Articles tagged with Osteoclasts
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the Weizmann Institute of Science have discovered that the impermeable ring formed by osteoclasts is composed of individual podosomes held together by protein filaments. This unique structure allows the cells to confine bone-eating acids and enzymes, enabling efficient bone digestion.
Researchers reveal that glucocorticoids, commonly used for inflammatory disorders, can cause osteoporosis by delaying osteoclast death and suppressing bone formation. Prolonged GC use affects bone health in mice with normal and disrupted GC receptors.
Cortisone has been found to weaken bones by targeting osteoclasts, which dismantle old bone. Researchers may now be able to develop therapeutic targets to prevent cortisone's damaging side effects on bone.
The inner walls of bones serve as sites for both bone breakdown and reconstruction, with osteoclasts playing a crucial role in releasing hematopoietic stem cells. This process is essential for maintaining balance in the body's response to injury or inflammation, and may have implications for bone marrow transplant techniques.
Dr. Teitelbaum's research reveals that blocking integrin receptors on osteoclasts can prevent bone loss in osteoporosis and rheumatoid arthritis, offering new drug targets. Additionally, his work has shed light on the effects of protease inhibitors on osteoclasts in HIV/AIDS patients.
Scientists discovered that interleukin-6 increases in TM patients' cerebrospinal fluid and is linked to tissue injury. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea.
Researchers at Yale University identified IRAK-M as a key regulator of bone cells, finding that its presence prevents bone loss and its absence leads to severe osteoporosis in mice. The study suggests IRAK-M could be a new target for treating or preventing osteoporosis.
A major axis within bone cells regulates bone production and loss, providing a potential new target for treating debilitating osteoporosis. Local regulation of bone mass is now believed to occur primarily in the bone, not in the brain as previously thought.
A study published in the Journal of Clinical Investigation reveals that M-CSF and alphaV beta3 integrin collaborate to regulate osteoclast differentiation. The discovery brings scientists closer to understanding the mechanisms behind osteoporosis, a condition affecting 50% of Caucasian and Asian women after age 65.
Researchers discover two compounds that inhibit parathyroid hormone-related protein production in human breast cancer cells, reducing metastatic bone breakdown and calcium levels. The findings suggest a novel therapeutic approach to treating bone metastasis and hypercalcemia in breast cancer patients.
Researchers created mice lacking SHIP gene to understand how bone forms and breaks down in diseases like JPD. The study reveals that mice with deficient SHIP develop osteoclasts similar to those found in humans with JPD, leading to severely osteoporotic conditions.
Researchers at Washington University in St. Louis discovered that blood vessels signal the onset of bone loss in diseases such as rheumatoid arthritis and osteoporosis. The discovery sheds light on how inflamed blood vessels trigger a cascade of events leading to local bone destruction.
Researchers found that alcohol feeding impaired osteoblast function and led to increased bone turnover, contributing to bone fragility. In contrast, mice lacking the interleukin-6 (IL-6) gene had better maintained bone mass and reduced fractures.
Researchers found that high concentrations of nitric oxide in osteoclasts prevent excessive bone resorption, a process linked to diseases like osteoporosis. This discovery may lead to new strategies for preventing bone loss and potentially treating inflammatory conditions.