Articles tagged with Skin Cells
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Researchers used induced pluripotent stem cells from patients with Wolfram syndrome to model beta-cell failure. They found that protein-folding stress caused cells to fail and discovered a chemical, 4-phenyl butyric acid, that relieves this stress, potentially leading to new treatments.
Researchers at Johns Hopkins Medicine discovered that exemestane not only inhibits estrogen production but also protects cells from UV radiation, inflammation, and oxidative damage. The drug may have applications beyond breast cancer treatment.
Researchers have developed a novel, non-invasive method to measure blood sugar levels using photoacoustic spectroscopy and infrared laser light. The technology has the potential to make diabetes management easier and more reliable without pricking or using test strips.
Researchers at Kyoto University successfully induced direct conversion of human dermal fibroblasts into induced chondrogenic cells, displaying the gene pattern of chondrocytes. Transplanted cells generated hyaline cartilage tissue in immunodeficient mice without forming tumors.
Researchers have discovered how an ALS mutation kills neurons and developed a therapeutic strategy to block this neurodegeneration. They used human skin cells from patients and converted them into neurons, finding that the abnormal genetic expansion causes cell death, dysregulated gene expression, and RNA toxicity.
Human skin stem cells have been found to possess a natural internal clock, which helps them regulate functions such as UV protection in response to circadian changes. This finding could lead to new strategies for preventing premature aging and cancer.
Researchers at Johns Hopkins Medicine have identified a defect in cell communication as the likely cause of systemic sclerosis, a disease affecting approximately 100,000 people in the US. They also developed treatment strategies using compounds that target the immune response and fibrosis.
Researchers at Université Laval have developed biomaterial-free biological wound dressings made from human skin grown in vitro. These dressings successfully treated venous ulcers in patients who had been chronically suffering from such wounds, with an average healing time of seven weeks.
Researchers found that some whale species darken their skin with UV exposure, accumulating DNA damage, similar to humans. Fin whales, however, were resistant to sun damage, offering insights into evolutionary adaptations to counteract UV radiation.
Researchers at Bonn University have discovered that UV-light induced DNA damage triggers lupus-like autoimmune symptoms by activating the cGAS signaling pathway. This study provides a crucial understanding of the immune mechanism behind lupus and offers potential new therapy targets.
A structural defect in skin cells, specifically desmoglein 1, contributes to allergy development, including skin and food allergies. This finding could lead to a better understanding of the importance of other structural proteins in the skin barrier.
Researchers developed a protocol for isolating and expanding large numbers of multipotent fetal dermal cells (MFDCs) that display several advantages over adult dermal cells, including greater cellular yield after isolation and the retention of differentiation potential. The MFDCs were proven safe and efficacious in treating pediatric b...
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
Scientists at EMBL discovered that endocytosis drives changes in cell shape by remodelling the cell membrane. Cells adapt their feeding strategy to suck in long tubes of membrane, processing them into smaller vesicles.
A new study published in PNAS reveals that the TRPV4 molecule plays a key role in sunburn pain, which is caused by UVB radiation. The researchers found that blocking this molecule could provide protection against painful effects of sunburn and possibly other causes of pain.
Researchers at the University of Luxembourg's LCSB have developed a computational model that accurately predicts cell reprogramming, eliminating the need for stem cells. The breakthrough could lead to treatments for diseases like Parkinson's by repurposing healthy skin cells into functional nerve cells.
Researchers have successfully reprogrammed skin cells from patients with rare blood disorders, such as Diamond Blackfan anemia and juvenile myelomonocytic leukemia, into induced pluripotent stem cells (iPSCs). The iPSCs can be used to understand the underlying mechanisms of these diseases and test innovative treatments.
A virtual skin model developed by researchers at the University of Sheffield and PÎG has revealed that skin has 'sleeping' stem cells which can be woken up to regenerate skin, explaining why our ability to do so reduces with age. The model has implications for combating aging effects and skin cancer.
Researchers at the University of Minnesota have discovered a way to correct genetic defects in skin cells of patients with epidermolysis bullosa. They used engineered transcription activator-like effector nucleases to target and fix mutation-causing genes, resulting in the production of missing proteins in living skin models.
Scientists have developed a method to derive mature human neurons from reprogrammed skin cells, enabling direct disease modeling and customized treatments. The new approach uses astrocytes to guide the growth of neurons, leading to more effective cell differentiation and improved neural function.
Researchers at the University of Edinburgh have made a breakthrough in understanding how induced pluripotent stem cells (iPSCs) are created. They found that the process is not just a reversal of normal cell generation, but involves changes to skin cells during reprogramming. This discovery could lead to more efficient and cost-effectiv...
Researchers discovered that immune system cells and lymph capillaries regulate sodium balance and blood pressure in the skin, contrary to traditional views focusing on the kidney and brain.
A breakthrough study led by Shoukhrat Mitalipov converts human skin cells into embryonic stem cells using a variation of somatic cell nuclear transfer. The reprogrammed cells can transform into various cell types, including nerve cells, liver cells, and heart cells, without the risk of transplant rejection.
Researchers have identified CD8αα+ T cells, which reside long-term in the genital skin and mucosa, suppressing recurring outbreaks of genital herpes. These immune cells play a crucial role in preventing reactivations of the virus, making them a potential target for vaccine development.
Researchers have developed a method to convert skin cells into neural progenitor cells without passing through the pluripotent stem cell stage. This breakthrough allows for the production of specific types of neural cells, enabling rapid drug screening and modeling of neurological diseases such as ALS and spinal muscular atrophy.
Researchers have identified a new type of immune cell in the skin that plays a role in fighting parasitic invaders and could be linked to eczema. The discovery sheds light on the causes of allergic skin diseases and offers new hope for treating hundreds of millions of people worldwide.
Researchers at the University of Luxembourg have developed a computer-based method to analyze biological data and identify unique factors for 166 different human cell types. These master regulators determine cell development and distinguish between cell types, paving the way for potential cell replacement therapies.
Researchers at Stanford University School of Medicine have successfully transformed skin cells directly into oligodendrocyte precursor cells, which can insulate neurons. This breakthrough could lead to cell therapies for diseases like multiple sclerosis and spinal cord injuries.
Scientists developed a cell-based alternative test that uses mouse skin cells in the laboratory to detect skin sensitisers. The test was found to be highly accurate, correctly identifying actual sensitizers in 92% of cases and producing no false positives.
Researchers successfully transplanted neural cells derived from adult monkey skin into their brains, developing into several types of mature brain cells. The transplants showed minimal immune rejection and no signs of cancer, paving the way for potential treatment for diseases like Parkinson's.
Researchers identified a molecular 'switch' controlling skin cell migration necessary for wound closure and healing. The discovery may hold the key to developing therapeutics that reduce or prevent chronic wounds.
Researchers from P&G Beauty & Grooming present advancements in skin aging and stress sweat, including a facial moisturizer that improves uneven skin texture and a study showing niacinamide's ability to prevent and restore cellular metabolism. The findings have potential for innovation in Olay and Secret brand products.
Researchers at King's College London have developed an injection-free vaccine technique that uses dried live vaccines delivered to the skin without needles, offering a potential solution to global vaccine challenges. The technique has been shown to be effective in inducing immune responses comparable to traditional needle-based methods.
Researchers at Penn have identified innate lymphoid cells as a possible therapeutic target for treating atopic dermatitis, also known as eczema. The study found that these cells contribute to disease progression and may be regulated by different pathways in the skin.
Researchers at Harvard University have developed color-changing photonic fibers inspired by nature, which can pass through a full rainbow of colors as they're stretched. The fibers' superior mechanical properties make them versatile for various applications, including smart sports textiles and sensors.
Researchers have discovered that cells in every part of a wounded skin patch exert force to pull their neighbors along, coordinating their motions to heal the wound. This new understanding could lead to insights into the process and its long-term implications for healing and cancer research.
Researchers created stunning images of branching patterns of individual sensory nerve cells, defining ten distinct groups that likely correspond to differences in what the nerves do. The branching patterns can help scientists make sense of known responses to stimulation of the skin and may hold clues for pain management.
Researchers at the University of Michigan have made skin cells in senior citizens act like younger cells again by adding more filler to the surrounding extracellular matrix. The study shows that this approach can trigger a signal for cells to wake up and respond positively to alterations in their environment.
Scientists at Johns Hopkins Medicine have successfully used human stem cells to test how diseased cells respond to drugs, paving the way for faster and cheaper drug development. The study identified a promising compound for treating Riley-Day syndrome and demonstrated the potential for tailored treatments for individual patients.
Researchers at Yale University have discovered that genetic variations are common in the body's tissues, with 30% of skin cells harboring copy number variations. This finding has significant implications for genetic screening and our understanding of human development and disease.
A Stanford/Yale study reveals that induced-pluripotent stem cells (iPS cells) are not as genetically unstable as previously thought. The research found that the perceived changes in iPS cell genetic makeup were actually accurate reflections of existing, but previously undetected, genetic variations among human cells. This discovery is ...
Researchers found that UVB exposure changes the structure of skin cells, making them more prone to tearing under pressure and increasing the risk of cracking and chapping. Wearing sunscreen can help protect the skin's integrity.
A new study confirms a link between indoor tanning and non-melanoma skin cancer, particularly among those exposed before age 25. The research estimates that indoor tanning accounts for hundreds of thousands of new cases each year in the US alone.
A study by Columbia University ophthalmologists and stem cell researchers found that induced pluripotent stem (iPS) cells can improve the vision of blind mice, suggesting a potential treatment for macular degeneration. The iPS cells were derived from adult human skin cells and functioned as normal retina cells in the animals' old age.
Huei-Sheng Vincent Chen, PhD, receives $1.58 million CIRM Basic Biology IV award to develop personalized models of inherited heart conditions using stem cells derived from patients' own skin cells. The goal is to develop new therapies for these diseases and better understand their causes.
Researchers have found that strawberry extract acts as a protector against ultraviolet radiation, increasing cell viability and reducing DNA damage. The study's findings suggest potential photoprotective properties of anthocyanins, which are also responsible for the red color of strawberries.
Researchers found that IL-10 production by keratinocytes in donor skin is crucial for successful skin grafting between genetically identical mice. Monitoring IL-10 levels may improve therapeutic success in human patients.
Researchers at the National Institutes of Health discovered that beneficial bacteria in the skin play a crucial role in protecting the body from infection. The study found that commensal bacteria work with immune cells to fight off harmful microbes, providing new insights into the importance of skin health and microbiota.
A lipid, ceramide, helps cells find their way by keeping their antennae up, enabling direction and signal response. This function is crucial for maintaining proper cell locations, such as brain cells staying in the correct region.
Researchers derived iPS cells from patients with genetic forms of Parkinson's and found common signs of distress in neurons, including abnormalities in mitochondria. The cells' responses to treatments depended on the type of Parkinson's each patient had.
Researchers at Northwestern University have developed a novel gene regulation technology that can selectively target disease-causing genes in skin cells. The treatment uses spherical arrangements of nucleic acids to penetrate the skin and deliver therapeutics, offering new hope for life-saving therapies for skin cancers and other skin ...
Researchers have identified a molecule called regenerating islet-derived protein 3-alpha (REG3A) that is highly expressed in skin cells during psoriasis and wound-healing, but not under normal skin conditions. Inhibiting REG3A may clear up psoriasis and slow down wound-healing.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
Researchers at Gladstone Institutes successfully transformed skin cells into brain cells using Sox2 gene, potentially leading to better models for testing drugs for devastating neurodegenerative conditions. The breakthrough could accelerate drug development and reduce risks associated with human trials.
Researchers at A*STAR's Singapore Immunology Network discovered that long-lived, skin-deep immune cells called Langerhans cells originate from two distinct embryonic sites - the early yolk sac and the foetal liver. These cells play a critical role in initiating protective responses against harmful foreign invaders.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.
A new device developed by researchers in Israel can reveal vital medical information from a single drop of blood in real-time. Using spectrally encoded confocal microscopy, the device creates high-resolution images of individual blood cells flowing through veins without the need for fluorescent dyes.
Researchers reveal that Langerhans cells can perform either immunosuppressive or immunostimulatory functions depending on the situation. They found that LCs induce proliferation of regulatory T cells to maintain tolerance under normal conditions, but also stimulate protective immune responses against pathogens.
Two scientists, Elaine Fuchs and Howard Green, have been awarded the March of Dimes Prize in Developmental Biology for their groundbreaking research on skin stem cells and inherited skin disorders. Their work has saved thousands of lives and holds promise for new therapies for baldness and other diseases.
Researchers created lab-made heart cells from patients with dilated cardiomyopathy, exhibiting abnormal structure and response to calcium signals. The cells responded to beta blocker treatment and gene therapy approach, offering potential for improving drug screening and saving lives.