Articles tagged with Endothelial Cells
Researchers successfully grew vascular endothelial cells from human induced pluripotent stem cells, mimicking the flow of blood to differentiate cell types. The iPS-derived cells display critical functions carried out by mature endothelium in the body, including mounting inflammatory responses and preventing blood clots.
IBN's novel technique allows researchers to incorporate different cell types into separate fibers, then assemble them into complex constructs with hierarchical tissue structures. This innovation enables the creation of prevascularized tissue constructs that have successfully integrated with the host circulatory system in a mouse model.
Scientists have developed a method to generate functional blood vessels lasting up to nine months using human induced pluripotent stem cells. The breakthrough could lead to new treatments for cardiovascular disease and diabetes.
The endothelium, a cellular layer lining blood vessels, has an efficient barrier function maintained by its ability to heal micro-wounds. New research shows that biomechanical signals trigger the recovery response, generating reactive oxygen species to close gaps and restore functionality.
A study published in Nature Medicine reveals that a mutation in the Semaphorin 3d molecule disrupts the development of pulmonary veins, leading to Total Anomalous Pulmonary Venous Connection (TAPVC). The condition causes poorly oxygenated blood throughout the body, resulting in cyanosis. Researchers found that Sema3d mutations cause ab...
Researchers grew and analysed stem cells from patients with von Willebrand disease to identify the cause of the disease in individual patients, enabling more effective treatments. The technique may also be used to treat diseases of the heart, blood and circulation, including haemophilia.
Researchers at Rice University created a computer model to study the growth of tiny blood vessels in the brain after a stroke. They found that individual cells respond to stimuli using rules and patterns, which can be replicated to guide vessel structure development.
Researchers at UT MD Anderson Cancer Center found that tumor endothelial cells can trigger changes in cancer cells, making them more resistant to chemotherapy and more likely to spread. This signaling process involves the activation of the Notch molecular pathway and may be targeted by existing drugs under development.
Researchers have identified the importance of Plvap/PV1 gene in forming endothelial caveolae diaphragms, which maintain basal permeability and homeostasis of blood plasma. The study found that PV1 is crucial for the survival of vascular endothelial cells and preventing protein loss.
Scientists have developed two novel model systems for human corneal endothelium, enabling reliable study of HCEnC cells in health and disease. The new model systems, HCENC-21 and HCEnC-21T, mimic the critical characteristics and functionalities of the tissue in the eye.
Researchers found that iron oxide nanoparticles can effectively label human endothelial cells for in vivo magnetic resonance tracking. However, high concentrations of INOPS can induce cell death and affect cell activity.
A protein pair called Norrin/Frizzled-4 plays a crucial role in managing the blood vessel network that serves the brain and retina. The study reveals a dual role for the protein pair, with one job forming the network's proper architecture during fetal development and another maintaining the blood-brain barrier after birth.
Researchers at Case Western Reserve University School of Medicine identified a genetic factor KLF4 that prevents blockages from forming in blood vessels. The study found that a shortage of KLF4 makes the lining more prone to plaque buildup and clot formation, while sufficient levels protect against toxins and disease.
Researchers at Beth Israel Deaconess Medical Center have discovered how MSCs traffic from circulation to damaged tissues, revealing a rate-limiting step that may explain their inefficiency in entering inflamed areas. The findings suggest enhancing MSC homing could improve delivery and therapeutic efficacy.
Endothelial cells, not muscle cells on the outside of blood vessels, are responsible for sensing low oxygen levels and triggering pulmonary hypertension. Researchers at St. Michael's Hospital found that blocking communication between endothelial cells and smooth muscle cells could potentially prevent right heart failure.
Researchers develop safe approach to produce stable vascular endothelial cells from human amniotic cells, opening door to treating diverse vascular disorders. The new cell-based strategy has promise in mice and may benefit millions of patients worldwide.
Researchers at Weill Cornell Medical College have discovered a way to utilize diagnostic prenatal amniocentesis cells to regenerate damaged blood vessels and repair injured organs. The study, published in Cell, shows that reprogrammed endothelial cells can be frozen and banked for potential use in patients with vascular diseases.
Researchers at Thomas Jefferson University have found that low levels of the protein S100A1 are associated with critical lower limb ischemia, a condition characterized by reduced blood flow to legs. The study suggests that S100A1 could be a potential therapeutic target in critical limb ischemia to promote revascularization.
Scientists at Joslin Diabetes Center have identified the biological mechanisms by which glucagon-like peptide-1 (GLP-1) protects against kidney disease, including its ability to inhibit the signaling pathway of angiotensin II. The study suggests that effective therapeutic agents could be developed to enhance GLP-1R on the endothelium, ...
Researchers discovered that tumor cells release chemokine CCL2, which docks onto endothelial cells and activates the CCR2 receptor, making them permeable. This pathway enables tumor cells to migrate and metastasize.
Scientists at the University of Wisconsin-Madison have created cells that mimic the blood-brain barrier, a filter that separates the brain from circulating blood. These cells hold promise for streamline drug discovery and modeling neurological diseases.
Researchers have developed a method to enhance adhesion of injected corneal endothelial cells, allowing for successful corneal transplantation and repair of pathological dysfunctions. Transplanting cultivated cells in combination with the ROCK inhibitor Y-27632 successfully restored corneal transparency in rabbit and monkey models.
Researchers developed a three-dimensional living tissue model to study brain tumors and therapeutics, confirming iron-oxide nanoparticles can deliver tumstatin to blood vessels surrounding gliomas. The model allows for testing of agent characteristics in a realistic environment.
Researchers have successfully identified the underlying mechanism of ischemia-reperfusion injury in isolated lungs, a major complication in lung transplantation. The study highlights two key proteins responsible for increased vascular permeability and inflammation, paving the way for potential therapeutic interventions.
Researchers discovered a biological pathway that increases the level of chemokine SDF-1, which stimulates cells to move and migrate. The study found that higher levels of this protein can predict who is most likely to develop HUS, allowing for closer monitoring.
New research at the Weizmann Institute shows how blood vessel cells 'hide' signals from immune cells, only allowing those with special training to cross. This selective barrier prevents certain immune cells from reaching tumors near blood vessels.
Researchers at Weill Cornell Medical College uncover biochemical signals that trigger generation of new lung alveoli in mice. The study identifies molecular triggers behind this process, which may be relevant to humans and potentially lead to treatment for chronic obstructive pulmonary disease (COPD).
A research team led by Professor Christian Weber has discovered a peptide that promotes the healing of damaged blood vessels and prevents restenosis in stent implantations. The peptide, cathelicidin, was found to improve endothelial cell recovery and prevent the formation of neointima.
A Stanford study on cox-2 inhibitors may lead to new stroke treatments by increasing blood flow and enhancing recovery. The research also sheds light on why some drugs failed to live up to their promise, revealing that blocking a specific receptor can be beneficial.
Researchers have identified a new strategy for preventing the migration of muscle cells that can lead to coronary artery reclogging after angioplasty. Introducing FRNK, a protein that inhibits muscle cell migration while allowing endothelial cell movement, could help prevent clots and reduce the need for repeat procedures.
Researchers found that African-American endothelial cells produce nearly 90% more microparticles during inflammation than Caucasian cells. This increased production is associated with higher levels of hypertension in individuals.
Acute lung injury is a life-threatening condition that occurs when blood vessels leak into the lungs, causing fluid buildup. Researchers are exploring new therapies to improve patient odds by identifying key events and developing treatments to block them. Potential treatments include HSP90 inhibitors and adenosine agonists.
A new study reveals that hydrogen sulfide helps protect blood vessels from the complications of diabetes by controlling an early checkpoint in related processes. The researchers found that diabetic rats have lower levels of 'swamp gas' and improved blood vessel function after treatment.
Chinese scientists have discovered genetic modifications that enable pigs to be transplanted into humans with fewer complications. Human PD-L1 overexpression in pig artery endothelial cells induces tolerance and reduces rejection response.
Researchers found that COPD patients' lung cells exhibit senescence, leading to increased inflammation. The study suggests that accelerated cellular aging contributes to persistent lung inflammation in COPD.
A study published in Cell Transplantation found that cryopreserved endothelial progenitor cells have the same phenotypic, structural, and functional properties as non-frozen cells. This discovery eliminates the need for cell isolation procedures before using these cells in clinical transplantation.
Research suggests Vitamin D supplementation improves vascular endothelial cell health, reducing cardiovascular disease risk in overweight African-American adults. The study found that supplementation with 60,000 IU monthly improved flow-mediated dilation, a key indicator of blood vessel health.
A new study suggests that Vitamin D supplementation can improve vascular endothelial cell function and flow-mediated dilation in overweight African-American adults. This improvement in cardiovascular health can decrease the risk of heart disease.
University of South Florida researchers have found that the blood-brain barrier is structurally and functionally damaged in mice with Sanfilippo syndrome type B. This damage may lead to destruction of the central nervous system equilibrium and accelerate neuropathological changes in the disease.
Researchers at Wake Forest University Baptist Medical Center successfully implanted laboratory-grown urethras in five boys, showing functional results throughout a six-year follow-up period. The engineered tissue replaced damaged segments of the urinary tube, providing an alternative to traditional tissue grafts with high failure rates.
Researchers found that endothelial cells lining blood vessels secrete molecules suppressing tumor growth and invasion. The discovery could lead to a new way to treat cancer by implanting these cells adjacent to the tumor.
Researchers at Harvard Medical School have found a way to rewind the internal clock of mature cells and drive them back into an adult stem-cell stage by mimicking a rare genetic disorder. This new approach has implications for personalized medicine, particularly in tissue engineering.
The study reveals that specialized blood vessel cells initiate and sustain liver regeneration by producing growth factors. This finding opens the door for designing new therapies to treat damaged livers. The researchers identified specific genes, such as Id1 and Wnt2, that enable endothelial cells to regulate liver regeneration.
Researchers discovered that GPR124 controls the growth of blood vessels into the developing brains of mice embryos. The protein is essential for normal blood vessel development in the nervous system but can lead to abnormal hypervasculature when overexpressed.
Researchers at Mayo Clinic found that healthy young people who gained as little as 9 pounds of fat in their abdomens developed endothelial cell dysfunction, impairing blood flow regulation. In contrast, those who gained weight evenly throughout their bodies showed less affected blood flow regulation.
A new cellular mechanism has been identified for modulating blood vessel permeability, which could have a significant impact on the treatment of cancerous tumours. Nitrosylation of beta-catenin protein by nitric oxide increases vascular permeability, potentially leading to the blockage of tumour growth.
Researchers identified a defective signaling pathway that leads to the development of vascular malformations in the brain. The study suggests that targeting this pathway may lead to new treatments for cerebral cavernomas, including the use of anticancer drugs.
Researchers found that Smurf1 is elevated in animal models of PAH and can degrade BMP receptors, leading to excessive growth of vascular cells. This suggests Smurf1 may be an attractive therapeutic target to block disease progression.
Researchers at Penn find that mechanical forces reinforce and grow endothelial cell connections, creating stronger adhesions. This discovery has implications for therapies targeting vascular dysfunction in diseases like septic shock and diabetes.
A study of 388 patients found that recipient diagnosis, not donor age or tissue preservation methods, is associated with corneal transplant failure. Transplant recipients with keratoconus had a lower risk of graft failure than those with endothelial dysfunction.
A study identifies HuR as a critical regulator of an inflammatory response in cells experiencing mechanical and chemical stresses, promoting the expression of genes that support atherosclerosis. Reducing HuR levels inhibits the inflammatory response and may lead to new treatments for metabolic diseases associated with inflammation.
Researchers at Northwestern University characterized a special type of stem cell, endothelial progenitor cells (EPCs), to see if they can behave as endothelial cells in the body when cultured on a bioengineered surface. The study shows promise for improving surgery success rates for peripheral arterial disease.
Researchers report that OSCC cells produce high levels of VEGF, promoting proliferation and invasion. A subpopulation of OSCC cells may undergo an epithelial-to-endothelial transition, facilitating tumor progression and metastases.
Researchers discovered endothelial cells can grow copious amounts of adult stem cells and their progeny over weeks, revolutionizing organ regeneration and cancer cell growth inhibition. This vascular-cell model could manufacture unlimited blood-related stem cells for transplantation.
Researchers found that an enzyme suspected of causing inflammation has only limited role in spurring edema. A two-hit model is proposed to explain vascular permeability regulation, suggesting other drug targets for preventing or reversing inflammation and edema.
A study led by NYSCF Fellow Daylon James has generated a human embryonic stem cell line to measure and boost endothelial cell production, establishing a standard methodology for producing functional endothelial cells from hESCs. The cells can now be used for pre-clinical assessment of vascular disease in large animal models.
A team of scientists at Weill Cornell Medical College has developed a new approach to turn human embryonic and pluripotent stem cells into plentiful, functional endothelial cells, critical for blood vessel formation. This breakthrough technique boosts the efficiency of producing these cells by up to 40-fold.
A new predictor of cornea transplant success has been identified by the Cornea Donor Study Investigator Group. The study found that a patient's endothelial cell count six months post-transplant is a better indicator of subsequent failure of the graft rather than the donor's cell count.
Scientists at NYU Langone Medical Center have discovered a new pathway that protects epithelial and endothelial cells from uncontrolled tuberculosis infection by producing an enzyme that inhibits Th17 cell production.
Researchers discovered a link between Wnt signaling pathway activation and diabetic retinopathy. Pro-NGF may play a pathogenic role in Alzheimer disease through oxidative stress-induced modifications. Abnormal endothelial cells contribute to tumor progression and metastasis in cancer.