Articles tagged with Skin Cells
Researchers at Northwestern University have developed a novel gene regulation technology that can selectively target disease-causing genes in skin cells. The treatment uses spherical arrangements of nucleic acids to penetrate the skin and deliver therapeutics, offering new hope for life-saving therapies for skin cancers and other skin ...
Researchers have identified a molecule called regenerating islet-derived protein 3-alpha (REG3A) that is highly expressed in skin cells during psoriasis and wound-healing, but not under normal skin conditions. Inhibiting REG3A may clear up psoriasis and slow down wound-healing.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
Researchers at Gladstone Institutes successfully transformed skin cells into brain cells using Sox2 gene, potentially leading to better models for testing drugs for devastating neurodegenerative conditions. The breakthrough could accelerate drug development and reduce risks associated with human trials.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.
Researchers at A*STAR's Singapore Immunology Network discovered that long-lived, skin-deep immune cells called Langerhans cells originate from two distinct embryonic sites - the early yolk sac and the foetal liver. These cells play a critical role in initiating protective responses against harmful foreign invaders.
A new device developed by researchers in Israel can reveal vital medical information from a single drop of blood in real-time. Using spectrally encoded confocal microscopy, the device creates high-resolution images of individual blood cells flowing through veins without the need for fluorescent dyes.
Researchers reveal that Langerhans cells can perform either immunosuppressive or immunostimulatory functions depending on the situation. They found that LCs induce proliferation of regulatory T cells to maintain tolerance under normal conditions, but also stimulate protective immune responses against pathogens.
Two scientists, Elaine Fuchs and Howard Green, have been awarded the March of Dimes Prize in Developmental Biology for their groundbreaking research on skin stem cells and inherited skin disorders. Their work has saved thousands of lives and holds promise for new therapies for baldness and other diseases.
Researchers created lab-made heart cells from patients with dilated cardiomyopathy, exhibiting abnormal structure and response to calcium signals. The cells responded to beta blocker treatment and gene therapy approach, offering potential for improving drug screening and saving lives.
Researchers at the University of Bonn have developed a method to convert skin and umbilical cord cells directly into nerve cells with high efficiency. The scientists achieved this by using small molecules to optimize signaling pathways and simplify the process, resulting in up to 80% human neurons being produced.
Researchers have developed a new method to induce somatic stem cells directly from fully differentiated skin cells. This breakthrough reduces the risk of tumor formation and increases their therapeutic potential for tissue regeneration.
A study at Tufts University has identified specific epigenetic signatures that can predict the expression of a wound-healing protein in reprogrammed skin cells. This breakthrough brings researchers closer to developing personalized tissue regeneration strategies using stem cells from patients, eliminating the need for human embryonic s...
Research found microneedle vaccine patches are more effective than traditional inoculation methods against influenza virus in mice. The patches trigger a local increase of cytokines and activate dendritic cells, leading to a strong innate immune response.
Researchers found that resident memory T cells in the skin, called TREMs, provide a powerful and effective immune response against infection. This new understanding challenges immunological dogma and suggests a more effective path to immunity through delivering vaccines to upper layers of the skin.
Researchers at Brigham and Women's Hospital discovered memory T cells living in skin that protect against infection and disease. These resident cells are more important for immunity than previously thought and suggest a fundamental shift in how vaccines are designed and delivered.
Researchers have developed a synthetic version of the essential protein Oct4, which enhances the effect of genes needed for stem cells. This breakthrough enables more efficient generation and maintenance of stem cells, with potential applications in regenerative medicine and disease treatment.
Researchers at Stanford University School of Medicine have successfully converted mouse skin cells into neural precursor cells with high efficiency. This breakthrough could potentially refute the need for pluripotency and offer a more direct way to generate specific cell types for therapy or research.
Researchers at Linköping University have identified a new target for treating psoriasis: the psoriasin protein, which stimulates cell division and angiogenesis. By inhibiting psoriasin, they believe they can reduce disease severity and minimize side effects.
Researchers have discovered that each type of hair follicle works like a distinct sensory organ, tuned to register different types of touches. This network of neurons allows us to perceive important differences in our surroundings.
Researchers at Stanford Medicine have shown that iPS cells can mirror the defining defects of Marfan syndrome as well as embryonic stem cells. This study advances the credibility of induced pluripotent stem cells for modeling human diseases and offers an ethically uncomplicated alternative to embryonic stem cells.
Male mice have lower catalase activity, leading to higher oxidative stress and increased susceptibility to UVB-induced skin damage. Women may have natural antioxidant protection that reduces their risk of developing skin cancer.
Researchers developed a method to characterize the optical properties of ZnO nanoparticles, allowing them to assess their safety in sunscreen. The study found that nanoparticles did not penetrate beneath the stratum corneum, the topmost layer of skin, after being applied and washed off.
Researchers have discovered that human skin can begin tanning in seconds after exposure to UV light, using a mechanism similar to the retina's detection of light. This early response provides rapid protection against UV damage and may impact sunscreen design.
Researchers have successfully joined epidermic stem cells to create healthy skin in the lab, preserving their regenerative potential. They can now use these cells to regenerate patients' skin, offering a new therapeutic strategy for those with limited treatment options.
Centenary Institute researchers have identified a set of immune cells in the outer layer of the skin that prevent the immune system from attacking friendly bacteria. This discovery opens up new possibilities for treating inflammatory bowel disease and other immune-mediated disorders.
Researchers identified genetic changes that led to the loss of E2A, a crucial gene regulator. The loss enables tumor cells to grow rapidly and uncontrolledly, contributing to the aggressive behavior of Sézary syndrome.
Columbia University researchers have successfully converted human skin cells directly into functional forebrain neurons, providing a promising alternative to traditional stem cell therapies. The induced neurons exhibit characteristics similar to those of healthy neurons and can transmit signals, indicating their potential for replaceme...
Researchers have discovered that certain grape extracts can protect human epidermis cells from UV radiation-induced cell damage and death. The study found that flavonoids in grapes inhibit the formation of reactive oxygen species, leading to a protective effect against UV radiation.
A scientist at the Gladstone Institutes has discovered a way to convert human skin cells into brain cells, offering new hope for regenerative medicine and personalized drug discovery. The breakthrough discovery allows for efficient and robust methods to transform adult skin cells into neurons capable of transmitting brain signals.
A new study reveals that subsets of dendritic cells in the skin can promote unique and opposite immune responses against the same type of infection. The research highlights the critical role of dendritic cells in initiating an effective immune response.
Researchers from Stanford University School of Medicine successfully converted skin cells into fully functional neurons using two specific gene snippets, known as microRNAs. This breakthrough finding opens up new avenues for studying neuronal development, modeling disease processes, and testing treatments.
A new Cardiff University study aims to develop a vaccine patch targeting immune cells in the skin to boost the body's response and prevent HIV transmission. The research uses microneedles to modulate dendritic cells, increasing their potency and inducing immunity.
Researchers have successfully implanted lab-grown blood vessels from donor skin cells into patients, a breakthrough that could improve treatment for kidney dialysis and coronary bypass surgery. The vessels withstood high pressure and frequent needle punctures without rejecting the immune system, paving the way for widespread use.
A new genetic technique reprograms mature skin cells directly into brain cells without passing through the stem cell stage, opening a field for cell transplants. The discovery represents a fundamental change in the view of mature cell function, offering potential to treat neurodegenerative diseases like Parkinson's.
Researchers created functional neurons from human skin cells using four proteins, bypassing the creation of induced pluripotent stem cells. This advancement enables the study of neural diseases and development of more effective treatments and cures.
Researchers at Stanford University School of Medicine successfully converted human skin cells into functional neurons in a period of four to five weeks. Adding a fourth transcription factor called NeuroD proved crucial for the transformation, generating electrical activity and integrating with mouse neurons.
Researchers at Stanford University School of Medicine used undifferentiated induced pluripotent stem cells to study dyskeratosis congenita, a rare genetic disease. They found that the activity of telomerase, an enzyme critical to aging and cell renewal, is correlated with the severity of symptoms.
Researchers at Schepens Eye Research Institute successfully regenerate large areas of damaged retinas and improve visual function using IPS cells derived from skin. The study holds promise for future treatments and cures for diseases such as age-related macular degeneration and retinitis pigmentosa.
Researchers at Duke-NUS Graduate Medical School have identified a new cell type that can sense and respond to the dengue virus, which is transmitted through mosquito bites. The discovery opens up new avenues for developing vaccines and treatments for the disease, which currently lacks effective therapies.
Jason S. Meyer, assistant professor of biology at IUPUI, is honored by the Association for Research in Vision and Ophthalmology (ARVO) for his groundbreaking study on modeling early retinal development using human embryonic and induced pluripotent stem cells.
Researchers found that synthetic skins reacted similarly to rat skin when exposed to a skin cream treatment, suggesting potential for true human skin simulation. The study has implications for treating burn victims, who may require synthetic or animal skin substitutes.
Researchers have identified specific bone marrow cells that can transform into skin cells to repair damaged tissue. The discovery provides new insights into the mechanisms behind skin repair and has the potential to revolutionize approaches to wound treatment.
A new 'molecular switch' regulates epidermal stem cells, controlling skin growth and development. The study provides clues to new treatments for squamous cell carcinoma and burn patients.
Researchers at Duke University developed a laser-based tool that can identify substantial chemical differences between cancerous and healthy skin tissues. The technique uses two lasers to pump energy into suspicious moles, analyzing the way it redistributes in the skin cells to pinpoint microscopic locations of different skin pigments.
Researchers created beating human heart cells from skin cells of patients with a severe genetic heart defect, allowing them to study and characterize the disorder at the cellular level. They also identified a promising drug to reverse the heart malfunction, which has no decent treatments currently available.
Researchers at Cold Spring Harbor Laboratory have identified a new role for the sister gene of p53, p63, in skin cancer and stem cell biology. The study reveals that increased activity of Ras combined with overly exuberant activity of ΔNp63α stimulates skin stem cells to promote carcinoma development.
A team at Sanford-Burnham identified specific microRNAs that enhance the reprogramming process from skin cells to induced pluripotent stem (iPS) cells. Adding these miRNAs increases cell survival and improves iPS cell generation.
Researchers at Johns Hopkins have found a way to reprogram adult cells with the properties of embryonic stem cells using a small blood sample. The new method avoids creating DNA changes that could lead to tumor formation, resulting in safer and more reliable iPS cells for research and potential clinical applications.
Researchers at Scripps Research Institute successfully converted adult skin cells into beating heart cells through a direct reprogramming strategy, bypassing the need for embryonic-like stem cells. This breakthrough discovery has the potential to lead to new treatments for diseases such as heart disease, Parkinson's, and Alzheimer's.
A University of Manchester scientist has discovered the mechanism behind skin cells' tight binding, which could lead to new treatments for debilitating skin diseases and heart problems. The study found that glue molecules bind specifically to similar molecules on neighboring cells, creating a resilient structure.
Researchers at EUREKA have developed a new laser-based technology to create nano-structured polymers that enable faster and more efficient growth of human skin cells. This innovation has the potential to revolutionize nanotech medicine, allowing for the creation of artificial implants and tissue engineering.
Scientists have developed Australia's first adult induced pluripotent stem cell lines for the rare genetic disease Friedreich Ataxia, enabling the development of new treatments. The iPS cells were characterized to become specific cell types, including heart and nerve cells, which are affected by the disease.
Researchers successfully transformed adult mouse skin cells into cartilage-producing cells, paving the way for potential therapy to repair cartilage injuries. The innovative method involves expressing proteins that induce pluripotency and promoting chondrocyte fate in fibroblasts from human skin.
Scientists at Scripps Research Institute have made a significant leap forward in finding chemicals needed to reprogram mature human cells and turn them into stem cells. The discovery represents a fundamentally different approach from previous methods and offers a new method for generating induced pluripotent stem cells with defined sma...
Researchers at Rockefeller University Press have successfully reprogrammed human skin cells to produce platelets that can be used in patients with thrombocytopenia. The breakthrough method involves culturing these cells in a cocktail of platelet-promoting factors, resulting in platelets that function like normal healthy platelets.
Scientists successfully replicated autism in the lab using human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome. The study revealed disease-specific cellular defects, such as reduced functional connections between neurons, which are reversible through insulin-like growth factor 1 (IGF-1) treatment.
Scientists at McMaster University have discovered how to make human blood directly from adult skin cells, bypassing the need for a pluripotent stem cell conversion. This breakthrough could lead to new treatments for patients in need of blood transfusions, reducing reliance on donor matches and increasing access to life-saving therapies.
A Stanford study finds that depletion of protein Perp, which hooks skin cells together, may be an early indicator of skin cancer development. The loss of Perp also promotes cancer by increasing inflammatory molecules and disrupting cell-cell adhesion.
University of Colorado Cancer Center researcher Chuan-Yuan Li and his team have discovered that caspase genes, known as 'grim-reaper' genes, are the gatekeepers that allow differentiated adult cells to regress to undifferentiated stem-like cells. This breakthrough discovery could lead to more efficient use of induced pluripotent stem c...