the lungs and prevent infection. The study shows that AHR activity is essential for lung barrier integrity during viral infections.
SourceThe Francis Crick Institute·JournalNature·TypeExperimental study·DateAug 16, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A team from Osaka University has uncovered the importance of Polydom and Tie1 in cell migration during lymphatic vessel remodeling. The study found that binding between these proteins facilitates lymphatic endothelial cell migration, highlighting a crucial role in lymphangiogenesis.
SourceOsaka University·JournalJournal of Cell Biology·TypeExperimental study·DateJun 21, 2023
Researchers have found that stimulating a specific bile acid receptor, FXR, may help prevent retinopathy of prematurity in premature babies. By targeting this receptor, the study aims to develop earlier and more effective treatments to protect their vision.
SourceMedical College of Georgia at Augusta University·DateMay 30, 2023
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 24, 2023
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers have developed a 'vein-on-a-chip' device that mimics the human vein, eliminating the need for animal models in some studies. The device, which includes structures called valves and endothelial cells, allows scientists to study mechanisms of blood clot formation in a realistic manner.
SourceUniversity of Birmingham·JournalFrontiers in Cardiovascular Medicine·DateApr 27, 2023
Rice University scientists developed a screening technique to identify high-performing biomaterials for encapsulating insulin-secreting cells, providing long-term blood sugar level control in diabetic mice. The study's findings have the potential to open the door to a more sustainable and self-regulating way to treat Type 1 diabetes.
SourceRice University·JournalNature Biomedical Engineering·TypeExperimental study·DateApr 27, 2023
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateApr 17, 2023
Researchers found that correctly occluded left atrial appendages minimized left atrial flow stasis and thrombogenicity using 4D flow MRI and 3D phantoms. The study provides a clinical goal for the procedure in patients with atrial fibrillation.
SourceAmerican Roentgen Ray Society·TypeImaging analysis·DateApr 17, 2023
A research team from Université Laval has identified a method to save corneal cells from death using healthy mitochondria, reducing mortality rates from 60% to 10%. This approach demonstrates high therapeutic potential for mitochondrial injection, which could maintain vision without transplantation if diagnosed at an early stage.
SourceUniversité Laval·JournalScientific Reports·DateApr 14, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers found that the Wt1 gene plays a key role in the development of endothelial cells during coronary vessel formation. The study's findings suggest that the deletion of this gene disrupts coronary angiogenesis and myocardium development.
SourceUniversity of Barcelona·JournalDevelopment·TypeExperimental study·DateApr 3, 2023
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
SourceKarolinska Institutet·JournalProceedings of the National Academy of Sciences·DateMar 30, 2023
A team of researchers from Ohio University discovered that CIDEC protein improves vascular and metabolic dysfunction, reducing insulin resistance and lipid levels in high-fat diet-induced mice. The study contributes to understanding the role of the vascular endothelium in regulating systemic metabolism.
SourceOhio University·JournalDiabetes·TypeExperimental study·DateMar 29, 2023
Three pre-clinical studies published in Journal of Pharmaceutical Analysis explore the molecular mechanisms underlying cardiovascular and neurological diseases, providing new avenues for therapeutic strategies.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateMar 28, 2023
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
SourceMedical College of Georgia at Augusta University·JournalEuropean Heart Journal·DateMar 14, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Scientists have developed a new technique using tissue-embedded nanoelectronic devices to study the functional maturation of stem-cell derived heart tissues. The research found that co-culturing stem-cell-derived cardiomyocytes with endothelial cells enables faster and more efficient maturation, with significant implications for engine...
SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalScience Advances·DateMar 8, 2023
Researchers at UIC hope to understand how the human immune system regulates lung tissue and develop new treatments for conditions like COPD and pulmonary fibrosis. The grant aims to create an infrastructure for collaboration among researchers studying lung endothelial cells and their role in inflammation.
Researchers at Indiana University School of Medicine have identified a new type of cell called the vasculogenic fibroblast, which can help create new blood vessels for treatment. This discovery could lead to improved treatments for ischemic diseases such as diabetic wounds.
SourceIndiana University School of Medicine·JournalNature Communications·DateMar 1, 2023
A new study by Osaka University researchers demonstrates that the endothelial cell-specific protein Robo4 plays a crucial role in reducing mortality in severe infection. By upregulating Robo4 expression, a drug treatment can decrease vascular permeability and increase survival rates.
SourceOsaka University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 17, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A new study from York University sheds light on biological underpinnings of sex differences in obesity-related disease. Female mice grow more new blood vessels to supply fat tissue with oxygen and nutrients, whereas males have a high level of inflammation-associated processes.
SourceYork University·JournaliScience·TypeExperimental study·DateJan 9, 2023
Vascular diseases such as atherosclerosis are associated with the reorganization of blood vessel structure through transdifferentiation. The researchers discovered that endothelial cells can transdifferentiate into smooth muscle cells, driven by HIF1α, and that this process contributes to neointima formation.
SourceUniversity of Tsukuba·JournalCardiovascular Research·DateDec 22, 2022
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
SourceAmerican Institute of Physics·JournalAPL Bioengineering·DateDec 6, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateNov 29, 2022
Researchers found that oral cancer cells releasing EVs under TGF-β induce EndoMT in endothelial cells, leading to vascular destabilization. This process may facilitate cancer cell entry into the bloodstream, promoting metastasis.
SourceTokyo Medical and Dental University·JournalInflammation and Regeneration·DateNov 10, 2022
Researchers at Linköping University identified the brain cells necessary for a fever reaction in mice, finding that prostaglandin production in these cells is both necessary and sufficient for triggering a fever response. This breakthrough sheds light on the body's defense mechanism against infection and inflammation.
SourceLinköping University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 26, 2022
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
SourceAmerican Heart Association·JournalArteriosclerosis Thrombosis and Vascular Biology·DateOct 26, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A recent study by Weill Cornell Medicine investigators found that corrupted endothelial cells can protect leukemia cells from chemotherapy drugs. The discovery has the potential to improve drug discovery programs and clinical trials for T-cell acute lymphoblastic leukemia (T-ALL) patients.
A new study from USC researchers uncovers the sequence of early molecular changes caused by APOE4, a discovery that may help identify potential treatment targets in the brain's blood vessels. The research reveals problems with the blood-brain barrier and synapses, leading to behavioral deficits and cognitive dysfunction.
SourceKeck School of Medicine of USC·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 30, 2022
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
SourceMedical College of Georgia at Augusta University·JournalGlia·DateAug 23, 2022
Researchers found a 20% decrease in coronary artery dilation and reduced myocardial flow reserve in patients with prior COVID-19 infection. This may lead to poor prognosis and higher risk of adverse cardiovascular events.
SourceHouston Methodist·JournalJACC Cardiovascular Imaging·TypeImaging analysis·DateAug 17, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Scientists aim to improve vein health for patients undergoing heart bypass surgery and dialysis. They discovered that two genes play a crucial role in smooth muscle cell differentiation, enabling veins to mature and function like arteries.
SourceMedical College of Georgia at Augusta University·DateAug 11, 2022