Articles tagged with Endothelial Cells
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Researchers at IBEC have created in vitro models of neuroblastoma vasculature, replicating the tumor's characteristic blood vessel formation and identifying GB3 as a potential therapeutic target. The study uses stiffness-based models and microfluidic chips to explore treatments for this pediatric cancer.
Researchers have mapped the protein composition of brain endothelial cells, revealing dysregulation of key molecules involved in cellular processes. This study provides a framework for understanding endothelial signaling pathways during aging and serves as a data basis for future analyses of brain endothelial function.
Researchers have found two proteins, SOX17 and FGF2, that can efficiently mature stem cells into endothelial cells, forming tubular-like vessels. This breakthrough could enable the growth of lab-grown vascular tissue to support heart transplants and develop artificial blood brain barriers for neurological drug testing.
A new study found that a viral infection can cause cognitive impairments by damaging the blood-brain barrier, leading to memory loss and learning difficulties. Researchers developed a gene therapy that stimulated the Wnt/beta-catenin pathway to prevent this damage and improve cognitive function in mice infected with SARS-CoV-2.
A study by University of Barcelona researchers reveals that TDP-43 protein is essential for forming stable blood vessels and maintaining the blood-brain barrier, which prevents toxins from reaching the central nervous system. Deficiency in this protein leads to vascular defects and neuroinflammation.
Researchers found that FOXO1 translocates to the nucleus specifically in Tip cells upon prolonged VEGF stimulation, guiding vascular branching. This activation triggers the expression of genes determining Tip cell fate and inhibits NOTCH signaling in stalk cells.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
A novel reporter cell experimental system enables the visualization of sequential changes during endothelial-mesenchymal transition (EndoMT) induced by transforming growth factor-β. Researchers identified CD40 as a potential partial EndoMT marker, which suppresses the transition from partial to full EndoMT.
Researchers have developed a new gene mapping technique that reveals how genetic alterations in cells lining blood vessels contribute to coronary artery disease. The technique, called Variant-to-Gene-to-Program (V2G2P), identifies biological mechanisms driving CAD risk by linking genetic variants to gene expression and function.
A new study found that nicotine-free vape fluid can increase inflammation and oxidative stress in the lungs, causing damage similar to patients with lung injury. The research identified a protein called ARF6 as a key regulator of this damage.
A pioneering study published in The American Journal of Pathology reveals the cytoprotective and proregenerative effects of neuropeptide α-MSH in promoting corneal healing after eye injury. The treatment has shown impressive therapeutic potential in reducing the need for corneal transplants.
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
A Brazilian study found that damage to small blood vessels in the lungs causes severe COVID-19. The researchers observed high prevalence of microscopic blood clots in lung endothelial cells, which led to organ damage and ischemic tissue injury.
Researchers at the Josep Carreras Institute have discovered a crucial protein, PI3K-C2b, that regulates mTORC1 signaling and angiogenic growth in blood vessels. This finding holds promise for developing new treatments for congenital vascular disorders.
Scientists at St. Jude Children's Research Hospital discovered that a fusion oncoprotein forces cells to become tumor-like, regardless of their original muscle or endothelial cell origin. The study suggests that focusing on the effects of this protein may be a better approach for identifying potential therapeutic interventions.
A collaborative study has developed an agarose spot migration assay to examine the ability of extracellular vesicles to attract other cells in a controlled environment. The assay revealed differences in EVs' recruitment capability for endothelial cells, particularly in highly metastatic cancer cells.
A study from the University of Wisconsin-Madison and Academia Sinica of Taiwan has successfully combined lab-grown cardiomyocytes with stem-cell-derived endothelial cells to regenerate damaged heart muscle after a heart attack. This combination therapy holds promise for tackling arrhythmia and could lead to improved clinical applications.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
Researchers developed a human in vitro model of radiation-induced lung injury, closely mimicking the complexities of the disease. The Human Lung Alveolus Chip recapitulates hallmarks of RILI, including DNA damage, inflammation, and injury to lung cells and blood vessels.
Researchers have developed a synthetic peptide that could help reduce vascular problems associated with acute respiratory distress syndrome in COVID-19. The peptide, called TIP, works by binding to a subunit of the epithelial sodium channel, which helps maintain barrier function and prevent damage from viral proteins.
A new NIH grant will investigate the impact of combined alcohol and e-cigarette use on the blood brain barrier, a cell layer regulating substance passage into the central nervous system. The study aims to identify mechanisms behind damage and potential biomarkers for clinical use.
A study at the Technical University of Munich found that people with long Covid experience altered blood vessels in the eye, which could be used to diagnose the condition. Persistent inflammatory responses were also linked to symptom severity and chronic inflammation.
The study reveals that NO forms a new compound, NO-ferroheme, which significantly expands blood vessels and directly activates guanylyl cyclase. This finding challenges the long-held hypothesis on nitric oxide signalling in blood vessels.
UTHealth Houston researchers have developed a new mouse model for brain arteriovenous malformations (AVMs) that will be presented at the NIH meeting. The research explored how humoral immune mediators interact with cells surrounding the AVM and found insights into finding therapeutic methods.
Researchers found that dietary AHR ligands from cruciferous vegetables, such as kale and broccoli, maintain a healthy barrier in the lungs and prevent infection. The study shows that AHR activity is essential for lung barrier integrity during viral infections.
A team from Osaka University has uncovered the importance of Polydom and Tie1 in cell migration during lymphatic vessel remodeling. The study found that binding between these proteins facilitates lymphatic endothelial cell migration, highlighting a crucial role in lymphangiogenesis.
Researchers have found that stimulating a specific bile acid receptor, FXR, may help prevent retinopathy of prematurity in premature babies. By targeting this receptor, the study aims to develop earlier and more effective treatments to protect their vision.
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
Rice University scientists developed a screening technique to identify high-performing biomaterials for encapsulating insulin-secreting cells, providing long-term blood sugar level control in diabetic mice. The study's findings have the potential to open the door to a more sustainable and self-regulating way to treat Type 1 diabetes.
Researchers have developed a 'vein-on-a-chip' device that mimics the human vein, eliminating the need for animal models in some studies. The device, which includes structures called valves and endothelial cells, allows scientists to study mechanisms of blood clot formation in a realistic manner.
Researchers found that correctly occluded left atrial appendages minimized left atrial flow stasis and thrombogenicity using 4D flow MRI and 3D phantoms. The study provides a clinical goal for the procedure in patients with atrial fibrillation.
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
A research team from Université Laval has identified a method to save corneal cells from death using healthy mitochondria, reducing mortality rates from 60% to 10%. This approach demonstrates high therapeutic potential for mitochondrial injection, which could maintain vision without transplantation if diagnosed at an early stage.
Researchers found that the Wt1 gene plays a key role in the development of endothelial cells during coronary vessel formation. The study's findings suggest that the deletion of this gene disrupts coronary angiogenesis and myocardium development.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
A team of researchers from Ohio University discovered that CIDEC protein improves vascular and metabolic dysfunction, reducing insulin resistance and lipid levels in high-fat diet-induced mice. The study contributes to understanding the role of the vascular endothelium in regulating systemic metabolism.
Three pre-clinical studies published in Journal of Pharmaceutical Analysis explore the molecular mechanisms underlying cardiovascular and neurological diseases, providing new avenues for therapeutic strategies.
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
Scientists have developed a new technique using tissue-embedded nanoelectronic devices to study the functional maturation of stem-cell derived heart tissues. The research found that co-culturing stem-cell-derived cardiomyocytes with endothelial cells enables faster and more efficient maturation, with significant implications for engine...
Researchers at UIC hope to understand how the human immune system regulates lung tissue and develop new treatments for conditions like COPD and pulmonary fibrosis. The grant aims to create an infrastructure for collaboration among researchers studying lung endothelial cells and their role in inflammation.
Researchers at Indiana University School of Medicine have identified a new type of cell called the vasculogenic fibroblast, which can help create new blood vessels for treatment. This discovery could lead to improved treatments for ischemic diseases such as diabetic wounds.
A new study by Osaka University researchers demonstrates that the endothelial cell-specific protein Robo4 plays a crucial role in reducing mortality in severe infection. By upregulating Robo4 expression, a drug treatment can decrease vascular permeability and increase survival rates.
A new study from York University sheds light on biological underpinnings of sex differences in obesity-related disease. Female mice grow more new blood vessels to supply fat tissue with oxygen and nutrients, whereas males have a high level of inflammation-associated processes.
Vascular diseases such as atherosclerosis are associated with the reorganization of blood vessel structure through transdifferentiation. The researchers discovered that endothelial cells can transdifferentiate into smooth muscle cells, driven by HIF1α, and that this process contributes to neointima formation.
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
Researchers found that oral cancer cells releasing EVs under TGF-β induce EndoMT in endothelial cells, leading to vascular destabilization. This process may facilitate cancer cell entry into the bloodstream, promoting metastasis.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
Researchers at Linköping University identified the brain cells necessary for a fever reaction in mice, finding that prostaglandin production in these cells is both necessary and sufficient for triggering a fever response. This breakthrough sheds light on the body's defense mechanism against infection and inflammation.
A recent study by Weill Cornell Medicine investigators found that corrupted endothelial cells can protect leukemia cells from chemotherapy drugs. The discovery has the potential to improve drug discovery programs and clinical trials for T-cell acute lymphoblastic leukemia (T-ALL) patients.
A new study from USC researchers uncovers the sequence of early molecular changes caused by APOE4, a discovery that may help identify potential treatment targets in the brain's blood vessels. The research reveals problems with the blood-brain barrier and synapses, leading to behavioral deficits and cognitive dysfunction.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
Researchers found a 20% decrease in coronary artery dilation and reduced myocardial flow reserve in patients with prior COVID-19 infection. This may lead to poor prognosis and higher risk of adverse cardiovascular events.
Scientists aim to improve vein health for patients undergoing heart bypass surgery and dialysis. They discovered that two genes play a crucial role in smooth muscle cell differentiation, enabling veins to mature and function like arteries.
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
A team of researchers has discovered that malignant tumors accumulate lipid delivery molecules called LDL and attract immune suppressor cells called neutrophils, leading to tumor progression. The study also shows that targeting the LOX-1/oxidized LDL axis may be a promising strategy for treating both cancer and cardiovascular disease.
Researchers have created a new DNA atlas that provides insights into how genes in specific cells contribute to coronary artery disease. The atlas identifies over 200 independent genetic markers associated with disease risk, offering a potential roadmap for interpreting non-coding variants.
Researchers have identified a crucial role for two proteins YAP and TAZ in angiogenesis, the process of new blood vessel formation. They also found that this process is regulated by nutrient absorption and can be linked to vascular diseases like macular degeneration.