Articles tagged with Metaplasia
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers identified 26 'driver genes' that play a pivotal role in the transition to stomach cancer, providing a critical window for early detection and targeted prevention. The study's findings offer new insights into the mechanisms governing the transformation of intestinal metaplasia into stomach cancer.
Scientists at the University of Florida have identified two small molecules that inhibit precancerous cell progression and reverse a key process involved in pancreatic cancer progression. This discovery could lead to earlier treatments and improved survival rates for patients with pancreatic cancer.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
Researchers have revealed mechanisms by which polyps develop into colorectal cancer, setting the stage for improved surveillance utilizing precision medicine. The study found that serrated polyps derive from metaplasia, an abnormal change of cells into non-native tissue.
A study by the California Academy of Sciences and colleagues found significant tissue abnormalities in oysters from the Gulf Coast, even years after the devastating oil spill. The researchers discovered higher rates of metaplasia in Eastern oysters, which can cause debilitating health issues.
Scientists at Université libre de Bruxelles discover a new mechanism behind the development of metaplasia in the oesophagus, a precursor to esophageal adenocarcinoma. The study reveals that reactivation of the Hedgehog pathway triggers cellular changes leading to the conversion of squamous cells into columnar cells.
Gastric intestinal metaplasia is a marker associated with increased risk of gastric cancer, prompting the need for standardized clinical practice. The new AGA guideline provides evidence-based recommendations for testing H. pylori eradication and surveillance strategies.
Two new studies evaluate the safety and effectiveness of endoscopic submucosal dissection (ESD) and liquid nitrogen spray cryotherapy (LNSCT) in treating Barrett's esophagus. ESD was found to have high en-bloc and curative resection rates, while LNSCT showed long-term efficacy in eliminating dysplasia and intestinal metaplasia.
Age-related inflammation drives metaplasia in flies, causing changes in gut tissue and gut bacteria. Inhibiting this pathway prevents abnormal changes, maintains a healthy commensal population, and extends lifespan by up to 18%.
A systematic review and meta-analysis found that radiofrequency ablation is a safe and effective treatment for most patients with dysplastic Barrett's esophagus. The procedure led to complete eradication of dysplasia in 91% of patients, while intestinal metaplasia was eradicated in 78%, and recurrent metaplasia occurred in 13%.
A study from researchers at the Hospital of the University of Pennsylvania reports that endoluminal therapies combining resection and ablation techniques have a high success rate in eradicating Barrett's esophagus, with durable results. Persistent vigilant surveillance is required due to recurrence risks.
Research found that IL-8 and MIF gene polymorphisms significantly increased the risk of severe atrophic gastritis and intestinal metaplasia, particularly when H. pylori infection was present. This study provides a basis for therapeutic decisions, such as H. pylori eradication therapy, to prevent gastric cancer progression.
A landmark UNC-led study finds radiofrequency ablation significantly effective in treating dysplasia in people with Barrett's esophagus, eradicating abnormal cells and reducing cancer risk. The procedure showed high rates of complete eradication of intestinal metaplasia and progression to disease.
Research published in the journal Gut indicates a projected 25% decline in stomach cancer cases in Western countries by 2030. The long-term nationwide study monitored three types of cell changes indicative of stomach cancer, tracking almost 98,000 patients from 1991 to 2005.