Articles tagged with Mammalian Cells
Researchers successfully converted adult human skin cells into medium spiny neurons, a subtype of brain cells affected in Huntington's disease. The newly generated cells survived and functioned like native cells in the mouse brain, demonstrating a promising approach for treating the disease.
A mouse model study suggests that elevated VEGF and sFLT1 levels during pregnancy can lead to preeclampsia-like symptoms and pregnancy loss. The findings highlight the potential consequences of therapies targeting these proteins for treating preeclampsia.
Casp8 activity arose over 500 million years ago and is universally conserved throughout evolution. Key protein interactions between Casp8 and FADD are also observed across the animal kingdom, suggesting a vital cell death toolkit in animal evolution.
Scientists discovered genes in humans that make repressor proteins to shut down specific jumping genes, a type of retrotransposon. The findings suggest an ongoing battle between mobile DNA sequences and the genes that control them, leading to the evolution of greater genomic complexity.
Scientists engineered a mouse model equipped with the CRISPR-Cas9 system to study disease mechanisms and inform drug discovery. The model allows researchers to easily perturb multiple genes in vivo, enabling rapid screening of gene functions implicated in diseases.
Researchers in Australia found that airborne dust particles stimulate inflammatory responses in airway cells, contributing to asthma development and worsening. The study suggests larger particles derived from dust may have important adverse effects on human health.
Researchers have identified a gene network that fuels aggressive Acute Myeloid Leukemia and its precursor disease Myelodysplastic Syndrome. Inhibiting a key protein in this network may prevent leukemia cell growth and expansion.
Researchers discovered a regulatory element controlling gene Cdx2's function, crucial for embryonic and extraembryonic cell lineages. This finding helps understand early specification of trophectoderm, essential for mammalian development.
Researchers discovered the brain circuit that links feelings to memories and found it possible to reverse emotional associations using optogenetics. This finding could lead to new treatments for post-traumatic stress disorder by strengthening positive memory associations.
Scientists alter emotional associations of specific memories by manipulating connections between the hippocampus and amygdala, finding that changing the emotional valence can transform a negative memory into a positive one. The research demonstrates potential for treating depression and anxiety.
Researchers have grown a fully functional thymus organ from transplanted laboratory-created cells in a living animal. This breakthrough discovery could lead to new treatments for people with weakened immune systems and may also offer a way of making patient-matched T cells for cell therapies.
The cytoplasm of mammalian cells is actually an elastic gel that creates random waves due to energetic processes in the cell. This new understanding provides a snapshot of the metabolic state of the cell and raises questions about cellular dynamics.
A study found that just a few nerve cells in the thalamic reticular nucleus (TRN) may control the switch between internal thoughts and external distractions. The TRN's firing patterns were altered using laser light, revealing its role in regulating consciousness and mental states.
A new study has found that BPS, a common chemical substitute for BPA, can cause disruptions to female heart rhythms. The research suggests that BPS, like its BPA counterpart, interferes with hormone regulation and causes abnormal calcium handling in cardiac muscle cells.
Researchers found that the unfolded protein response (UPR) signaling cascade plays a crucial role in protecting intestinal cells from damage. However, an overactive UPR caused by the CHOP protein can slow down tissue repair and lead to chronic inflammation.
Researchers at UCSB's Neuroscience Research Institute found a remarkable degree of variation in cell number across 30 genetically distinct lines of mice for 12 different retinal cell types. The variation was largely independent of one another, with few significant correlations between the cell types.
Researchers at North Carolina State University have developed a neural transplant that significantly reduces absence epilepsy seizures in mice. The treatment targets specific areas of the brain affected by the disease, offering hope for developing new therapies for humans suffering from various forms of epilepsies.
Researchers discovered that blocking pain receptors, specifically TRPV1, can extend lifespan in mice by promoting a youthful metabolism and reducing the risk of age-related diseases like diabetes. The study also found that diets rich in capsaicin, a compound found in chili peppers, may help improve metabolic health and longevity.
Scientists have made significant breakthroughs with pluripotent stem cell therapy in monkeys, producing new bone tissue and minimizing the risk of tumors. The study uses autologous iPSCs derived from individual monkeys' skin cells, eliminating the need for immune suppression drugs.
Scientists discovered a surge of heart muscle cell division in young mice, increasing cardiac muscle cells by 40% and suggesting thyroid hormone could aid in children's treatment, offering an alternative to focusing on stem cells.
Researchers found that heart muscle cells in mice undergo a brief proliferative burst prior to adolescence, increasing in number by about 40% to meet the body's growing needs. This discovery suggests that thyroid hormone therapy could stimulate this process, enhancing the heart's ability to regenerate in patients with heart disease.
Researchers found that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease, concomitant with amyloid pathology and behavioral deficits. The study, published in Neural Regeneration Research, used a mouse model to investigate the relationship between Cajal-Retzius cells and Alzheimer's disease.
Researchers successfully restored damaged heart muscles in monkeys using human embryonic stem cells, suggesting a promising approach for human treatment. The therapy regenerated 40% of the damaged heart tissue and improved cardiac function in some treated animals, but also raised concerns about arrhythmias.
Scientists at the University of Texas at Dallas are investigating the potential human health effects of multi-walled carbon nanotubes, tiny structures used in various products. The researchers will use advanced microscopy techniques to track how these nanotubes interact with human cells and determine their impact on health.
Researchers at Scripps Research Institute discover a dual-sensor system for the sense of touch, involving Merkel cells and nerves. The study provides new insights into how gentle touch sensations are detected by the skin.
Scientists discover that when one cell dies due to DNA damage, its neighbors are alerted and become harder to kill. This finding challenges previous views on apoptosis and could have implications for cancer therapy.
Researchers developed SIF-seq to identify mammalian enhancers, which amplify specific gene expression, and validate ChIP-seq results. The technique offers a higher-throughput functional assay for various cell types and developmental contexts.
Researchers have developed a versatile mouse that expresses a fluorescent biosensor, enabling the tracking of diseased cells and drugs in real-time. This technology has been used to monitor Rac activation in various organs in response to drug treatment, providing valuable information on cancer progression.
Scientists have made a breakthrough in treating type 1 and type 2 diabetes by successfully converting gut cells into functional insulin-producing cells. The new method involves introducing specific transcription factors into intestinal crypt cells, which can then produce insulin and improve hyperglycemia in diabetic mice.
Researchers at UC San Diego discovered that direction-sensing cells in the retina send signals to the cortex, enabling brains to process directional movements. The study has practical implications for understanding and treating disabilities related to motion processing.
Dr. Gyorgy Fejer has developed a method to create continuously growing macrophage cells in the lab from mice, reducing the need for live animals in research. This could lead to significant reductions in animal usage and improve research effectiveness.
New research reveals that supporting cells in the ear can turn into hair cells in newborn mice, leading to potential cell replacement strategies for adults and new treatment approaches for deafness. The study found that blocking the Notch signaling pathway increases the formation of new hair cells from nearby Lgr5-expressing cells.
Researchers from the University of Cambridge have discovered a way to study and film embryo development during implantation, revealing a 'rosette' structure that challenges current understanding. This breakthrough could improve IVF success rates and advance regenerative medicine.
Innate lymphoid cells play key roles in protecting against infection or parasites, but their origin and function were unknown until now. Researchers identify ILCPs in fetal liver and adult bone marrow, paving the way for a better understanding of the immune system's first line of defense.
Researchers have created a novel scaffold for growing cardiac muscle cells using carbon nanofibers, which can conduct electricity and promote better metabolic activity. This breakthrough aims to repair damaged hearts through tissue engineering.
Researchers at UNC School of Medicine deploy a combination therapy targeting persistent HIV-infected cells that standard therapies cannot kill. The study uses mouse models and finds that an antibody combined with a bacterial toxin can penetrate infected cells and kill them, resulting in a six-fold drop in the number of infected cells.
Researchers at the University of Cambridge have created a technique that can pinpoint the factors driving cell differentiation, including previously unidentified genes. The method uses haploid embryonic stem cells to uncover how cell differentiation works.
Scientists have developed a new technique to visualize the silencing of one X chromosome in females, revealing wide-ranging variation in patterns across tissues and individuals. The study's findings offer insights into genetic diversity and disease causes, particularly for X-linked variations like hemophilia and color blindness.
A new study published in Cell journal strengthens the understanding that gut microbes can affect brain function and behavior, particularly in individuals with autism spectrum disorder. Feeding mice a beneficial type of bacteria has been shown to reduce autism-like behaviors.
Researchers have made a breakthrough in printing cells from the human retina using piezoelectric inkjet technology, opening up new possibilities for treating blindness. The study successfully printed two types of cells, ganglion cells and glial cells, which remained healthy and retained their ability to survive and grow in culture.
Researchers from the University of Pennsylvania have discovered a way to reduce disease toxicity associated with Lou Gehrig's disease in animal models. By targeting stress granules and modulating cellular structures, they slowed neuron dysfunction and showed promise in mammalian cells.
Researchers have identified Sca1 stem cells as the key players in the regeneration of heart muscle cells in mammals. These stem cells increase their activity in response to heart damage, leading to the formation of new heart muscle cells.
Researchers found that co-transplanting Schwann cells and olfactory ensheathing cells, combined with daily treadmill training, promotes functional recovery in rats with spinal cord injuries. The study reveals a synergistic benefit of the combined therapy on axonal regeneration and motor function improvement.
Researchers found a new mechanism regulating the earliest stages of embryo development, where arm-like structures called filopodia control cell shape and compaction. The discovery could help improve IVF treatment outcomes by identifying suitable embryos for implantation.
A study investigated the optimal site for cell transplantation to treat spinal cord injury, using laboratory mice with contusive spinal cord injuries. The researchers found that intralesional injection of neural stem/progenitor cells led to motor functional recovery and improved survival rates compared to other sites.
A study published in Cell Reports found that Amphotericin B, a common antifungal medication, can render a protein important for antiviral defense ineffective in both cells and mice. This makes patients receiving the therapy more vulnerable to influenza and other viral infections.
A new USC study found that the protein Lkb1 promotes orderly skeletal growth and prevents skeletal tumors by controlling the progression of immature cartilage cells. This discovery sheds light on how this protein helps keep people organized, with implications for understanding human diseases such as cancer and diabetes.
Researchers have identified a crucial intermediate step in the formation of plaque that causes type 2 diabetes. The protein amylin aggregates into plaques that kill cells, but animals resistant to the disease prevent this by targeting an earlier clumping process.
Researchers found that disrupting the circadian clock in mice increases susceptibility to inflammatory disease by controlling the development of key immune cells called interleukin-17-producing CD4+ T helper cells. This discovery could lead to new ways to regulate the immune response and prevent autoimmune diseases.
Researchers have identified a source of gut stem cells that can repair damaged gut tissue in mice with inflammatory bowel disease. These stem cells were found to be actively dividing and could form mature intestinal tissue under the right conditions.
Marmosets exhibit cooperative vocal exchange in a conversational manner, taking turns without interruptions, and follow unspoken rules of etiquette. This unique behavior is distinct from other animals and shares similarities with human communication patterns.
Researchers at CU University of Colorado discovered that maximum heart rate drops with age because the sinoatrial node's natural pacemaker cells beat more slowly in older individuals. This decrease limits athletic performance and is a leading cause for nursing home admissions among otherwise healthy seniors.
Researchers at Johns Hopkins Medicine have identified a defect in cell communication as the likely cause of systemic sclerosis, a disease affecting approximately 100,000 people in the US. They also developed treatment strategies using compounds that target the immune response and fibrosis.
Researchers have found a new compound that targets the fungus without harming humans, offering hope for safer treatment options for life-threatening fungal lung infections. The discovery has potential to combat histoplasmosis and cryptococcosis, which can cause flu-like symptoms and severe complications.
Researchers discovered that mammalian cells prefer disc-shaped nanoparticles over rod-shaped ones under typical culture conditions. The study's findings could help design better therapies for various diseases by understanding how nanoparticle shape affects transport into cells.
Researchers have discovered a key signal that keeps oocytes alive: coenzyme A, which maintains enzyme CaMKII on, preventing cell death. This mechanism appears to be conserved in animals, offering potential therapies for preserving women's egg supply and fertility.
Researchers used cynomolgus monkeys to compare autologous and allogeneic transplantation of iPS cell-derived neural cells. Autologous transplantation produced almost no immune reaction, while allogeneic transplantation provoked an immune response.
Researchers used iPSCs from nonhuman primates to develop neural cells depleted by Parkinson's disease, eliciting only a minimal immune response. This breakthrough suggests autologous transplantation could be a viable option for humans, offering promise as a treatment for the disease.
Researchers developed a new method to control genes by targeting transcription, allowing for positive and negative regulation with the same protein. The technique has the potential to enable complex synthetic biology circuits and applications such as disease detection and drug production.
The researcher aims to establish permanently growing, alternatively activated M2 macrophage cell lines to reduce animal use in studies. This innovation could provide scientists with almost limitless cells for study without the need for live mice.