Articles tagged with Genetic Interaction
A study found that naltrexone increased the urge to drink in individuals with a positive family history, suggesting genetic factors at play. The OPRM1 gene was identified as a key genetic moderator of naltrexone's effects on alcohol cue reactivity.
Scientists have discovered that an enzyme called RNA-dependent RNA polymerase is needed for paramutation, a phenomenon where one version of a gene can order another to act differently. This finding has significant implications for breeding better crop plants and unraveling complex genetic diseases, including some human health conditions.
A comprehensive literature-derived database of yeast interactions has been created, containing over 22,000 protein interactions and 11,000 genetic interactions. The database is publicly available and enables researchers to gain further insight into individual gene functions and biological network features in yeast.
Researchers identified a genetic network in yeast that guards against lethal DNA damage, which could lead to new therapies for human diseases such as cancer and aging. The study used a technology called dSLAM to map the interactions between genes involved in DNA repair, replication, and cell cycle progression.
Recent genetic epidemiology studies have empirically supported Mayr's ideas on genetic interaction and its impact on evolutionary change. These studies show that genes interact extensively, leading to a strong interaction between natural selection and genetic drift, resulting in 'genetic revolution.'
E-MAP technique enables researchers to analyze epistatic interactions between genes in a systematic way, revealing new insights into protein functions and evolutionary processes. By quantifying the effects of interacting mutant genes, E-MAPs help optimize drug treatments and improve our understanding of biological systems.
Researchers discovered a genetic basis for idiopathic pulmonary fibrosis, with those having ever smoked cigarettes being 3.6 times more likely to develop the disease. The study also highlights the importance of avoiding cigarette smoking as a preventive measure for this devastating lung condition.
A study by University of Florida researchers found that certain gene variants interact with physical activity to affect mobility in seniors. Those with specific genes, such as the DD genotype, were more likely to remain mobile and experienced less decline, even among those who exercised regularly.
The study found that complex gene-gene interactions are likely responsible for the development of autism. The GABA brain system is implicated in this process, with multiple genes working together to influence the disease.
Researchers found that asthma is caused by the interaction of multiple genetic loci, contradicting earlier studies that suggested a single-gene solution. The study used an elaborate mouse model to identify specific regions on chromosomes 2 and 6 associated with airway hyperresponsiveness.
Professor Carsten Peterson and his team demonstrate how genes interact to produce stable systems, using the fruit fly as a model organism. They found that canalyzing rules, where one controlling gene activates another without affecting it, are present in almost 200 genetic networks in fruit flies.
Scientists found that Condensin compacts DNA against a weak stretching force, but increasing the force reverses compaction. The researchers observed jumps in distance between DNA ends during compaction and decompaction.
Researchers mapped yeast genetic interaction networks, finding that genes interact in 'neighbourhoods' and predicting traits. The study provides new insights into how genes contribute to human disease.
A Cardiff-based team investigates the impact of genetic testing on insurance costs and behavior in the UK. They gather data on families affected by inherited diseases to determine the potential for adverse selection and its effect on insurance claims and premiums.
Researchers have identified the first genetic loci associated with aerobic capacity in rats, revealing a complex relationship between inherited traits and exercise. The study used a genome scan to find quantitative trait loci (QTLs) linked to aerobic running capacity and found significant associations on chromosomes RNO16 and RNO8.
The pituitary gland develops from a common primordium into multiple endocrine cell types through intricate signaling and nuclear events. Researchers describe the complex interactions of transcriptional regulatory factors controlling this process.
Researchers have created a comprehensive map of yeast protein interactions, revealing intriguing connections between proteins involved in different cellular processes. The network analysis suggests that these interactions can aid in predicting protein functions and uncovering new hypotheses about gene function.
Streptococcal bacteria use the bacterial capsule containing hyaluronic acid to bind to epithelial cells of the pharynx and cause sore throats. Suppression of CD44 levels or use of antibodies/ exogenous hyaluronic acid can block this interaction.