Articles tagged with Skin Cells
In this study, researchers identified a unique regulatory T cell population in human skin that plays a crucial role in dampening the immune response against self-antigens. However, in inflamed skin, such as in psoriasis, this population is dysfunctional and fails to suppress autoimmunity.
A team of researchers has found a link between chloracne and a molecular switch called Nrf2, which causes skin changes similar to those in dioxin victims. The study suggests that therapeutic targeting of Nrf2 may be problematic due to its role in detoxification.
Scientists have successfully engineered dermo-epidermal skin grafts that contain functional blood and lymphatic capillaries, which can rapidly supply tissue fluid and prevent accumulation. This breakthrough could improve wound healing and organ structure of these skin grafts.
A study published in PLOS ONE reveals that multiple pigment cell types from different skin layers contribute to the formation of guppies' colorful spots. The research found that transparent, reflective, and iridescent cells called iridophores play a crucial role in these patterns.
Researchers found that overproduction of SRSF6 promotes abnormal growth and prevents normal tissue repair, leading to early changes seen in skin cancer. The study suggests a new link between wound healing and cancer.
Researchers at CNIO discovered a connection between microtubules and cell-cell junctions that holds skin stem cells together to support skin architecture. This finding sheds light on the importance of cellular components in maintaining skin function and may lead to new regenerative or anti-cancer therapies.
Researchers have identified a potent antioxidant called Tiron that provides complete protection against UVA radiation and oxidative stress, offering potential benefits for anti-aging and sun-damaged skin. The study suggests that Tiron could be used to develop new skincare products or supplements, but further testing is needed.
Researchers found that a small number of transplanted stem cells was sufficient to restore normal skin function without adverse side effects. The treatment resulted in long-term restoration of normal skin, even after 80 cycles of renewal.
Scientists at King's College London have discovered two distinct types of fibroblasts in the skin, one responsible for hair growth and the other for repairing wounds. Increasing these cells may lead to new treatments for scarring and aging-related skin issues.
Scientists have identified a crucial class of neurons responsible for mosquito attraction to human skin odor, offering potential solutions for effective mosquito control. Researchers discovered that compounds targeting these neurons can inhibit the attraction of mosquitoes, paving the way for new repellents and traps.
Researchers at the University of Granada have successfully grown artificial skin using Wharton jelly mesenchymal stem cells from the umbilical cord. This breakthrough could provide instant use for burn victims, reducing the need for weeks-long growth periods.
Scientists at the Walter and Eliza Hall Institute have discovered that Langerhans cells, a single cell type thought to be behind the skin's immune defense, are actually two different types. This finding could lead to new insights into treating skin infections and skin cancers.
Researchers used induced pluripotent stem cells from patients with Wolfram syndrome to model beta-cell failure. They found that protein-folding stress caused cells to fail and discovered a chemical, 4-phenyl butyric acid, that relieves this stress, potentially leading to new treatments.
Researchers at Johns Hopkins Medicine discovered that exemestane not only inhibits estrogen production but also protects cells from UV radiation, inflammation, and oxidative damage. The drug may have applications beyond breast cancer treatment.
Researchers have developed a novel, non-invasive method to measure blood sugar levels using photoacoustic spectroscopy and infrared laser light. The technology has the potential to make diabetes management easier and more reliable without pricking or using test strips.
Researchers have discovered how an ALS mutation kills neurons and developed a therapeutic strategy to block this neurodegeneration. They used human skin cells from patients and converted them into neurons, finding that the abnormal genetic expansion causes cell death, dysregulated gene expression, and RNA toxicity.
Researchers at Kyoto University successfully induced direct conversion of human dermal fibroblasts into induced chondrogenic cells, displaying the gene pattern of chondrocytes. Transplanted cells generated hyaline cartilage tissue in immunodeficient mice without forming tumors.
Human skin stem cells have been found to possess a natural internal clock, which helps them regulate functions such as UV protection in response to circadian changes. This finding could lead to new strategies for preventing premature aging and cancer.
Researchers at Johns Hopkins Medicine have identified a defect in cell communication as the likely cause of systemic sclerosis, a disease affecting approximately 100,000 people in the US. They also developed treatment strategies using compounds that target the immune response and fibrosis.
Researchers at Université Laval have developed biomaterial-free biological wound dressings made from human skin grown in vitro. These dressings successfully treated venous ulcers in patients who had been chronically suffering from such wounds, with an average healing time of seven weeks.
Researchers found that some whale species darken their skin with UV exposure, accumulating DNA damage, similar to humans. Fin whales, however, were resistant to sun damage, offering insights into evolutionary adaptations to counteract UV radiation.
Researchers at Bonn University have discovered that UV-light induced DNA damage triggers lupus-like autoimmune symptoms by activating the cGAS signaling pathway. This study provides a crucial understanding of the immune mechanism behind lupus and offers potential new therapy targets.
A structural defect in skin cells, specifically desmoglein 1, contributes to allergy development, including skin and food allergies. This finding could lead to a better understanding of the importance of other structural proteins in the skin barrier.
Researchers developed a protocol for isolating and expanding large numbers of multipotent fetal dermal cells (MFDCs) that display several advantages over adult dermal cells, including greater cellular yield after isolation and the retention of differentiation potential. The MFDCs were proven safe and efficacious in treating pediatric b...
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
Scientists at EMBL discovered that endocytosis drives changes in cell shape by remodelling the cell membrane. Cells adapt their feeding strategy to suck in long tubes of membrane, processing them into smaller vesicles.
A new study published in PNAS reveals that the TRPV4 molecule plays a key role in sunburn pain, which is caused by UVB radiation. The researchers found that blocking this molecule could provide protection against painful effects of sunburn and possibly other causes of pain.
Researchers at the University of Luxembourg's LCSB have developed a computational model that accurately predicts cell reprogramming, eliminating the need for stem cells. The breakthrough could lead to treatments for diseases like Parkinson's by repurposing healthy skin cells into functional nerve cells.
Researchers have successfully reprogrammed skin cells from patients with rare blood disorders, such as Diamond Blackfan anemia and juvenile myelomonocytic leukemia, into induced pluripotent stem cells (iPSCs). The iPSCs can be used to understand the underlying mechanisms of these diseases and test innovative treatments.
A virtual skin model developed by researchers at the University of Sheffield and PÎG has revealed that skin has 'sleeping' stem cells which can be woken up to regenerate skin, explaining why our ability to do so reduces with age. The model has implications for combating aging effects and skin cancer.
Scientists have developed a method to derive mature human neurons from reprogrammed skin cells, enabling direct disease modeling and customized treatments. The new approach uses astrocytes to guide the growth of neurons, leading to more effective cell differentiation and improved neural function.
Researchers at the University of Minnesota have discovered a way to correct genetic defects in skin cells of patients with epidermolysis bullosa. They used engineered transcription activator-like effector nucleases to target and fix mutation-causing genes, resulting in the production of missing proteins in living skin models.
Researchers at the University of Edinburgh have made a breakthrough in understanding how induced pluripotent stem cells (iPSCs) are created. They found that the process is not just a reversal of normal cell generation, but involves changes to skin cells during reprogramming. This discovery could lead to more efficient and cost-effectiv...
Researchers discovered that immune system cells and lymph capillaries regulate sodium balance and blood pressure in the skin, contrary to traditional views focusing on the kidney and brain.
A breakthrough study led by Shoukhrat Mitalipov converts human skin cells into embryonic stem cells using a variation of somatic cell nuclear transfer. The reprogrammed cells can transform into various cell types, including nerve cells, liver cells, and heart cells, without the risk of transplant rejection.
Researchers have identified CD8αα+ T cells, which reside long-term in the genital skin and mucosa, suppressing recurring outbreaks of genital herpes. These immune cells play a crucial role in preventing reactivations of the virus, making them a potential target for vaccine development.
Researchers have developed a method to convert skin cells into neural progenitor cells without passing through the pluripotent stem cell stage. This breakthrough allows for the production of specific types of neural cells, enabling rapid drug screening and modeling of neurological diseases such as ALS and spinal muscular atrophy.
Researchers have identified a new type of immune cell in the skin that plays a role in fighting parasitic invaders and could be linked to eczema. The discovery sheds light on the causes of allergic skin diseases and offers new hope for treating hundreds of millions of people worldwide.
Researchers at the University of Luxembourg have developed a computer-based method to analyze biological data and identify unique factors for 166 different human cell types. These master regulators determine cell development and distinguish between cell types, paving the way for potential cell replacement therapies.
Researchers at Stanford University School of Medicine have successfully transformed skin cells directly into oligodendrocyte precursor cells, which can insulate neurons. This breakthrough could lead to cell therapies for diseases like multiple sclerosis and spinal cord injuries.
Scientists developed a cell-based alternative test that uses mouse skin cells in the laboratory to detect skin sensitisers. The test was found to be highly accurate, correctly identifying actual sensitizers in 92% of cases and producing no false positives.
Researchers successfully transplanted neural cells derived from adult monkey skin into their brains, developing into several types of mature brain cells. The transplants showed minimal immune rejection and no signs of cancer, paving the way for potential treatment for diseases like Parkinson's.
Researchers identified a molecular 'switch' controlling skin cell migration necessary for wound closure and healing. The discovery may hold the key to developing therapeutics that reduce or prevent chronic wounds.
Researchers from P&G Beauty & Grooming present advancements in skin aging and stress sweat, including a facial moisturizer that improves uneven skin texture and a study showing niacinamide's ability to prevent and restore cellular metabolism. The findings have potential for innovation in Olay and Secret brand products.
Researchers at King's College London have developed an injection-free vaccine technique that uses dried live vaccines delivered to the skin without needles, offering a potential solution to global vaccine challenges. The technique has been shown to be effective in inducing immune responses comparable to traditional needle-based methods.
Researchers at Penn have identified innate lymphoid cells as a possible therapeutic target for treating atopic dermatitis, also known as eczema. The study found that these cells contribute to disease progression and may be regulated by different pathways in the skin.
Researchers at Harvard University have developed color-changing photonic fibers inspired by nature, which can pass through a full rainbow of colors as they're stretched. The fibers' superior mechanical properties make them versatile for various applications, including smart sports textiles and sensors.
Researchers have discovered that cells in every part of a wounded skin patch exert force to pull their neighbors along, coordinating their motions to heal the wound. This new understanding could lead to insights into the process and its long-term implications for healing and cancer research.
Researchers created stunning images of branching patterns of individual sensory nerve cells, defining ten distinct groups that likely correspond to differences in what the nerves do. The branching patterns can help scientists make sense of known responses to stimulation of the skin and may hold clues for pain management.
Researchers at the University of Michigan have made skin cells in senior citizens act like younger cells again by adding more filler to the surrounding extracellular matrix. The study shows that this approach can trigger a signal for cells to wake up and respond positively to alterations in their environment.
Scientists at Johns Hopkins Medicine have successfully used human stem cells to test how diseased cells respond to drugs, paving the way for faster and cheaper drug development. The study identified a promising compound for treating Riley-Day syndrome and demonstrated the potential for tailored treatments for individual patients.
A Stanford/Yale study reveals that induced-pluripotent stem cells (iPS cells) are not as genetically unstable as previously thought. The research found that the perceived changes in iPS cell genetic makeup were actually accurate reflections of existing, but previously undetected, genetic variations among human cells. This discovery is ...
Researchers at Yale University have discovered that genetic variations are common in the body's tissues, with 30% of skin cells harboring copy number variations. This finding has significant implications for genetic screening and our understanding of human development and disease.
Researchers found that UVB exposure changes the structure of skin cells, making them more prone to tearing under pressure and increasing the risk of cracking and chapping. Wearing sunscreen can help protect the skin's integrity.
A new study confirms a link between indoor tanning and non-melanoma skin cancer, particularly among those exposed before age 25. The research estimates that indoor tanning accounts for hundreds of thousands of new cases each year in the US alone.
A study by Columbia University ophthalmologists and stem cell researchers found that induced pluripotent stem (iPS) cells can improve the vision of blind mice, suggesting a potential treatment for macular degeneration. The iPS cells were derived from adult human skin cells and functioned as normal retina cells in the animals' old age.
Huei-Sheng Vincent Chen, PhD, receives $1.58 million CIRM Basic Biology IV award to develop personalized models of inherited heart conditions using stem cells derived from patients' own skin cells. The goal is to develop new therapies for these diseases and better understand their causes.
Researchers have found that strawberry extract acts as a protector against ultraviolet radiation, increasing cell viability and reducing DNA damage. The study's findings suggest potential photoprotective properties of anthocyanins, which are also responsible for the red color of strawberries.
Researchers found that IL-10 production by keratinocytes in donor skin is crucial for successful skin grafting between genetically identical mice. Monitoring IL-10 levels may improve therapeutic success in human patients.
Researchers at the National Institutes of Health discovered that beneficial bacteria in the skin play a crucial role in protecting the body from infection. The study found that commensal bacteria work with immune cells to fight off harmful microbes, providing new insights into the importance of skin health and microbiota.