Articles tagged with Endothelial Cells
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30% of coronary heart disease and stroke can be prevented with 2.5 hours of brisk walking per week, reducing cardiovascular deaths by 284,886 annually. Regular exercise also improves glycemic control and insulin action, enhancing endothelial function.
Researchers at Keio University found that matrix metalloproteinases improve wound healing in mice, while a complement inhibitor FUT-175 delays autoimmune disease onset. Additionally, a new target for tumor angiogenesis inhibition and bone morphogenic protein-7 (BMP-7) have been identified as potential therapies for liver high blood pre...
Researchers found higher levels of endothelial progenitor cells in pediatric patients with metastatic disease compared to healthy participants. This study provides new insights into the role of circulating endothelial cells and progenitor cells in cancer progression in children.
Researchers found that inhibiting Nox4 substantially inhibits hemangioma growth in a mouse model, while transplantation of cardiac progenitor cells improves heart function after myocardial infarction. Additionally, IL-17 and IL-22 play a crucial role in protecting individuals from developing kala azar, a lethal parasite disease.
Researchers at the University of Minnesota Medical School have successfully provided long-term expression of Factor VIII in hemophilia A mice using a new gene therapy approach, marking a promising step toward human clinical trials.
Researchers have identified a mechanism by which influenza virus makes individuals more susceptible to secondary bacterial pneumonia. Type I IFNs, key mediators of the antiviral immune response, impair the ability to mount an adequate immune response to subsequent pneumonia-causing bacterial infection.
Researchers have developed a credit card-sized device that can detect heart disease using just 200 microliters of blood, a significant improvement over current techniques. The device collects endothelial progenitor cells, which can be used to grow new vascular tissue for transplants and bypass surgeries.
Researchers at Helmholtz Munich have discovered the last step leading to blood cell formation, which has important implications for the development of new therapies. The study found that a special type of endothelial cell can transform into blood cells, providing a key insight into the mechanisms of hematopoiesis.
Researchers used transparent zebrafish to study atherosclerosis development, revealing plaque buildup in blood vessels. The study showed that ezetimibe significantly improved vascular wall thickness and barrier function.
Researchers at the Centenary Institute have discovered a mechanism controlling endothelial cell growth and function. The process of differentiation, triggered by high levels of sphingosine kinase-1, allows cells to mature into functional endothelial cells, potentially leading to new treatments for cardiovascular disease and diabetes.
Researchers at UCLA have discovered that blood stem cells are made by endothelial cells during mid-gestational embryonic development. This finding has significant implications for the treatment of blood disorders and cancers, as it could lead to new therapies for conditions such as leukemia.
Scientists at St. Jude Children's Research Hospital discovered that a specific differentiated cell type requires constant expression of the Prox1 gene to maintain its identity. In its absence, lymphatic endothelial cells reprogram into blood endothelial cells, gaining new characteristics.
A study published in Atherosclerosis reveals that binge drinking causes an irregular pattern of heavy drinking to clog blood vessels, leading to a two-fold increase in fatal heart attack risk. Acetaldehyde levels found in the blood after binge drinking increase monocyte adhesion to blood vessel walls.
Researchers have identified a key signaling pathway, Notch, that stimulates endothelial cells to form new blood vessels in wounds. This discovery has significant implications for treating chronic skin wounds in diabetic patients and those with morbid obesity.
Researchers from Emory University School of Medicine have found daily rhythms in blood vessel activity may help explain morning peak in heart attacks. The study revealed that the lining of blood vessels functions better at night, with endothelial function being particularly depressed in early morning hours.
A new role for the protein PrP has been identified in regulating food intake, with mice lacking PrP becoming obese in adulthood. Additionally, a protein FHL1 has been found to help heart muscle cells respond to high pressure, while a protein AIP1 regulates blood vessel formation under inflammatory conditions.
Researchers have identified Wnt/b-catenin signaling as a key pathway regulating brain development and maintaining the integrity of the blood-brain barrier. The study suggests that tweaking this signaling pathway could potentially mend damaged blood-brain barriers in patients with stroke or other conditions.
Researchers have identified a molecular defect underlying male infertility and its link to melanoma development. The discovery highlights the potential for targeting specific signaling pathways to develop new treatments.
Researchers at Indiana University discovered that healthy endothelial cells lining blood vessels can reduce the tendency of precursor cells to develop into fat cells. This finding could lead to new treatment options for cardiovascular diseases and obesity.
Researchers at the University of Granada have identified the genes responsible for corneal edema-induced blindness. The study revealed that altered ion concentration in endothelial cells leads to barrier dysfunction and oedema. New treatments, including gene therapy, may soon be available to address this condition.
Scientists discovered the earliest form of human blood stem cells, called hemangioblasts, which can be replicated in unlimited supply using ACE as a marker. This breakthrough could lead to new treatments for heart diseases, anemias, leukemia and autoimmune diseases by mass-producing progenitor blood cells.
Researchers discovered ABC-transporters expressed on vascular endothelial cells, which decrease the intracellular concentrations of anti-HIV drugs like saquinavir and zidovudine. Inhibiting these transporters with verapamil or MK-571 increases drug retention, suggesting a potential therapeutic strategy to improve HAART efficacy.
Researchers at UT Southwestern Medical Center found that miR-126 is essential for creating new vessels in developing embryos and repair of injured blood vessels. However, its role in maintaining established vascular systems is unclear.
Researchers found that microRNA miR-126 regulates vascular development, structure, migration, proliferation and survival of endothelial cells. The study provides clues to potential therapeutic targets for diseases impacted by the vascular system.
A new group of stem cells in the epicardium can regenerate cardiomyocytes, smooth muscle cells, endothelial cells, and fibroblasts. This finding advances the hope of recapitulating developmental events to regenerate injured heart tissue, with potential applications for treating adults with heart failure.
A team of researchers led by Dr. Petri Salvén found that circulating endothelial precursor cells, crucial for angiogenesis and cancer growth, do not exist. Instead, ordinary white blood cells near blood vessel walls may have been misinterpreted as ECs in earlier studies.
A team of researchers created a functional human vascular system in mice by injecting spheroids of endothelial cells into the skin. The newly formed blood vessels are exclusively made of human endothelial cells and establish contact with mouse vessels, allowing for study of tumor growth and angiogenesis inhibitor effects.
Scientists discovered that HOXA11, a homeobox gene, is essential for the development of uterosacral ligaments, which are weakened in women with pelvic organ prolapse. In another study, researchers found that increased expression of the WNT antagonist sFRP-1 contributes to elevated intraocular pressure in glaucoma patients.
Researchers at Einstein College of Medicine successfully cured hemophilia A in an animal model by transplanting healthy liver endothelial cells from donor mice. The study overturned conventional wisdom regarding the source of factor VIII, a crucial clotting protein lacking in people with type A hemophilia.
A study by Yale School of Medicine identified a genetic mutation that expands lesions in the aorta and promotes coronary atherosclerosis. The researchers found that mice lacking the Akt1 gene developed more severe aortic atherosclerosis, highlighting the importance of this gene in regulating endothelial cell development
A University of Missouri-Columbia research team has developed a biology-based process for printing organ tissue structures, maintaining cell properties and allowing nature to take over. The breakthrough enables the creation of functional tissue structures without needing to control cell location or function.
A molecular pathway that plays a critical role in blood vessel growth has been identified by researchers. The finding suggests a potential target for inhibiting the growth of blood vessels that fuel cancers, diabetic eye complications, and atherosclerosis. The study used zebrafish as a model organism to discover the pathway.
Children’s Hospital Boston researchers have developed a solution to the repeat operations faced by infants and children receiving artificial heart-valve replacements. They created living, growing valves using tissue engineering techniques, which provide one-way blood flow from the heart’s right ventricle into the pulmonary artery.
Researchers at UCLA's Jonsson Cancer Center found that blocking angiogenesis signaling from inside endothelial cells can result in heart attacks, fatal strokes, and systemic vascular illness. The study suggests a more targeted approach to drug delivery may be necessary to minimize side effects.
Researchers found that patients with obstructive sleep apnea (OSA) have higher levels of dead cells from the lining of their blood vessels, which may explain why they are at a higher risk for cardiovascular disease. Treatment with nasal CPAP reduced levels of these cells.
Biomedical engineers create implant materials with nanostructured surface textures that mimic the natural lining of blood vessels. The results show rapid colonization of endothelial cells, preventing overgrowth of smooth muscle cells and reducing restenosis.
Researchers at Mayo Clinic have devised a novel approach to improving the effectiveness and safety of heart stents by magnetizing healing cells from a patient's blood. The cells are quickly drawn to magnetically coated stents, reducing blood clot formation by lining the site fully and quickly.
Researchers discovered that liver cells can activate T cells independently of the lymph system, potentially contributing to impaired immune responses in chronic hepatitis C. The study found that T cells interact with liver cells through fenestrations in sinusoidal endothelial cells.
Two studies published in the Journal of Clinical Investigation reveal key roles for PLC-gamma-2 and NF-kappa-B in immune responses. PLC-gamma-2 regulates osteoclast development and B cell differentiation, while NF-kappa-B controls endothelial cell function in models of sepsis and cancer.
Researchers at Beth Israel Deaconess Medical Center have discovered that carbon monoxide can reverse symptoms of pulmonary arterial hypertension by arresting smooth muscle cell growth and inducing apoptosis. The gas works with nitric oxide to target problematic cells, offering a potential new therapy for the debilitating condition.
Researchers at the University of Illinois College of Medicine identified a molecule that plays a critical role in lung tissue recovery following severe injury. The study found that FoxM1, a protein controlling cell proliferation, is involved in endothelial regeneration and barrier integrity restoration.
Researchers discovered that specialized skin cells direct embryonic patterning and wound healing by sending vital location cues to their neighbors. This finding has implications for regenerating certain parts of the body and understanding metastatic cancer.
Researchers at University of California - San Diego found that mechanical stretching activates cellular protein JNK, damaging cells and contributing to atherosclerosis. This discovery may help design better treatment approaches for cardiovascular disease.
Researchers found that an intracellular protein called synectin is a key regulator of arterial growth, impairing development when disrupted. This discovery could lead to new therapeutic approaches for coronary artery disease and vascular biology research.
A study by William D. Toff and colleagues found no significant difference in markers of coagulation activation between long-haul flights and controlled environments. The researchers tested the effects of hypobaric and hypoxia on healthy volunteers, but found that prolonged sitting did not enhance clot formation.
Researchers identify EP1R as a key player in failed asthma treatments, revealing its interaction with beta2-adrenergic receptors. The discovery opens up new avenues for developing selective drugs to treat severe asthma in individuals who don't respond to current therapies.
In a study on Huntington disease, researchers found that cystamine increased brain levels of protective protein HSJ1b and BDNF, suggesting a promising candidate for treatment. The study also revealed that cystamine raises BDNF in an HSJ1b-dependent manner.
Researchers at Medical College of Wisconsin discovered that high levels of endothelial-derived microparticles inhibit growth and migration of endothelial cells in the mitral valve tissue. This finding may help prevent endothelial injury in valvular disease and other forms of heart disease.
Researchers at UVa Health System have identified a critical role of the CXCR2 receptor in acute respiratory distress syndrome (ARDS), a leading cause of lung failure. The discovery opens new avenues for developing targeted therapies, including aerosol treatments that could potentially hit the lungs without compromising the immune system.
The Tumor-Host Genomics project aims to understand the molecular and cellular interactions between tumor cells and their microenvironment. By developing advanced functional genomics instruments and technologies, researchers hope to identify new targets for anti-cancer therapy.
Researchers discovered that stressed endothelial cells form healthy alignment of stress fibers perpendicular to the axis of stretch, a hallmark of healthy blood vessels. Inhibition of Rho protein causes stress fibers to grow in an unhealthy direction parallel to the axis of stretch.
Researchers discover that CA4P selectively targets endothelial cells, inducing regression of unstable blood vessels by disrupting VE-cadherin signaling. This breakthrough could lead to new avenues for targeting tumor neo-vessels and increasing the therapeutic window of anti-angiogenic agents.
Researchers found that CA4P selectively targets endothelial cells, inducing regression of unstable vessels by disrupting VE-cadherin signaling. This discovery may lead to new avenues for targeting tumor neo-vessels and increasing the therapeutic window of anti-angiogenic agents.
Researchers discovered a new compound, LMP-420, that potently reduces activation of endothelial cells and inflammation in cerebral malaria. This finding offers a promising avenue for treating the condition, which has a high fatality rate despite existing treatments.
Research reveals PTEN regulates VGF signaling, enhancing angiogenesis and accelerating tumor growth in mice. Individuals with mutated PTEN alleles are at risk for increased tumorigenic mutations and accelerated tumor growth due to enhanced angiogenesis.
Researchers at UC Davis have discovered a receptor pathway for C-reactive protein, a known risk marker for heart disease. Blocking this pathway with specific antibodies reverses the detrimental effects of CRP on endothelial cells.
Researchers at MIT have developed a novel approach to creating vascularized muscle tissue using a tri-culture scaffold composed of myoblasts, endothelial cells, and fibroblasts. The resulting implants showed improved integration with the host tissues and functioned in living mice and rats.
A study found that patients with high circulating endothelial cell counts before treatment were more likely to have growing tumors, while those with low counts remained stable. This test may predict patient outcomes and survival, allowing doctors to tailor treatment and spare unnecessary side effects.
Researchers discovered FGF-21 regulates glucose uptake in human fat cells, decreasing plasma glucose levels and triglycerides in diabetic animals. Additionally, FGF-21 protected animals from diet-induced obesity, defining a functional role for FGF-21 in vivo.
Researchers found that simvastatin prevents or reverses vascular injury by vasoprotective means, protecting against diabetes-induced endothelial cell dysfunction. The study suggests a potential role for statins in treating diabetic patients.