Articles tagged with Endothelial Cells
Researchers have identified a crucial role for two proteins YAP and TAZ in angiogenesis, the process of new blood vessel formation. They also found that this process is regulated by nutrient absorption and can be linked to vascular diseases like macular degeneration.
Researchers developed a low-cost 3D model of the brain to study SARS-CoV-2's neurological effects. The adapted virus replicates 30 times more efficiently in astrocytes than neurons, highlighting the importance of these cells in central nervous system infection.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
Researchers at Institute for Basic Science discovered Merlin's crucial role in regulating angiogenesis. By suppressing VEGFR2 internalization, Merlin prevents tip EC induction and promotes balanced sprouting angiogenesis. This study sheds light on the importance of Merlin in maintaining capillary integrity and proper angiogenesis.
Researchers engineered mini liver tumours co-cultured with endothelial cells to investigate their crosstalk. The team found that endothelial cells promote the production of CXCL1, a protein associated with poor survival outcome in liver cancer patients.
Researchers from NTU and NUS found a link between NAFLD and blood vessel damage, leading to increased risks of cardiovascular diseases. High levels of chemokines attract immune cells into blood vessels, causing inflammation and damage.
A research team discovered that an excessive number of thromboxane A2 receptors in blood vessel cells hinders the formation of new blood vessels, leading to vascular and cardiovascular diseases. The finding offers a promising biomarker for treatment and potential therapeutic benefits from blocking the receptor's action.
Researchers discovered that blood vessels have a sophisticated network of cells and connections that communicate with each other to control cardiovascular functions. This network, similar to the internet, is robust and effective in determining overall cardiovascular activity.
Researchers found that pericyte precursor cells and endothelial cells work together simultaneously during embryonic development, contrary to previous theories. This discovery may lead to new strategies for repairing damaged tissue after stroke or heart attack.
Scientists found that a single 45-minute session of moderate-intensity exercise enables the growth of new blood vessels in people with type 2 diabetes. The exercise increases levels of ATP7A, a protein carried by exosomes that helps deliver essential copper to endothelial cells, promoting angiogenesis and reducing oxidative stress.
A study published in Nature Communications found that BMP9 treatment restored capillary density and improved alveolarization in mice with ACDMPV. The treatment showed promise for improving care for BPD and CDH, two conditions that also affect lung development.
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
The blood-brain barrier is regulated by a signaling pathway involving vitronectin and integrin α5, which inhibits transcytosis and maintains barrier integrity. The findings offer insights into the microenvironment's role in maintaining the barrier's permeability.
Scientists at the Josep Carreras Institute and CIC Biogune discovered that blood vessels use small molecules to instruct adipose tissue to release fat. This finding sheds light on the importance of blood vessels in regulating obesity and opens up opportunities for improving human health through vascular regulation.
Researchers successfully differentiated human induced pluripotent stem cells into specific mesoderm subset for use as a novel therapy to rescue ischemic tissues and repair blood vessels. The results demonstrate significant improvement in visual acuity and electroretinograms with restoration of vascular perfusion in animal models.
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Researchers found higher-than-expected levels of antiphospholipid autoantibodies in COVID-19 patients, causing endothelial cell activation and promoting clotting. Removing these antibodies from blood samples lost the activation effect, suggesting a potential cause of severe COVID-19 symptoms.
A team of researchers from MIT created a comprehensive atlas of cerebrovascular cells in human brain tissue, identifying 11 subtypes and their functions. The study reveals differences between healthy and diseased cells, potentially leading to new targets for treating Huntington's disease.
A new study suggests that incomplete lung cell repair may contribute to the development of chronic fibrotic lung disease in COVID-19 and non-COVID patients. The research proposes novel therapies to promote healthy regeneration and prevent scarring.
Researchers found a unique bivalent histone-mark switch specific to critical transcription factors that induce genes essential for angiogenesis. The histone modifiers responsible for this modification are vital for postnatal angiogenesis.
Melanoma cells release small packages containing the protein NGFR, which primes nearby lymph nodes to form new vessels and encourage cancer spread. This process, called lymphangiogenesis, may help doctors determine which patients need more aggressive treatment.
Researchers have successfully genome-edited vascular endothelial cells using a novel nanoparticle delivery system, which could treat diseases such as acute respiratory distress syndrome and coronary artery disease. The technology has the potential to correct gene mutations, promote vascular repair, and inhibit vascular injury.
Recent research reveals that endothelial cells produce all necessary coagulation proteins for thrombin generation, enabling the clotting process to occur on their surfaces. This finding shifts our understanding of blood clot development and treatment strategies.
A study examining autopsy tissue samples from COVID-19 patients found frequent and extensive blood clots within heart vessels, but no typical endothelial cell changes. Instead, hypercoagulability of the blood caused by activated neutrophils was detected as a likely culprit.
A study published in the American Journal of Respiratory and Critical Care Medicine found that prostacyclin treatment reduced damage to vital organs and halved mortality rates among critically ill Covid-19 patients. The research team hopes to investigate larger patient populations in future studies.
Researchers at Harvard's Wyss Institute have developed a microfluidic Organ Chip device that accurately models cystic fibrosis lung airway pathology. The model replicates key pathological hallmarks, including mucus layer changes and inflammatory responses, providing a comprehensive preclinical human model for investigating new therapies.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
A study by Karolinska Institutet found that low levels of microRNA-210 in red blood cells cause vascular damage in type 2 diabetes. The reduction in microRNA-210 levels impaired blood vessel endothelial cell function and led to increased risk of cardiovascular disease.
A team of experts from Tel Aviv University has identified 5 coronavirus proteins responsible for damaging blood vessels. The researchers hope that the identification will lead to the development of targeted drugs that reduce vascular damage in COVID-19 patients.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
Researchers have found that breast cancer stem cells accumulate near a tumor arteriole, which they call the arteriolar niche. This niche promotes cancer cell features and potential development through the LPA/PKD-1 signaling pathway.
Researchers used a hamster model to study COVID-19 lung damage, discovering that the immune system's response plays a crucial role in disease progression. They found that certain cells involved in lung immunity ingest the virus, triggering an inflammatory response that can be brought under control by T cells.
Researchers at the University of Oregon used CRISPR-Cas9 gene editing to target a specific mutation causing Fuchs' corneal dystrophy, preserving endothelial cell density and function. The study lays the groundwork for future research on using this technique to treat genetic disorders in post-mitotic cells.
Researchers at Weill Cornell Medicine have discovered that injecting mice with pulmonary endothelial cells can reverse the symptoms of emphysema. The study found that targeting endothelial cell function may represent a strategy for treating patients with advanced COPD or emphysema. Injecting healthy lung endothelial cells and/or inhibi...
Cells undergoing EMT promote tumor growth by acquiring an endothelial phenotype or contributing to vascular transdifferentiation. FOXC2 is crucial for these processes.
A team of researchers has developed a combined imaging and machine learning technique that can measure glycolysis in single endothelial cells, revealing a new mechanism of glucose transport. This breakthrough could lead to better treatments for cancer, vascular diseases, and COVID-19.
Researchers discovered that primary miRNA precursor forms are highly expressed in cell-type-specific manner, while mature miRNAs dominate common to all cell types. The study also uncovered microRNA-messenger RNA networks driving cell-type-specific responses.
Researchers rationally designed a new monoclonal antibody HA98 with improved affinity for CD146, a key adhesion molecule in angiogenesis and cancer metastasis. The study revealed superior inhibitory effects on tumor growth compared to the original AA98 antibody.
The study reveals the involvement of SARAF and Orai1 proteins in VEGF-mediated activation of endothelial cells, affecting blood vessel development. This discovery could lead to therapeutic strategies controlling angiogenesis in pathological conditions.
Scientists at BIH have found a new metabolite, S-2-hydroxyglutarate, that regulates endothelial cell quiescence and prevents excessive vessel growth. This discovery brings the researchers closer to developing targeted therapies for vascular diseases.
Researchers developed an exosome-coated stent that heals vascular injury by delivering regenerative stem cell-derived therapy to ischemic tissue. The stent reduces restenosis and promotes endothelial coverage compared to traditional drug-eluting and bare metal stents.
Researchers have developed a way to restore dysfunctional lymphatic networks using hydrogels made from hyaluronic acid. This allows the body to better defend itself against diseases such as cancer, cardiovascular disease, and diabetes. The study's findings have been published in The FASEB Journal.
A team of researchers from Texas A&M University developed an organ-on-a-chip device that can model the disease physiology of patients with sickle cell disease. The device uses blood outgrowth endothelial cells to mimic a patient's vessel, allowing for personalized treatment and predicting disease progression.
Researchers developed a next-generation nanotherapy that specifically targets injured regions of arteries in mouse models mimicking angioplasty. The nanoparticles containing an microRNA switch offer promising biotechnology to advance the fight against atherosclerotic cardiovascular disease.
Researchers found that a widely used cell type for brain research was misidentified as an endothelial cell, but could be reprogrammed to resemble one using gene expression manipulation. This study highlights the importance of rigorously evaluating stem cell models before embracing them.
A study from Columbia University suggests that cells used to study the human blood-brain barrier in labs aren't what they seem. The researchers discovered a possible way to correct the error, raising hopes for creating a more accurate model for studying certain neurological diseases and developing drugs.
A study by Kumamoto University researchers found that the molecule Folliculin (FLCN) acts as a gatekeeper to maintain separation between blood and lymphatic vessels. The discovery sheds light on how these two vessel types form independent networks, with potential implications for cancer metastasis and treatment of lymphedema.
Researchers have made significant breakthroughs in generating human hemogenic endothelial cells outside the body, paving the way for growing organs and treating blood disorders. The discovery, published in prestigious journals Science and Cell Reports, reveals a key trigger that causes these cells to form during embryonic development.
Researchers observed fibroblasts circling the edge of the wound for about 50 hours, when cells began to close the void. Fibroblasts were found to be the primary drivers of wound closure, with endothelial cells playing a supporting role.
A team of researchers identified an antibody called 2B7 that neutralizes the NS1 protein, a key factor in dengue virus replication and disease. The findings offer a potential strategy for developing effective treatments and vaccines against dengue and similar diseases.
A UCLA-led study uses 3D-printed models to identify possible link between COVID-19 and stroke. The researchers found that the coronavirus increases the production of a molecule called angiotensin-converting enzyme 2 (ACE2), which affects blood vessel cells in the brain.
Researchers found that SARS-CoV-2 indirectly activates endothelial cell responses, leading to coagulation and inflammation associated with severe Covid-19 disease. Targeting endothelial cells may be a novel approach to resolving Covid-19 symptoms.
Researchers at CNIC have identified a novel cellular and molecular mechanism that promotes vascular arterialization, enabling the development of arteries from blood capillaries. This breakthrough has significant implications for treating cardiovascular diseases, including coronary artery disease and myocardial infarction.
Researchers at HKUST have identified novel molecular targets for Alzheimer's drug development, focusing on endothelial cells and microglia. The study reveals a link between blood vessel dysregulation and AD pathogenesis, as well as potential therapeutic interventions through the cytokine IL-33.
Scientists have discovered a novel mechanism to increase arterial diameter by selectively increasing endothelial cell size, allowing for rapid increases in blood flow. This approach has significant advantages over conventional angiogenesis methods, enabling faster restoration of blood flow and oxygen delivery.
Researchers found that exosomes secreted by cardiac cells derived from human induced pluripotent stem cells improved myocardial recovery and reduced arrhythmia in pigs. The treatment showed regenerative benefits equivalent to injecting living cells, without increasing the risk of tumorigenesis.
Researchers at North Carolina State University developed a prototype vascular graft that combines synthetic fibers and collagen filaments to aid in regeneration of the coronary artery lining. The design showed improved strength, flexibility, and biological response compared to previous models.