Articles tagged with Skin Cells
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Researchers have developed a new approach to treating cancer using viruses to infect and kill cancer cells. In mice, combining this with standard therapy led to substantial tumor regression and cure. Additionally, modulating VEGF signaling allowed the cells lining tumor blood vessels to be targeted by viruses, suggesting a potential wi...
A recent study by Mount Sinai researchers demonstrates that skin cells found in human amniotic fluid can be efficiently 'reprogrammed' to pluripotency, a characteristic similar to human embryonic stem cells. This breakthrough has significant implications for stem cell research and patient care.
Researchers discovered Sonic hedgehog gene presence in ectoderm of mice limb buds, indicating a new role in digit formation and possible implications for human birth defects. Disrupting this signaling led to extra digits forming.
A single layer of cells controls leaf size, with epidermal cells influencing overall size and cell division rates. Epidermal cells also affect the number of cells produced in the mesophyll layer.
Researchers are developing non-controversial alternatives to human embryonic stem cells by transforming adult skin cells into stem cells using a molecular toolkit. Chemists aim to identify drug-like substances that can reprogram mature cells into stem cells, bypassing the need for gene therapies.
The SRC-3 gene enhances breast cancer growth and invasion by activating cell motility, allowing cancer cells to invade surrounding tissue. Researchers found that the gene enables an alternative form of its coactivator protein to function at the cell membrane, leading to increased cancer spread.
Researchers at Stanford University School of Medicine have successfully converted mouse skin cells directly into functional nerve cells using just three genes. This breakthrough finding could revolutionize human stem cell therapy and change our understanding of cellular specialization.
Researchers explore the development and morphology of insect-mimicking spots on the flower petals of a South African beetle daisy. The study found that these spots are composed of three types of epidermal cells, each spanning four fused petal lobes, and are influenced by UV reflectivity and anthocyanin pigment.
Scientists have discovered a new type of stem cell in the skin that acts like embryonic stem cells, generating various cell types and aiding in hair growth and wound healing. The dermal stem cells may hold the key to treating baldness and other neurological disorders.
Merkel cells are essential for distinguishing shapes and textures, enabling hand dexterity through the sensory coding of light touch. The discovery confirms these cells are required for this function.
Researchers at Helmholtz Munich have discovered Th22 cells, a previously unknown subset of T helper cells that aid in tissue repair and prevent inflammation. The newly found cells hold promise for developing new treatment methods for inflammatory skin diseases and potentially also allergic respiratory diseases.
A new type of T-helper cell, called Th22 cells, has been discovered by researchers from Imperial College London. These cells play a special role in overseeing and coordinating immune cells that cause inflammation in chronic and allergic inflammatory diseases.
The National Institute of General Medical Sciences (NIGMS) is accelerating basic studies of induced pluripotent stem cells (iPS) using $5.4 million in Recovery Act funding. Scientists at 16 institutions will investigate iPS cell properties and derivatives for therapeutic applications.
Researchers at Medical College of Wisconsin successfully produced patient-specific liver cells from skin cells, enabling potential treatment of metabolic liver diseases. The study builds on previous work by James Thomson and colleagues, showing that skin cells can be reprogrammed into embryonic stem cells.
Researchers at Case Western Reserve University found that Merkel cells, responsible for touch perception, originate from the skin, contradicting previous speculation. The study's results provide significant insights into the development and function of Merkel cells, which may hold implications for understanding Merkel cell carcinoma.
A new study resolves the mystery of Merkel cell development, finding that they originate from the embryonic epidermis. Adult skin stem cells also replenish the Merkel cell population as they die off over time.
A new study has associated Merkel cell polyomavirus (MCPyV) with Merkel cell carcinoma, a rare and aggressive skin cancer. The study found that nearly all patients with Merkel cell carcinoma carried antibodies against MCPyV, suggesting a strong link between the virus and the disease.
Researchers found that green tea component EGCG can prolong the preservation of stored blood platelets by up to six days via anti-apoptosis properties. Additionally, EGCG was shown to preserve skin tissues by controlling cell division and preventing oxidation, allowing for the storage of skin grafts up to seven weeks.
Researchers identified two proteins, C/EBPα and β, that control the transition from stem cell to skin cell development in mice. Mice lacking these proteins had defective skin formation and died shortly after birth. The study sheds light on the mechanisms involved in skin cancer and other epithelial cancers.
Researchers are studying skin's complex structure to create products that appeal to consumers, with a focus on lipid bilayers and ceramide molecules. The goal is to develop ingredients that improve skin's strength, elasticity, and overall feeling.
Researchers have identified versatile cells in liposuction leftovers that can be quickly converted into induced pluripotent stem cells (iPS cells), potentially revolutionizing regenerative medicine. The study shows a 20-fold improvement in efficiency compared to skin cells, which are more challenging to reprogram.
A study found that amateur designers have lower self-evaluations of their products when compared to professionals. However, consumers enjoy intentionally competing against professionals, leading to more favorable self-evaluations when informed of contests beforehand.
A University of Wisconsin-Madison team successfully grew multiple types of retina cells from two types of stem cells, suggesting a potential future in repairing damaged retinas. The discovery will also lead to laboratory models for studying genetically linked eye conditions and screening new drugs.
Researchers are developing a new technique using human stem cells to study ALS, reducing the need for animal experiments. Dr Vasanta Subramanian will use Induced Pluripotent Stem cells (iPS cells) from adult skin cells to analyze genes causing the disease.
A team at WPI and CellThera has discovered a novel method to turn on stem cell genes in human fibroblasts by manipulating culture conditions. This breakthrough could lead to treatments for human diseases and traumatic injuries by coaxing patient cells to repair and regenerate damaged tissues.
Researchers at Tufts University have created skin-like tissues using human embryonic stem cells, which can be used to treat oral and skin conditions. The breakthrough uses three-dimensional tissue engineering techniques to mimic the growth environment of human skin.
Researchers engineered mice with a persistent wound-like skin condition to study tumor growth. The study found that chronic skin wounds promote skin tumors by secreting molecules that activate dermal cells and increase inflammation. Notch1 signaling plays a critical role in this process, suggesting potential complications for drug design.
Researchers found distinct gene expression signatures in embryonic stem cells and induced pluripotent stem (iPS) cells, indicating they are not perfectly similar despite sharing potential to become all body tissues. The study aims to understand the biological significance of these differences and their impact on iPS cell function.
Researchers found that salamanders' regenerative cells retain the 'memory' of their original tissue, contributing only to the same type of tissue. This suggests that harnessing salamander's regenerative wonders may be within the realm of possibility for human medical science.
Researchers have finally proven the link between Merkel cells and light touch sensation, a discovery that resolves a 100-year-old mystery in neuroscience. The study found that Merkel cells, typically associated with texture and shape perception, play a crucial role in detecting light touch.
Researchers successfully treated basal cell carcinoma with a non-toxic radioactive patch, showing minimal scarring and no toxicity. The treatment delivered beta radiation to the cancer site, effectively eradicating the malignant cells.
Researchers at Fraunhofer-Gesellschaft have developed a fully automatic production system for two-layer skin models, which can be produced in large quantities with perfect quality. The technique has already proven its use in practice, but was previously too expensive and complicated for mass production.
Researchers found skin cells can become muscle-like and vice versa by changing who they associate with, providing insight into genetic reprogramming. This discovery may lead to more efficient ways to create stem cells and treat diseases like diabetes.
Researchers successfully transform human skin cells into mouse muscle cells and vice versa, providing insight into cell specialization and potentially bypassing stem cells. This breakthrough may lead to novel treatments for diseases by directly generating necessary cells.
Researchers discovered an antioxidant, ellagic acid, which prevents collagen destruction and inflammatory response in human skin cells and mice exposed to UV-B. The study found that ellagic acid reduces MMP secretion and inflammation, demonstrating its potential to prevent wrinkle formation and photo-aging.
Researchers identify previously unrecognized defense mechanisms that improve treatment of viral skin infections. They found that immune cells in the skin, such as dendritic cells and memory T cells, can trigger a strong response to infections, providing efficient and long-lasting immunity.
A study published in PLoS ONE found that people perceive a healthy appearance when looking at faces with more oxygen-rich blood and less pale undertones. Physically fit individuals tend to have healthier-looking skin due to increased blood vessels and higher oxygen levels.
A team of scientists has developed a new method to create stem cells with embryonic-like properties without using viruses, which can trigger cancer. This approach imports necessary genes on a small DNA circle and naturally disappears from the cell population over time.
CTIP2 is a transcriptional factor controlling skin development and lipid biosynthesis, potentially playing a role in skin disorders and wrinkling. Understanding its mechanisms may provide a solution to these issues.
Scientists at Rockefeller University have uncovered a gene control mechanism that guides epidermal skin stem cells in mouse embryos, tempering the development of the skin barrier. The findings provide insights into therapeutic advances for prematurely born infants with underdeveloped skin.
A new approach to generate induced pluripotent stem (iPS) cells has been developed by Austin Smith's team. They used a single reprogramming factor called Klf4 and a transposable element called Piggybac to persuade partly specialised mouse cells to reprogram into iPS cells.
Researchers at VIB have identified a key gene that suppresses cancer across species, including humans. The Atonal gene regulates the final step of cell specialization, which is lost in cancer cells, offering new hope for therapy.
A new study describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation. Limiting the activity of a tumor suppressor protein, p53, restores cell regeneration but also advances skin cancer progression.
Researchers at the University of Wisconsin-Madison have made a breakthrough in growing functional heart cells from induced pluripotent stem cells, paving the way for potential therapies for heart failure patients. The discovery uses a virus to reprogram skin cells into embryo-like states and could potentially lead to new treatments.
A new study suggests that adult bone marrow stem cells can be used to construct artificial skin, advancing wound healing and potentially pioneering organ reconstruction. The engineered skin containing stem cells showed better healing, less wound contraction, and improved blood vessel development.
Stanford researchers have discovered a connection between two aging pathways, SIRT6 and NF-kB, which could lead to a new understanding of how cells age. The study found that SIRT6 regulates gene expression by modifying histones, making it harder for NF-kB to trigger the expression of genes associated with aging.
A new study published in the Journal of Prosthodontics found that the absence of Human calmodulin-like protein (CLP) in oral epithelial cells may indicate oral cancer. The researchers used staining to compare CLP expression in normal and cancerous tissues, revealing a significant decrease or complete lack of CLP in malignant regions.
A key gene has been identified as a factor in maintaining the potency of various stem cells, preventing them from differentiating into specialized cell types. The scrawny gene modifies chromosomal proteins to silence genes that would cause differentiation, ensuring stem cells remain undifferentiated.
Scientists at Northwestern University found that HIV can penetrate female genital tissue by moving quickly between skin cells, allowing the virus to reach immune cells. This discovery challenges the long-held assumption that the female genital tract is an efficient barrier to viral penetration.
HIV can infect immune cells in a woman's vaginal tract through the skin, not just through breaks or lesions. The virus penetrates healthy genital skin to reach its targets within four hours.
Researchers created a model that explains how genes are turned on and off by analyzing DNA sequences and transcription factor interactions. The study found that simple rules govern gene expression patterns, accounting for 65% of variation between cells.
Researchers found that stress activates immune cells, which initiate and perpetuate skin diseases. Blocking specific proteins prevented the increase in white blood cells, suggesting a key role for ICAM-1/LFA-1 interactions.
Scientists at Karolinska Institutet discovered skin stem cells can divide actively and transport themselves through skin tissue, contradicting previous assumptions. The study's findings also suggest a link between hedgehog signaling and the development of basal cell carcinoma, the most common form of skin cancer.
Researchers at UNC School of Medicine have transformed human skin cells into insulin-producing cells using pluripotent stem cell technology. This breakthrough may lead to new treatments or even a cure for the millions of people affected by diabetes.
Researchers at Monell Chemical Senses Center have discovered a unique scent associated with basal cell carcinoma, the most common form of skin cancer. By analyzing volatile organic compounds in the air above skin lesions, they found distinct profiles that could potentially be used to screen for and diagnose skin cancers at early stages.
Scientists at Harvard University have successfully created human stem cells from the skin cells of elderly ALS patients, paving the way for potential treatments. The breakthrough uses induced pluripotent stem (iPS) cells to differentiate into motor neurons, which can be studied in a lab dish to understand the disease process.
A supercomputer was used to explore the biochemical landscape and find memory switches. Researchers found nearly 4,500 reaction topologies that demonstrate switching behavior, revealing a comprehensive map of biochemical switches.
Researchers discovered a molecular alarm system in the skin that detects defects and triggers an immune response, leading to potentially harmful effects. The study found that genetic abnormalities in the skin can lead to an overproduction of white blood cells, which can be life-threatening.
Researchers found that transplanted subcutaneous fat into mice visceral cavity showed improved blood sugar and insulin levels, while visceral fat had detrimental effects. The findings suggest fat cells in different depots have intrinsically different properties.
Biologists at UC San Diego have found that mouse skin responds to low oxygen levels by regulating EPO production, a hormone that stimulates red blood cell creation. This discovery could revolutionize treatment for anemia and improve endurance athlete performance.