Articles tagged with Skin Cells
Chronic wounds like bedsores affect millions in US, causing widespread infections and limb amputations. Researchers found skin cells get stuck in healing process due to overabundance of c-myc, a molecule that suppresses cell migration and causes thickened layers around the wound.
A new study at the University of Wisconsin-Madison has streamlined a method for making large quantities of human papillomavirus, a major human pathogen. The technique allows scientists to culture any of the virus's 100 subtypes and genetically manipulate it, enabling faster development of therapeutic drugs and new vaccines.
Scientists have made a significant breakthrough in understanding pemphigus, a deadly skin blistering disease. Researchers engineered antibodies that reproduce the disease in vitro and in mice, offering a new opportunity for targeted therapy development.
Researchers found a defect in the ATP2C1 gene causing type 2 mosaicism in Hailey-Hailey disease. Skin cells from patterned lesions possessed the mutant gene, while others had the normal chromosome.
Researchers discovered a complete deficiency in the CD3 epsilon chain of the T cell receptor causes SCID, leading to normal B cells but no T cells development. The absence of this chain blocks T cell development at a specific stage in the thymus.
A new study reveals that sanguinarine enhances protein production inducing cell death and restricts pro-proliferation proteins, potentially protecting against UV radiation-induced skin cancer. Topical application of sanguinarine with sunscreen may also be effective in preventing skin cancer.
Scientists found that people with psoriasis have transit amplifying cells divide without signal, leading to rapid skin renewal and increased cell layers. This discovery may lead to new treatments for the disease, which affects 300,000 people in the Netherlands.
A U-M team, led by Dr. Stephen Feinberg, is engineering tissue grafts to treat mouth wounds in patients with diabetes or undergoing chemotherapy. The grafts, made from a combination of mucosal cells and AlloDerm, show promise for smaller donor sites and faster healing times.
Researchers found that bone marrow-derived cells cluster within the healing area of a wound, producing collagen type III, a key component of skin. This discovery suggests new ways to treat serious wounds, as these cells also maintain the matrix environment and integrity of the skin.
Researchers at Rockefeller University have successfully isolated a single mouse skin cell that can differentiate into various epidermal tissues, including hair and sebaceous glands. The study's findings hold promise for potential future applications in treating human skin and hair conditions.
Researchers have identified stem cells in skin that can self-renew and differentiate into multiple cell types, offering new insights into regenerative medicine. The discovery holds promise for treating hair loss and wound healing.
Researchers isolated stem cells from the bulge of hair follicles in hairless mice, finding two distinct populations that can produce hair follicles. These stem cells also showed 'stemness' genes, indicating their ability to self-renew and differentiate into various cell types.
The green tea gum helps eliminate free radicals that can damage DNA and lead to cancer. It also protects healthy cells by targeting cancer cells for destruction.
Researchers found minor molecular abnormalities in Huntington's disease cells, but only specific groups degenerate and die. The study suggests that therapies for neurodegenerative diseases like Alzheimer's and Parkinson's may need to address multiple cellular processes.
Researchers have successfully generated nerve precursor cells from adult skin cells using a two-step process involving soluble agents called growth factors. This breakthrough raises the possibility of generating nerve cells from an individual's own skin cells, overcoming issues of rejection.
Scientists Gary Bokoch and colleagues discovered the mechanism by which Rac is released from RhoGDI, revealing a critical role for p21-activated kinase (Pak) in regulating cell motility. This breakthrough offers insights into tumor growth, immune responses, and neurological diseases.
Researchers discover that Kaposi's sarcoma virus can reprogram blood vessel endothelial cells into lymphatic cells, driven by the gene Prox1. This finding provides a potential target for new therapies against the disease.
Researchers at Stanford Medicine identified Langerhans cells as the principal culprit behind graft-versus-host disease (GVHD) in transplanted mice. Eliminating these cells using ultraviolet light reduced GVHD symptoms, offering a potential prevention method for transplant patients.
A new study found that even a small amount of psoriasis can significantly affect daily life, impacting over 4.5 million Americans with the disease. Psoriasis patients often feel like their condition is a burden and are dissatisfied with treatment options.
A recent study provides new hope for understanding autoimmune diseases like pemphigus foliaceus by identifying an inexpensive blood test that can detect antibodies and intervene to halt disease progression. Environmental factors, including mercury exposure, ultraviolet radiation, and female hormones, are also being investigated as pote...
A recent study found that efalizumab, a new biologic drug, significantly improves psoriasis symptoms and quality of life for adult patients. The treatment reduced the frequency and severity of itching and scaling, offering a potential breakthrough for those suffering from this chronic skin condition.
A new system has been developed to identify and isolate stem cells, providing a key to understanding regenerative medicine. The discovery offers promise for treating skin injuries, hair loss, and other conditions by identifying stem cells that can create tissue as needed.
Researchers used endothelial progenitor cells from bone marrow to repair damaged blood vessels in rats with pulmonary arterial hypertension (PAH), reducing systolic pressure and improving microcirculation. The study suggests a regenerative approach that could lead to a new clinical therapy for this devastating disease.
Researchers at Thomas Jefferson University have identified a new cell type, the dermal dendrocyte, that increases in number in tumors of early human Kaposi's sarcoma. The discovery offers a potential tool for studying the disease and its connection to abnormal wound healing and other conditions.
Researchers have made significant progress in isolating skin stem cells, with the discovery that these cells can be found in the basal epidermis layer. This breakthrough has the potential to treat wounds, including burns, by transplanting stem cells directly onto the damaged area.
Researchers used a gene gun to target dendritic cells, the 'security cameras' of the immune system, and found that their number is 100 times higher than previously thought. This discovery could lead to more efficient vaccine development using abundant, long-lived dendritic cells.
Researchers uncover unexpected new role for GATA-3 in hair follicle development, shedding light on parallel molecular cues between skin and immune systems. GATA-3-deficient mice exhibit severe structural anomalies in hair development, including bent whiskers and irregular thickenings.
Researchers discover genetic connection between hair and hair channels, finding that GATA-3 is crucial for hair channel development. Without this protein, mice grew short and stubby coats, highlighting the importance of the hair channel for proper hair growth.
Researchers at UC San Diego discovered that a protein essential for fruit fly embryonic development also plays a crucial role in mammalian wound healing. The study reveals that the loss of this protein causes skin cells to bunch up and stall, leading to slower wound healing rates.
Researchers used a laser scalpel to dissect fruit fly tissue and understand the complex process of dorsal closure, which is crucial for human spinal malformation prevention. The team's findings showed that the system is resilient and can compensate for individual tissue disruptions.
Researchers found that a small region of tissue at the front edge of what in humans would be the upper lip controls development of the upper half of the face. Facial tissues remain responsive to their environment for about nine weeks, or through most of the first trimester.
Researchers have identified two natural proteins, Wnt and noggin, that promote the development of hair follicles in stem cells. These proteins work together to change the stem cell's shape and separate from adjoining cells, a crucial step for hair growth.
A recent study found that white tea extract protects the skin's immune system by preventing oxidative stress. The extract also limits DNA damage and promotes anti-aging benefits, suggesting potential protection against skin cancer.
Researchers have found that topical retinoids, such as tazarotene, may be a safer alternative for preventing skin cancer in individuals at risk. The study used mice with basal cell nevus syndrome, a genetic disorder that predisposes them to developing large numbers of basal cell carcinomas.
A novel gene therapy technique developed by Stanford researchers allows for the integration of large genes into human chromosomes, enabling continuous production of proteins. This technique has the potential to treat a variety of diseases, including Duchenne's muscular dystrophy and cystic fibrosis.
A new study investigates blood flow in toads' pelvic skin while absorbing water, finding a significant increase in red cell velocity prior to water exposure and a seven-fold increase within one minute. The results support the initial hypothesis that increased blood flow is associated with water absorption behavior.
A team of researchers discovered a protein that controls animal cell fusion, which is crucial for proper development and tissue formation. The study found that mutations in this gene lead to birth defects and organ malformations, highlighting the importance of understanding the fusion mechanism.
A new study found that individuals who used tanning devices were 2.5 times more likely to develop squamous cell carcinoma and 1.5 times more likely to develop basal cell carcinoma compared to those who did not use them. The risk of these cancers increased with the age at which participants started using tanning devices.
Biologists at UCSD observed a protein gradient in developing fruit fly embryos that triggers division into nervous system and epidermis. The findings confirm Alan Turing's hypothesis from the 1950s, providing insights into embryonic development.
Researchers at UT Southwestern Medical Center have developed a new procedure for delivering vaccines by manipulating dendritic cells in the skin, reducing production time from 10 days to just 24 hours. This breakthrough could lead to more effective cancer treatments and broader clinical applications.
Researchers at University of Pittsburgh identified Langerhans cell precursors that can be targeted to initiate or down-regulate the immune response, potentially leading to novel treatments for asthma and transplant rejection. The discovery could also enhance vaccine development.
Researchers found that gamma-delta T cells play a crucial role in local immunity and can kill tumor cells by expressing NKG2d protein. In contrast, alpha-beta T cells surprisingly promote skin cancer development and progression in models of skin cancer.
QSulf1 enables embryonic cells to express muscle-specific proteins by modifying signaling co-factors. This discovery sheds light on the complex process of cell differentiation and has implications for regenerative medicine.
Scientists at the University of Illinois have developed a novel laser technique to study chromatin movement in living cells. By measuring the movement of DNA, they found evidence of subdiffusion within the cell nucleus, suggesting that molecular crowding is crucial for life.
Researchers at UC Davis successfully cloned the first calf using a skin cell from an adult cow, but unfortunately, the calf died just three days after birth. The cloning technique holds promise for improving meat and milk production, with ongoing research aiming to overcome existing challenges.
A study by University of Illinois researchers has identified a mechanism that determines whether pigment moves within cells. The discovery reveals that the motor protein is disengaged as a result of phosphorylation during cell division. If confirmed, this finding could lead to new cancer treatments targeting specific mechanisms.
The skin's acid coating, composed of fatty acids, helps maintain strength and cohesiveness. The discovery could aid in developing therapies for skin problems like psoriasis.
Researchers have identified a pivotal early event in breast cancer development, where mammary epithelial cells spontaneously surmount senescence and acquire genomic instability. This finding could lead to new targets for very early detection and treatment of breast cancer, as well as broader implications for understanding carcinogenesis.
Researchers have discovered a new protein component that controls calcium entry into cells and activates itself and other proteins, making it a potential new drug target for diseases like cancer and heart conditions. The protein, TRP-PLIK, is present in many tissues and its unique dual function has sparked interest among scientists.
Researchers at Dana-Farber Cancer Institute uncovered how retroviruses like HIV make their escape from infected cells by using ubiquitin and a viral segment called the late domain. This study sheds light on previously unknown aspects of viral assembly and budding, potentially leading to new techniques for arresting viral spread.
Carolina scientists have identified and purified hepatic stem cells, which can regenerate liver and bile duct tissue. The accomplishment marks a milestone for future liver regeneration through cellular therapy, potentially reducing the need for whole-organ transplants in patients with various liver diseases.
Researchers identified a protein in vertebrates that detects cell salt concentration and regulates its balance. The discovery may lead to improved treatment of kidney disorders and high blood pressure.
A study published in Cancer Research reveals that a gene called RhoC GTPase contributes to the development of an aggressive and deadly form of breast cancer. The research found that overexpression of this gene in normal cells leads to rapid tumor growth, invasion, and metastasis.
Researchers at Howard Hughes Medical Institute successfully directed human embryonic stem cells to differentiate into three germ layers: ectodermal (brain, skin), mesodermal (muscle) and endodermal (liver and pancreas). The study suggests that a combination of growth factors may be needed to achieve specific cell lineages.
Researchers have identified key molecules on the surface of blood cells that guide them to their rightful targets in the body's tissues. This process, known as cell trafficking, is crucial for the proper function of the immune response and helps prevent cancerous cells from spreading.
Researchers at BresaGen are working on developing cell-based therapies for Parkinson's Disease and genetic diseases using human embryonic stem cells. The company is focusing on deriving stem cells from normal adult cells to overcome ethical concerns.
Researchers at UC Davis discovered that multiple protein-based motors work together to build the spindle and move chromosomes during cell division. This new understanding of cellular machines could help prevent or treat disorders related to cell-division defects.
A plant compound, cyclopamine, has been found to block the action of mutated cancer genes that produce basal cell skin carcinomas. The drug may be used to treat various types of cancers, including medulloblastomas in the brain and rhabdomyosarcomas in muscle.
A protein called Wnt-10b appears to help prevent fat formation by quieting two molecules that promote it. The discovery offers fundamental new information on obesity and may suggest targets for anti-obesity drugs.
A new study finds that the 'cell crisis' theory explains why certain cancers become more common with age. Genetic mutations cause cells to divide uncontrollably after telomeres shorten, leading to cancer development.